bortezomib 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
proteasome inhibitors 391 179324-69-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • LDP-341
  • PS-341
  • bortezomib
  • velcade
  • radiciol
A pyrazine and boronic acid derivative that functions as a reversible PROTEASOME INHIBITOR. It is used as an ANTINEOPLASTIC AGENT in the treatment of MULTIPLE MYELOMA and MANTLE CELL LYMPHOMA.
  • Molecular weight: 384.24
  • Formula: C19H25BN4O4
  • CLOGP: 0.80
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 4
  • TPSA: 124.44
  • ALOGS: -3.86
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 3.30 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.08 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 10 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 19 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.17 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 18 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 1 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Nov. 14, 2019 EMA FRESENIUS KABI DEUTSCHLAND GMBH
Aug. 22, 2019 PMDA Janssen Pharmaceutical K.K.
May 13, 2003 FDA MILLENNIUM PHARMS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuropathy peripheral 3377.15 13.52 1870 78782 135100 90412695
Plasma cell myeloma 1803.92 13.52 829 79823 39999 90507796
Plasma cell myeloma recurrent 1396.87 13.52 384 80268 3844 90543951
Thrombocytopenia 900.47 13.52 1016 79636 207709 90340086
Disease progression 675.97 13.52 763 79889 155852 90391943
Polyneuropathy 558.05 13.52 294 80358 19047 90528748
Neutropenia 536.12 13.52 818 79834 224086 90323709
Platelet count decreased 505.40 13.52 616 80036 136353 90411442
Plasma cell myeloma refractory 467.84 13.52 121 80531 935 90546860
Diarrhoea 458.16 13.52 1845 78807 937345 89610450
Plasmacytoma 439.09 13.52 143 80509 2650 90545145
Off label use 410.12 13.52 1997 78655 1100255 89447540
Pancytopenia 348.24 13.52 480 80172 119783 90428012
Constipation 312.19 13.52 737 79915 279658 90268137
Pneumonia 311.90 13.52 1256 79396 636803 89910992
Systemic lupus erythematosus 305.66 13.52 3 80649 361893 90185902
Anaemia 294.47 13.52 832 79820 351970 90195825
Sepsis 266.79 13.52 531 80121 179283 90368512
White blood cell count decreased 264.34 13.52 507 80145 166602 90381193
Cytopenia 254.91 13.52 171 80481 17278 90530517
Glossodynia 253.86 13.52 7 80645 321772 90226023
Maternal exposure during pregnancy 248.31 13.52 19 80633 360044 90187751
Therapy partial responder 245.44 13.52 183 80469 21860 90525935
Rheumatoid arthritis 231.76 13.52 26 80626 362588 90185207
Plasma cell leukaemia 230.58 13.52 71 80581 1087 90546708
Contraindicated product administered 223.28 13.52 16 80636 320123 90227672
Synovitis 214.92 13.52 22 80630 329730 90218065
Drug hypersensitivity 208.71 13.52 76 80576 463533 90084262
Posterior reversible encephalopathy syndrome 199.97 13.52 163 80489 22176 90525619
Exposure during pregnancy 196.66 13.52 3 80649 238407 90309388
Septic shock 195.70 13.52 303 80349 83857 90463938
Pericarditis 192.77 13.52 12 80640 270139 90277656
Arthralgia 188.20 13.52 251 80401 778271 89769524
Headache 185.34 13.52 302 80350 862444 89685351
Full blood count decreased 182.42 13.52 175 80477 29514 90518281
Renal failure 180.11 13.52 375 80277 130632 90417163
Wound 178.58 13.52 28 80624 302952 90244843
Swelling 175.00 13.52 77 80575 418981 90128814
Deep vein thrombosis 173.97 13.52 301 80351 91319 90456476
Helicobacter infection 171.58 13.52 7 80645 226843 90320952
Stem cell transplant 165.98 13.52 65 80587 2089 90545706
Pain 164.98 13.52 406 80246 995935 89551860
Discomfort 164.77 13.52 24 80628 274311 90273484
Febrile neutropenia 163.91 13.52 405 80247 157944 90389851
Peripheral sensory neuropathy 163.02 13.52 102 80550 9148 90538647
Folliculitis 162.79 13.52 4 80648 204349 90343446
Fibromyalgia 160.75 13.52 5 80647 206264 90341531
Osteolysis 159.42 13.52 73 80579 3477 90544318
Arthropathy 156.55 13.52 65 80587 366177 90181618
Tumour lysis syndrome 152.67 13.52 105 80547 11047 90536748
Cardiac failure 152.33 13.52 315 80337 109181 90438614
Mobility decreased 148.12 13.52 23 80629 250711 90297084
Alopecia 142.95 13.52 138 80514 494933 90052862
Irritable bowel syndrome 142.78 13.52 11 80641 207437 90340358
Unevaluable event 141.04 13.52 207 80445 54641 90493154
B-cell type acute leukaemia 140.59 13.52 42 80610 577 90547218
Intentional product use issue 139.99 13.52 468 80184 216424 90331371
Abdominal discomfort 139.04 13.52 132 80520 477196 90070599
Dehydration 138.53 13.52 434 80218 194013 90353782
Light chain analysis increased 137.75 13.52 52 80600 1510 90546285
Blister 134.46 13.52 31 80621 254967 90292828
Joint swelling 134.36 13.52 150 80502 503150 90044645
Death 127.47 13.52 767 79885 455784 90092011
Cytomegalovirus infection reactivation 127.45 13.52 82 80570 7718 90540077
Cardiac amyloidosis 127.01 13.52 44 80608 992 90546803
Herpes zoster 126.64 13.52 268 80384 94376 90453419
Type 2 diabetes mellitus 126.24 13.52 16 80636 203228 90344567
Musculoskeletal stiffness 122.91 13.52 55 80597 296477 90251318
Amyloidosis 122.42 13.52 45 80607 1211 90546584
Therapeutic product effect decreased 120.63 13.52 48 80604 277523 90270272
Injury 119.08 13.52 17 80635 197332 90350463
Atrial fibrillation 118.95 13.52 323 80329 133288 90414507
Primary amyloidosis 118.77 13.52 26 80626 86 90547709
Cytomegalovirus infection 118.58 13.52 132 80520 26470 90521325
Blood cholesterol increased 118.58 13.52 21 80631 207991 90339804
Neutrophil count decreased 117.88 13.52 221 80431 71311 90476484
Psoriasis 117.25 13.52 3 80649 147751 90400044
Impaired healing 116.65 13.52 32 80620 234167 90313628
Wheezing 110.50 13.52 37 80615 238043 90309752
Hypercalcaemia 107.09 13.52 142 80510 34098 90513697
Chalazion 105.18 13.52 33 80619 539 90547256
Myelosuppression 104.23 13.52 178 80474 53413 90494382
Myelodysplastic syndrome 104.15 13.52 110 80542 20793 90527002
Joint range of motion decreased 103.17 13.52 4 80648 135639 90412156
Peripheral sensorimotor neuropathy 101.19 13.52 45 80607 2000 90545795
Laboratory test abnormal 100.50 13.52 153 80499 41701 90506094
Hypogammaglobulinaemia 100.00 13.52 80 80572 10594 90537201
Thrombosis 99.82 13.52 209 80443 73042 90474753
Condition aggravated 99.59 13.52 241 80411 595304 89952491
Autonomic neuropathy 99.28 13.52 40 80612 1387 90546408
Orthostatic hypotension 99.16 13.52 152 80500 41675 90506120
Haematotoxicity 98.80 13.52 85 80567 12450 90535345
Ill-defined disorder 98.40 13.52 22 80630 184869 90362926
Liver injury 97.69 13.52 17 80635 170550 90377245
Completed suicide 96.21 13.52 9 80643 145049 90402746
Haemoglobin decreased 91.06 13.52 334 80318 161622 90386173
Rheumatoid factor positive 90.19 13.52 21 80631 171629 90376166
Osteoarthritis 89.80 13.52 31 80621 195699 90352096
Overdose 89.70 13.52 16 80636 157693 90390102
Pathological fracture 89.64 13.52 72 80580 9588 90538207
Hepatic enzyme increased 89.27 13.52 114 80538 360622 90187173
Migraine 87.62 13.52 30 80622 190362 90357433
Hordeolum 86.48 13.52 54 80598 4824 90542971
Acute kidney injury 85.33 13.52 532 80120 319855 90227940
Bursitis 82.62 13.52 10 80642 131644 90416151
Obesity 80.61 13.52 3 80649 105504 90442291
Injection site pain 80.57 13.52 27 80625 173672 90374123
Pleural effusion 79.72 13.52 250 80402 111741 90436054
Hypersensitivity 79.14 13.52 180 80472 454497 90093298
Malignant neoplasm progression 77.39 13.52 240 80412 106630 90441165
COVID-19 76.95 13.52 326 80326 168517 90379278
Hypercholesterolaemia 76.64 13.52 3 80649 100889 90446906
Acute lymphocytic leukaemia 75.67 13.52 41 80611 2807 90544988
Sleep disorder 71.29 13.52 44 80608 197986 90349809
Hyperviscosity syndrome 69.65 13.52 20 80632 237 90547558
Wound infection 69.50 13.52 7 80645 106395 90441400
Pneumonia pneumococcal 66.55 13.52 37 80615 2665 90545130
Grip strength decreased 66.32 13.52 4 80648 92572 90455223
Monoclonal immunoglobulin present 66.15 13.52 34 80618 2090 90545705
Urticaria 65.45 13.52 111 80541 312623 90235172
Transplant 64.78 13.52 27 80625 1022 90546773
Asthma 64.70 13.52 72 80580 242088 90305707
Drug interaction 64.67 13.52 91 80561 276362 90271433
Osteonecrosis of jaw 64.64 13.52 121 80531 38982 90508813
Bone pain 64.56 13.52 159 80493 61824 90485971
Treatment failure 64.41 13.52 107 80545 303821 90243974
Depression 63.55 13.52 106 80546 300495 90247300
Cardiac failure congestive 62.74 13.52 212 80440 98482 90449313
Acute respiratory distress syndrome 62.10 13.52 100 80552 28586 90519209
Weight increased 61.52 13.52 180 80472 417747 90130048
Hypocalcaemia 61.37 13.52 124 80528 42244 90505551
Inappropriate antidiuretic hormone secretion 61.16 13.52 81 80571 19424 90528371
Syncope 61.10 13.52 257 80395 132406 90415389
Ileus paralytic 60.61 13.52 44 80608 5041 90542754
Protein total increased 60.09 13.52 38 80614 3471 90544324
Bone marrow failure 60.00 13.52 105 80547 32116 90515679
Renal impairment 59.72 13.52 218 80434 105203 90442592
Sinusitis 59.52 13.52 136 80516 342952 90204843
Graft versus host disease 57.73 13.52 52 80600 8092 90539703
Bone lesion 57.66 13.52 47 80605 6390 90541405
Contusion 57.46 13.52 84 80568 251132 90296663
C-reactive protein abnormal 57.04 13.52 21 80631 127408 90420387
Disease recurrence 56.70 13.52 112 80540 37541 90510254
Nasopharyngitis 56.59 13.52 180 80472 406924 90140871
Toxic skin eruption 56.53 13.52 70 80582 15704 90532091
Hypertension 56.39 13.52 213 80439 457319 90090476
Anxiety 55.19 13.52 121 80531 309651 90238144
Neurotoxicity 55.14 13.52 81 80571 21386 90526409
Coombs indirect test positive 54.98 13.52 12 80640 39 90547756
Infection in an immunocompromised host 54.88 13.52 23 80629 883 90546912
Product use in unapproved indication 54.65 13.52 497 80155 335739 90212056
Pneumococcal sepsis 54.59 13.52 23 80629 895 90546900
Dry mouth 54.55 13.52 50 80602 184009 90363786
Fatigue 53.42 13.52 1373 79279 1152650 89395145
Sciatica 52.07 13.52 13 80639 101369 90446426
Therapy non-responder 51.83 13.52 250 80402 136454 90411341
Ageusia 50.77 13.52 67 80585 16009 90531786
Pyrexia 50.65 13.52 847 79805 659638 89888157
Respiratory failure 50.38 13.52 224 80428 118194 90429601
Multiple organ dysfunction syndrome 49.96 13.52 154 80498 68182 90479613
Product quality issue 49.83 13.52 6 80646 79319 90468476
Meningitis listeria 49.81 13.52 20 80632 687 90547108
Hip arthroplasty 49.81 13.52 5 80647 76203 90471592
Stomatitis 49.17 13.52 107 80545 274591 90273204
Hepatitis B reactivation 48.77 13.52 35 80617 3939 90543856
Urosepsis 48.70 13.52 76 80576 21156 90526639
Guillain-Barre syndrome 48.47 13.52 37 80615 4575 90543220
Large intestine perforation 48.18 13.52 51 80601 9661 90538134
Pulmonary embolism 47.27 13.52 236 80416 130584 90417211
Toxicity to various agents 47.02 13.52 426 80226 287420 90260375
Mucosal inflammation 47.00 13.52 135 80517 57490 90490305
Malaise 46.45 13.52 318 80334 585668 89962127
Joint stiffness 46.41 13.52 7 80645 78035 90469760
Road traffic accident 46.08 13.52 19 80633 107607 90440188
Renal amyloidosis 45.55 13.52 15 80637 288 90547507
Lower respiratory tract infection 45.39 13.52 97 80555 250562 90297233
Blood potassium decreased 45.08 13.52 118 80534 47609 90500186
Cardiotoxicity 44.82 13.52 53 80599 11336 90536459
Endocarditis bacterial 44.60 13.52 18 80634 627 90547168
Suicide attempt 44.30 13.52 7 80645 75392 90472403
Drug resistance 43.96 13.52 89 80563 30360 90517435
Toxic neuropathy 43.86 13.52 17 80635 531 90547264
Electrolyte imbalance 43.72 13.52 77 80575 23668 90524127
Acute myeloid leukaemia 43.38 13.52 71 80581 20569 90527226
Inappropriate schedule of product administration 42.93 13.52 42 80610 149891 90397904
Mesenteric abscess 42.41 13.52 11 80641 86 90547709
Pneumonia fungal 42.34 13.52 41 80611 6990 90540805
Enterococcal sepsis 42.20 13.52 23 80629 1593 90546202
Colitis ulcerative 42.00 13.52 3 80649 60263 90487532
Inflammation 41.53 13.52 59 80593 178533 90369262
Bronchopulmonary aspergillosis 41.52 13.52 51 80601 11347 90536448
Foot deformity 41.48 13.52 3 80649 59648 90488147
Musculoskeletal pain 41.40 13.52 55 80597 171196 90376599
Wrong technique in product usage process 41.26 13.52 7 80645 71564 90476231
Autoimmune disorder 41.08 13.52 9 80643 76735 90471060
Body dysmorphic disorder 41.08 13.52 15 80637 396 90547399
Colitis 40.76 13.52 146 80506 69796 90477999
Drug reaction with eosinophilia and systemic symptoms 40.68 13.52 106 80546 42652 90505143
Morganella infection 40.51 13.52 18 80634 798 90546997
Pneumonia influenzal 40.22 13.52 25 80627 2215 90545580
Spinal cord compression 40.13 13.52 34 80618 4877 90542918
Thrombotic microangiopathy 39.85 13.52 59 80593 15684 90532111
Large intestinal ulcer perforation 39.77 13.52 10 80642 68 90547727
