Stem definition | Drug id | CAS RN |
---|---|---|
proteasome inhibitors | 391 | 179324-69-7 |
None
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 3.30 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.08 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Vd (Volume of distribution) | 10 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 19 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.17 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 18 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 14, 2019 | EMA | FRESENIUS KABI DEUTSCHLAND GMBH | |
Aug. 22, 2019 | PMDA | Janssen Pharmaceutical K.K. | |
May 13, 2003 | FDA | MILLENNIUM PHARMS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 2595.04 | 14.08 | 1565 | 65225 | 112102 | 63310130 |
Plasma cell myeloma | 1523.98 | 14.08 | 747 | 66043 | 35158 | 63387074 |
Plasma cell myeloma recurrent | 719.15 | 14.08 | 224 | 66566 | 2989 | 63419243 |
Thrombocytopenia | 693.96 | 14.08 | 824 | 65966 | 150333 | 63271899 |
Disease progression | 494.69 | 14.08 | 627 | 66163 | 122131 | 63300101 |
Platelet count decreased | 450.33 | 14.08 | 582 | 66208 | 115540 | 63306692 |
Diarrhoea | 414.45 | 14.08 | 1663 | 65127 | 713703 | 62708529 |
Plasmacytoma | 345.14 | 14.08 | 122 | 66668 | 2457 | 63419775 |
Neutropenia | 325.70 | 14.08 | 626 | 66164 | 174379 | 63247853 |
Polyneuropathy | 323.95 | 14.08 | 198 | 66592 | 14391 | 63407841 |
Pneumonia | 279.52 | 14.08 | 1082 | 65708 | 455685 | 62966547 |
Constipation | 271.66 | 14.08 | 676 | 66114 | 224267 | 63197965 |
Rheumatoid arthritis | 242.64 | 14.08 | 5 | 66785 | 253814 | 63168418 |
White blood cell count decreased | 230.24 | 14.08 | 474 | 66316 | 138630 | 63283602 |
Plasma cell myeloma refractory | 224.35 | 14.08 | 56 | 66734 | 303 | 63421929 |
Pancytopenia | 217.17 | 14.08 | 376 | 66414 | 96557 | 63325675 |
Contraindicated product administered | 209.16 | 14.08 | 4 | 66786 | 217644 | 63204588 |
Plasma cell leukaemia | 204.35 | 14.08 | 67 | 66723 | 1063 | 63421169 |
Maternal exposure during pregnancy | 190.45 | 14.08 | 10 | 66780 | 220052 | 63202180 |
Arthralgia | 183.25 | 14.08 | 198 | 66592 | 569512 | 62852720 |
Drug hypersensitivity | 179.82 | 14.08 | 52 | 66738 | 310635 | 63111597 |
Sepsis | 175.04 | 14.08 | 451 | 66339 | 152672 | 63269560 |
Headache | 171.47 | 14.08 | 251 | 66539 | 632990 | 62789242 |
Glossodynia | 165.29 | 14.08 | 5 | 66785 | 178871 | 63243361 |
Cytopenia | 164.29 | 14.08 | 119 | 66671 | 11482 | 63410750 |
Anaemia | 161.24 | 14.08 | 673 | 66117 | 292757 | 63129475 |
Full blood count decreased | 158.90 | 14.08 | 165 | 66625 | 25859 | 63396373 |
Off label use | 157.73 | 14.08 | 1229 | 65561 | 673233 | 62748999 |
Exposure during pregnancy | 148.83 | 14.08 | 3 | 66787 | 155544 | 63266688 |
Pain | 144.86 | 14.08 | 357 | 66433 | 740271 | 62681961 |
Tumour lysis syndrome | 143.00 | 14.08 | 99 | 66691 | 8891 | 63413341 |
Therapy partial responder | 132.28 | 14.08 | 101 | 66689 | 10557 | 63411675 |
Posterior reversible encephalopathy syndrome | 131.95 | 14.08 | 124 | 66666 | 17221 | 63405011 |
Febrile neutropenia | 129.27 | 14.08 | 343 | 66447 | 118106 | 63304126 |
Therapeutic product effect decreased | 128.20 | 14.08 | 24 | 66766 | 193163 | 63229069 |
Arthropathy | 127.40 | 14.08 | 44 | 66746 | 234748 | 63187484 |
Alopecia | 123.85 | 14.08 | 104 | 66686 | 337432 | 63084800 |
Light chain analysis increased | 123.01 | 14.08 | 48 | 66742 | 1285 | 63420947 |
Peripheral sensory neuropathy | 120.75 | 14.08 | 83 | 66707 | 7368 | 63414864 |
Unevaluable event | 119.82 | 14.08 | 203 | 66587 | 51183 | 63371049 |
Swelling | 119.22 | 14.08 | 71 | 66719 | 275307 | 63146925 |
Completed suicide | 118.89 | 14.08 | 9 | 66781 | 145664 | 63276568 |
Laboratory test abnormal | 118.64 | 14.08 | 144 | 66646 | 26768 | 63395464 |
Renal failure | 117.71 | 14.08 | 330 | 66460 | 117322 | 63304910 |
Deep vein thrombosis | 116.16 | 14.08 | 266 | 66524 | 83534 | 63338698 |
Septic shock | 115.97 | 14.08 | 232 | 66558 | 66397 | 63355835 |
Abdominal discomfort | 115.12 | 14.08 | 101 | 66689 | 320784 | 63101448 |
Discomfort | 114.96 | 14.08 | 19 | 66771 | 167355 | 63254877 |
Cardiac amyloidosis | 114.25 | 14.08 | 40 | 66750 | 782 | 63421450 |
Pericarditis | 113.72 | 14.08 | 6 | 66784 | 131573 | 63290659 |
Neutrophil count decreased | 111.14 | 14.08 | 207 | 66583 | 56199 | 63366033 |
Dehydration | 109.01 | 14.08 | 415 | 66375 | 172939 | 63249293 |
Musculoskeletal stiffness | 108.39 | 14.08 | 30 | 66760 | 184588 | 63237644 |
Chalazion | 106.10 | 14.08 | 32 | 66758 | 380 | 63421852 |
Amyloidosis | 105.19 | 14.08 | 41 | 66749 | 1094 | 63421138 |
Wound | 104.71 | 14.08 | 22 | 66768 | 163241 | 63258991 |
Joint swelling | 100.59 | 14.08 | 118 | 66672 | 327548 | 63094684 |
Condition aggravated | 99.51 | 14.08 | 169 | 66621 | 402048 | 63020184 |
Herpes zoster | 97.35 | 14.08 | 246 | 66544 | 82216 | 63340016 |
Treatment failure | 87.97 | 14.08 | 50 | 66740 | 198993 | 63223239 |
Hordeolum | 84.31 | 14.08 | 49 | 66741 | 3243 | 63418989 |
Monoclonal immunoglobulin present | 83.35 | 14.08 | 32 | 66758 | 819 | 63421413 |
Product use in unapproved indication | 83.20 | 14.08 | 391 | 66399 | 178689 | 63243543 |
Mobility decreased | 80.46 | 14.08 | 15 | 66775 | 121144 | 63301088 |
Helicobacter infection | 77.82 | 14.08 | 5 | 66785 | 92780 | 63329452 |
Myelodysplastic syndrome | 77.69 | 14.08 | 92 | 66698 | 16662 | 63405570 |
Atrial fibrillation | 77.24 | 14.08 | 284 | 66506 | 116352 | 63305880 |
Cardiac failure | 76.66 | 14.08 | 237 | 66553 | 88905 | 63333327 |
Death | 74.61 | 14.08 | 659 | 66131 | 373722 | 63048510 |
Hypersensitivity | 73.22 | 14.08 | 122 | 66668 | 292563 | 63129669 |
