kojic acid đŸ¶ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3977 501-30-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • kojic acid
  • 5-Hydroxy-2-hydroxymethyl-4H-pyran-4-one
  • Molecular weight: 142.11
  • Formula: C6H6O4
  • CLOGP: -1.39
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 2
  • TPSA: 66.76
  • ALOGS: -0.19
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.425 Moderate 0.67
caco2-efflux Caco-2 efflux ratio (BA/AB) 1.429 Moderate 0.67
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 8.222 10^-6 cm/s Moderate 0.67
dh-clint Dog hepatocyte intrinsic clearance 1.652 uL/min/10^6 cells Moderate 0.67
dppb Dog plasma protein binding (% unbound) 75.470 % Moderate 0.67
fcs-ppb Fetal calf serum protein binding (% unbound) 77.780 % Moderate 0.67
herg hERG pIC50 4.127 pIC50 Moderate 0.67
hh-clint Human hepatocyte intrinsic clearance 2.612 uL/min/10^6 cells Moderate 0.67
hlm-clint Human liver microsomal intrinsic clearance 3.228 uL/min/mg protein Moderate 0.67
hppb Human plasma protein binding (% unbound) 60.820 % Moderate 0.67
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,ALK,AURKA,AURKB,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK2,CDK4,CDK5,CDK9,CHEK1,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IGF1R,IKBKB,IRAK1,ITK,JAK1,JAK2,JAK3,KDR,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MARK4,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIM1,PIM2,PLK1,PLK2,PLK3,PLK4,PRKCD,PRKDC,PTK2,SGK1,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 81
kinase-selectivity-class ACVR2A,ACVR2B,ACVRL1,AURKB,AXL,BMX,BRAF,CAMK2B,CAMK2D,CDK4,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,IRAK1,JAK2,KIT,MAP2K6,MAP3K14,MAPK1,MAPK12,MAPK7,MAPK8,MARK4,PIK3CA,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK 36
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 2.133 Moderate 0.67
mh-clint Mouse hepatocyte intrinsic clearance 31.915 Moderate 0.67
mppb Mouse plasma protein binding (% unbound) 87.570 Moderate 0.67
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.199 Moderate 0.67
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 53.510 % Moderate 0.67
rh-clint Rat hepatocyte intrinsic clearance 11.885 uL/min/10^6 cells Moderate 0.67
rh-fuinc Rat hepatocyte fraction unbound in incubation 97.360 % Moderate 0.67
rppb Rat plasma protein binding (% unbound) 46.320 % Moderate 0.67
solubility-dd Solubility at pH 7.4 in DMSO 1142.878 uM Moderate 0.67

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
MeSH PA D000975 Antioxidants
MeSH PA D020011 Protective Agents
CHEBI has role CHEBI:59997 EC 1.14.18.1 (tyrosinase) inhibitor
CHEBI has role CHEBI:73240 NF-ÎșB inhibitor
CHEBI has role CHEBI:76956 <em>Aspergillus </em> metabolite
CHEBI has role CHEBI:85046 skin lightening agent
CHEBI has role CHEBI:85049 EC 1.10.3.1 (catechol oxidase) inhibitor
CHEBI has role CHEBI:85050 EC 1.10.3.2 (laccase) inhibitor
CHEBI has role CHEBI:85051 EC 1.13.11.24 (quercetin 2,3-dioxygenase) inhibitor
CHEBI has role CHEBI:85052 EC 1.4.3.3 (<small>D</small>-amino-acid oxidase) inhibitor

Drug Use | Suggest Off label Use Form| |View source of the data|

None




đŸ¶ Veterinary Drug Use

None

đŸ¶ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.13 acidic
pKa2 12.5 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Tyrosinase Enzyme IC50 5.13 CHEMBL
D-amino-acid oxidase Enzyme IC50 5.70 CHEMBL
Polyphenol oxidase 2 Enzyme Ki 4.65 CHEMBL
D-amino-acid oxidase Enzyme Ki 4.68 CHEMBL
Tyrosinase Enzyme IC50 4.21 CHEMBL
Polymerase acidic protein Enzyme IC50 4.91 CHEMBL
Tyrosinase Enzyme IC50 4.28 CHEMBL
Polyphenol oxidase 1 Enzyme IC50 4.82 CHEMBL

External reference:

IDSource
C0064401 UMLSCUI
CHEBI:43572 CHEBI
KOJ PDB_CHEM_ID
CHEMBL287556 ChEMBL_ID
DB01759 DRUGBANK_ID
3840 PUBCHEM_CID
C011890 MESH_SUPPLEMENTAL_RECORD_UI
6K23F1TT52 UNII
1426451 RXNORM
NOCODE MMSL
007822 NDDF
6K23F1TT52 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
MELAO Whitening Cream HUMAN OTC DRUG LABEL 3 74458-134 CREAM 0.70 g TOPICAL OTC Monograph Drug 10 sections
GZE KOJIC ACID CORRECTOR SERUM HUMAN OTC DRUG LABEL 3 74458-315 CAPSULE 1.30 g TOPICAL OTC Monograph Drug 10 sections
GZE KOJIC ACID TURMERIC CLEANSING PADS HUMAN OTC DRUG LABEL 3 74458-351 PATCH 0.80 g TOPICAL OTC Monograph Drug 11 sections
MELAO Kojic Acid BodyLotion HUMAN OTC DRUG LABEL 2 74458-357 LOTION 0.50 g TOPICAL OTC Monograph Drug 10 sections
GZE Lemon Turmeric Kojic Acid LiquidSoap HUMAN OTC DRUG LABEL 1 74458-404 LIQUID 0.60 g TOPICAL OTC Monograph Drug 11 sections
AnubisMed HUMAN OTC DRUG LABEL 14 83021-401 LIQUID 2.50 g TOPICAL OTC monograph final 9 sections
Deodorant Underarms Body Skin HUMAN OTC DRUG LABEL 1 84019-008 PASTE 1 g CUTANEOUS OTC Monograph Drug 11 sections
Kojic Acid Turmeric Cleansing Pads HUMAN OTC DRUG LABEL 1 84019-015 CLOTH 100 mg CUTANEOUS OTC Monograph Drug 8 sections
TurmericKojicSoap HUMAN OTC DRUG LABEL 1 84019-017 SOAP 100 mg CUTANEOUS OTC Monograph Drug 8 sections
KOJIC ACID Cream HUMAN OTC DRUG LABEL 2 84025-095 CREAM 5 mg CUTANEOUS OTC Monograph Drug 5 sections
Firming NeckStick HUMAN OTC DRUG LABEL 2 84025-102 CREAM 5 mg CUTANEOUS OTC Monograph Drug 5 sections
GLYCOLIC ACID PADS HUMAN OTC DRUG LABEL 2 84025-162 DRESSING 5 mg CUTANEOUS OTC Monograph Drug 5 sections
TURMERIC KOJIC ACIDCLEANSINGPADS HUMAN OTC DRUG LABEL 2 84025-163 SPONGE 5 mg CUTANEOUS OTC Monograph Drug 5 sections
Turmeric Facial cleanser HUMAN OTC DRUG LABEL 2 84025-185 LIQUID 3 mg CUTANEOUS OTC Monograph Drug 5 sections
Kojic acid and turmeric interface pad HUMAN OTC DRUG LABEL 2 84025-299 SWAB 3 mg CUTANEOUS OTC Monograph Drug 5 sections
remove black milk cream HUMAN OTC DRUG LABEL 2 84025-307 CREAM 5 mg CUTANEOUS OTC Monograph Drug 5 sections
Whitening Turmeric Oil HUMAN OTC DRUG LABEL 2 84423-003 OIL 0.40 mg CUTANEOUS OTC Monograph Drug 8 sections
Glutathione And Kojic Atid Exfoliating BlackSoap HUMAN OTC DRUG LABEL 3 84423-011 SOAP 0.25 mg CUTANEOUS OTC Monograph Drug 9 sections
Whitening ExfoliatingSoap HUMAN OTC DRUG LABEL 2 84423-012 SOAP 1.25 mg CUTANEOUS OTC Monograph Drug 8 sections
MIRACLE SUPER WHITE BODYLOTION HUMAN OTC DRUG LABEL 5 84423-031 EMULSION 4 mg CUTANEOUS OTC Monograph Drug 8 sections
7Days Advanced Whitening BodyLotion HUMAN OTC DRUG LABEL 3 84423-032 EMULSION 5 mg CUTANEOUS OTC Monograph Drug 8 sections
strong whitening bodylotion HUMAN OTC DRUG LABEL 4 84423-045 EMULSION 2.50 mg CUTANEOUS OTC Monograph Drug 8 sections
ULTIMATE WHITENING BODYLOTION HUMAN OTC DRUG LABEL 3 84423-047 EMULSION 5 g CUTANEOUS OTC Monograph Drug 8 sections
Motherrepairoil HUMAN OTC DRUG LABEL 3 84423-050 EXTRACT 0.40 g CUTANEOUS OTC Monograph Drug 8 sections
Morocco Argan Oil HUMAN OTC DRUG LABEL 3 84423-051 OIL 0.40 g CUTANEOUS OTC Monograph Drug 8 sections
StrongWhiteningSoap HUMAN OTC DRUG LABEL 5 84423-053 SOAP 0.25 g CUTANEOUS OTC Monograph Drug 8 sections
RetinolOil HUMAN OTC DRUG LABEL 3 84423-059 OIL 0.40 g CUTANEOUS OTC Monograph Drug 8 sections
KnucklePeelingCream HUMAN OTC DRUG LABEL 6 84423-063 CREAM, AUGMENTED 0.05 g CUTANEOUS OTC Monograph Drug 8 sections
KNUCKLEPEELINGBODYOIL HUMAN OTC DRUG LABEL 2 84423-065 CREAM, AUGMENTED 2.50 g CUTANEOUS OTC Monograph Drug 8 sections
Super Lightening Based on Gold 24k and Kojic Acid Cream HUMAN OTC DRUG LABEL 6 84423-068 CREAM, AUGMENTED 0.50 g CUTANEOUS OTC Monograph Drug 8 sections