B precursor type acute leukaemia 39.41 13.52 13 80639 251 90547544
Nasal abscess 39.26 13.52 12 80640 179 90547616
Peripheral venous disease 38.98 13.52 13 80639 83908 90463887
Hypokalaemia 38.84 13.52 224 80428 130892 90416903
Disturbance in social behaviour 38.40 13.52 31 80621 4157 90543638
Blood stem cell harvest failure 38.35 13.52 10 80642 80 90547715
Pregnancy 38.22 13.52 5 80647 62042 90485753
Night sweats 38.12 13.52 35 80617 128731 90419064
Blepharospasm 37.95 13.52 3 80649 55442 90492353
Peripheral motor neuropathy 37.93 13.52 23 80629 1950 90545845
Pseudomonal sepsis 37.67 13.52 31 80621 4271 90543524
N-terminal prohormone brain natriuretic peptide decreased 37.65 13.52 8 80644 22 90547773
Gait inability 37.53 13.52 45 80607 146411 90401384
Hypotension 37.23 13.52 448 80204 324949 90222846
Gastrointestinal toxicity 37.17 13.52 44 80608 9423 90538372
Monoclonal immunoglobulin increased 37.07 13.52 14 80638 407 90547388
Blood pressure increased 36.81 13.52 75 80577 197142 90350653
Oedema peripheral 36.80 13.52 371 80281 257544 90290251
Blood lactate dehydrogenase increased 36.49 13.52 75 80577 25857 90521938
Lower limb fracture 36.41 13.52 15 80637 84998 90462797
Ileus 36.25 13.52 58 80594 16488 90531307
Urinary tract infection 35.93 13.52 423 80229 305209 90242586
Lymphopenia 35.59 13.52 69 80583 22812 90524983
Crossmatch incompatible 35.56 13.52 8 80644 31 90547764
Blood disorder 35.31 13.52 39 80613 7751 90540044
Skin neoplasm excision 35.24 13.52 21 80631 1725 90546070
Pain in extremity 34.92 13.52 246 80406 450283 90097512
Hypersensitivity myocarditis 34.50 13.52 12 80640 274 90547521
Aspiration bone marrow 34.38 13.52 11 80641 192 90547603
Pulmonary alveolar haemorrhage 34.30 13.52 34 80618 5964 90541831
Asthenia 33.98 13.52 665 79987 533086 90014709
Osteoporosis 33.96 13.52 22 80630 96509 90451286
Nail disorder 33.56 13.52 6 80646 59061 90488734
Prohormone brain natriuretic peptide increased 33.44 13.52 12 80640 301 90547494
Cerebellar haemangioma 32.91 13.52 9 80643 88 90547707
Gastrointestinal fungal infection 32.87 13.52 13 80639 429 90547366
Myeloma cast nephropathy 32.48 13.52 10 80642 153 90547642
COVID-19 pneumonia 32.25 13.52 58 80594 18119 90529676
Paraproteinaemia 31.84 13.52 11 80641 246 90547549
Leukaemic infiltration extramedullary 31.78 13.52 10 80642 165 90547630
Arthritis 31.76 13.52 63 80589 167252 90380543
Precursor B-lymphoblastic lymphoma 31.35 13.52 7 80645 26 90547769
Bone marrow disorder 31.15 13.52 24 80628 3008 90544787
Light chain analysis abnormal 31.07 13.52 10 80642 178 90547617
Exostosis 31.06 13.52 5 80647 53129 90494666
Blood pressure systolic increased 30.91 13.52 7 80645 58338 90489457
Rhinovirus infection 30.81 13.52 32 80620 5931 90541864
Human chorionic gonadotropin increased 30.67 13.52 20 80632 1926 90545869
Target skin lesion 30.44 13.52 9 80643 119 90547676
Bone marrow transplant 30.40 13.52 15 80637 845 90546950
Gait disturbance 30.31 13.52 124 80528 260372 90287423
Sinus polyp 29.92 13.52 12 80640 411 90547384
Staphylococcal bacteraemia 29.79 13.52 35 80617 7434 90540361
Engraftment syndrome 29.73 13.52 14 80638 711 90547084
Clostridium difficile colitis 29.40 13.52 70 80582 26636 90521159
Respiratory tract infection 29.19 13.52 117 80535 58961 90488834
Surgery 29.19 13.52 3 80649 44884 90502911
Back pain 28.90 13.52 419 80233 316756 90231039
Hypoalbuminaemia 28.55 13.52 51 80601 15846 90531949
Hyperproteinaemia 28.35 13.52 9 80643 153 90547642
Febrile bone marrow aplasia 28.33 13.52 39 80613 9699 90538096
Clostridium bacteraemia 28.12 13.52 10 80642 244 90547551
Frequent bowel movements 27.91 13.52 8 80644 56927 90490868
Underdose 27.59 13.52 7 80645 54010 90493785
Pulmonary oedema 27.58 13.52 119 80533 61961 90485834
Drug ineffective for unapproved indication 27.53 13.52 125 80527 66519 90481276
Plasma cells increased 27.40 13.52 8 80644 101 90547694
Adenoviral haemorrhagic cystitis 27.37 13.52 9 80643 172 90547623
Ocular toxicity 27.22 13.52 15 80637 1062 90546733
Febrile infection 27.19 13.52 19 80633 2050 90545745
Diarrhoea haemorrhagic 27.04 13.52 40 80612 10623 90537172
Rash maculo-papular 26.95 13.52 89 80563 40844 90506951
Neuralgia 26.86 13.52 75 80577 31425 90516370
Nasal congestion 26.73 13.52 21 80631 83393 90464402
Salmonella sepsis 26.73 13.52 10 80642 283 90547512
Bronchiolitis 26.61 13.52 23 80629 3389 90544406
Progressive multifocal leukoencephalopathy 26.56 13.52 49 80603 15606 90532189
Heart rate increased 26.54 13.52 37 80615 112865 90434930
Tooth disorder 26.48 13.52 74 80578 31016 90516779
Failure to thrive 26.48 13.52 35 80617 8376 90539419
Spinal compression fracture 26.38 13.52 48 80604 15130 90532665
Neoplasm skin 26.18 13.52 22 80630 3120 90544675
Memory impairment 26.13 13.52 89 80563 197155 90350640
Drug abuse 26.05 13.52 21 80631 82326 90465469
Osteonecrosis 25.94 13.52 66 80586 26175 90521620
Suicidal ideation 25.75 13.52 17 80635 73838 90473957
Abdominal pain upper 25.59 13.52 182 80470 332492 90215303
Refractory cytopenia with multilineage dysplasia 25.42 13.52 8 80644 132 90547663
Rash pruritic 25.36 13.52 142 80510 82072 90465723
Loss of personal independence in daily activities 25.18 13.52 52 80600 136053 90411742
Bacteraemia 25.14 13.52 59 80593 22241 90525554
Hypothyroidism 25.08 13.52 8 80644 53119 90494676
Red blood cell sedimentation rate increased 24.98 13.52 22 80630 82573 90465222
Anal squamous cell carcinoma 24.78 13.52 12 80640 649 90547146
Spondylolysis 24.62 13.52 8 80644 147 90547648
Joint ankylosis 24.56 13.52 15 80637 1288 90546507
Bacterial sepsis 24.55 13.52 26 80626 4929 90542866
Meningitis cryptococcal 24.48 13.52 17 80635 1816 90545979
Monoclonal gammopathy 24.38 13.52 13 80639 862 90546933
Cytokine release syndrome 24.24 13.52 67 80585 27906 90519889
Stress 24.24 13.52 22 80630 81373 90466422
Varicella zoster virus infection 24.09 13.52 23 80629 3854 90543941
Chills 23.95 13.52 200 80452 131781 90416014
Acute myopia 23.80 13.52 8 80644 164 90547631
Compression fracture 23.79 13.52 34 80618 8755 90539040
Blood creatinine increased 23.66 13.52 163 80489 101223 90446572
Listeria sepsis 23.55 13.52 12 80640 724 90547071
Nocardiosis 23.52 13.52 19 80633 2551 90545244
Serotonin syndrome 23.46 13.52 3 80649 37884 90509911
Disability 23.45 13.52 4 80648 40741 90507054
Injection site swelling 23.38 13.52 12 80640 59827 90487968
Light chain analysis 23.21 13.52 5 80647 15 90547780
Sedation 23.19 13.52 7 80645 48164 90499631
Amnesia 23.14 13.52 38 80614 108467 90439328
Leukoencephalopathy 23.13 13.52 25 80627 4848 90542947
Drug intolerance 23.05 13.52 271 80381 447320 90100475
Peritonitis viral 23.01 13.52 6 80646 48 90547747
Fungal oesophagitis 22.77 13.52 12 80640 777 90547018
Klebsiella sepsis 22.58 13.52 16 80636 1765 90546030
Intraductal proliferative breast lesion 22.44 13.52 21 80631 3432 90544363
Klebsiella infection 22.43 13.52 36 80616 10261 90537534
Spinal fracture 22.41 13.52 56 80596 21960 90525835
Joint dislocation 22.35 13.52 6 80646 44576 90503219
Cardiomyopathy 22.28 13.52 53 80599 20153 90527642
Venoocclusive liver disease 22.13 13.52 27 80625 5966 90541829
Dyspepsia 22.01 13.52 96 80556 198064 90349731
Serum sickness 21.98 13.52 21 80631 3521 90544274
Bone disorder 21.67 13.52 57 80595 23063 90524732
Laryngitis 21.66 13.52 9 80643 50744 90497051
Atrial rupture 21.64 13.52 6 80646 62 90547733
Incorrect dose administered 21.58 13.52 23 80629 78907 90468888
5q minus syndrome 21.50 13.52 8 80644 223 90547572
Pulmonary sepsis 21.49 13.52 17 80635 2214 90545581
Oncologic complication 21.43 13.52 8 80644 225 90547570
Blood pressure fluctuation 21.25 13.52 10 80642 52403 90495392
Escherichia infection 21.23 13.52 45 80607 15850 90531945
Hyperintensity in brain deep nuclei 21.19 13.52 5 80647 25 90547770
Injection site bruising 21.18 13.52 10 80642 52297 90495498
Escherichia sepsis 21.15 13.52 26 80626 5790 90542005
Hypophosphataemia 20.95 13.52 43 80609 14811 90532984
Blood calcium increased 20.79 13.52 38 80614 12020 90535775
Gastrooesophageal reflux disease 20.73 13.52 77 80575 166260 90381535
Pruritus 20.73 13.52 348 80304 541177 90006618
Gastrointestinal infection 20.70 13.52 36 80616 10954 90536841
Neck pain 20.70 13.52 44 80608 113919 90433876
Dysgeusia 20.54 13.52 97 80555 52463 90495332
Haemorrhagic occlusive retinal vasculitis 20.53 13.52 6 80646 76 90547719
VIth nerve paresis 20.32 13.52 6 80646 79 90547716
Erysipelas 20.20 13.52 32 80620 9020 90538775
Acute erythroid leukaemia 19.95 13.52 7 80645 164 90547631
Blepharitis 19.94 13.52 21 80631 3955 90543840
Drug eruption 19.85 13.52 73 80579 35334 90512461
Mucosal erosion 19.83 13.52 15 80637 1830 90545965
Clostridium difficile infection 19.72 13.52 74 80578 36171 90511624
Ornithine transcarbamoylase deficiency 19.71 13.52 4 80648 8 90547787
Renal vein thrombosis 19.69 13.52 10 80642 599 90547196
Rash 19.67 13.52 881 79771 795219 89752576
Enterocolitis bacterial 19.52 13.52 8 80644 290 90547505
Plasma cells decreased 19.52 13.52 5 80647 37 90547758
Hepatitis E 19.44 13.52 15 80637 1884 90545911
Metapneumovirus infection 19.29 13.52 13 80639 1322 90546473
Atelectasis 18.76 13.52 56 80596 24353 90523442
Hypervolaemia 18.76 13.52 68 80584 32689 90515106
Cardiac failure acute 18.58 13.52 36 80616 11893 90535902
Palpitations 18.58 13.52 61 80591 136667 90411128
Pneumonia cytomegaloviral 18.47 13.52 18 80634 3093 90544702
Anaphylactic reaction 18.34 13.52 31 80621 87493 90460302
Hypoglossal nerve paresis 18.33 13.52 6 80646 113 90547682
Bing-Neel syndrome 18.33 13.52 4 80648 13 90547782
Blood creatine phosphokinase increased 18.19 13.52 4 80648 34019 90513776
Hypoperfusion 18.06 13.52 14 80638 1770 90546025
Hyponatraemia 18.03 13.52 190 80462 133348 90414447
Pneumonia bacterial 18.01 13.52 37 80615 12753 90535042
Leukopenia 17.94 13.52 152 80500 100558 90447237
Seasonal allergy 17.92 13.52 53 80599 22930 90524865
Infusion related reaction 17.91 13.52 262 80390 416518 90131277
General physical health deterioration 17.89 13.52 216 80436 354899 90192896
Lung infiltration 17.85 13.52 41 80611 15241 90532554
Melanoderma 17.84 13.52 7 80645 226 90547569
Procedural pain 17.67 13.52 4 80648 33356 90514439
Full blood count increased 17.67 13.52 12 80640 1236 90546559
Malnutrition 17.64 13.52 46 80606 18512 90529283
Parvovirus B19 infection 17.49 13.52 11 80641 995 90546800
Chest pain 17.44 13.52 191 80461 319454 90228341
Eczema 17.34 13.52 13 80639 52857 90494938
Accidental exposure to product 17.31 13.52 8 80644 42358 90505437
Drug-induced liver injury 17.14 13.52 34 80618 90284 90457511
Autologous haematopoietic stem cell transplant 17.12 13.52 4 80648 19 90547776
Flushing 17.06 13.52 33 80619 88458 90459337
Factor VII deficiency 17.06 13.52 5 80647 64 90547731
Hepatitis C 16.97 13.52 23 80629 5637 90542158
Pseudomyopia 16.92 13.52 5 80647 66 90547729
Shock 16.70 13.52 60 80592 28718 90519077
Blood immunoglobulin M decreased 16.61 13.52 12 80640 1365 90546430
H1N1 influenza 16.60 13.52 14 80638 1996 90545799
Small intestinal obstruction 16.59 13.52 49 80603 21185 90526610
Duodenal stenosis 16.54 13.52 9 80643 621 90547174
Sensory level abnormal 16.44 13.52 6 80646 158 90547637
Clostridium colitis 16.39 13.52 14 80638 2031 90545764
Granulicatella bacteraemia 16.34 13.52 4 80648 24 90547771
Cytomegalovirus enterocolitis 16.32 13.52 10 80642 864 90546931
Somnolence 16.25 13.52 114 80538 208970 90338825
Creatinine renal clearance 16.20 13.52 4 80648 25 90547770
Rib fracture 16.10 13.52 56 80596 26379 90521416
Superficial spreading melanoma stage unspecified 16.10 13.52 6 80646 168 90547627
Pulmonary haemorrhage 16.08 13.52 27 80625 7986 90539809
Blood magnesium decreased 16.06 13.52 40 80612 15653 90532142
Liver function test increased 16.05 13.52 32 80620 84823 90462972
Blood stem cell harvest 16.00 13.52 3 80649 3 90547792
Hypoglobulinaemia 15.93 13.52 6 80646 173 90547622
Cryptococcosis 15.90 13.52 12 80640 1459 90546336
Back injury 15.89 13.52 11 80641 46611 90501184
Thrombotic thrombocytopenic purpura 15.86 13.52 19 80633 4119 90543676
Chronic graft versus host disease 15.86 13.52 19 80633 4120 90543675
Injection site haemorrhage 15.82 13.52 3 80649 28315 90519480
Oculomotor study abnormal 15.81 13.52 4 80648 28 90547767
Meningitis pneumococcal 15.76 13.52 8 80644 479 90547316
Dyspnoea 15.72 13.52 633 80019 880322 89667473
Endocarditis 15.67 13.52 25 80627 7088 90540707
Human metapneumovirus test positive 15.64 13.52 5 80647 87 90547708
Walking aid user 15.63 13.52 6 80646 35500 90512295
Lactose intolerance 15.50 13.52 17 80635 3352 90544443
N-terminal prohormone brain natriuretic peptide increased 15.49 13.52 16 80636 2946 90544849