Overdose | 72.77 | 14.08 | 16 | 66774 | 115062 | 63307170 |
Hepatic enzyme increased | 72.11 | 14.08 | 64 | 66726 | 202264 | 63219968 |
Therapy non-responder | 72.08 | 14.08 | 209 | 66581 | 75692 | 63346540 |
Thrombosis | 71.08 | 14.08 | 188 | 66602 | 64567 | 63357665 |
Orthostatic hypotension | 70.34 | 14.08 | 132 | 66658 | 36028 | 63386204 |
Peripheral sensorimotor neuropathy | 68.85 | 14.08 | 33 | 66757 | 1470 | 63420762 |
Fibromyalgia | 68.44 | 14.08 | 4 | 66786 | 80416 | 63341816 |
Hyperviscosity syndrome | 67.84 | 14.08 | 19 | 66771 | 170 | 63422062 |
Drug ineffective | 66.53 | 14.08 | 742 | 66048 | 1044023 | 62378209 |
Injection site pain | 65.88 | 14.08 | 27 | 66763 | 129773 | 63292459 |
Drug interaction | 65.56 | 14.08 | 87 | 66703 | 229044 | 63193188 |
Blister | 64.28 | 14.08 | 28 | 66762 | 129786 | 63292446 |
Haemoglobin decreased | 64.18 | 14.08 | 313 | 66477 | 145172 | 63277060 |
Pathological fracture | 63.09 | 14.08 | 61 | 66729 | 8773 | 63413459 |
Primary amyloidosis | 62.90 | 14.08 | 14 | 66776 | 41 | 63422191 |
Protein total increased | 62.42 | 14.08 | 38 | 66752 | 2739 | 63419493 |
Haematotoxicity | 61.86 | 14.08 | 62 | 66728 | 9314 | 63412918 |
Cytomegalovirus infection | 61.53 | 14.08 | 92 | 66698 | 20860 | 63401372 |
Folliculitis | 61.40 | 14.08 | 3 | 66787 | 70314 | 63351918 |
Stem cell transplant | 60.01 | 14.08 | 32 | 66758 | 1790 | 63420442 |
Osteolysis | 58.70 | 14.08 | 37 | 66753 | 2837 | 63419395 |
Acute lymphocytic leukaemia | 55.46 | 14.08 | 34 | 66756 | 2482 | 63419750 |
Irritable bowel syndrome | 55.14 | 14.08 | 10 | 66780 | 82402 | 63339830 |
Autonomic neuropathy | 54.78 | 14.08 | 26 | 66764 | 1133 | 63421099 |
Hypercalcaemia | 54.60 | 14.08 | 103 | 66687 | 28219 | 63394013 |
Bone marrow failure | 54.59 | 14.08 | 105 | 66685 | 29185 | 63393047 |
Coombs indirect test positive | 53.70 | 14.08 | 12 | 66778 | 36 | 63422196 |
Osteonecrosis of jaw | 50.31 | 14.08 | 113 | 66677 | 35010 | 63387222 |
Blood cholesterol increased | 50.30 | 14.08 | 18 | 66772 | 94014 | 63328218 |
Ageusia | 50.28 | 14.08 | 67 | 66723 | 13661 | 63408571 |
Cytomegalovirus infection reactivation | 50.15 | 14.08 | 38 | 66752 | 3925 | 63418307 |
Hypocalcaemia | 49.94 | 14.08 | 106 | 66684 | 31607 | 63390625 |
Ileus paralytic | 49.71 | 14.08 | 40 | 66750 | 4511 | 63417721 |
Pneumonia pneumococcal | 48.99 | 14.08 | 30 | 66760 | 2185 | 63420047 |
Wrong technique in product usage process | 47.74 | 14.08 | 5 | 66785 | 62335 | 63359897 |
Bone pain | 47.63 | 14.08 | 146 | 66644 | 54495 | 63367737 |
Pneumonia fungal | 47.35 | 14.08 | 42 | 66748 | 5413 | 63416819 |
Migraine | 47.02 | 14.08 | 25 | 66765 | 103321 | 63318911 |
Malignant neoplasm progression | 47.01 | 14.08 | 191 | 66599 | 81930 | 63340302 |
Hepatitis B reactivation | 46.29 | 14.08 | 33 | 66757 | 3104 | 63419128 |
Pyrexia | 45.19 | 14.08 | 720 | 66070 | 469758 | 62952474 |
Pleural effusion | 45.07 | 14.08 | 206 | 66584 | 93004 | 63329228 |
Meningitis listeria | 44.60 | 14.08 | 19 | 66771 | 640 | 63421592 |
Suicide attempt | 43.90 | 14.08 | 6 | 66784 | 60912 | 63361320 |
Inappropriate schedule of product administration | 43.27 | 14.08 | 28 | 66762 | 103937 | 63318295 |
Blood pressure increased | 42.89 | 14.08 | 65 | 66725 | 161997 | 63260235 |
Bone lesion | 42.73 | 14.08 | 41 | 66749 | 5840 | 63416392 |
Acute kidney injury | 42.63 | 14.08 | 444 | 66346 | 262971 | 63159261 |
Endocarditis bacterial | 41.77 | 14.08 | 18 | 66772 | 624 | 63421608 |
Syncope | 41.74 | 14.08 | 238 | 66552 | 117147 | 63305085 |
Body dysmorphic disorder | 41.23 | 14.08 | 15 | 66775 | 329 | 63421903 |
Morganella infection | 41.00 | 14.08 | 18 | 66772 | 653 | 63421579 |
Nasal abscess | 40.88 | 14.08 | 13 | 66777 | 186 | 63422046 |
Impaired healing | 40.82 | 14.08 | 29 | 66761 | 102513 | 63319719 |
Mesenteric abscess | 40.70 | 14.08 | 11 | 66779 | 85 | 63422147 |
Oedema peripheral | 40.48 | 14.08 | 339 | 66451 | 189172 | 63233060 |
Pneumococcal sepsis | 40.27 | 14.08 | 18 | 66772 | 682 | 63421550 |
B-cell type acute leukaemia | 40.14 | 14.08 | 13 | 66777 | 198 | 63422034 |
Cardiac failure congestive | 40.11 | 14.08 | 198 | 66592 | 92235 | 63329997 |
Infection in an immunocompromised host | 39.60 | 14.08 | 18 | 66772 | 710 | 63421522 |
Osteoarthritis | 39.24 | 14.08 | 26 | 66764 | 95317 | 63326915 |
Colitis | 38.93 | 14.08 | 126 | 66664 | 48402 | 63373830 |
Anxiety | 38.37 | 14.08 | 110 | 66680 | 217431 | 63204801 |
Large intestinal ulcer perforation | 38.24 | 14.08 | 10 | 66780 | 67 | 63422165 |
Transplant | 38.02 | 14.08 | 18 | 66772 | 780 | 63421452 |
Peripheral motor neuropathy | 37.78 | 14.08 | 23 | 66767 | 1658 | 63420574 |
Electrolyte imbalance | 37.44 | 14.08 | 72 | 66718 | 20004 | 63402228 |
Arthritis | 37.41 | 14.08 | 40 | 66750 | 115881 | 63306351 |
Hypertension | 37.32 | 14.08 | 159 | 66631 | 279144 | 63143088 |
Gastrointestinal fungal infection | 37.30 | 14.08 | 14 | 66776 | 336 | 63421896 |
Blood potassium decreased | 37.29 | 14.08 | 113 | 66677 | 41913 | 63380319 |
Inappropriate antidiuretic hormone secretion | 37.24 | 14.08 | 62 | 66728 | 15400 | 63406832 |
Disturbance in social behaviour | 37.18 | 14.08 | 32 | 66758 | 3961 | 63418271 |
Asthenia | 37.15 | 14.08 | 588 | 66202 | 383016 | 63039216 |
Liver injury | 37.08 | 14.08 | 9 | 66781 | 60511 | 63361721 |
N-terminal prohormone brain natriuretic peptide decreased | 36.32 | 14.08 | 8 | 66782 | 22 | 63422210 |
Hip arthroplasty | 36.03 | 14.08 | 4 | 66786 | 47642 | 63374590 |
Injury | 35.93 | 14.08 | 16 | 66774 | 73231 | 63349001 |
Depression | 35.66 | 14.08 | 98 | 66692 | 196394 | 63225838 |
Loss of personal independence in daily activities | 35.57 | 14.08 | 30 | 66760 | 97260 | 63324972 |
