clorotepine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
tricyclic compounds 3912 13448-22-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clorotepine
  • (+/-)-Clothepin
  • octoclothepin
  • chlorothepin
  • clotepin
  • clothepin
  • octoclothepine
major tranquilizer with action similar to those of the phenothiazines; used in schizophrenic & manic psychoses; minor decriptor (77-86); on-line & INDEX MEDICUS search DIBENZOTHIEPINS (77-86); RN given refers to parent cpd without isomeric designation
  • Molecular weight: 344.90
  • Formula: C19H21ClN2S
  • CLOGP: 5.59
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 6.48
  • ALOGS: -5.21
  • ROTB: 1

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.35 Basic
pKa2 1.0 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR Ki 9.17 CHEMBL
5-hydroxytryptamine receptor 2C GPCR Ki 9.24 CHEMBL
5-hydroxytryptamine receptor 6 GPCR Ki 8.67 PDSP
D(3) dopamine receptor GPCR Ki 9.37 PDSP
Histamine H1 receptor GPCR Ki 9.72 CHEMBL
D(4) dopamine receptor GPCR Ki 9.40 PDSP
Trace amine-associated receptor 1 GPCR Ki 6.31 PDSP
Potassium channel subfamily K member 9 Ion channel IC50 4.13 CHEMBL
Alpha-1D adrenergic receptor GPCR Ki 9.11 CHEMBL
D(2) dopamine receptor GPCR Ki 9.30 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 9.64 CHEMBL
D(1A) dopamine receptor GPCR Ki 8.64 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 9.18 CHEMBL
D(3) dopamine receptor GPCR Ki 8.62 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 9.25 CHEMBL
Dopamine receptor GPCR IC50 8.52 CHEMBL
Adrenergic receptor alpha-1 GPCR IC50 9.74 CHEMBL
Serotonin 2 (5-HT2) receptor GPCR IC50 9.24 CHEMBL

External reference:

IDSource
C0069353 UMLSCUI
CHEBI:135459 CHEBI
CHEMBL64249 ChEMBL_ID
DB15971 DRUGBANK_ID
C100288 MESH_SUPPLEMENTAL_RECORD_UI
1238 PUBCHEM_CID
3423 INN_ID
E65W20MU7A UNII

Pharmaceutical products:

None