Paranoia 15.49 13.52 35 80617 12873 90534922
Hypergammaglobulinaemia benign monoclonal 15.40 13.52 10 80642 956 90546839
Hepatotoxicity 15.36 13.52 81 80571 45761 90502034
Pneumococcal infection 15.36 13.52 11 80641 1234 90546561
Performance status decreased 15.35 13.52 19 80633 4261 90543534
Sudden cardiac death 15.33 13.52 14 80638 2218 90545577
Ischaemic stroke 15.32 13.52 49 80603 22117 90525678
Ear infection 15.29 13.52 24 80628 69751 90478044
Medication error 15.11 13.52 33 80619 84619 90463176
Clavicle fracture 15.04 13.52 18 80634 3898 90543897
Haemorrhoidal haemorrhage 15.01 13.52 21 80631 5302 90542493
Infection reactivation 14.97 13.52 13 80639 1927 90545868
JC virus CSF test positive 14.92 13.52 4 80648 36 90547759
Hyperamylasaemia 14.90 13.52 8 80644 538 90547257
Dysarthria 14.75 13.52 16 80636 54466 90493329
Throat irritation 14.69 13.52 13 80639 48682 90499113
Rash pustular 14.68 13.52 26 80626 8023 90539772
Urea cycle disorder 14.64 13.52 4 80648 39 90547756
Hyperammonaemia 14.60 13.52 23 80629 6452 90541343
Sleep apnoea syndrome 14.60 13.52 5 80647 31742 90516053
Pneumonia respiratory syncytial viral 14.55 13.52 11 80641 1340 90546455
Hypophagia 14.54 13.52 67 80585 35870 90511925
Hepatitis B 14.53 13.52 19 80633 4500 90543295
Pneumomediastinum 14.46 13.52 13 80639 2018 90545777
Device dislocation 14.40 13.52 5 80647 31477 90516318
Therapy interrupted 14.38 13.52 14 80638 50094 90497701
Hypoxia 14.37 13.52 112 80540 72287 90475508
Human herpesvirus 8 infection 14.36 13.52 7 80645 384 90547411
Macular degeneration 14.27 13.52 8 80644 37962 90509833
Bronchitis pneumococcal 14.19 13.52 3 80649 8 90547787
Clostridial infection 14.14 13.52 19 80633 4617 90543178
Decubitus ulcer 14.14 13.52 32 80620 11781 90536014
Generalised oedema 13.98 13.52 43 80609 19010 90528785
Oral fungal infection 13.94 13.52 16 80636 3316 90544479
Diverticular perforation 13.94 13.52 17 80635 3755 90544040
Central-alveolar hypoventilation 13.93 13.52 3 80649 9 90547786
Plasmablastic lymphoma 13.92 13.52 6 80646 247 90547548
Dialysis 13.91 13.52 31 80621 11298 90536497
Exposure via body fluid 13.90 13.52 8 80644 616 90547179
Delirium 13.87 13.52 47 80605 104312 90443483
Pneumonia streptococcal 13.87 13.52 13 80639 2128 90545667
Atrial flutter 13.84 13.52 30 80622 10728 90537067
Urethritis 13.81 13.52 6 80646 252 90547543
Joint injury 13.60 13.52 6 80646 32658 90515137
Prescribed underdose 13.59 13.52 29 80623 74990 90472805
Refractory anaemia with an excess of blasts 13.53 13.52 7 80645 436 90547359

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuropathy peripheral 2964.83 13.18 2154 91613 99699 42427869
Plasma cell myeloma 1585.64 13.18 1095 92672 46483 42481085
Plasma cell myeloma recurrent 1322.42 13.18 492 93275 5265 42522303
Polyneuropathy 777.05 13.18 494 93273 18167 42509401
Thrombocytopenia 621.24 13.18 1322 92445 188957 42338611
Plasma cell myeloma refractory 533.99 13.18 175 93592 1235 42526333
Pneumonia 401.12 13.18 1910 91857 420239 42107329
Platelet count decreased 397.47 13.18 915 92852 137666 42389902
Plasmacytoma 392.94 13.18 192 93575 4172 42523396
Disease progression 382.09 13.18 921 92846 142735 42384833
Drug interaction 333.68 13.18 88 93679 266911 42260657
Intentional product use issue 307.37 13.18 560 93207 71273 42456295
Off label use 246.41 13.18 2306 91461 636029 41891539
Therapy partial responder 221.41 13.18 246 93521 19775 42507793
Unevaluable event 218.18 13.18 320 93447 33968 42493600
Drug abuse 214.75 13.18 3 93764 104768 42422800
Autonomic neuropathy 199.37 13.18 78 93689 965 42526603
Completed suicide 196.68 13.18 3 93764 96462 42431106
Neutropenia 178.62 13.18 889 92878 198542 42329026
Pancytopenia 166.18 13.18 603 93164 117140 42410428
Plasma cell leukaemia 163.15 13.18 71 93696 1169 42526399
Peripheral sensory neuropathy 160.92 13.18 142 93625 8620 42518948
Orthostatic hypotension 159.03 13.18 260 93507 30310 42497258
Tumour lysis syndrome 152.40 13.18 215 93552 22016 42505552
Herpes zoster 142.57 13.18 284 93483 38593 42488975
Diarrhoea 138.37 13.18 1584 92183 459265 42068303
Overdose 136.46 13.18 32 93735 105232 42422336
White blood cell count decreased 126.90 13.18 530 93237 109866 42417702
Inappropriate schedule of product administration 124.61 13.18 29 93738 95873 42431695
Cytopenia 122.58 13.18 171 93596 17326 42510242
Stem cell transplant 116.80 13.18 73 93694 2599 42524969
Therapy non-responder 114.52 13.18 316 93451 53043 42474525
Constipation 113.11 13.18 676 93091 161615 42365953
Headache 110.77 13.18 225 93542 239144 42288424
Acute lymphocytic leukaemia 109.41 13.18 77 93690 3354 42524214
Deep vein thrombosis 105.00 13.18 390 93377 76567 42451001
Arthralgia 104.54 13.18 182 93585 205056 42322512
Rhabdomyolysis 102.53 13.18 23 93744 77996 42449572
Product use issue 102.25 13.18 386 93381 76365 42451203
Osteonecrosis of jaw 101.75 13.18 164 93603 18885 42508683
Hypercalcaemia 99.93 13.18 158 93609 17900 42509668
Rash 95.78 13.18 980 92787 275974 42251594
Sepsis 93.70 13.18 754 93013 198580 42328988
Light chain analysis increased 93.29 13.18 55 93712 1759 42525809
Fatigue 92.31 13.18 1406 92361 434235 42093333
Myelodysplastic syndrome 91.72 13.18 173 93594 22572 42504996
Amyloidosis 90.69 13.18 60 93707 2359 42525209
B precursor type acute leukaemia 86.54 13.18 29 93738 221 42527347
Suicide attempt 84.54 13.18 4 93763 46096 42481472
B-cell type acute leukaemia 83.23 13.18 39 93728 769 42526799
Haematotoxicity 82.43 13.18 111 93656 10874 42516694
Depression 81.37 13.18 75 93692 111288 42416280
Rheumatoid arthritis 80.10 13.18 3 93764 42437 42485131
Ileus paralytic 79.53 13.18 91 93676 7550 42520018
Cystitis haemorrhagic 79.19 13.18 89 93678 7240 42520328
Drug hypersensitivity 78.64 13.18 62 93705 99327 42428241
Hyperviscosity syndrome 77.69 13.18 28 93739 271 42527297
Condition aggravated 77.65 13.18 303 93464 260451 42267117
Anxiety 76.29 13.18 89 93678 118471 42409097
Infection 75.57 13.18 463 93304 111605 42415963
Spinal compression fracture 74.33 13.18 87 93680 7396 42520172
Keratopathy 72.85 13.18 34 93733 664 42526904
Primary amyloidosis 71.87 13.18 25 93742 216 42527352
Septic shock 71.73 13.18 394 93373 91278 42436290
Drug reaction with eosinophilia and systemic symptoms 69.29 13.18 227 93540 41848 42485720
Full blood count decreased 69.20 13.18 145 93622 20415 42507153
Spinal cord compression 68.81 13.18 64 93703 4160 42523408
Hypogammaglobulinaemia 68.51 13.18 106 93661 11785 42515783
Blood creatine phosphokinase increased 68.21 13.18 12 93755 48326 42479242
Infusion related reaction 63.70 13.18 284 93483 60522 42467046
Suicidal ideation 63.66 13.18 14 93753 48147 42479421
Stress 62.33 13.18 11 93756 44201 42483367
Aggression 62.24 13.18 11 93756 44152 42483416
Pseudomyopia 62.23 13.18 18 93749 78 42527490
Guillain-Barre syndrome 61.67 13.18 78 93689 7185 42520383
Atrial fibrillation 61.20 13.18 520 93247 139073 42388495
Haematochezia 61.06 13.18 26 93741 58410 42469158
Hypertension 60.83 13.18 178 93589 167026 42360542
Asthma 60.07 13.18 31 93736 62283 42465285
Somnolence 59.90 13.18 139 93628 140966 42386602
Blood pressure increased 59.86 13.18 82 93685 101846 42425722
Abdominal pain 58.80 13.18 218 93549 190253 42337315
Psoriasis 58.71 13.18 17 93750 48587 42478981
Wrong technique in product usage process 57.16 13.18 12 93755 42623 42484945
Cardiac amyloidosis 57.07 13.18 42 93725 1963 42525605
Pyrexia 56.38 13.18 1196 92571 392846 42134722
IVth nerve paralysis 56.20 13.18 27 93740 564 42527004
Seizure 55.94 13.18 113 93654 120448 42407120
Peripheral sensorimotor neuropathy 55.70 13.18 41 93726 1917 42525651
Injection site pain 55.34 13.18 29 93738 57769 42469799
Hypoaesthesia 54.45 13.18 305 93462 71158 42456410
Osteolysis 54.03 13.18 52 93715 3528 42524040
Paraesthesia 52.36 13.18 308 93459 73151 42454417
Thrombosis 51.93 13.18 292 93475 68219 42459349
Visceral leishmaniasis 51.63 13.18 32 93735 1122 42526446
Bradycardia 50.97 13.18 68 93699 85416 42442152
Chalazion 50.71 13.18 18 93749 166 42527402
Monoclonal immunoglobulin present 50.58 13.18 32 93735 1164 42526404
Bone marrow failure 50.46 13.18 174 93593 32919 42494649
Compression fracture 50.25 13.18 51 93716 3691 42523877
Protein total increased 49.79 13.18 43 93724 2535 42525033
Renal failure 49.72 13.18 509 93258 143217 42384351
Progressive multifocal leukoencephalopathy 49.33 13.18 90 93677 11446 42516122
Hypoglycaemia 49.04 13.18 36 93731 59818 42467750
Hordeolum 48.88 13.18 35 93732 1567 42526001
Device related sepsis 48.63 13.18 51 93716 3836 42523732
Bone lesion 47.94 13.18 48 93719 3418 42524150
Ageusia 47.69 13.18 89 93678 11516 42516052
Polyomavirus-associated nephropathy 47.19 13.18 60 93707 5555 42522013
Squamous cell carcinoma of skin 46.67 13.18 93 93674 12633 42514935
Acute myeloid leukaemia 45.94 13.18 130 93637 22126 42505442
Incorrect dose administered 45.87 13.18 30 93737 52944 42474624
Bone pain 45.29 13.18 135 93632 23657 42503911
Intentional product misuse 44.82 13.18 42 93725 61858 42465710
Loss of personal independence in daily activities 44.81 13.18 27 93740 49789 42477779
Hallucination 42.85 13.18 38 93729 57469 42470099
Autologous haematopoietic stem cell transplant 42.68 13.18 14 93753 99 42527469
Laboratory test abnormal 42.43 13.18 129 93638 22849 42504719
Erythema 42.38 13.18 112 93655 108681 42418887
Anaemia 42.38 13.18 858 92909 279420 42248148
Pathological fracture 42.04 13.18 55 93712 5238 42522330
H1N1 influenza 41.54 13.18 28 93739 1136 42526432
Cardiac failure 41.12 13.18 387 93380 106469 42421099
Wheezing 41.06 13.18 36 93731 54745 42472823
Product use in unapproved indication 40.25 13.18 599 93168 183857 42343711
Neurogenic bladder 40.25 13.18 36 93731 2224 42525344
Obstructive airways disorder 40.04 13.18 4 93763 24755 42502813
Angioedema 39.66 13.18 22 93745 42455 42485113
Enterococcal infection 39.46 13.18 84 93683 11955 42515613
Musculoskeletal stiffness 38.62 13.18 42 93725 57723 42469845
Peripheral motor neuropathy 38.23 13.18 35 93732 2229 42525339
Monoclonal immunoglobulin increased 38.21 13.18 19 93748 429 42527139
Colitis ulcerative 38.03 13.18 6 93761 26169 42501399
Basal cell carcinoma 37.73 13.18 123 93644 22610 42504958
Lactic acidosis 37.37 13.18 27 93740 45234 42482334
Hemianopia 37.09 13.18 24 93743 908 42526660
Hyperhidrosis 36.93 13.18 91 93676 90421 42437147
Ileus 36.81 13.18 109 93658 19030 42508538
Accidental overdose 35.93 13.18 9 93758 28321 42499247
Malignant syphilis 35.82 13.18 10 93757 37 42527531
Myelosuppression 35.81 13.18 180 93587 40281 42487287
Empyema 35.66 13.18 45 93722 4135 42523433
Hepatitis B reactivation 35.48 13.18 47 93720 4531 42523037
Flushing 34.82 13.18 19 93748 37009 42490559
Respiratory tract infection 34.70 13.18 132 93635 26190 42501378
Agitation 34.56 13.18 55 93712 64259 42463309
Oroantral fistula 34.22 13.18 14 93753 196 42527372
Accidental exposure to product 33.76 13.18 3 93764 20390 42507178
Metapneumovirus infection 33.70 13.18 25 93742 1183 42526385
Clostridium difficile colitis 33.50 13.18 113 93654 21139 42506429
Adverse drug reaction 33.46 13.18 167 93600 37267 42490301
Sleep disorder 33.24 13.18 34 93733 48061 42479507
BK virus infection 33.18 13.18 65 93702 8719 42518849
Ascites 32.85 13.18 46 93721 56632 42470936
Eczema 32.78 13.18 17 93750 34069 42493499
Bone disorder 32.70 13.18 55 93712 6558 42521010
Medication error 32.68 13.18 16 93751 33138 42494430
Pneumonia pneumococcal 32.53 13.18 34 93733 2547 42525021
Neuralgic amyotrophy 32.42 13.18 15 93752 287 42527281
Vomiting 32.34 13.18 446 93321 289277 42238291
Dehydration 32.33 13.18 464 93303 141303 42386265
Parainfluenzae virus infection 32.33 13.18 40 93727 3603 42523965
Adenocarcinoma of colon 32.16 13.18 41 93726 3806 42523762
Anaphylactic reaction 32.14 13.18 28 93739 42715 42484853
Hyperkalaemia 31.96 13.18 82 93685 80376 42447192
Drug level increased 31.94 13.18 9 93758 26191 42501377
Gastrointestinal amyloidosis 31.89 13.18 8 93759 17 42527551
Nightmare 31.61 13.18 8 93759 25004 42502564
Febrile neutropenia 31.60 13.18 579 93188 185124 42342444
Blood stem cell harvest failure 31.30 13.18 9 93758 38 42527530
Hiccups 31.12 13.18 77 93690 12094 42515474
Chronic inflammatory demyelinating polyradiculoneuropathy 30.94 13.18 24 93743 1215 42526353
Bacteraemia 30.91 13.18 123 93644 24917 42502651
Neutropenic sepsis 30.84 13.18 91 93676 15855 42511713
Electrocardiogram QT prolonged 30.81 13.18 36 93731 47909 42479659
Pruritus 30.47 13.18 267 93500 188504 42339064
Malaise 30.43 13.18 309 93458 211847 42315721
Listeriosis 30.26 13.18 25 93742 1386 42526182
Contraindicated product administered 30.22 13.18 9 93758 25263 42502305
Clostridium difficile infection 30.17 13.18 114 93653 22545 42505023