B precursor type acute leukaemia | 34.94 | 14.08 | 12 | 66778 | 221 | 63422011 |
Blood pressure fluctuation | 34.74 | 14.08 | 4 | 66786 | 46313 | 63375919 |
Fatigue | 34.44 | 14.08 | 1197 | 65593 | 886831 | 62535401 |
Wheezing | 34.31 | 14.08 | 30 | 66760 | 95565 | 63326667 |
Neurotoxicity | 34.26 | 14.08 | 63 | 66727 | 16927 | 63405305 |
Crossmatch incompatible | 34.23 | 14.08 | 8 | 66782 | 31 | 63422201 |
Ill-defined disorder | 34.04 | 14.08 | 22 | 66768 | 81733 | 63340499 |
Renal impairment | 33.98 | 14.08 | 183 | 66607 | 88172 | 63334060 |
Cardiotoxicity | 33.73 | 14.08 | 43 | 66747 | 8395 | 63413837 |
Joint stiffness | 33.00 | 14.08 | 3 | 66787 | 41866 | 63380366 |
Type 2 diabetes mellitus | 32.86 | 14.08 | 13 | 66777 | 63855 | 63358377 |
COVID-19 | 32.45 | 14.08 | 217 | 66573 | 112886 | 63309346 |
Spinal cord compression | 32.21 | 14.08 | 30 | 66760 | 4118 | 63418114 |
Hypokalaemia | 32.13 | 14.08 | 203 | 66587 | 103601 | 63318631 |
Hypersensitivity myocarditis | 31.91 | 14.08 | 11 | 66779 | 205 | 63422027 |
Sinus polyp | 31.86 | 14.08 | 13 | 66777 | 392 | 63421840 |
Urosepsis | 31.61 | 14.08 | 64 | 66726 | 18460 | 63403772 |
Cerebellar haemangioma | 31.42 | 14.08 | 9 | 66781 | 88 | 63422144 |
Renal amyloidosis | 31.20 | 14.08 | 10 | 66780 | 147 | 63422085 |
Blood pressure systolic increased | 31.17 | 14.08 | 6 | 66784 | 47391 | 63374841 |
Mucosal inflammation | 30.81 | 14.08 | 114 | 66676 | 46814 | 63375418 |
Hyperproteinaemia | 30.55 | 14.08 | 9 | 66781 | 98 | 63422134 |
Precursor B-lymphoblastic lymphoma | 30.18 | 14.08 | 7 | 66783 | 26 | 63422206 |
Guillain-Barre syndrome | 29.93 | 14.08 | 28 | 66762 | 3865 | 63418367 |
Sinusitis | 29.67 | 14.08 | 130 | 66660 | 226523 | 63195709 |
Blood stem cell harvest failure | 29.36 | 14.08 | 8 | 66782 | 64 | 63422168 |
Taste disorder | 29.25 | 14.08 | 52 | 66738 | 13610 | 63408622 |
Target skin lesion | 29.10 | 14.08 | 9 | 66781 | 117 | 63422115 |
Thrombotic microangiopathy | 29.07 | 14.08 | 45 | 66745 | 10516 | 63411716 |
Acute myeloid leukaemia | 28.97 | 14.08 | 59 | 66731 | 17088 | 63405144 |
Large intestine perforation | 28.94 | 14.08 | 40 | 66750 | 8442 | 63413790 |
Lymphopenia | 28.55 | 14.08 | 61 | 66729 | 18266 | 63403966 |
Suicidal ideation | 28.54 | 14.08 | 15 | 66775 | 62406 | 63359826 |
Clostridium bacteraemia | 28.54 | 14.08 | 10 | 66780 | 196 | 63422036 |
Blood lactate dehydrogenase increased | 28.34 | 14.08 | 70 | 66720 | 23046 | 63399186 |
Stress | 28.07 | 14.08 | 18 | 66772 | 67149 | 63355083 |
Varicella zoster virus infection | 28.03 | 14.08 | 23 | 66767 | 2666 | 63419566 |
Contusion | 27.84 | 14.08 | 74 | 66716 | 149970 | 63272262 |
Heart rate increased | 27.73 | 14.08 | 35 | 66755 | 94203 | 63328029 |
Pneumonia influenzal | 27.72 | 14.08 | 19 | 66771 | 1678 | 63420554 |
Ileus | 27.69 | 14.08 | 53 | 66737 | 14672 | 63407560 |
Refractory cytopenia with multilineage dysplasia | 27.67 | 14.08 | 9 | 66781 | 139 | 63422093 |
Sleep disorder | 27.61 | 14.08 | 27 | 66763 | 81539 | 63340693 |
Hypoaesthesia | 27.28 | 14.08 | 284 | 66506 | 168109 | 63254123 |
Clostridium difficile colitis | 27.05 | 14.08 | 64 | 66726 | 20505 | 63401727 |
Diarrhoea haemorrhagic | 26.97 | 14.08 | 40 | 66750 | 9002 | 63413230 |
Drug abuse | 26.95 | 14.08 | 22 | 66768 | 72496 | 63349736 |
Nasal congestion | 26.89 | 14.08 | 18 | 66772 | 65642 | 63356590 |
Malaise | 26.82 | 14.08 | 294 | 66496 | 415660 | 63006572 |
Adenoviral haemorrhagic cystitis | 26.82 | 14.08 | 9 | 66781 | 154 | 63422078 |
Rhinovirus infection | 26.36 | 14.08 | 28 | 66762 | 4501 | 63417731 |
Graft versus host disease | 26.30 | 14.08 | 34 | 66756 | 6729 | 63415503 |
Light chain analysis abnormal | 26.09 | 14.08 | 9 | 66781 | 168 | 63422064 |
Pseudomonal sepsis | 26.01 | 14.08 | 21 | 66769 | 2380 | 63419852 |
Enterococcal sepsis | 25.86 | 14.08 | 17 | 66773 | 1401 | 63420831 |
Pregnancy | 25.68 | 14.08 | 4 | 66786 | 36832 | 63385400 |
Bronchiolitis | 25.55 | 14.08 | 22 | 66768 | 2725 | 63419507 |
Joint ankylosis | 25.29 | 14.08 | 15 | 66775 | 1031 | 63421201 |
Gait disturbance | 25.24 | 14.08 | 103 | 66687 | 183075 | 63239157 |
Myelosuppression | 25.17 | 14.08 | 68 | 66722 | 23635 | 63398597 |
Weight increased | 25.04 | 14.08 | 166 | 66624 | 260626 | 63161606 |
Toxic skin eruption | 25.00 | 14.08 | 47 | 66743 | 12838 | 63409394 |
Oncologic complication | 24.80 | 14.08 | 9 | 66781 | 196 | 63422036 |
Febrile infection | 24.42 | 14.08 | 17 | 66773 | 1540 | 63420692 |
Fungal oesophagitis | 24.31 | 14.08 | 13 | 66777 | 731 | 63421501 |
Toxicity to various agents | 23.89 | 14.08 | 379 | 66411 | 246871 | 63175361 |
Palpitations | 23.78 | 14.08 | 52 | 66738 | 112718 | 63309514 |
Monoclonal immunoglobulin increased | 23.78 | 14.08 | 8 | 66782 | 138 | 63422094 |
Disease recurrence | 23.59 | 14.08 | 74 | 66716 | 27956 | 63394276 |
Failure to thrive | 23.15 | 14.08 | 33 | 66757 | 7165 | 63415067 |
Hypothyroidism | 23.07 | 14.08 | 8 | 66782 | 42624 | 63379608 |
Flushing | 23.03 | 14.08 | 27 | 66763 | 75060 | 63347172 |
Compression fracture | 22.89 | 14.08 | 31 | 66759 | 6417 | 63415815 |
Product quality issue | 22.63 | 14.08 | 5 | 66785 | 35860 | 63386372 |
Hypoglobulinaemia | 22.59 | 14.08 | 6 | 66784 | 43 | 63422189 |
Acute respiratory distress syndrome | 22.51 | 14.08 | 65 | 66725 | 23469 | 63398763 |
Mucosal erosion | 22.49 | 14.08 | 16 | 66774 | 1500 | 63420732 |
Injection site swelling | 22.39 | 14.08 | 11 | 66779 | 47561 | 63374671 |
Myalgia | 22.38 | 14.08 | 79 | 66711 | 146450 | 63275782 |
Salmonella sepsis | 22.36 | 14.08 | 9 | 66781 | 262 | 63421970 |
Intraductal proliferative breast lesion | 22.29 | 14.08 | 21 | 66769 | 2924 | 63419308 |
