kojic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3977 | 501-30-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000975 | Antioxidants |
| MeSH PA | D020011 | Protective Agents |
| CHEBI has role | CHEBI:59997 | tyrosinase inhibitors |
| CHEBI has role | CHEBI:73240 | NF-kappaB inhibitors |
| CHEBI has role | CHEBI:76956 | Aspergillus metabolites |
| CHEBI has role | CHEBI:85046 | skin lightening agents |
| CHEBI has role | CHEBI:85049 | EC 1.10.3.1 inhibitors |
| CHEBI has role | CHEBI:85050 | laccase inhibitors |
| CHEBI has role | CHEBI:85051 | quercetin 2,3-dioxygenase inhibitor |
| CHEBI has role | CHEBI:85052 | D-amino-acid oxidase inhibitors |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.13 | acidic |
| pKa2 | 12.5 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Tyrosinase | Enzyme | IC50 | 5.13 | CHEMBL | |||||
| D-amino-acid oxidase | Enzyme | IC50 | 5.70 | CHEMBL | |||||
| Polyphenol oxidase 2 | Enzyme | Ki | 4.65 | CHEMBL | |||||
| D-amino-acid oxidase | Unclassified | Ki | 4.68 | CHEMBL | |||||
| Tyrosinase | Enzyme | IC50 | 4.21 | CHEMBL | |||||
| Polymerase acidic protein | Enzyme | IC50 | 4.91 | CHEMBL | |||||
| Tyrosinase | Unclassified | IC50 | 4.28 | CHEMBL | |||||
| Polyphenol oxidase 1 | Enzyme | IC50 | 4.82 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| C0064401 | UMLSCUI |
| CHEBI:43572 | CHEBI |
| KOJ | PDB_CHEM_ID |
| CHEMBL287556 | ChEMBL_ID |
| DB01759 | DRUGBANK_ID |
| 3840 | PUBCHEM_CID |
| C011890 | MESH_SUPPLEMENTAL_RECORD_UI |
| 6K23F1TT52 | UNII |
| 1426451 | RXNORM |
| NOCODE | MMSL |
| 007822 | NDDF |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| AnubisMed | HUMAN OTC DRUG LABEL | 14 | 83021-401 | LIQUID | 2.50 g | TOPICAL | OTC monograph final | 9 sections |