Metabolic acidosis 30.15 13.18 42 93725 51816 42475752
Rash pruritic 30.09 13.18 150 93617 33453 42494115
Increased viscosity of upper respiratory secretion 30.03 13.18 15 93752 342 42527226
Blood pressure systolic increased 29.93 13.18 12 93755 27956 42499612
Performance status decreased 29.92 13.18 44 93723 4676 42522892
Blood pressure fluctuation 29.70 13.18 11 93756 26897 42500671
Myalgia 29.58 13.18 110 93657 95970 42431598
Bacterial sepsis 29.54 13.18 52 93715 6430 42521138
Spinal column injury 29.10 13.18 18 93749 629 42526939
Anaphylactic shock 28.81 13.18 8 93759 23509 42504059
Frequent bowel movements 28.74 13.18 6 93761 21401 42506167
Escherichia sepsis 28.69 13.18 48 93719 5699 42521869
Cellulitis orbital 28.64 13.18 16 93751 461 42527107
Pallor 28.38 13.18 14 93753 28872 42498696
Pain 28.36 13.18 374 93393 244474 42283094
Osteonecrosis 28.30 13.18 88 93679 15777 42511791
Product prescribing error 28.28 13.18 11 93756 26101 42501467
Asthenia 28.25 13.18 813 92954 279980 42247588
Neutrophil count decreased 28.15 13.18 237 93530 63178 42464390
Renal amyloidosis 27.91 13.18 10 93757 95 42527473
Dry mouth 27.77 13.18 28 93739 39851 42487717
IgA nephropathy 27.67 13.18 30 93737 2344 42525224
Dysarthria 27.67 13.18 28 93739 39779 42487789
Ventricular fibrillation 27.55 13.18 16 93751 30107 42497461
Abdominal abscess 27.40 13.18 44 93723 5049 42522519
Autonomic nervous system imbalance 27.31 13.18 34 93733 3082 42524486
Heart rate increased 27.26 13.18 47 93720 53208 42474360
Respirovirus test positive 26.92 13.18 9 93758 68 42527500
Coma 26.74 13.18 48 93719 53506 42474062
Neurotoxicity 26.69 13.18 113 93654 23538 42504030
Spinal fracture 26.59 13.18 61 93706 9129 42518439
Campylobacter colitis 26.40 13.18 8 93759 42 42527526
COVID-19 26.23 13.18 379 93388 115569 42411999
Hallucination, visual 26.04 13.18 7 93760 21013 42506555
Staphylococcal bacteraemia 25.99 13.18 68 93699 11053 42516515
Respiratory depression 25.93 13.18 5 93762 18863 42508705
Tooth deposit 25.65 13.18 9 93758 80 42527488
Bladder sphincter atony 25.51 13.18 8 93759 48 42527520
Blepharitis 25.33 13.18 26 93741 1907 42525661
Demyelinating polyneuropathy 25.29 13.18 24 93743 1600 42525968
Palmar-plantar erythrodysaesthesia syndrome 25.22 13.18 7 93760 20575 42506993
Depressed mood 25.08 13.18 10 93757 23374 42504194
Thrombotic thrombocytopenic purpura 24.90 13.18 36 93731 3768 42523800
Precursor B-lymphoblastic lymphoma 24.45 13.18 7 93760 29 42527539
Nephrolithiasis 24.37 13.18 27 93740 36803 42490765
Bronchiectasis 24.30 13.18 5 93762 18014 42509554
Product dose omission issue 24.17 13.18 220 93547 154145 42373423
Tear break up time decreased 24.16 13.18 6 93761 12 42527556
Fat tissue increased 24.12 13.18 15 93752 529 42527039
Synovitis 23.95 13.18 3 93764 15564 42512004
Meningitis listeria 23.59 13.18 16 93751 656 42526912
Cytomegalovirus infection 23.35 13.18 136 93631 32170 42495398
Extrapyramidal disorder 23.31 13.18 4 93763 16408 42511160
Diabetic ketoacidosis 23.28 13.18 10 93757 22357 42505211
Drug-induced liver injury 23.26 13.18 30 93737 38243 42489325
Meibomian gland dysfunction 23.25 13.18 9 93758 108 42527460
Type III immune complex mediated reaction 23.20 13.18 15 93752 567 42527001
VIth nerve paralysis 23.10 13.18 18 93749 917 42526651
Corticobasal degeneration 22.97 13.18 6 93761 16 42527552
Hypothyroidism 22.95 13.18 22 93745 32062 42495506
Gastrooesophageal reflux disease 22.80 13.18 40 93727 44983 42482585
Cytomegalovirus infection reactivation 22.78 13.18 65 93702 11113 42516455
Tachycardia 22.64 13.18 130 93637 100957 42426611
Diverticular perforation 22.64 13.18 34 93733 3682 42523886
Dyskinesia 22.50 13.18 14 93753 25376 42502192
Metastases to testicle 22.33 13.18 8 93759 76 42527492
Paraproteinaemia 22.33 13.18 13 93754 406 42527162
Monoclonal gammopathy 22.18 13.18 14 93753 507 42527061
Varicella 22.18 13.18 25 93742 2040 42525528
Phrenic nerve paralysis 21.97 13.18 10 93757 184 42527384
Blood immunoglobulin G increased 21.96 13.18 19 93748 1123 42526445
Meningitis pneumococcal 21.74 13.18 11 93756 258 42527310
Diffuse axonal injury 21.68 13.18 5 93762 6 42527562
Hepatic steatosis 21.68 13.18 10 93757 21438 42506130
Neuralgia 21.23 13.18 112 93655 25535 42502033
Migraine 21.18 13.18 15 93752 25399 42502169
Conjunctival irritation 20.66 13.18 8 93759 96 42527472
Emotional distress 20.62 13.18 5 93762 16088 42511480
Ureteric haemorrhage 20.26 13.18 10 93757 222 42527346
Nasal congestion 20.22 13.18 21 93746 29480 42498088
Pneumonia influenzal 20.12 13.18 23 93744 1906 42525662
Therapy interrupted 20.09 13.18 12 93755 22238 42505330
Protein total decreased 19.93 13.18 42 93725 5934 42521634
Papilloedema 19.92 13.18 30 93737 3256 42524312
Hepatitis B 19.92 13.18 45 93722 6666 42520902
Swollen tongue 19.81 13.18 11 93756 21220 42506348
Blood glucose increased 19.78 13.18 89 93678 73610 42453958
Myocardial infarction 19.72 13.18 176 93591 123833 42403735
Coronary artery disease 19.64 13.18 57 93710 53663 42473905
Mantle cell lymphoma recurrent 19.63 13.18 17 93750 1006 42526562
Therapeutic response decreased 19.54 13.18 144 93623 36868 42490700
Haemoglobin decreased 19.45 13.18 404 93363 132067 42395501
Blood immunoglobulin A increased 19.38 13.18 12 93755 420 42527148
Bacterial parotitis 19.28 13.18 6 93761 35 42527533
Sopor 19.24 13.18 3 93764 13199 42514369
Palpitations 19.23 13.18 53 93714 50744 42476824
Periodontitis 19.17 13.18 24 93743 2187 42525381
Aphasia 19.06 13.18 15 93752 24068 42503500
JC virus infection 19.04 13.18 28 93739 2976 42524592
Arthritis 19.01 13.18 40 93727 42025 42485543
Heart rate decreased 18.91 13.18 32 93735 36500 42491068
Tubulointerstitial nephritis 18.89 13.18 25 93742 31523 42496045
Arteriosclerosis 18.79 13.18 8 93759 17981 42509587
Restlessness 18.75 13.18 22 93745 29227 42498341
Brief psychotic disorder with marked stressors 18.69 13.18 10 93757 264 42527304
Glycosylated haemoglobin increased 18.69 13.18 3 93764 12921 42514647
Transplant 18.60 13.18 16 93751 938 42526630
Light chain analysis decreased 18.60 13.18 6 93761 40 42527528
Blood immunoglobulin M increased 18.56 13.18 10 93757 268 42527300
Malignant fibrous histiocytoma 18.52 13.18 10 93757 269 42527299
Dystonia 18.43 13.18 3 93764 12787 42514781
Cardiac murmur 18.40 13.18 3 93764 12772 42514796
COVID-19 pneumonia 18.31 13.18 95 93672 21518 42506050
Melaena 18.22 13.18 36 93731 38710 42488858
Rectal adenocarcinoma 18.14 13.18 16 93751 970 42526598
Hepatitis 18.08 13.18 20 93747 27280 42500288
Type 2 diabetes mellitus 18.08 13.18 9 93758 18462 42509106
Alanine aminotransferase increased 18.06 13.18 117 93650 88289 42439279
Nodule 17.92 13.18 3 93764 12531 42515037
Pneumonia parainfluenzae viral 17.81 13.18 10 93757 291 42527277
HCoV-OC43 infection 17.65 13.18 6 93761 48 42527520
Psychotic disorder 17.64 13.18 23 93744 29185 42498383
Pulmonary embolism 17.63 13.18 365 93402 119247 42408321
Blood stem cell harvest 17.60 13.18 5 93762 20 42527548
Lip swelling 17.59 13.18 10 93757 19043 42508525
Bronchopulmonary aspergillosis 17.58 13.18 87 93680 19342 42508226
Speech disorder 17.51 13.18 23 93744 29098 42498470
Upper respiratory tract infection 17.35 13.18 155 93612 42018 42485550
Blood cholesterol increased 17.26 13.18 20 93747 26721 42500847
Drug ineffective for unapproved indication 17.15 13.18 166 93601 45997 42481571
Product quality issue 17.07 13.18 9 93758 17873 42509695
Thrombotic microangiopathy 16.97 13.18 71 93696 14711 42512857
Autologous bone marrow transplantation therapy 16.87 13.18 5 93762 24 42527544
Paranoia 16.76 13.18 5 93762 14021 42513547
Blood triglycerides increased 16.72 13.18 7 93760 15889 42511679
Micturition urgency 16.68 13.18 3 93764 11895 42515673
Prescribed overdose 16.60 13.18 4 93763 12923 42514645
Laryngeal cancer metastatic 16.56 13.18 6 93761 59 42527509
Respiratory arrest 16.54 13.18 23 93744 28401 42499167
Myositis 16.53 13.18 6 93761 14860 42512708
General physical condition abnormal 16.52 13.18 32 93735 4257 42523311
Hypercholesterolaemia 16.45 13.18 4 93763 12845 42514723
Mobility decreased 16.44 13.18 33 93734 35273 42492295
Hospitalisation 16.42 13.18 96 93671 74234 42453334
Weight increased 16.41 13.18 155 93612 107828 42419740
Liver function test increased 16.41 13.18 12 93755 19986 42507582
Administration related reaction 16.40 13.18 8 93759 173 42527395
Haemorrhagic fever 16.39 13.18 5 93762 27 42527541
Refractory anaemia with an excess of blasts 16.36 13.18 10 93757 342 42527226
Rib fracture 16.30 13.18 76 93691 16495 42511073
Acute erythroid leukaemia 16.25 13.18 9 93758 255 42527313
Confusional state 16.24 13.18 265 93502 167332 42360236
Cutaneous T-cell lymphoma 16.24 13.18 21 93746 1977 42525591
Movement disorder 16.23 13.18 6 93761 14692 42512876
Cardiac arrest 16.16 13.18 158 93609 109162 42418406
Discomfort 16.13 13.18 19 93748 25200 42502368
Human herpesvirus 6 infection reactivation 16.11 13.18 11 93756 456 42527112
Parophthalmia 16.10 13.18 7 93760 115 42527453
Cholestasis 15.94 13.18 30 93737 32849 42494719
Hepatic cirrhosis 15.94 13.18 12 93755 19690 42507878
Neuromuscular toxicity 15.88 13.18 7 93760 119 42527449
Cerebrovascular accident 15.84 13.18 137 93630 97023 42430545
Abnormal behaviour 15.80 13.18 21 93746 26430 42501138
Pulmonary oedema 15.77 13.18 183 93584 53089 42474479
Bile acid malabsorption 15.72 13.18 7 93760 122 42527446
Malignant neoplasm progression 15.71 13.18 330 93437 108070 42419498
Agranulocytosis 15.68 13.18 27 93740 30585 42496983
Neuromyotonia 15.54 13.18 5 93762 33 42527535
Product substitution issue 15.50 13.18 3 93764 11287 42516281
Adenovirus infection 15.27 13.18 41 93726 6768 42520800
Product storage error 15.21 13.18 3 93764 11137 42516431
Hypersensitivity 15.18 13.18 95 93672 72275 42455293
Refractory cytopenia with multilineage dysplasia 15.17 13.18 7 93760 133 42527435
Hyperlipidaemia 15.10 13.18 15 93752 21501 42506067
Dry skin 15.09 13.18 55 93712 48283 42479285
Hypocalcaemic seizure 15.07 13.18 6 93761 78 42527490
Eosinophilic pneumonia chronic 14.98 13.18 9 93758 298 42527270
Cerebral aspergillosis 14.95 13.18 19 93748 1758 42525810
Intervertebral disc disorder 14.89 13.18 20 93747 1954 42525614
Haematuria 14.80 13.18 71 93696 57728 42469840
Mucosal inflammation 14.79 13.18 170 93597 49204 42478364
Abdominal pain upper 14.60 13.18 114 93653 82495 42445073
Oxygen saturation decreased 14.58 13.18 83 93684 64604 42462964
Ill-defined disorder 14.42 13.18 9 93758 16287 42511281
Benign prostatic hyperplasia 14.41 13.18 15 93752 21037 42506531
Chest pain 14.40 13.18 218 93549 139312 42388256
Irritability 14.23 13.18 25 93742 28103 42499465
Oesophageal adenocarcinoma 14.23 13.18 14 93753 976 42526592
Dyspnoea 14.21 13.18 813 92954 441808 42085760
Muscle spasms 14.16 13.18 267 93500 85777 42441791
Chest discomfort 14.14 13.18 82 93685 63534 42464034
Urticaria 14.12 13.18 100 93667 73936 42453632
Gynaecomastia 14.10 13.18 5 93762 12562 42515006
Prostatic specific antigen increased 14.09 13.18 10 93757 16915 42510653
Acute febrile neutrophilic dermatosis 14.08 13.18 19 93748 1865 42525703
Blood culture positive 14.03 13.18 33 93734 5020 42522548
Blood phosphorus increased 14.02 13.18 5 93762 12520 42515048
Therapeutic product effect decreased 13.98 13.18 42 93725 39108 42488460
Full blood count increased 13.97 13.18 14 93753 998 42526570
Influenza 13.95 13.18 203 93564 61972 42465596
Jaundice 13.92 13.18 35 93732 34554 42493014
Chromaturia 13.91 13.18 9 93758 15980 42511588
Rectal abscess 13.90 13.18 18 93749 1697 42525871
Body height decreased 13.89 13.18 29 93738 4071 42523497
Meningioma 13.80 13.18 18 93749 1709 42525859
Swelling 13.72 13.18 68 93699 54817 42472751
Hepatic enzyme increased 13.71 13.18 53 93714 45731 42481837
Mental impairment 13.65 13.18 5 93762 12312 42515256
White blood cell count increased 13.62 13.18 52 93715 45035 42482533
Troponin T increased 13.58 13.18 23 93744 2757 42524811
Large intestine perforation 13.55 13.18 49 93718 9487 42518081
Hepatitis G 13.53 13.18 4 93763 19 42527549
TP53 gene mutation 13.47 13.18 5 93762 53 42527515
Klebsiella infection 13.45 13.18 55 93712 11277 42516291
Superinfection bacterial 13.41 13.18 16 93751 1388 42526180
VIth nerve paresis 13.39 13.18 5 93762 54 42527514
Atrial flutter 13.37 13.18 74 93693 17177 42510391
Morganella infection 13.34 13.18 11 93756 608 42526960
Tooth disorder 13.33 13.18 57 93710 11922 42515646
Pneumocystis jirovecii pneumonia 13.31 13.18 98 93669 25083 42502485
Iron deficiency anaemia 13.30 13.18 6 93761 13033 42514535
Hypercapnic coma 13.29 13.18 7 93760 179 42527389
Anger 13.26 13.18 6 93761 13012 42514556
Breath sounds abnormal 13.25 13.18 5 93762 12088 42515480