Anaphylactic reaction | 22.24 | 14.08 | 22 | 66768 | 66078 | 63356154 |
Peritonitis viral | 22.02 | 14.08 | 6 | 66784 | 48 | 63422184 |
Respiratory tract infection | 21.79 | 14.08 | 94 | 66696 | 41389 | 63380843 |
Bacteraemia | 21.76 | 14.08 | 53 | 66737 | 17295 | 63404937 |
Listeria sepsis | 21.68 | 14.08 | 12 | 66778 | 723 | 63421509 |
Hypoalbuminaemia | 21.60 | 14.08 | 42 | 66748 | 11763 | 63410469 |
Sedation | 21.49 | 14.08 | 7 | 66783 | 38802 | 63383430 |
Pulmonary embolism | 21.42 | 14.08 | 202 | 66588 | 116482 | 63305750 |
Neuralgia | 21.41 | 14.08 | 68 | 66722 | 25858 | 63396374 |
Hypophosphataemia | 21.33 | 14.08 | 41 | 66749 | 11385 | 63410847 |
Drug intolerance | 21.16 | 14.08 | 215 | 66575 | 308446 | 63113786 |
Pain in extremity | 21.07 | 14.08 | 235 | 66555 | 331251 | 63090981 |
Back pain | 20.86 | 14.08 | 392 | 66398 | 263753 | 63158479 |
Nocardiosis | 20.81 | 14.08 | 17 | 66773 | 1959 | 63420273 |
Hypotension | 20.65 | 14.08 | 402 | 66388 | 272202 | 63150030 |
Atrial rupture | 20.65 | 14.08 | 6 | 66784 | 62 | 63422170 |
5q minus syndrome | 20.37 | 14.08 | 8 | 66782 | 218 | 63422014 |
Hyperintensity in brain deep nuclei | 20.36 | 14.08 | 5 | 66785 | 25 | 63422207 |
Serotonin syndrome | 20.25 | 14.08 | 3 | 66787 | 28679 | 63393553 |
Pulmonary oedema | 19.98 | 14.08 | 112 | 66678 | 54761 | 63367471 |
Osteonecrosis | 19.95 | 14.08 | 64 | 66726 | 24466 | 63397766 |
Tooth disorder | 19.83 | 14.08 | 70 | 66720 | 28087 | 63394145 |
Blepharitis | 19.80 | 14.08 | 19 | 66771 | 2706 | 63419526 |
Blood creatine phosphokinase increased | 19.70 | 14.08 | 4 | 66786 | 30426 | 63391806 |
Pulmonary sepsis | 19.70 | 14.08 | 15 | 66775 | 1561 | 63420671 |
Human chorionic gonadotropin increased | 19.62 | 14.08 | 15 | 66775 | 1570 | 63420662 |
Therapy interrupted | 19.54 | 14.08 | 5 | 66785 | 32450 | 63389782 |
Foot deformity | 19.47 | 14.08 | 3 | 66787 | 27850 | 63394382 |
Rash | 19.43 | 14.08 | 747 | 66043 | 560124 | 62862108 |
Infusion related reaction | 19.41 | 14.08 | 165 | 66625 | 245356 | 63176876 |
Escherichia infection | 19.35 | 14.08 | 42 | 66748 | 12712 | 63409520 |
Asthma | 19.33 | 14.08 | 69 | 66721 | 127492 | 63294740 |
VIth nerve paresis | 19.33 | 14.08 | 6 | 66784 | 79 | 63422153 |
Injection site bruising | 19.26 | 14.08 | 10 | 66780 | 41900 | 63380332 |
Nasopharyngitis | 19.16 | 14.08 | 173 | 66617 | 254084 | 63168148 |
Underdose | 19.10 | 14.08 | 3 | 66787 | 27453 | 63394779 |
Somnolence | 19.08 | 14.08 | 110 | 66680 | 178575 | 63243657 |
Respiratory failure | 19.02 | 14.08 | 177 | 66613 | 101681 | 63320551 |
Hypogammaglobulinaemia | 19.01 | 14.08 | 30 | 66760 | 7125 | 63415107 |
Incorrect dose administered | 19 | 14.08 | 21 | 66769 | 59947 | 63362285 |
Meningitis pneumococcal | 18.82 | 14.08 | 8 | 66782 | 268 | 63421964 |
Plasma cells decreased | 18.69 | 14.08 | 5 | 66785 | 37 | 63422195 |
Infection reactivation | 18.59 | 14.08 | 13 | 66777 | 1186 | 63421046 |
Toxic neuropathy | 18.41 | 14.08 | 9 | 66781 | 419 | 63421813 |
Paraproteinaemia | 18.27 | 14.08 | 7 | 66783 | 178 | 63422054 |
Osteoporosis | 18.25 | 14.08 | 20 | 66770 | 57318 | 63364914 |
Light chain analysis | 18.16 | 14.08 | 4 | 66786 | 11 | 63422221 |
Spinal fracture | 18.00 | 14.08 | 51 | 66739 | 18220 | 63404012 |
Bone disorder | 17.67 | 14.08 | 56 | 66734 | 21270 | 63400962 |
Cough | 17.63 | 14.08 | 210 | 66580 | 292533 | 63129699 |
Acute myopia | 17.60 | 14.08 | 6 | 66784 | 108 | 63422124 |
Full blood count increased | 17.59 | 14.08 | 12 | 66778 | 1052 | 63421180 |
Clostridium difficile infection | 17.43 | 14.08 | 70 | 66720 | 29852 | 63392380 |
Hypoglossal nerve paresis | 17.34 | 14.08 | 6 | 66784 | 113 | 63422119 |
Drug reaction with eosinophilia and systemic symptoms | 17.26 | 14.08 | 76 | 66714 | 33760 | 63388472 |
Meningitis cryptococcal | 16.98 | 14.08 | 13 | 66777 | 1364 | 63420868 |
Pseudomyopia | 16.92 | 14.08 | 5 | 66785 | 55 | 63422177 |
Myeloma cast nephropathy | 16.83 | 14.08 | 6 | 66784 | 124 | 63422108 |
Bursitis | 16.78 | 14.08 | 9 | 66781 | 37032 | 63385200 |
Urticaria | 16.68 | 14.08 | 104 | 66686 | 165698 | 63256534 |
Sleep apnoea syndrome | 16.59 | 14.08 | 5 | 66785 | 29128 | 63393104 |
Hyperhidrosis | 16.56 | 14.08 | 58 | 66732 | 107778 | 63314454 |
Inflammation | 16.48 | 14.08 | 39 | 66751 | 82234 | 63339998 |
Duodenal stenosis | 16.40 | 14.08 | 9 | 66781 | 533 | 63421699 |
Urinary tract infection | 16.37 | 14.08 | 379 | 66411 | 264305 | 63157927 |
Cardiac failure acute | 16.36 | 14.08 | 33 | 66757 | 9490 | 63412742 |
Multiple organ dysfunction syndrome | 16.34 | 14.08 | 109 | 66681 | 56643 | 63365589 |
Superficial spreading melanoma stage unspecified | 16.31 | 14.08 | 6 | 66784 | 136 | 63422096 |
Hypoperfusion | 16.25 | 14.08 | 13 | 66777 | 1454 | 63420778 |
Spinal compression fracture | 16.20 | 14.08 | 42 | 66748 | 14241 | 63407991 |
Injection site haemorrhage | 16.15 | 14.08 | 3 | 66787 | 24311 | 63397921 |
Chronic graft versus host disease in skin | 16.15 | 14.08 | 10 | 66780 | 743 | 63421489 |
Bronchopulmonary aspergillosis | 16.14 | 14.08 | 31 | 66759 | 8604 | 63413628 |
Paranoia | 16.08 | 14.08 | 37 | 66753 | 11642 | 63410590 |
Human herpesvirus 8 infection | 16.02 | 14.08 | 7 | 66783 | 251 | 63421981 |
Pulmonary alveolar haemorrhage | 15.91 | 14.08 | 22 | 66768 | 4646 | 63417586 |
Coma | 15.90 | 14.08 | 27 | 66763 | 64337 | 63357895 |
Haemorrhoidal haemorrhage | 15.85 | 14.08 | 21 | 66769 | 4258 | 63417974 |
Sensory level abnormal | 15.83 | 14.08 | 6 | 66784 | 148 | 63422084 |
Staphylococcal bacteraemia | 15.83 | 14.08 | 24 | 66766 | 5506 | 63416726 |
Bacterial sepsis | 15.55 | 14.08 | 20 | 66770 | 3938 | 63418294 |
