kojic acid indications/contra

Stem definitionDrug idCAS RN
3977 501-30-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • kojic acid
  • 5-Hydroxy-2-hydroxymethyl-4H-pyran-4-one
  • Molecular weight: 142.11
  • Formula: C6H6O4
  • CLOGP: -1.39
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 66.76
  • ALOGS: -0.19
  • ROTB: 1

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
CHEBI has role CHEBI:85046 skin lightening agent
MeSH PA D000975 Antioxidants
MeSH PA D020011 Protective Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.13 acidic
pKa2 12.5 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D-amino-acid oxidase Enzyme IC50 5.70 CHEMBL
Tyrosinase Enzyme IC50 5.13 CHEMBL
D-amino-acid oxidase Unclassified Ki 4.68 CHEMBL
Tyrosinase Unclassified IC50 4.21 CHEMBL
Polyphenol oxidase 2 Enzyme Ki 4.65 CHEMBL

External reference:

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IDSource
CHEBI:43572 CHEBI
C0064401 UMLSCUI
6K23F1TT52 UNII
CHEMBL287556 ChEMBL_ID
NOCODE MMSL
1426451 RXNORM
007822 NDDF
C011890 MESH_SUPPLEMENTAL_RECORD_UI
DB01759 DRUGBANK_ID
3840 PUBCHEM_CID
KOJ PDB_CHEM_ID

Pharmaceutical products:

None