Impaired work ability 13.25 13.18 5 93762 12086 42515482
Hyperphosphataemia 13.24 13.18 6 93761 12998 42514570
Delusion 13.23 13.18 8 93759 14726 42512842
Coombs indirect test positive 13.20 13.18 4 93763 21 42527547

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Neuropathy peripheral 4734.05 12.65 2935 142124 176342 110267898
Plasma cell myeloma recurrent 2735.91 12.65 790 144269 6252 110437988
Plasma cell myeloma 2671.56 12.65 1407 143652 61529 110382711
Thrombocytopenia 1589.70 12.65 2115 142944 346770 110097470
Polyneuropathy 1341.30 12.65 710 144349 31302 110412938
Disease progression 1090.94 12.65 1467 143592 242567 110201673
Platelet count decreased 875.90 12.65 1282 143777 229161 110215079
Plasma cell myeloma refractory 860.15 12.65 243 144816 1758 110442482
Pneumonia 818.03 12.65 2763 142296 873951 109570289
Plasmacytoma 801.21 12.65 290 144769 4972 110439268
Off label use 770.52 12.65 3931 141128 1496254 108947986
Neutropenia 697.18 12.65 1525 143534 373095 110071145
Pancytopenia 476.07 12.65 927 144132 208686 110235554
Intentional product use issue 447.89 12.65 998 144061 246908 110197332
Sepsis 409.20 12.65 1145 143914 326201 110118039
Therapy partial responder 397.77 12.65 354 144705 36707 110407533
Cytopenia 374.62 12.65 313 144746 29803 110414437
Plasma cell leukaemia 355.39 12.65 125 144934 1963 110442277
Unevaluable event 355.10 12.65 413 144646 58814 110385426
Peripheral sensory neuropathy 347.32 12.65 236 144823 16444 110427796
Drug hypersensitivity 340.24 12.65 88 144971 454002 109990238
Headache 337.62 12.65 397 144662 881980 109562260
Arthralgia 336.08 12.65 317 144742 779315 109664925
Autonomic neuropathy 332.44 12.65 122 144937 2178 110442062
Diarrhoea 326.05 12.65 2578 142481 1136927 109307313
Systemic lupus erythematosus 307.98 12.65 5 145054 254333 110189907
Septic shock 303.39 12.65 651 144408 156877 110287363
Anaemia 302.26 12.65 1468 143591 545618 109898622
Tumour lysis syndrome 300.72 12.65 279 144780 30522 110413718
Rheumatoid arthritis 299.59 12.65 25 145034 299588 110144652
White blood cell count decreased 278.18 12.65 794 144265 228596 110215644
Synovitis 270.95 12.65 24 145035 274068 110170172
Completed suicide 266.93 12.65 12 145047 242369 110201871
Maternal exposure during pregnancy 264.08 12.65 18 145041 254865 110189375
Drug interaction 258.68 12.65 169 144890 500014 109944226
Glossodynia 258.38 12.65 7 145052 221997 110222243
Deep vein thrombosis 255.56 12.65 566 144493 139321 110304919
Orthostatic hypotension 254.67 12.65 371 144688 65878 110378362
Myelodysplastic syndrome 252.95 12.65 278 144781 37206 110407034
Stem cell transplant 252.30 12.65 121 144938 4306 110439934
Contraindicated product administered 236.79 12.65 25 145034 248242 110195998
Febrile neutropenia 230.08 12.65 923 144136 315844 110128396
Amyloidosis 228.24 12.65 102 144957 3079 110441161
Herpes zoster 226.21 12.65 463 144596 107916 110336324
Constipation 220.73 12.65 992 144067 356794 110087446
Pain 219.19 12.65 591 144468 954364 109489876
Arthropathy 218.54 12.65 54 145005 287468 110156772
Cardiac failure 217.33 12.65 639 144420 186987 110257253
B-cell type acute leukaemia 216.58 12.65 79 144980 1385 110442855
Swelling 212.84 12.65 97 144962 350944 110093296
Joint swelling 212.62 12.65 162 144897 442683 110001557
Helicobacter infection 210.66 12.65 6 145053 181871 110262369
Alopecia 210.17 12.65 108 144951 364645 110079595
Duodenal ulcer perforation 209.06 12.65 5 145054 177695 110266545
Renal failure 206.98 12.65 711 144348 225863 110218377
Fibromyalgia 204.24 12.65 4 145055 170905 110273335
Atrial fibrillation 204.02 12.65 714 144345 228928 110215312
Wound 201.11 12.65 33 145026 234404 110209836
Exposure during pregnancy 199.75 12.65 4 145055 167420 110276820
Acute lymphocytic leukaemia 194.79 12.65 111 144948 5654 110438586
Light chain analysis increased 189.98 12.65 82 144977 2273 110441967
Hypercalcaemia 187.67 12.65 267 144792 46390 110397850
Blood cholesterol increased 185.82 12.65 15 145044 184770 110259470
Haematotoxicity 183.04 12.65 179 144880 20903 110423337
Discomfort 182.44 12.65 31 145028 214676 110229564
Musculoskeletal stiffness 181.36 12.65 70 144989 279752 110164488
Irritable bowel syndrome 181.20 12.65 8 145051 164207 110280033
Overdose 179.43 12.65 43 145016 233751 110210489
Folliculitis 179.16 12.65 10 145049 167643 110276597
Osteolysis 177.69 12.65 103 144956 5420 110438820
Wheezing 177.14 12.65 57 145002 255173 110189067
Abdominal discomfort 174.27 12.65 156 144903 393702 110050538
Mobility decreased 173.91 12.65 48 145011 237374 110206866
Hypogammaglobulinaemia 173.45 12.65 170 144889 19906 110424334
Death 171.74 12.65 1530 143529 697339 109746901
Weight increased 166.38 12.65 183 144876 419461 110024779
Cardiac amyloidosis 166.12 12.65 79 144980 2758 110441482
Type 2 diabetes mellitus 166.05 12.65 19 145040 177213 110267027
Pericarditis 161.04 12.65 44 145015 219070 110225170
Blister 160.96 12.65 49 145010 227327 110216913
Anxiety 158.33 12.65 132 144927 344946 110099294
Dehydration 157.54 12.65 755 144304 278756 110165484
Primary amyloidosis 157.29 12.65 43 145016 271 110443969
Therapeutic product effect decreased 156.85 12.65 62 144997 244254 110199986
Drug abuse 156.63 12.65 23 145036 177388 110266852
Ill-defined disorder 154.24 12.65 14 145045 156839 110287401
Product use in unapproved indication 152.01 12.65 1056 144003 446321 109997919
Hypersensitivity 150.64 12.65 185 144874 403813 110040427
Ileus paralytic 150.13 12.65 124 144935 11613 110432627
Posterior reversible encephalopathy syndrome 148.47 12.65 202 144857 33659 110410581
Peripheral sensorimotor neuropathy 147.04 12.65 81 144978 3862 110440378
Nasopharyngitis 146.61 12.65 181 144878 394180 110050060
Malignant neoplasm progression 145.78 12.65 532 144527 174035 110270205
Migraine 145.35 12.65 25 145034 171627 110272613
Cytomegalovirus infection 144.93 12.65 258 144801 54186 110390054
Depression 141.17 12.65 125 144934 317210 110127030
Injury 139.19 12.65 31 145028 177234 110267006
Condition aggravated 137.11 12.65 499 144560 734337 109709903
Myelosuppression 136.78 12.65 349 144710 93991 110350249
Impaired healing 136.36 12.65 44 145015 196673 110247567
Drug reaction with eosinophilia and systemic symptoms 136.36 12.65 320 144739 81775 110362465
Neutrophil count decreased 136.27 12.65 408 144651 120533 110323707
Pyrexia 135.58 12.65 1784 143275 896481 109547759
Chalazion 135.36 12.65 46 145013 648 110443592
Osteoarthritis 133.58 12.65 37 145022 182586 110261654
Asthma 131.38 12.65 83 144976 250208 110194032
Psoriasis 131.15 12.65 15 145044 139978 110304262
Joint range of motion decreased 130.99 12.65 7 145052 121825 110322415
Dry mouth 129.56 12.65 50 145009 199898 110244342
Bursitis 129.36 12.65 11 145048 129907 110314333
B precursor type acute leukaemia 129.13 12.65 41 145018 460 110443780
Osteonecrosis of jaw 127.11 12.65 227 144832 47790 110396450
Full blood count decreased 126.60 12.65 182 144877 31917 110412323
Cytomegalovirus infection reactivation 125.47 12.65 137 144922 18196 110426044
Sleep disorder 124.91 12.65 52 145007 198592 110245648
Hyperviscosity syndrome 124.29 12.65 41 145018 524 110443716
Obesity 123.49 12.65 6 145053 113345 110330895
Injection site pain 122.96 12.65 40 145019 177882 110266358
Bone marrow failure 122.87 12.65 249 144810 57599 110386641
Guillain-Barre syndrome 117.99 12.65 104 144955 10640 110433600
Inappropriate schedule of product administration 117.66 12.65 60 144999 203577 110240663
Urticaria 116.75 12.65 148 144911 318709 110125531
Malaise 116.38 12.65 470 144589 671349 109772891
Lip dry 113.37 12.65 4 145055 100079 110344161
Hepatic enzyme increased 112.32 12.65 154 144905 320738 110123502
Pathological fracture 111.69 12.65 106 144953 11926 110432314
COVID-19 109.03 12.65 620 144439 244440 110199800
Blood pressure increased 108.73 12.65 107 144952 258266 110185974
Spinal cord compression 107.64 12.65 85 144974 7467 110436773
Rheumatoid factor positive 107.51 12.65 21 145038 131619 110312621
Acute myeloid leukaemia 107.14 12.65 185 144874 37925 110406315
C-reactive protein abnormal 105.27 12.65 21 145038 129674 110314566
Suicide attempt 102.26 12.65 9 145050 103385 110340855
Hypertension 99.97 12.65 339 144720 509745 109934495
Hepatitis B reactivation 99.77 12.65 81 144978 7403 110436837
Thrombosis 97.39 12.65 339 144720 108323 110335917
Liver injury 96.79 12.65 38 145021 150375 110293865
Pleural effusion 96.43 12.65 475 144584 177234 110267006
Hypercholesterolaemia 95.26 12.65 6 145053 90831 110353409
Pulmonary embolism 93.02 12.65 539 144520 213935 110230305
Therapy non-responder 91.51 12.65 429 144630 156878 110287362
Respiratory failure 91.34 12.65 538 144521 214794 110229446
Prescribed overdose 91.21 12.65 6 145053 87575 110356665
Haemoglobin decreased 90.85 12.65 598 144461 248129 110196111
Sinusitis 90.75 12.65 156 144903 296532 110147708
Progressive multifocal leukoencephalopathy 90.47 12.65 136 144923 24820 110419420
Pruritus 87.87 12.65 428 144631 581132 109863108
Neurotoxicity 87.65 12.65 180 144879 42027 110402213
Cystitis haemorrhagic 86.63 12.65 93 144966 12116 110432124
Keratopathy 85.83 12.65 40 145019 1333 110442907
Peripheral motor neuropathy 85.50 12.65 58 145001 4028 110440212
Grip strength decreased 84.97 12.65 5 145054 80169 110364071
Ileus 84.85 12.65 148 144911 30581 110413659
Contusion 84.68 12.65 109 144950 233252 110210988
Inflammation 83.65 12.65 78 144981 193160 110251080
Pseudomyopia 82.68 12.65 23 145036 156 110444084
Thrombotic microangiopathy 82.59 12.65 142 144917 29007 110415233
Stress 81.53 12.65 19 145040 105329 110338911
Abdominal pain upper 81.34 12.65 214 144845 348897 110095343
Bone pain 81.31 12.65 228 144831 64905 110379335
Hordeolum 80.45 12.65 60 144999 4841 110439399
Memory impairment 80.07 12.65 84 144975 196860 110247380
Pneumonia pneumococcal 77.55 12.65 59 145000 4906 110439334
Stomatitis 77.36 12.65 148 144911 270094 110174146
Musculoskeletal pain 76.75 12.65 76 144983 182947 110261293
Gastrooesophageal reflux disease 76.32 12.65 74 144985 179902 110264338
Product quality issue 75.71 12.65 7 145052 77292 110366948
Polyomavirus-associated nephropathy 75.65 12.65 72 144987 8129 110436111
Meningitis listeria 75.58 12.65 36 145023 1261 110442979
Monoclonal immunoglobulin present 75.48 12.65 45 145014 2495 110441745
Sciatica 74.90 12.65 15 145044 92384 110351856
Arthritis 74.49 12.65 66 144993 167520 110276720
Wound infection 73.47 12.65 18 145041 96447 110347793
Wrong technique in product usage process 73.32 12.65 13 145046 87335 110356905
Colitis ulcerative 73.18 12.65 8 145051 77355 110366885
Dyspepsia 72.64 12.65 86 144973 190879 110253361
Squamous cell carcinoma of skin 71.46 12.65 100 144959 17103 110427137
COVID-19 pneumonia 69.70 12.65 152 144907 36991 110407249
Peripheral venous disease 69.57 12.65 13 145046 84104 110360136
Protein total increased 69.12 12.65 54 145005 4670 110439570
Rhabdomyolysis 68.75 12.65 36 145023 120365 110323875
Frequent bowel movements 68.51 12.65 7 145052 71383 110372857
Night sweats 68.15 12.65 46 145013 133937 110310303
Visceral leishmaniasis 68.04 12.65 37 145022 1719 110442521
Bacterial sepsis 68.04 12.65 76 144983 10350 110433890
Bacteraemia 67.95 12.65 163 144896 42227 110402013
Respiratory tract infection 67.28 12.65 227 144832 71390 110372850
Syncope 66.83 12.65 475 144584 202061 110242179
IVth nerve paralysis 66.79 12.65 27 145032 632 110443608
Bronchopulmonary aspergillosis 66.35 12.65 131 144928 29732 110414508
Joint stiffness 66.10 12.65 6 145053 67237 110377003
Multiple organ dysfunction syndrome 65.58 12.65 381 144678 151329 110292911
Coombs indirect test positive 65.56 12.65 16 145043 59 110444181
Bone lesion 64.95 12.65 62 144997 7025 110437215
Blood stem cell harvest failure 64.72 12.65 18 145041 122 110444118
Blood lactate dehydrogenase increased 64.23 12.65 164 144895 44170 110400070
Sedation 63.94 12.65 8 145051 69675 110374565
Staphylococcal bacteraemia 63.44 12.65 93 144966 16595 110427645
Mucosal inflammation 63.26 12.65 272 144787 95869 110348371
Road traffic accident 62.99 12.65 31 145028 107367 110336873
Somnolence 62.16 12.65 192 144867 297257 110146983
Basal cell carcinoma 62.03 12.65 164 144895 45106 110399134
Toxic skin eruption 61.50 12.65 121 144938 27394 110416846
Clostridium difficile colitis 61.42 12.65 160 144899 43618 110400622
Autoimmune disorder 61.37 12.65 7 145052 65476 110378764
Blood pressure fluctuation 60.95 12.65 12 145047 74812 110369428
Renal amyloidosis 60.77 12.65 21 145038 312 110443928
Spinal compression fracture 60.73 12.65 96 144963 18296 110425944
Loss of personal independence in daily activities 59.84 12.65 65 144994 149955 110294285