Seasonal allergy | 15.55 | 14.08 | 53 | 66737 | 20897 | 63401335 |
Erysipelas | 15.54 | 14.08 | 29 | 66761 | 7876 | 63414356 |
Rhabdomyolysis | 15.52 | 14.08 | 14 | 66776 | 43937 | 63378295 |
Capnocytophaga infection | 15.50 | 14.08 | 3 | 66787 | 3 | 63422229 |
Aggression | 15.40 | 14.08 | 3 | 66787 | 23495 | 63398737 |
Cardiomyopathy | 15.33 | 14.08 | 47 | 66743 | 17537 | 63404695 |
Venoocclusive liver disease | 15.31 | 14.08 | 22 | 66768 | 4813 | 63417419 |
Metapneumovirus infection | 15.29 | 14.08 | 11 | 66779 | 1049 | 63421183 |
Joint injury | 15.24 | 14.08 | 6 | 66784 | 29566 | 63392666 |
Performance status decreased | 15.11 | 14.08 | 19 | 66771 | 3659 | 63418573 |
Rash pruritic | 14.96 | 14.08 | 111 | 66679 | 59688 | 63362544 |
Drug withdrawal syndrome | 14.89 | 14.08 | 5 | 66785 | 27189 | 63395043 |
Atelectasis | 14.78 | 14.08 | 53 | 66737 | 21430 | 63400802 |
Hyponatraemia | 14.62 | 14.08 | 181 | 66609 | 111719 | 63310513 |
Hyperamylasaemia | 14.61 | 14.08 | 8 | 66782 | 472 | 63421760 |
Hepatitis B | 14.57 | 14.08 | 19 | 66771 | 3793 | 63418439 |
Clavicle fracture | 14.43 | 14.08 | 18 | 66772 | 3437 | 63418795 |
Cryptococcosis | 14.43 | 14.08 | 11 | 66779 | 1146 | 63421086 |
Therapy cessation | 14.40 | 14.08 | 7 | 66783 | 30450 | 63391782 |
Oral fungal infection | 14.37 | 14.08 | 17 | 66773 | 3074 | 63419158 |
Lower respiratory tract infection | 14.36 | 14.08 | 81 | 66709 | 132226 | 63290006 |
JC virus CSF test positive | 14.36 | 14.08 | 4 | 66786 | 35 | 63422197 |
Klebsiella sepsis | 14.24 | 14.08 | 12 | 66778 | 1443 | 63420789 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 2654.45 | 12.95 | 1873 | 76342 | 81390 | 34797326 |
Plasma cell myeloma | 1487.00 | 12.95 | 1010 | 77205 | 41027 | 34837689 |
Plasma cell myeloma recurrent | 793.02 | 12.95 | 318 | 77897 | 4147 | 34874569 |
Polyneuropathy | 566.76 | 12.95 | 375 | 77840 | 14521 | 34864195 |
Thrombocytopenia | 493.48 | 12.95 | 1082 | 77133 | 155165 | 34723551 |
Platelet count decreased | 407.42 | 12.95 | 855 | 77360 | 118862 | 34759854 |
Disease progression | 378.32 | 12.95 | 781 | 77434 | 107296 | 34771420 |
Pneumonia | 327.80 | 12.95 | 1637 | 76578 | 360990 | 34517726 |
Plasmacytoma | 313.77 | 12.95 | 157 | 78058 | 3534 | 34875182 |
Plasma cell myeloma refractory | 308.73 | 12.95 | 95 | 78120 | 520 | 34878196 |
Drug interaction | 277.38 | 12.95 | 81 | 78134 | 225865 | 34652851 |
Unevaluable event | 225.10 | 12.95 | 319 | 77896 | 32271 | 34846445 |
Drug abuse | 206.12 | 12.95 | 3 | 78212 | 99093 | 34779623 |
Completed suicide | 204.07 | 12.95 | 3 | 78212 | 98165 | 34780551 |
Tumour lysis syndrome | 184.72 | 12.95 | 209 | 78006 | 16850 | 34861866 |
Plasma cell leukaemia | 166.76 | 12.95 | 67 | 78148 | 877 | 34877839 |
Orthostatic hypotension | 160.51 | 12.95 | 241 | 77974 | 25678 | 34853038 |
Herpes zoster | 152.40 | 12.95 | 275 | 77940 | 34124 | 34844592 |
Therapy partial responder | 143.81 | 12.95 | 140 | 78075 | 9476 | 34869240 |
Diarrhoea | 131.60 | 12.95 | 1390 | 76825 | 388522 | 34490194 |
White blood cell count decreased | 131.00 | 12.95 | 490 | 77725 | 94955 | 34783761 |
Overdose | 124.42 | 12.95 | 26 | 78189 | 91033 | 34787683 |
Peripheral sensory neuropathy | 123.44 | 12.95 | 110 | 78105 | 6650 | 34872066 |
Constipation | 122.52 | 12.95 | 618 | 77597 | 136364 | 34742352 |
Neutropenia | 120.92 | 12.95 | 679 | 77536 | 156099 | 34722617 |
Deep vein thrombosis | 120.40 | 12.95 | 370 | 77845 | 64878 | 34813838 |
Autonomic neuropathy | 112.70 | 12.95 | 51 | 78164 | 909 | 34877807 |
Off label use | 110.94 | 12.95 | 1427 | 76788 | 418097 | 34460619 |
Product use issue | 109.74 | 12.95 | 351 | 77864 | 62865 | 34815851 |
Fatigue | 104.41 | 12.95 | 1276 | 76939 | 369377 | 34509339 |
Pancytopenia | 100.79 | 12.95 | 451 | 77764 | 94706 | 34784010 |
Cytopenia | 92.95 | 12.95 | 128 | 78087 | 12595 | 34866121 |
Rash | 92.43 | 12.95 | 830 | 77385 | 221922 | 34656794 |
Rhabdomyolysis | 92.00 | 12.95 | 20 | 78195 | 68143 | 34810573 |
Light chain analysis increased | 91.62 | 12.95 | 50 | 78165 | 1351 | 34877365 |
Therapy non-responder | 90.67 | 12.95 | 241 | 77974 | 38905 | 34839811 |
B precursor type acute leukaemia | 86.28 | 12.95 | 28 | 78187 | 187 | 34878529 |
Hypercalcaemia | 86.17 | 12.95 | 137 | 78078 | 15331 | 34863385 |
Inappropriate schedule of product administration | 82.62 | 12.95 | 19 | 78196 | 62277 | 34816439 |
Headache | 82.05 | 12.95 | 207 | 78008 | 200428 | 34678288 |
Amyloidosis | 82.03 | 12.95 | 54 | 78161 | 2069 | 34876647 |
Myelodysplastic syndrome | 81.80 | 12.95 | 151 | 78064 | 19057 | 34859659 |
Osteonecrosis of jaw | 80.46 | 12.95 | 144 | 78071 | 17745 | 34860971 |
Ileus paralytic | 79.88 | 12.95 | 82 | 78133 | 5915 | 34872801 |
Cystitis haemorrhagic | 78.09 | 12.95 | 79 | 78136 | 5600 | 34873116 |
Full blood count decreased | 76.78 | 12.95 | 142 | 78073 | 17946 | 34860770 |
Thrombosis | 75.87 | 12.95 | 267 | 77948 | 50191 | 34828525 |
Arthralgia | 74.61 | 12.95 | 169 | 78046 | 169872 | 34708844 |
Rheumatoid arthritis | 72.55 | 12.95 | 3 | 78212 | 38235 | 34840481 |
Product use in unapproved indication | 66.81 | 12.95 | 471 | 77744 | 117028 | 34761688 |
Blood creatine phosphokinase increased | 65.10 | 12.95 | 11 | 78204 | 44846 | 34833870 |
Infection | 64.89 | 12.95 | 386 | 77829 | 90529 | 34788187 |
Primary amyloidosis | 63.73 | 12.95 | 20 | 78195 | 118 | 34878598 |
Depression | 63.69 | 12.95 | 74 | 78141 | 97024 | 34781692 |
Psoriasis | 62.25 | 12.95 | 7 | 78208 | 38805 | 34839911 |
Acute lymphocytic leukaemia | 60.75 | 12.95 | 52 | 78163 | 2977 | 34875739 |
Abdominal pain | 60.69 | 12.95 | 177 | 78038 | 163441 | 34715275 |
Condition aggravated | 59.56 | 12.95 | 225 | 77990 | 191971 | 34686745 |
