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2022 Update-Veterinary Drugs & Uses
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
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L1000
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
kojic acid 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
3977
501-30-4
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
kojic acid
5-Hydroxy-2-hydroxymethyl-4H-pyran-4-one
Molecular weight: 142.11
Formula: C6H6O4
CLOGP: -1.39
LIPINSKI: 0
HAC: 4
HDO: 2
TPSA: 66.76
ALOGS: -0.19
ROTB: 1
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
CHEBI has role
CHEBI:59997
tyrosinase inhibitors
CHEBI has role
CHEBI:73240
NF-kappaB inhibitors
CHEBI has role
CHEBI:76956
Aspergillus metabolites
CHEBI has role
CHEBI:85046
skin lightening agents
CHEBI has role
CHEBI:85049
EC 1.10.3.1 inhibitors
CHEBI has role
CHEBI:85050
laccase inhibitors
CHEBI has role
CHEBI:85051
quercetin 2,3-dioxygenase inhibitor
CHEBI has role
CHEBI:85052
D-amino-acid oxidase inhibitors
MeSH PA
D000975
Antioxidants
MeSH PA
D020011
Protective Agents
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
8.13
acidic
pKa2
12.5
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Tyrosinase
Enzyme
P14679
TYRO_HUMAN
IC50
5.13
CHEMBL
D-amino-acid oxidase
Enzyme
P14920
OXDA_HUMAN
IC50
5.70
CHEMBL
Polyphenol oxidase 2
Enzyme
PPO2_AGABI
Ki
4.65
CHEMBL
D-amino-acid oxidase
Unclassified
OXDA_PIG
Ki
4.68
CHEMBL
Tyrosinase
Enzyme
TYRO_MOUSE
IC50
4.21
CHEMBL
Polymerase acidic protein
Enzyme
PA_I34A1
IC50
4.91
CHEMBL
Tyrosinase
Unclassified
B2ZB02_BACME
IC50
4.28
CHEMBL
Polyphenol oxidase 1
Enzyme
PPO1_AGABI
IC50
4.82
CHEMBL
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External reference:
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ID
Source
007822
NDDF
1426451
RXNORM
3840
PUBCHEM_CID
6K23F1TT52
UNII
C0064401
UMLSCUI
C011890
MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:43572
CHEBI
CHEMBL287556
ChEMBL_ID
DB01759
DRUGBANK_ID
KOJ
PDB_CHEM_ID
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Pharmaceutical products:
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Product
Category
Ingredients
NDC
Form
Quantity
Route
Marketing
Label
AnubisMed
HUMAN OTC DRUG LABEL
14
83021-401
LIQUID
2.50 g
TOPICAL
OTC monograph final
9 sections
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kojic acid