Drug ineffective for unapproved indication 59.45 12.65 280 144779 102558 110341682
Enterococcal infection 58.73 12.65 100 144959 20266 110423974
Lymphopenia 58.61 12.65 149 144910 40021 110404219
Acute respiratory distress syndrome 58.51 12.65 178 144881 53020 110391220
Blood pressure systolic increased 58.49 12.65 18 145041 82973 110361267
Pain in extremity 58.13 12.65 387 144672 486731 109957509
Colitis 57.99 12.65 277 144782 102046 110342194
Blood creatine phosphokinase increased 56.91 12.65 13 145046 73064 110371176
Metapneumovirus infection 56.71 12.65 37 145022 2407 110441833
Underdose 56.63 12.65 8 145051 63546 110380694
Amnesia 56.61 12.65 34 145025 105374 110338866
Empyema 55.41 12.65 51 145008 5519 110438721
Suicidal ideation 55.26 12.65 27 145032 93910 110350330
Nasal congestion 55.21 12.65 30 145029 98252 110345988
Renal impairment 54.82 12.65 429 144630 188016 110256224
Nail disorder 54.78 12.65 6 145053 57929 110386311
Pregnancy 54.68 12.65 3 145056 51064 110393176
Pneumonia influenzal 54.60 12.65 43 145016 3762 110440478
Osteoporosis 54.47 12.65 23 145036 87129 110357111
H1N1 influenza 54.18 12.65 39 145020 2979 110441261
Lower limb fracture 53.72 12.65 16 145043 75332 110368908
Toxicity to various agents 53.65 12.65 907 144152 479648 109964592
Morganella infection 53.28 12.65 29 145030 1350 110442890
Flushing 53.20 12.65 36 145023 104700 110339540
Compression fracture 52.65 12.65 63 144996 9236 110435004
Heart rate increased 52.35 12.65 67 144992 143767 110300473
Hip arthroplasty 52.22 12.65 6 145053 55807 110388433
Hypocalcaemia 51.83 12.65 196 144863 65170 110379070
Engraftment syndrome 51.69 12.65 32 145027 1900 110442340
Monoclonal immunoglobulin increased 51.33 12.65 22 145037 599 110443641
Medication error 51.18 12.65 38 145021 105328 110338912
Large intestine perforation 51.09 12.65 84 144975 16545 110427695
Pulmonary oedema 51.02 12.65 264 144795 100395 110343845
Febrile bone marrow aplasia 50.69 12.65 86 144973 17379 110426861
Back injury 50.09 12.65 3 145056 47396 110396844
Cardiac failure congestive 49.14 12.65 353 144706 150647 110293593
Bone erosion 48.81 12.65 3 145056 46368 110397872
Clostridium difficile infection 48.76 12.65 165 144894 51964 110392276
Device related sepsis 48.63 12.65 55 145004 7592 110436648
Thrombotic thrombocytopenic purpura 48.41 12.65 53 145006 7058 110437182
Inappropriate antidiuretic hormone secretion 47.77 12.65 124 144935 33727 110410513
Paraproteinaemia 47.49 12.65 20 145039 521 110443719
Anaphylactic reaction 47.29 12.65 48 145011 114252 110329988
Klebsiella infection 47.17 12.65 90 144969 19919 110424321
Cytokine release syndrome 47.09 12.65 200 144859 70106 110374134
Infection in an immunocompromised host 46.75 12.65 30 145029 1897 110442343
Escherichia sepsis 46.12 12.65 62 144997 10210 110434030
Foot deformity 45.89 12.65 5 145054 48475 110395765
Incorrect dose administered 45.83 12.65 41 145018 103600 110340640
Performance status decreased 45.77 12.65 52 145007 7214 110437026
Neurogenic bladder 45.73 12.65 44 145015 5035 110439205
Dislocation of vertebra 45.51 12.65 3 145056 43718 110400522
Monoclonal gammopathy 45.47 12.65 25 145034 1187 110443053
Exostosis 45.44 12.65 4 145055 45952 110398288
Myalgia 44.72 12.65 146 144913 222235 110222005
Diverticular perforation 44.33 12.65 48 145011 6314 110437926
Blepharitis 43.97 12.65 41 145018 4511 110439729
Red blood cell sedimentation rate increased 43.84 12.65 24 145035 78278 110365962
Light chain analysis abnormal 43.52 12.65 15 145044 221 110444019
Pneumonia fungal 43.28 12.65 73 144986 14681 110429559
Erythema 43.07 12.65 216 144843 291231 110153009
BK virus infection 42.71 12.65 68 144991 13038 110431202
Hyperhidrosis 42.69 12.65 116 144943 187182 110257058
Palpitations 42.29 12.65 91 144968 159121 110285119
Infection 42.00 12.65 688 144371 361512 110082728
Transplant 41.62 12.65 24 145035 1250 110442990
Hepatitis B 41.61 12.65 57 145002 9555 110434685
Crossmatch incompatible 41.61 12.65 10 145049 34 110444206
Acute kidney injury 41.48 12.65 1109 143950 634321 109809919
Angioedema 41.17 12.65 41 145018 98459 110345781
Erysipelas 41.14 12.65 67 144992 13091 110431149
Chronic inflammatory demyelinating polyradiculoneuropathy 40.87 12.65 29 145030 2166 110442074
Disease recurrence 40.77 12.65 173 144886 60611 110383629
Accidental exposure to product 40.77 12.65 8 145051 50000 110394240
Gastrointestinal toxicity 40.76 12.65 61 144998 11087 110433153
Product use issue 40.68 12.65 604 144455 311091 110133149
Liver function test increased 40.40 12.65 34 145025 88514 110355726
Drug intolerance 40.35 12.65 340 144719 406172 110038068
Feeling hot 40.33 12.65 36 145023 91070 110353170
Drug resistance 39.81 12.65 163 144896 56211 110388029
Pneumocystis jirovecii pneumonia 39.73 12.65 135 144924 42600 110401640
Neck pain 39.23 12.65 63 144996 123067 110321173
Autonomic nervous system imbalance 39.21 12.65 43 145016 5737 110438503
Drug-induced liver injury 38.67 12.65 61 144998 120006 110324234
Malignant syphilis 38.53 12.65 10 145049 50 110444190
Lactic acidosis 38.37 12.65 39 145020 92772 110351468
Refractory cytopenia with multilineage dysplasia 38.19 12.65 14 145045 249 110443991
Rhinovirus infection 38.19 12.65 61 144998 11728 110432512
Demyelinating polyneuropathy 37.96 12.65 28 145031 2221 110442019
Neutropenic sepsis 37.75 12.65 107 144952 30639 110413601
Graft versus host disease 37.63 12.65 79 144980 18727 110425513
Injection site swelling 37.51 12.65 17 145042 61773 110382467
General physical condition abnormal 37.47 12.65 48 145011 7542 110436698
Osteonecrosis 37.20 12.65 113 144946 33628 110410612
Hypothyroidism 37.10 12.65 25 145034 72874 110371366
Neuralgic amyotrophy 37.07 12.65 15 145044 352 110443888
Sopor 36.63 12.65 3 145056 36543 110407697
Heart rate decreased 36.28 12.65 33 145026 82723 110361517
Toxic neuropathy 36.28 12.65 21 145038 1102 110443138
Cardiotoxicity 36.24 12.65 73 144986 16808 110427432
Large intestinal ulcer perforation 35.55 12.65 10 145049 71 110444169
Rash 35.32 12.65 1363 143696 819601 109624639
JC virus infection 35.27 12.65 39 145020 5251 110438989
Accidental overdose 35.19 12.65 12 145047 51822 110392418
Abdominal pain 35.10 12.65 468 144591 512521 109931719
Illness 34.57 12.65 34 145025 82137 110362103
Parainfluenzae virus infection 34.26 12.65 44 145015 6930 110437310
Treatment failure 34.17 12.65 218 144841 277016 110167224
Ageusia 34.17 12.65 78 144981 19567 110424673
Neuralgia 34.10 12.65 140 144919 48338 110395902
Nasal abscess 34.08 12.65 12 145047 189 110444051
Lip swelling 33.93 12.65 12 145047 50655 110393585
Eczema 33.92 12.65 27 145032 72266 110371974
Pneumonia bacterial 33.83 12.65 93 144966 26168 110418072
Rash maculo-papular 33.76 12.65 189 144870 74033 110370207
Adenocarcinoma of colon 33.63 12.65 41 145018 6127 110438113
IgA nephropathy 33.42 12.65 30 145029 3143 110441097
Drug withdrawal syndrome 33.42 12.65 5 145054 38049 110406191
VIth nerve paresis 33.32 12.65 11 145048 141 110444099
Mesenteric abscess 33.10 12.65 11 145048 144 110444096
Swollen tongue 33.07 12.65 19 145040 60343 110383897
Acute erythroid leukaemia 32.95 12.65 14 145045 373 110443867
Venoocclusive liver disease 32.93 12.65 66 144993 15141 110429099
Varicella 32.81 12.65 32 145027 3723 110440517
Rib fracture 32.56 12.65 108 144951 33662 110410578
Listeriosis 32.43 12.65 28 145031 2786 110441454
Atrial flutter 32.33 12.65 87 144972 24175 110420065
Blood stem cell harvest 31.88 12.65 8 145051 34 110444206
Abdominal abscess 31.88 12.65 48 145011 8771 110435469
Nocardiosis 31.82 12.65 44 145015 7442 110436798
Tear break up time decreased 31.79 12.65 7 145052 14 110444226
Retinitis 31.46 12.65 3 145056 32324 110411916
Aspiration bone marrow 31.37 12.65 11 145048 171 110444069
Joint injury 31.37 12.65 7 145052 39987 110404253
Staphylococcal sepsis 31.14 12.65 70 144989 17384 110426856
Pneumonia parainfluenzae viral 31.06 12.65 16 145043 665 110443575
Leukopenia 31.01 12.65 315 144744 148476 110295764
Hypoalbuminaemia 30.97 12.65 96 144963 28878 110415362
Fatigue 30.88 12.65 1917 143142 1214041 109230199
Leukaemic infiltration extramedullary 30.85 12.65 13 145046 339 110443901
Dysarthria 30.80 12.65 39 145020 84082 110360158
Fungal oesophagitis 30.78 12.65 19 145040 1122 110443118
Gait inability 30.67 12.65 85 144974 136291 110307949
Throat irritation 30.58 12.65 16 145043 53536 110390704
Procedural pain 30.49 12.65 5 145054 35560 110408680
Hiccups 30.48 12.65 58 145001 12811 110431429
Adenovirus infection 30.41 12.65 53 145006 10941 110433299
Klebsiella sepsis 30.11 12.65 32 145027 4121 110440119
Asthenia 30.11 12.65 1146 143913 687853 109756387
Anaphylactic shock 30.04 12.65 15 145044 51531 110392709
Ear infection 29.98 12.65 23 145036 62709 110381531
Gastrointestinal disorder 29.95 12.65 190 144869 241762 110202478
Oropharyngeal pain 29.91 12.65 85 144974 135191 110309049
Diabetic ketoacidosis 29.86 12.65 9 145050 42049 110402191
Gait disturbance 29.75 12.65 228 144831 277980 110166260
Pseudomonal sepsis 29.57 12.65 47 145012 8999 110435241
Failure to thrive 29.50 12.65 59 145000 13515 110430725
Hypoglycaemia 29.49 12.65 68 144991 116036 110328204
Cerebellar haemangioma 29.46 12.65 9 145050 88 110444152
Confusional state 29.41 12.65 435 144624 468245 109975995
Endocarditis bacterial 29.41 12.65 22 145037 1783 110442457
Gastrointestinal infection 29.39 12.65 60 144999 13945 110430295
Blood disorder 29.39 12.65 49 145010 9761 110434479
Ureteric haemorrhage 29.29 12.65 10 145049 143 110444097
Increased viscosity of upper respiratory secretion 29.26 12.65 15 145044 617 110443623
Cough 29.13 12.65 428 144631 461213 109983027
Oroantral fistula 29.10 12.65 13 145046 392 110443848
Disability 28.90 12.65 3 145056 30220 110414020
Meibomian gland dysfunction 28.73 12.65 12 145047 306 110443934
Pulmonary sepsis 28.64 12.65 35 145024 5243 110438997
Visual impairment 28.61 12.65 86 144973 134342 110309898
Enterococcal sepsis 28.52 12.65 28 145031 3284 110440956
Factor VII deficiency 28.51 12.65 9 145050 99 110444141
Rectal adenocarcinoma 28.45 12.65 21 145038 1668 110442572
Sudden cardiac death 28.38 12.65 36 145023 5601 110438639
Nightmare 28.17 12.65 8 145051 38855 110405385
Listeria sepsis 28.16 12.65 16 145043 810 110443430
Therapeutic response shortened 28.13 12.65 3 145056 29580 110414660
Hemianopia 28.03 12.65 26 145033 2842 110441398
Refractory anaemia with an excess of blasts 27.79 12.65 16 145043 831 110443409
Autologous haematopoietic stem cell transplant 27.65 12.65 9 145050 110 110444130
VIth nerve paralysis 27.60 12.65 21 145038 1746 110442494
Hypersensitivity myocarditis 27.52 12.65 12 145047 341 110443899
N-terminal prohormone brain natriuretic peptide decreased 27.31 12.65 7 145052 33 110444207
Dyskinesia 27.05 12.65 17 145042 51429 110392811
Plasma cells increased 26.87 12.65 9 145050 121 110444119
Therapy interrupted 26.85 12.65 16 145043 49806 110394434
Blood potassium decreased 26.77 12.65 141 144918 53973 110390267
Autologous bone marrow transplantation therapy 26.65 12.65 7 145052 37 110444203
Respirovirus test positive 26.60 12.65 9 145050 125 110444115
Cellulitis 26.36 12.65 267 144792 125749 110318491
Bone marrow disorder 26.22 12.65 30 145029 4193 110440047
Seizure 26.20 12.65 176 144883 221009 110223231
Hepatic cirrhosis 26.19 12.65 30 145029 67596 110376644
Cardiomyopathy 26.14 12.65 100 144959 33425 110410815
Electrolyte imbalance 26.09 12.65 107 144952 36921 110407319
Obstructive airways disorder 26.04 12.65 14 145045 46135 110398105
Haematochezia 25.98 12.65 72 144987 115452 110328788
Plasmablastic lymphoma 25.78 12.65 15 145044 795 110443445
Prohormone brain natriuretic peptide increased 25.77 12.65 12 145047 399 110443841
Lung infiltration 25.77 12.65 81 144978 24547 110419693
Chills 25.51 12.65 371 144688 190209 110254031
Hallucination, visual 25.48 12.65 10 145049 39595 110404645
Pneumonia cytomegaloviral 25.35 12.65 38 145021 6916 110437324
Hyperproteinaemia 25.35 12.65 11 145048 309 110443931
Hyperthyroidism 25.34 12.65 4 145055 29257 110414983
Congestive cardiomyopathy 25.33 12.65 57 145002 14162 110430078
Body dysmorphic disorder 25.12 12.65 12 145047 423 110443817
Anal squamous cell carcinoma 25.07 12.65 15 145044 837 110443403
Peripheral swelling 25.00 12.65 376 144683 403658 110040582
Meningitis cryptococcal 24.91 12.65 31 145028 4731 110439509
Hepatitis E 24.90 12.65 30 145029 4429 110439811
Extrapyramidal disorder 24.88 12.65 4 145055 28863 110415377
Blood creatinine increased 24.86 12.65 357 144702 182532 110261708
Cerebral aspergillosis 24.71 12.65 22 145037 2280 110441960
End stage renal disease 24.69 12.65 73 144986 21400 110422840