Sepsis | 58.74 | 12.95 | 600 | 77615 | 165961 | 34712755 |
Spinal compression fracture | 57.18 | 12.95 | 75 | 78140 | 7041 | 34871675 |
Hypertension | 57.10 | 12.95 | 139 | 78076 | 136304 | 34742412 |
Blood pressure increased | 56.86 | 12.95 | 68 | 78147 | 88034 | 34790682 |
Drug hypersensitivity | 56.53 | 12.95 | 58 | 78157 | 80471 | 34798245 |
Septic shock | 55.82 | 12.95 | 312 | 77903 | 71522 | 34807194 |
Anxiety | 55.81 | 12.95 | 85 | 78130 | 99343 | 34779373 |
Pyrexia | 53.47 | 12.95 | 1043 | 77172 | 331970 | 34546746 |
Hypoaesthesia | 53.26 | 12.95 | 275 | 77940 | 61169 | 34817547 |
Guillain-Barre syndrome | 51.80 | 12.95 | 66 | 78149 | 6021 | 34872695 |
Chalazion | 51.71 | 12.95 | 18 | 78197 | 153 | 34878563 |
Protein total increased | 51.54 | 12.95 | 42 | 78173 | 2245 | 34876471 |
Aggression | 51.42 | 12.95 | 12 | 78203 | 38952 | 34839764 |
Suicidal ideation | 50.30 | 12.95 | 14 | 78201 | 40374 | 34838342 |
Atrial fibrillation | 49.56 | 12.95 | 454 | 77761 | 121939 | 34756777 |
Peripheral sensorimotor neuropathy | 48.74 | 12.95 | 35 | 78180 | 1547 | 34877169 |
Spinal cord compression | 48.73 | 12.95 | 52 | 78163 | 3923 | 34874793 |
Adverse drug reaction | 48.24 | 12.95 | 160 | 78055 | 29182 | 34849534 |
Stem cell transplant | 47.61 | 12.95 | 39 | 78176 | 2100 | 34876616 |
Seizure | 46.11 | 12.95 | 104 | 78111 | 104753 | 34773963 |
Wrong technique in product usage process | 45.71 | 12.95 | 12 | 78203 | 35974 | 34842742 |
BK virus infection | 45.37 | 12.95 | 60 | 78155 | 5678 | 34873038 |
Haematochezia | 44.94 | 12.95 | 24 | 78191 | 46510 | 34832206 |
Compression fracture | 44.81 | 12.95 | 44 | 78171 | 3008 | 34875708 |
Monoclonal immunoglobulin present | 44.33 | 12.95 | 28 | 78187 | 998 | 34877718 |
Paraesthesia | 44.19 | 12.95 | 270 | 77945 | 63902 | 34814814 |
Hypoglycaemia | 43.53 | 12.95 | 35 | 78180 | 54605 | 34824111 |
Hordeolum | 43.45 | 12.95 | 28 | 78187 | 1034 | 34877682 |
Neuralgia | 43.36 | 12.95 | 101 | 78114 | 15012 | 34863704 |
Laboratory test abnormal | 42.68 | 12.95 | 121 | 78094 | 20270 | 34858446 |
Intentional product misuse | 41.93 | 12.95 | 25 | 78190 | 45586 | 34833130 |
Cardiac amyloidosis | 41.61 | 12.95 | 29 | 78186 | 1222 | 34877494 |
Bradycardia | 40.86 | 12.95 | 66 | 78149 | 75352 | 34803364 |
Haematotoxicity | 40.80 | 12.95 | 69 | 78146 | 8125 | 34870591 |
Hyperviscosity syndrome | 40.20 | 12.95 | 16 | 78199 | 204 | 34878512 |
Asthma | 39.75 | 12.95 | 23 | 78192 | 42633 | 34836083 |
Chronic inflammatory demyelinating polyradiculoneuropathy | 39.03 | 12.95 | 23 | 78192 | 722 | 34877994 |
Ageusia | 38.91 | 12.95 | 77 | 78138 | 10231 | 34868485 |
Stress | 38.77 | 12.95 | 10 | 78205 | 30337 | 34848379 |
Rash pruritic | 37.45 | 12.95 | 139 | 78076 | 26802 | 34851914 |
Bone pain | 36.90 | 12.95 | 116 | 78099 | 20570 | 34858146 |
Dehydration | 36.56 | 12.95 | 448 | 77767 | 129521 | 34749195 |
Osteolysis | 36.52 | 12.95 | 40 | 78175 | 3108 | 34875608 |
Pathological fracture | 36.40 | 12.95 | 47 | 78168 | 4344 | 34874372 |
Renal failure | 36.29 | 12.95 | 449 | 77766 | 130108 | 34748608 |
Neutrophil count decreased | 35.80 | 12.95 | 216 | 77999 | 50888 | 34827828 |
Ileus | 35.60 | 12.95 | 99 | 78116 | 16400 | 34862316 |
Hallucination | 35.11 | 12.95 | 38 | 78177 | 51460 | 34827256 |
Metapneumovirus infection | 34.76 | 12.95 | 22 | 78193 | 787 | 34877929 |
Parainfluenzae virus infection | 34.65 | 12.95 | 37 | 78178 | 2793 | 34875923 |
Progressive multifocal leukoencephalopathy | 34.55 | 12.95 | 71 | 78144 | 9693 | 34869023 |
Agitation | 34.23 | 12.95 | 47 | 78168 | 57352 | 34821364 |
Keratopathy | 34.02 | 12.95 | 20 | 78195 | 625 | 34878091 |
Oroantral fistula | 33.99 | 12.95 | 14 | 78201 | 196 | 34878520 |
Asthenia | 33.02 | 12.95 | 749 | 77466 | 244502 | 34634214 |
Squamous cell carcinoma of skin | 32.63 | 12.95 | 74 | 78141 | 10807 | 34867909 |
Somnolence | 32.50 | 12.95 | 133 | 78082 | 110983 | 34767733 |
Malaise | 32.47 | 12.95 | 263 | 77952 | 185562 | 34693154 |
Flushing | 32.38 | 12.95 | 16 | 78199 | 32404 | 34846312 |
Angioedema | 32.27 | 12.95 | 22 | 78193 | 37352 | 34841364 |
Incorrect dose administered | 32.21 | 12.95 | 26 | 78189 | 40489 | 34838227 |
Bone disorder | 31.83 | 12.95 | 53 | 78162 | 6162 | 34872554 |
H1N1 influenza | 31.29 | 12.95 | 22 | 78193 | 940 | 34877776 |
Adenocarcinoma of colon | 30.82 | 12.95 | 38 | 78177 | 3353 | 34875363 |
Pseudomyopia | 30.78 | 12.95 | 9 | 78206 | 40 | 34878676 |
Erythema | 30.76 | 12.95 | 99 | 78116 | 88681 | 34790035 |
Drug-induced liver injury | 30.70 | 12.95 | 13 | 78202 | 28819 | 34849897 |
Hypogammaglobulinaemia | 30.65 | 12.95 | 59 | 78156 | 7681 | 34871035 |
Hyperhidrosis | 30.17 | 12.95 | 79 | 78136 | 75613 | 34803103 |
Bone lesion | 29.87 | 12.95 | 35 | 78180 | 2928 | 34875788 |
Injection site pain | 29.81 | 12.95 | 26 | 78189 | 38979 | 34839737 |
Visceral leishmaniasis | 29.74 | 12.95 | 18 | 78197 | 594 | 34878122 |
Bone marrow failure | 29.68 | 12.95 | 137 | 78078 | 29116 | 34849600 |
Hiccups | 29.60 | 12.95 | 68 | 78147 | 10014 | 34868702 |
Infusion related reaction | 28.55 | 12.95 | 210 | 78005 | 52847 | 34825869 |
Febrile neutropenia | 28.44 | 12.95 | 447 | 77768 | 136402 | 34742314 |
Pulmonary embolism | 28.17 | 12.95 | 316 | 77899 | 89430 | 34789286 |
Peripheral motor neuropathy | 28.08 | 12.95 | 27 | 78188 | 1799 | 34876917 |
Osteonecrosis | 27.95 | 12.95 | 85 | 78130 | 14805 | 34863911 |
Contraindicated product administered | 27.59 | 12.95 | 7 | 78208 | 21474 | 34857242 |
Blood pressure fluctuation | 27.51 | 12.95 | 11 | 78204 | 25238 | 34853478 |
Blepharitis | 27.35 | 12.95 | 24 | 78191 | 1421 | 34877295 |