Depressed mood 24.63 12.65 26 145033 60783 110383457
Dyspnoea 24.62 12.65 1194 143865 1105678 109338562
N-terminal prohormone brain natriuretic peptide increased 24.56 12.65 35 145024 6086 110438154
Injection site bruising 24.24 12.65 19 145040 51244 110392996
Small intestinal obstruction 24.23 12.65 95 144964 32118 110412122
Hypotension 24.23 12.65 877 144182 522972 109921268
Bacterial infection 24.20 12.65 122 144937 45914 110398326
Acne 24.11 12.65 7 145052 33513 110410727
Rash pruritic 24.10 12.65 215 144844 97854 110346386
Impaired quality of life 24.06 12.65 5 145054 30012 110414228
Campylobacter colitis 23.85 12.65 8 145051 108 110444132
Neoplasm skin 23.78 12.65 25 145034 3179 110441061
Hot flush 23.78 12.65 31 145028 66005 110378235
Myeloma cast nephropathy 23.65 12.65 10 145049 263 110443977
Drug ineffective 23.64 12.65 2307 142752 1518233 108926007
Corticobasal degeneration 23.63 12.65 6 145053 27 110444213
Intentional product misuse 23.55 12.65 92 144967 132812 110311428
Respiratory syncytial virus infection 23.54 12.65 56 145003 14428 110429812
Refractory cancer 23.51 12.65 10 145049 267 110443973
Disturbance in social behaviour 23.43 12.65 31 145028 5027 110439213
Squamous cell carcinoma 23.40 12.65 65 144994 18398 110425842
Coma 23.26 12.65 78 144981 117791 110326449
Pneumonia respiratory syncytial viral 23.23 12.65 23 145036 2726 110441514
Insomnia 23.20 12.65 333 144726 360257 110083983
Blood culture positive 23.19 12.65 42 145017 8934 110435306
Nodule 23.13 12.65 7 145052 32624 110411616
Pallor 23.03 12.65 24 145035 56443 110387797
Skin neoplasm excision 22.75 12.65 20 145039 2038 110442202
Periodontitis 22.72 12.65 31 145028 5177 110439063
Malnutrition 22.63 12.65 83 144976 27196 110417044
Surgery 22.61 12.65 13 145046 41270 110402970
Lower respiratory tract infection 22.48 12.65 207 144852 242899 110201341
Laryngitis 22.32 12.65 14 145045 42397 110401843
Feeling abnormal 22.31 12.65 142 144917 180569 110263671
Transitional cell carcinoma 22.20 12.65 24 145035 3151 110441089
Conjunctival irritation 22.16 12.65 8 145051 136 110444104
Type III immune complex mediated reaction 22.16 12.65 15 145044 1038 110443202
Aggression 22.15 12.65 27 145032 59183 110385057
Protein total decreased 22.08 12.65 46 145013 10844 110433396
Oedema peripheral 22.08 12.65 576 144483 328084 110116156
Ejection fraction decreased 21.96 12.65 109 144950 40771 110403469
Nephrolithiasis 21.93 12.65 33 145026 66179 110378061
Urosepsis 21.90 12.65 89 144970 30586 110413654
Blood immunoglobulin G increased 21.89 12.65 26 145033 3782 110440458
Oral surgery 21.87 12.65 17 145042 1459 110442781
Leukaemia 21.79 12.65 37 145022 7481 110436759
Spondylolysis 21.75 12.65 9 145050 224 110444016
Gastrointestinal amyloidosis 21.70 12.65 7 145052 83 110444157
Hypokalaemia 21.65 12.65 348 144711 182100 110262140
Meningitis pneumococcal 21.57 12.65 13 145046 735 110443505
Bacterial parotitis 21.53 12.65 6 145053 41 110444199
Pneumococcal sepsis 21.51 12.65 20 145039 2192 110442048
Fat tissue increased 21.47 12.65 15 145044 1093 110443147
Light chain analysis 21.28 12.65 5 145054 15 110444225
Crying 21.10 12.65 4 145055 25624 110418616
Gastrointestinal fungal infection 21.09 12.65 13 145046 766 110443474
Glycosylated haemoglobin increased 20.98 12.65 3 145056 23616 110420624
Venous thrombosis 20.97 12.65 39 145020 8466 110435774
Blood immunoglobulin A increased 20.96 12.65 17 145042 1551 110442689
Sudden death 20.89 12.65 75 144984 24320 110419920
Product prescribing error 20.73 12.65 22 145037 51309 110392931
Respiratory depression 20.72 12.65 8 145051 31993 110412247
Superficial spreading melanoma stage unspecified 20.72 12.65 10 145049 361 110443879
Clostridium bacteraemia 20.72 12.65 11 145048 487 110443753
Malignant fibrous histiocytoma 20.31 12.65 9 145050 266 110443974
Chest discomfort 20.25 12.65 139 144920 173709 110270531
Sinus polyp 20.23 12.65 12 145047 659 110443581
Prescribed underdose 20.15 12.65 34 145025 65140 110379100
Superinfection bacterial 20.12 12.65 20 145039 2381 110441859
Bone marrow transplant 20.11 12.65 17 145042 1643 110442597
Bronchiolitis 20.00 12.65 30 145029 5463 110438777
Philadelphia chromosome negative 19.97 12.65 5 145054 21 110444219
Pulmonary haemorrhage 19.94 12.65 57 145002 16399 110427841
Light chain disease 19.88 12.65 9 145050 280 110443960
Musculoskeletal disorder 19.85 12.65 3 145056 22661 110421579
Myositis 19.78 12.65 8 145051 31108 110413132
Torsade de pointes 19.78 12.65 3 145056 22597 110421643
Target skin lesion 19.74 12.65 9 145050 285 110443955
Body temperature decreased 19.71 12.65 12 145047 36923 110407317
Peritonitis viral 19.70 12.65 6 145053 58 110444182
Hypophosphataemia 19.65 12.65 91 144968 33091 110411149
Clostridial infection 19.58 12.65 32 145027 6270 110437970
Chromaturia 19.58 12.65 7 145052 29353 110414887
Respiratory distress 19.57 12.65 156 144903 68718 110375522
Acute febrile neutrophilic dermatosis 19.48 12.65 28 145031 4908 110439332
Pneumonia herpes viral 19.37 12.65 8 145051 198 110444042
Vomiting 19.32 12.65 987 144072 909688 109534552
Poisoning 19.31 12.65 7 145052 29098 110415142
Lymphocytic leukaemia 19.20 12.65 9 145050 304 110443936
Cytomegalovirus viraemia 19.12 12.65 59 145000 17705 110426535
Cytomegalovirus enterocolitis 19.11 12.65 19 145040 2262 110441978
Acute graft versus host disease 19.02 12.65 48 145011 12833 110431407
Therapeutic response decreased 19.02 12.65 202 144857 96297 110347943
Normal newborn 18.95 12.65 3 145056 21893 110422347
Ocular toxicity 18.94 12.65 15 145044 1323 110442917
Tooth deposit 18.93 12.65 9 145050 314 110443926
Infection reactivation 18.89 12.65 25 145034 4056 110440184
Device dislocation 18.82 12.65 9 145050 31695 110412545
Bradycardia 18.79 12.65 123 144936 155394 110288846
Generalised oedema 18.77 12.65 85 144974 30619 110413621
Spinal column injury 18.77 12.65 19 145040 2312 110441928
Pneumococcal infection 18.77 12.65 17 145042 1802 110442438
Irritability 18.74 12.65 21 145038 47788 110396452
Hypocalcaemic seizure 18.72 12.65 7 145052 132 110444108
Malignant neoplasm of unknown primary site 18.55 12.65 12 145047 769 110443471
Escherichia infection 18.54 12.65 71 144988 23745 110420495
Second primary malignancy 18.52 12.65 59 145000 18009 110426231
Bladder sphincter atony 18.29 12.65 8 145051 229 110444011
Immunosuppression 18.21 12.65 58 145001 17701 110426539
Vertigo 18.18 12.65 56 145003 86814 110357426
Plasma cells present 18.17 12.65 4 145055 8 110444232
Product substitution issue 18.16 12.65 4 145055 23057 110421183
Pneumonia haemophilus 18.08 12.65 20 145039 2695 110441545
Aphasia 18.03 12.65 31 145028 58966 110385274
Clostridium colitis 18.02 12.65 22 145037 3293 110440947
Dysgeusia 18.01 12.65 155 144904 69830 110374410
Brief psychotic disorder with marked stressors 18 12.65 9 145050 351 110443889
Chest pain 17.91 12.65 367 144692 376008 110068232
Brain abscess 17.89 12.65 32 145027 6742 110437498
Sleep apnoea syndrome 17.88 12.65 16 145043 40431 110403809
Movement disorder 17.84 12.65 13 145046 36391 110407849
Troponin T increased 17.84 12.65 25 145034 4281 110439959
Cellulitis orbital 17.78 12.65 13 145046 1017 110443223
Hepatitis viral 17.66 12.65 15 145044 1460 110442780
Enteric neuropathy 17.55 12.65 4 145055 10 110444230
TP53 gene mutation 17.55 12.65 7 145052 158 110444082
Panic attack 17.51 12.65 8 145051 28932 110415308
Pneumocystis jirovecii infection 17.42 12.65 25 145034 4375 110439865
Multiple sclerosis 17.36 12.65 6 145053 25692 110418548
Epilepsy 17.35 12.65 70 144989 100139 110344101
Incorrect product administration duration 17.31 12.65 3 145056 20495 110423745
Pulmonary alveolar haemorrhage 17.30 12.65 62 144997 20088 110424152
Febrile infection 17.21 12.65 25 145034 4423 110439817
Iron deficiency anaemia 17.19 12.65 10 145049 31549 110412691
White blood cell count increased 17.18 12.65 67 144992 96775 110347465
Ear pain 17.17 12.65 27 145032 53199 110391041
Pityriasis rubra pilaris 17.10 12.65 8 145051 269 110443971
Joint dislocation 17.03 12.65 12 145047 34178 110410062
Staphylococcal infection 17.01 12.65 153 144906 69791 110374449
Intraductal proliferative breast lesion 16.97 12.65 20 145039 2885 110441355
Haemorrhagic occlusive retinal vasculitis 16.95 12.65 6 145053 96 110444144
Enterocolitis bacterial 16.80 12.65 11 145048 720 110443520
Human herpesvirus 6 infection reactivation 16.72 12.65 13 145046 1116 110443124
Laboratory test abnormal 16.69 12.65 107 144952 43972 110400268
Sputum discoloured 16.48 12.65 8 145051 27937 110416303
Scrotal pain 16.47 12.65 10 145049 573 110443667
Spinal fracture 16.42 12.65 66 144993 22567 110421673
Phrenic nerve paralysis 16.41 12.65 10 145049 577 110443663
Pneumonia staphylococcal 16.38 12.65 29 145030 6062 110438178
C-reactive protein increased 16.30 12.65 195 144864 217724 110226516
Laryngeal cancer metastatic 16.27 12.65 5 145054 50 110444190
Injection site reaction 16.20 12.65 61 144998 89009 110355231
Administration related reaction 16.12 12.65 8 145051 307 110443933
Tendonitis 16.11 12.65 7 145052 26076 110418164
Graft versus host disease in gastrointestinal tract 16.03 12.65 36 145023 8932 110435308
Mouth ulceration 15.93 12.65 24 145035 48114 110396126
Nervous system disorder 15.93 12.65 83 144976 31638 110412602
Hypoglossal nerve paresis 15.91 12.65 6 145053 116 110444124
Tachycardia 15.75 12.65 206 144853 226439 110217801
Bile acid malabsorption 15.67 12.65 9 145050 465 110443775
Diverticulitis 15.63 12.65 122 144937 53400 110390840
Mantle cell lymphoma recurrent 15.60 12.65 12 145047 1014 110443226
Drug level increased 15.59 12.65 24 145035 47695 110396545
Musculoskeletal chest pain 15.55 12.65 77 144982 28770 110415470
Hepatitis 15.53 12.65 63 144996 89991 110354249
Atrial rupture 15.52 12.65 5 145054 59 110444181
Candida infection 15.47 12.65 112 144947 47897 110396343
Cholangiocarcinoma 15.44 12.65 19 145040 2866 110441374
Precursor B-lymphoblastic lymphoma 15.41 12.65 4 145055 20 110444220
Pseudomembranous colitis 15.38 12.65 29 145030 6362 110437878
Capillary leak syndrome 15.36 12.65 25 145034 4883 110439357
Psychotic disorder 15.36 12.65 27 145032 50910 110393330
Genital erythema 15.32 12.65 8 145051 342 110443898
Ventricular fibrillation 15.28 12.65 19 145040 41294 110402946
Weight fluctuation 15.25 12.65 5 145054 22140 110422100
Bing-Neel syndrome 15.25 12.65 4 145055 21 110444219
Human chorionic gonadotropin increased 15.19 12.65 14 145045 1518 110442722
Cardiomegaly 15.17 12.65 77 144982 29053 110415187
Hypervolaemia 15.15 12.65 114 144945 49346 110394894
Atelectasis 15.08 12.65 91 144968 36621 110407619
Cardiac pacemaker evaluation 15.02 12.65 6 145053 136 110444104
Device related infection 15.00 12.65 96 144963 39423 110404817
Nephrotic syndrome 14.94 12.65 46 145013 13785 110430455
Impaired work ability 14.93 12.65 8 145051 26411 110417829
Streptococcal bacteraemia 14.90 12.65 24 145035 4645 110439595
Adenoviral haemorrhagic cystitis 14.88 12.65 10 145049 684 110443556
Dialysis 14.87 12.65 58 145001 19561 110424679
Pneumonia viral 14.86 12.65 40 145019 11117 110433123
Rectal abscess 14.83 12.65 18 145041 2678 110441562
Granulicatella bacteraemia 14.80 12.65 4 145055 24 110444216
Macular degeneration 14.73 12.65 5 145054 21654 110422586
Fear 14.68 12.65 6 145053 23187 110421053
Plasma cells decreased 14.68 12.65 5 145054 71 110444169
Cytomegalovirus hepatitis 14.67 12.65 11 145048 895 110443345
Metastases to lung 14.55 12.65 6 145053 23057 110421183
Cutaneous T-cell lymphoma 14.55 12.65 20 145039 3364 110440876
Blood immunoglobulin M increased 14.40 12.65 14 145045 1623 110442617
Rectal haemorrhage 14.36 12.65 95 144964 119738 110324502
Dizziness 14.35 12.65 759 144300 697434 109746806
Bronchiectasis 14.34 12.65 16 145043 36477 110407763
Faeces discoloured 14.33 12.65 14 145045 33934 110410306
Cytomegalovirus chorioretinitis 14.33 12.65 30 145029 7098 110437142
Ischaemic stroke 14.31 12.65 98 144961 41165 110403075
Disseminated intravascular coagulation 14.29 12.65 98 144961 41188 110403052
Restlessness 14.24 12.65 33 145026 56226 110388014
Cardiac failure acute 14.23 12.65 66 144993 24012 110420228
Varicella zoster virus infection 14.22 12.65 28 145031 6340 110437900
Eosinophilic pneumonia chronic 14.18 12.65 9 145050 558 110443682
Minimal residual disease 14.17 12.65 11 145048 942 110443298
Metastatic squamous cell carcinoma 14.16 12.65 10 145049 741 110443499
Organising pneumonia 14.13 12.65 46 145013 14197 110430043
Eosinophil count increased 14.08 12.65 5 145054 21053 110423187
Pneumonia streptococcal 14.07 12.65 20 145039 3469 110440771
Ulcer haemorrhage 14.03 12.65 6 145053 22565 110421675
Neoplasm 14.02 12.65 39 145020 11048 110433192