Spinal column injury | 26.89 | 12.95 | 17 | 78198 | 607 | 34878109 |
Drug level increased | 26.88 | 12.95 | 8 | 78207 | 22088 | 34856628 |
Bacteraemia | 26.80 | 12.95 | 101 | 78114 | 19616 | 34859100 |
Wheezing | 26.65 | 12.95 | 32 | 78183 | 41370 | 34837346 |
Respirovirus test positive | 26.55 | 12.95 | 9 | 78206 | 70 | 34878646 |
Hyperkalaemia | 26.46 | 12.95 | 74 | 78141 | 69315 | 34809401 |
Performance status decreased | 26.35 | 12.95 | 39 | 78176 | 4098 | 34874618 |
Gastrointestinal amyloidosis | 26.33 | 12.95 | 7 | 78208 | 20 | 34878696 |
Phrenic nerve paralysis | 26.13 | 12.95 | 10 | 78205 | 114 | 34878602 |
Musculoskeletal stiffness | 26.08 | 12.95 | 40 | 78175 | 46640 | 34832076 |
Metabolic acidosis | 25.80 | 12.95 | 36 | 78179 | 43644 | 34835072 |
Renal amyloidosis | 25.70 | 12.95 | 9 | 78206 | 78 | 34878638 |
Lactic acidosis | 25.59 | 12.95 | 24 | 78191 | 34748 | 34843968 |
Blood stem cell harvest failure | 25.15 | 12.95 | 7 | 78208 | 25 | 34878691 |
Product prescribing error | 24.96 | 12.95 | 10 | 78205 | 22917 | 34855799 |
Cytomegalovirus infection | 24.77 | 12.95 | 120 | 78095 | 26015 | 34852701 |
Myocardial infarction | 24.67 | 12.95 | 164 | 78051 | 120921 | 34757795 |
VIth nerve paralysis | 24.67 | 12.95 | 18 | 78197 | 816 | 34877900 |
Monoclonal gammopathy | 24.60 | 12.95 | 14 | 78201 | 411 | 34878305 |
Therapeutic response decreased | 24.55 | 12.95 | 130 | 78085 | 29183 | 34849533 |
Mobility decreased | 24.37 | 12.95 | 19 | 78196 | 30109 | 34848607 |
Tooth deposit | 24.30 | 12.95 | 9 | 78206 | 93 | 34878623 |
Diverticular perforation | 24.26 | 12.95 | 34 | 78181 | 3400 | 34875316 |
Disturbance in attention | 24.15 | 12.95 | 14 | 78201 | 25931 | 34852785 |
Demyelinating polyneuropathy | 24.12 | 12.95 | 21 | 78194 | 1230 | 34877486 |
Colitis ulcerative | 24.08 | 12.95 | 4 | 78211 | 16516 | 34862200 |
Tachycardia | 23.83 | 12.95 | 103 | 78112 | 84669 | 34794047 |
Hepatitis B reactivation | 23.81 | 12.95 | 36 | 78179 | 3855 | 34874861 |
JC virus infection | 23.80 | 12.95 | 27 | 78188 | 2181 | 34876535 |
Spinal fracture | 23.61 | 12.95 | 52 | 78163 | 7446 | 34871270 |
Blood pressure systolic increased | 23.42 | 12.95 | 11 | 78204 | 22941 | 34855775 |
Pallor | 23.36 | 12.95 | 14 | 78201 | 25466 | 34853250 |
Meningitis pneumococcal | 23.29 | 12.95 | 11 | 78204 | 217 | 34878499 |
Ascites | 23.17 | 12.95 | 43 | 78172 | 46528 | 34832188 |
Myalgia | 23.16 | 12.95 | 103 | 78112 | 84007 | 34794709 |
Loss of personal independence in daily activities | 23.15 | 12.95 | 24 | 78191 | 33155 | 34845561 |
Anaphylactic reaction | 22.95 | 12.95 | 23 | 78192 | 32278 | 34846438 |
Anaphylactic shock | 22.92 | 12.95 | 4 | 78211 | 15937 | 34862779 |
Meibomian gland dysfunction | 22.78 | 12.95 | 8 | 78207 | 70 | 34878646 |
Abnormal behaviour | 22.50 | 12.95 | 14 | 78201 | 24955 | 34853761 |
Palmar-plantar erythrodysaesthesia syndrome | 22.50 | 12.95 | 5 | 78210 | 16790 | 34861926 |
B-cell type acute leukaemia | 22.34 | 12.95 | 12 | 78203 | 314 | 34878402 |
Haemoglobin decreased | 22.31 | 12.95 | 387 | 77828 | 120385 | 34758331 |
Dysarthria | 22.26 | 12.95 | 27 | 78188 | 34755 | 34843961 |
Enterococcal infection | 22.25 | 12.95 | 58 | 78157 | 9248 | 34869468 |
Basal cell carcinoma | 22.16 | 12.95 | 95 | 78120 | 19563 | 34859153 |
Obstructive airways disorder | 22.04 | 12.95 | 4 | 78211 | 15490 | 34863226 |
Electrocardiogram QT prolonged | 22.02 | 12.95 | 36 | 78179 | 40916 | 34837800 |
Acute myeloid leukaemia | 21.92 | 12.95 | 90 | 78125 | 18180 | 34860536 |
Depressed level of consciousness | 21.80 | 12.95 | 39 | 78176 | 42802 | 34835914 |
Clostridium difficile colitis | 21.73 | 12.95 | 81 | 78134 | 15649 | 34863067 |
Anaemia | 21.68 | 12.95 | 679 | 77536 | 232656 | 34646060 |
Accidental overdose | 21.57 | 12.95 | 9 | 78206 | 20131 | 34858585 |
Mantle cell lymphoma recurrent | 21.51 | 12.95 | 16 | 78199 | 747 | 34877969 |
Respiratory depression | 21.44 | 12.95 | 5 | 78210 | 16240 | 34862476 |
Synovitis | 21.43 | 12.95 | 3 | 78212 | 14063 | 34864653 |
Bacterial infection | 21.23 | 12.95 | 85 | 78130 | 16978 | 34861738 |
Heart rate increased | 21.15 | 12.95 | 45 | 78170 | 46298 | 34832418 |
Neurogenic bladder | 20.97 | 12.95 | 23 | 78192 | 1790 | 34876926 |
Medication error | 20.83 | 12.95 | 16 | 78199 | 25549 | 34853167 |
Hallucination, visual | 20.65 | 12.95 | 7 | 78208 | 17784 | 34860932 |
Hepatitis B | 20.57 | 12.95 | 43 | 78172 | 5940 | 34872776 |
Blood immunoglobulin G increased | 20.50 | 12.95 | 17 | 78198 | 931 | 34877785 |
Rectal adenocarcinoma | 20.35 | 12.95 | 16 | 78199 | 812 | 34877904 |
Conjunctival irritation | 20.17 | 12.95 | 8 | 78207 | 101 | 34878615 |
Brief psychotic disorder with marked stressors | 20.14 | 12.95 | 10 | 78205 | 221 | 34878495 |
Tear break up time decreased | 20.05 | 12.95 | 5 | 78210 | 10 | 34878706 |
Pityriasis rubra pilaris | 20.03 | 12.95 | 8 | 78207 | 103 | 34878613 |
Rib fracture | 19.76 | 12.95 | 74 | 78141 | 14326 | 34864390 |
Blood immunoglobulin A increased | 19.55 | 12.95 | 11 | 78204 | 316 | 34878400 |
Acute febrile neutrophilic dermatosis | 19.53 | 12.95 | 19 | 78196 | 1284 | 34877432 |
Neurotoxicity | 19.51 | 12.95 | 86 | 78129 | 17924 | 34860792 |
Coma | 19.50 | 12.95 | 46 | 78169 | 45632 | 34833084 |
Ventricular fibrillation | 19.17 | 12.95 | 14 | 78201 | 22940 | 34855776 |
Emotional distress | 19.10 | 12.95 | 5 | 78210 | 15021 | 34863695 |
Light chain analysis decreased | 19.03 | 12.95 | 6 | 78209 | 36 | 34878680 |
Bacterial parotitis | 19.03 | 12.95 | 6 | 78209 | 36 | 34878680 |
Accidental exposure to product | 18.88 | 12.95 | 3 | 78212 | 12799 | 34865917 |
Coronary artery disease | 18.80 | 12.95 | 51 | 78164 | 48254 | 34830462 |