Hyperglycaemia 14.01 12.65 172 144887 84918 110359322
Hypoperfusion 13.98 12.65 19 145040 3162 110441078
Dilatation atrial 13.97 12.65 21 145038 3831 110440409
Bone disorder 13.97 12.65 60 144999 21132 110423108
Laryngitis bacterial 13.92 12.65 4 145055 31 110444209
Oculomotor study abnormal 13.92 12.65 4 145055 31 110444209
Cholelithiasis 13.91 12.65 40 145019 63382 110380858
Blood sodium decreased 13.89 12.65 92 144967 38227 110406013
Blood triglycerides increased 13.88 12.65 7 145052 23919 110420321
Proteinuria 13.85 12.65 95 144964 39923 110404317
Malignant melanoma in situ 13.84 12.65 20 145039 3522 110440718
Nephropathy 13.82 12.65 44 145015 13423 110430817
Blood pressure diastolic decreased 13.81 12.65 16 145043 35869 110408371
Ornithine transcarbamoylase deficiency 13.80 12.65 4 145055 32 110444208
Giardiasis 13.77 12.65 9 145050 587 110443653
Hyperamylasaemia 13.77 12.65 12 145047 1209 110443031
Delayed engraftment 13.72 12.65 7 145052 285 110443955
Humerus fracture 13.72 12.65 38 145021 10738 110433502
Oesophageal adenocarcinoma 13.71 12.65 11 145048 988 110443252
Delusion 13.71 12.65 7 145052 23748 110420492
Acinetobacter infection 13.71 12.65 20 145039 3553 110440687
Bence Jones proteinuria 13.63 12.65 3 145056 6 110444234
Haemorrhagic fever 13.59 12.65 4 145055 34 110444206
Glioblastoma 13.53 12.65 15 145044 2025 110442215
Intraocular pressure test 13.43 12.65 5 145054 93 110444147
Aplasia 13.41 12.65 31 145028 7842 110436398
Follicle centre lymphoma, follicular grade I, II, III recurrent 13.31 12.65 3 145056 7 110444233
Dermatitis exfoliative generalised 13.29 12.65 38 145021 10934 110433306
Oncologic complication 13.28 12.65 8 145051 452 110443788
Encephalitis viral 13.27 12.65 18 145041 2989 110441251
Thyroid disorder 13.25 12.65 3 145056 16966 110427274
Plasma cell myeloma in remission 13.20 12.65 4 145055 38 110444202
Paranoid personality disorder 13.20 12.65 4 145055 38 110444202
Serum sickness 13.19 12.65 22 145037 4384 110439856
Procalcitonin increased 13.15 12.65 21 145038 4035 110440205
Product storage error 13.15 12.65 6 145053 21722 110422518
Clostridial sepsis 13.13 12.65 11 145048 1050 110443190
Iron deficiency 13.03 12.65 4 145055 18472 110425768
Squamous cell carcinoma of lung 12.92 12.65 17 145042 2742 110441498
Arrhythmia supraventricular 12.92 12.65 16 145043 2430 110441810
Hypergammaglobulinaemia benign monoclonal 12.88 12.65 11 145048 1078 110443162
Plasmacytosis 12.79 12.65 6 145053 203 110444037
Infectious pleural effusion 12.78 12.65 23 145036 4868 110439372
Electrodesiccation 12.77 12.65 3 145056 9 110444231
Female genital tract fistula 12.74 12.65 3 145056 16516 110427724
Exposed bone in jaw 12.73 12.65 20 145039 3791 110440449
Bacillus infection 12.71 12.65 13 145046 1601 110442639
Neuromyotonia 12.70 12.65 5 145054 109 110444131
Acute pulmonary oedema 12.68 12.65 50 145009 16946 110427294
Adverse event 12.67 12.65 87 144972 108722 110335518
Vascular device infection 12.67 12.65 49 145010 16463 110427777

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L01XG01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Proteasome inhibitors
FDA MoA N0000175075 Proteasome Inhibitors
MeSH PA D000970 Antineoplastic Agents
FDA EPC N0000175604 Proteasome Inhibitor
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35820 antiprotozoal drug
CHEBI has role CHEBI:37670 protease inhibitor
CHEBI has role CHEBI:52726 proteasome inhibitor

Related Drugs by ATC class:

L01XG Proteasome inhibitors 2 drugs
carfilzomibixazomib

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Systemic AL amyloidosis indication 23132008
Multiple myeloma indication 109989006 DOID:9538
Mantle cell lymphoma indication 443487006
Orthostatic hypotension contraindication 28651003
Dehydration contraindication 34095006
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Interstitial pneumonia contraindication 64667001
Adult respiratory distress syndrome contraindication 67782005 DOID:11394
Pulmonary hypertension contraindication 70995007 DOID:6432
Diabetes mellitus contraindication 73211009 DOID:9351
Intestinal obstruction contraindication 81060008 DOID:8437
Prolonged QT interval contraindication 111975006
Pneumonia contraindication 233604007 DOID:552
Disease of liver contraindication 235856003 DOID:409
Syncope contraindication 271594007
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Peripheral nerve disease contraindication 302226006
Neutropenic disorder contraindication 303011007 DOID:1227
Breastfeeding (mother) contraindication 413712001
Posterior reversible encephalopathy syndrome contraindication 450886002
Chemotherapy-Induced Hyperuricemia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.39 acidic
pKa2 12.09 acidic
pKa3 13.65 acidic
pKa4 2.9 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
3.5MG/1.4ML (2.5MG/ML) BORTEZOMIB MAIA PHARMS INC N215331 July 27, 2022 DISCN SOLUTION INTRAVENOUS 11679119 Sept. 23, 2042 TREATMENT OF ADULT PATIENTS WITH MANTLE CELL LYMPHOMA
3.5MG/1.4ML (2.5MG/ML) BORTEZOMIB MAIA PHARMS INC N215331 July 27, 2022 DISCN SOLUTION INTRAVENOUS 11679119 Sept. 23, 2042 TREATMENT OF ADULT PATIENTS WITH MULTIPLE MYELOMA
3.5MG/1.4ML (2.5MG/ML) BORTEZOMIB MAIA PHARMS INC N215331 July 27, 2022 DISCN SOLUTION INTRAVENOUS 11752164 Sept. 23, 2042 TREATMENT OF ADULT PATIENTS WITH MANTLE CELL LYMPHOMA
3.5MG/1.4ML (2.5MG/ML) BORTEZOMIB MAIA PHARMS INC N215331 July 27, 2022 DISCN SOLUTION INTRAVENOUS 11752164 Sept. 23, 2042 TREATMENT OF ADULT PATIENTS WITH MULTIPLE MYELOMA
3.5MG/3.5ML (1MG/ML) BORTEZOMIB MAIA PHARMS INC N215331 July 27, 2022 DISCN SOLUTION INTRAVENOUS 11679119 Sept. 23, 2042 TREATMENT OF ADULT PATIENTS WITH MANTLE CELL LYMPHOMA
3.5MG/3.5ML (1MG/ML) BORTEZOMIB MAIA PHARMS INC N215331 July 27, 2022 DISCN SOLUTION INTRAVENOUS 11679119 Sept. 23, 2042 TREATMENT OF ADULT PATIENTS WITH MULTIPLE MYELOMA
3.5MG/3.5ML (1MG/ML) BORTEZOMIB MAIA PHARMS INC N215331 July 27, 2022 DISCN SOLUTION INTRAVENOUS 11752164 Sept. 23, 2042 TREATMENT OF ADULT PATIENTS WITH MANTLE CELL LYMPHOMA
3.5MG/3.5ML (1MG/ML) BORTEZOMIB MAIA PHARMS INC N215331 July 27, 2022 DISCN SOLUTION INTRAVENOUS 11752164 Sept. 23, 2042 TREATMENT OF ADULT PATIENTS WITH MULTIPLE MYELOMA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Proteasome subunit beta type-2 Enzyme INHIBITOR IC50 6.23 CHEMBL CHEMBL
Proteasome subunit beta type-5 Enzyme INHIBITOR Ki 9.26 CHEMBL CHEMBL
Proteasome subunit beta type-8 Enzyme INHIBITOR IC50 8.09 CHEMBL CHEMBL
Proteasome subunit alpha type-1 Enzyme INHIBITOR Ki 9.21 WOMBAT-PK CHEMBL
Proteasome subunit beta type-1 Enzyme INHIBITOR IC50 7.28 CHEMBL CHEMBL
Carbonic anhydrase 9 Enzyme Ki 5.47 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 5.23 CHEMBL
Prothrombin Enzyme Ki 4.89 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 5.16 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 5.17 CHEMBL
Carbonic anhydrase 7 Enzyme Ki 5.16 CHEMBL
Cytochrome P450 2C19 Enzyme Ki 4.75 WOMBAT-PK
26S proteasome non-ATPase regulatory subunit 1 Cytosolic other Ki 7.75 WOMBAT-PK
Histone deacetylase 2 Enzyme IC50 6.10 CHEMBL
Histone deacetylase 1 Enzyme IC50 6.21 CHEMBL
Histone deacetylase 3 Enzyme IC50 5.93 CHEMBL
Histone deacetylase 6 Enzyme IC50 4.16 CHEMBL
Neutrophil elastase Enzyme Ki 5.64 CHEMBL
Carbonic anhydrase 3 Enzyme Ki 5.34 CHEMBL
Carbonic anhydrase 6 Enzyme Ki 5.36 CHEMBL
Histone deacetylase 8 Enzyme IC50 7.14 CHEMBL
Cathepsin G Enzyme Ki 6.20 CHEMBL
Carbonic anhydrase 14 Enzyme Ki 5.48 CHEMBL
Lysosomal protective protein Enzyme IC50 5.04 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 5.07 CHEMBL
PH and SEC7 domain-containing protein 1 Cytosolic other Ki 7.75 WOMBAT-PK
Nuclear factor NF-kappa-B complex Transcription factor IC50 8.01 CHEMBL
Proteasome subunit beta type-9 Enzyme IC50 8.52 CHEMBL
Proteasome subunit beta type-10 Enzyme IC50 6.03 CHEMBL
Lon protease homolog, mitochondrial Enzyme IC50 6.74 CHEMBL
Proteasome subunit beta type-6 Enzyme IC50 7.60 CHEMBL
Chymase Enzyme IC50 5.92 CHEMBL
Proteasome subunit beta type-7 Enzyme IC50 4.89 CHEMBL
Chymotrypsinogen B Enzyme Ki 6.49 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 5.94 CHEMBL
Carbonic anhydrase 1 Enzyme Ki 5.89 CHEMBL
Carbonic anhydrase 4 Enzyme Ki 5.19 CHEMBL
Carbonic anhydrase 15 Enzyme Ki 5.57 CHEMBL
Beta-carbonic anhydrase 1 Enzyme Ki 5.14 CHEMBL
Alpha-chymotrypsin Enzyme Ki 5.62 CHEMBL
Proteasome subunit beta Enzyme IC50 7.51 IUPHAR
Proteasome subunit beta type-8 Enzyme IC50 7.78 CHEMBL
ATP-dependent Clp protease proteolytic subunit Enzyme IC50 5.28 CHEMBL
NACHT, LRR and PYD domains-containing protein 3 Cytosolic other IC50 7.39 CHEMBL

External reference:

IDSource
4021393 VUID
N0000148811 NUI
D03150 KEGG_DRUG
356733 RXNORM
C1176309 UMLSCUI
CHEBI:52717 CHEBI
BO2 PDB_CHEM_ID
CHEMBL325041 ChEMBL_ID
CHEMBL5315122 ChEMBL_ID
DB00188 DRUGBANK_ID
D000069286 MESH_DESCRIPTOR_UI
387447 PUBCHEM_CID
6391 IUPHAR_LIGAND_ID
8331 INN_ID
69G8BD63PP UNII
17263 MMSL
233935 MMSL
46756 MMSL
d04871 MMSL
398907002 SNOMEDCT_US
407097007 SNOMEDCT_US
4021393 VANDF
009985 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 0143-9098 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 31 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 0409-1700 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 31 sections
BORTEZOMIB HUMAN PRESCRIPTION DRUG LABEL 1 0409-1703 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 2.50 mg INTRAVENOUS NDA 32 sections
BORTEZOMIB HUMAN PRESCRIPTION DRUG LABEL 1 0409-1704 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 mg INTRAVENOUS NDA 32 sections
BORTEZOMIB HUMAN PRESCRIPTION DRUG LABEL 1 25021-262 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 33 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 31722-303 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 28 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 43598-426 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 30 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 51817-586 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 32 sections
BORTEZOMIB Human Prescription Drug Label 1 55150-337 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 28 sections
BORTEZOMIB Human Prescription Drug Label 1 55150-337 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 28 sections
BORTEZOMIB HUMAN PRESCRIPTION DRUG LABEL 1 60505-6050 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 28 sections
VELCADE HUMAN PRESCRIPTION DRUG LABEL 1 63020-049 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS NDA 31 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 63323-821 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 29 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 63759-3032 INJECTION 3.50 mg INTRAVENOUS NDA 25 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 67184-0530 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 31 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 68001-534 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 31 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 68001-540 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 31 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 68001-541 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 26 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 70069-836 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg SUBCUTANEOUS ANDA 29 sections
BORUZU HUMAN PRESCRIPTION DRUG LABEL 1 70121-2484 INJECTION 3.50 mg INTRAVENOUS NDA 26 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 70511-161 INJECTION 1 mg INTRAVENOUS NDA 31 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 70511-162 INJECTION 2.50 mg INTRAVENOUS NDA 31 sections
BORTEZOMIB HUMAN PRESCRIPTION DRUG LABEL 1 70710-1411 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 mg INTRAVENOUS ANDA 26 sections
BORTEZOMIB HUMAN PRESCRIPTION DRUG LABEL 1 70771-1708 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 1 mg INTRAVENOUS ANDA 2 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 71288-118 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 28 sections
Bortezomib Human Prescription Drug Label 1 72205-183 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 26 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 72338-200 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 29 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 72603-270 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 30 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 75007-501 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 31 sections
Bortezomib HUMAN PRESCRIPTION DRUG LABEL 1 83090-008 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 3.50 mg INTRAVENOUS ANDA 30 sections