Cerebrovascular accident | 18.75 | 12.95 | 112 | 78103 | 84699 | 34794017 |
Blood immunoglobulin M increased | 18.74 | 12.95 | 10 | 78205 | 258 | 34878458 |
Dry mouth | 18.69 | 12.95 | 24 | 78191 | 30141 | 34848575 |
Polyomavirus-associated nephropathy | 18.65 | 12.95 | 32 | 78183 | 3812 | 34874904 |
Neuromyotonia | 18.63 | 12.95 | 6 | 78209 | 39 | 34878677 |
Depressed mood | 18.59 | 12.95 | 10 | 78205 | 19307 | 34859409 |
Gastric ulcer | 18.44 | 12.95 | 6 | 78209 | 15644 | 34863072 |
Dyskinesia | 18.29 | 12.95 | 14 | 78201 | 22399 | 34856317 |
HCoV-OC43 infection | 18.25 | 12.95 | 6 | 78209 | 42 | 34878674 |
Cardiac failure | 18.16 | 12.95 | 296 | 77919 | 90952 | 34787764 |
Hyperlipidaemia | 18.15 | 12.95 | 5 | 78210 | 14524 | 34864192 |
Vomiting | 18.10 | 12.95 | 419 | 77796 | 247202 | 34631514 |
End stage renal disease | 17.97 | 12.95 | 52 | 78163 | 8809 | 34869907 |
Periodontitis | 17.94 | 12.95 | 22 | 78193 | 1930 | 34876786 |
Haematuria | 17.92 | 12.95 | 55 | 78160 | 50011 | 34828705 |
Nephrolithiasis | 17.91 | 12.95 | 25 | 78190 | 30308 | 34848408 |
Pneumonia pneumococcal | 17.83 | 12.95 | 23 | 78192 | 2123 | 34876593 |
Sopor | 17.55 | 12.95 | 3 | 78212 | 12133 | 34866583 |
Blood calcium increased | 17.54 | 12.95 | 30 | 78185 | 3564 | 34875152 |
Malignant fibrous histiocytoma | 17.46 | 12.95 | 9 | 78206 | 216 | 34878500 |
Autologous haematopoietic stem cell transplant | 17.44 | 12.95 | 6 | 78209 | 49 | 34878667 |
Type 2 diabetes mellitus | 17.44 | 12.95 | 7 | 78208 | 16025 | 34862691 |
Chest discomfort | 17.39 | 12.95 | 63 | 78152 | 54467 | 34824249 |
Melaena | 17.30 | 12.95 | 33 | 78182 | 35347 | 34843369 |
Bacterial sepsis | 17.20 | 12.95 | 37 | 78178 | 5213 | 34873503 |
Gastrooesophageal reflux disease | 17.16 | 12.95 | 37 | 78178 | 37887 | 34840829 |
Hepatic steatosis | 16.96 | 12.95 | 10 | 78205 | 18352 | 34860364 |
Extrapyramidal disorder | 16.92 | 12.95 | 4 | 78211 | 12876 | 34865840 |
Pain | 16.78 | 12.95 | 340 | 77875 | 204335 | 34674381 |
Monoclonal immunoglobulin increased | 16.70 | 12.95 | 8 | 78207 | 163 | 34878553 |
Cytomegalovirus infection reactivation | 16.69 | 12.95 | 36 | 78179 | 5082 | 34873634 |
Respiratory arrest | 16.67 | 12.95 | 23 | 78192 | 28020 | 34850696 |
Laryngeal cancer metastatic | 16.46 | 12.95 | 6 | 78209 | 59 | 34878657 |
Diabetic ketoacidosis | 16.40 | 12.95 | 10 | 78205 | 18022 | 34860694 |
Escherichia sepsis | 16.40 | 12.95 | 34 | 78181 | 4670 | 34874046 |
Muscle spasms | 16.33 | 12.95 | 247 | 77968 | 74754 | 34803962 |
Haemorrhagic fever | 16.30 | 12.95 | 5 | 78210 | 27 | 34878689 |
Jaundice | 16.24 | 12.95 | 29 | 78186 | 31853 | 34846863 |
Respiratory tract infection | 16.22 | 12.95 | 87 | 78128 | 19625 | 34859091 |
Autonomic nervous system imbalance | 16.18 | 12.95 | 24 | 78191 | 2527 | 34876189 |
Product quality issue | 16.13 | 12.95 | 9 | 78206 | 17026 | 34861690 |
Cholestasis | 16.12 | 12.95 | 22 | 78193 | 26926 | 34851790 |
Troponin T increased | 16.04 | 12.95 | 23 | 78192 | 2348 | 34876368 |
Glycosylated haemoglobin increased | 16.01 | 12.95 | 3 | 78212 | 11357 | 34867359 |
Sleep disorder | 15.99 | 12.95 | 29 | 78186 | 31659 | 34847057 |
Neutropenic sepsis | 15.88 | 12.95 | 67 | 78148 | 13700 | 34865016 |
Alanine aminotransferase increased | 15.69 | 12.95 | 111 | 78104 | 80704 | 34798012 |
Aphasia | 15.56 | 12.95 | 15 | 78200 | 21439 | 34857277 |
Injury | 15.55 | 12.95 | 14 | 78201 | 20673 | 34858043 |
Full blood count increased | 15.40 | 12.95 | 14 | 78201 | 868 | 34877848 |
Oesophageal adenocarcinoma | 15.36 | 12.95 | 14 | 78201 | 871 | 34877845 |
Neuromuscular toxicity | 15.33 | 12.95 | 6 | 78209 | 73 | 34878643 |
Pleural effusion | 15.30 | 12.95 | 262 | 77953 | 81284 | 34797432 |
Pleuritic pain | 15.27 | 12.95 | 28 | 78187 | 3513 | 34875203 |
Cutaneous T-cell lymphoma | 15.22 | 12.95 | 18 | 78197 | 1520 | 34877196 |
Eosinophilic pneumonia chronic | 15.17 | 12.95 | 9 | 78206 | 286 | 34878430 |
Upper respiratory tract infection | 15.10 | 12.95 | 126 | 78089 | 32933 | 34845783 |
Hypocalcaemic seizure | 15.08 | 12.95 | 5 | 78210 | 36 | 34878680 |
Refractory cytopenia with multilineage dysplasia | 15.06 | 12.95 | 7 | 78208 | 133 | 34878583 |
Cardiac arrest | 15.03 | 12.95 | 140 | 78075 | 96019 | 34782697 |
Dystonia | 15.00 | 12.95 | 3 | 78212 | 10842 | 34867874 |
Blood culture positive | 14.87 | 12.95 | 33 | 78182 | 4750 | 34873966 |
Body height decreased | 14.86 | 12.95 | 29 | 78186 | 3814 | 34874902 |
Morganella infection | 14.84 | 12.95 | 11 | 78204 | 511 | 34878205 |
Hepatitis | 14.83 | 12.95 | 19 | 78196 | 23885 | 34854831 |
Blood glucose increased | 14.80 | 12.95 | 88 | 78127 | 66630 | 34812086 |
Refractory anaemia with an excess of blasts | 14.65 | 12.95 | 10 | 78205 | 407 | 34878309 |
Prescribed overdose | 14.61 | 12.95 | 3 | 78212 | 10644 | 34868072 |
Fat tissue increased | 14.48 | 12.95 | 10 | 78205 | 415 | 34878301 |
Malignant neoplasm progression | 14.45 | 12.95 | 277 | 77938 | 87769 | 34790947 |
Chest pain | 14.16 | 12.95 | 199 | 78016 | 126563 | 34752153 |
Blood triglycerides increased | 14.12 | 12.95 | 7 | 78208 | 14152 | 34864564 |
Restlessness | 14.07 | 12.95 | 22 | 78193 | 25460 | 34853256 |
Cellulitis orbital | 14.05 | 12.95 | 9 | 78206 | 329 | 34878387 |
VIth nerve paresis | 14.01 | 12.95 | 5 | 78210 | 46 | 34878670 |
Iron deficiency anaemia | 13.99 | 12.95 | 3 | 78212 | 10326 | 34868390 |
General physical condition abnormal | 13.88 | 12.95 | 28 | 78187 | 3771 | 34874945 |
Adenovirus infection | 13.86 | 12.95 | 34 | 78181 | 5223 | 34873493 |
Pregnancy of partner | 13.85 | 12.95 | 9 | 78206 | 337 | 34878379 |
Colitis | 13.74 | 12.95 | 137 | 78078 | 37613 | 34841103 |
Agranulocytosis | 13.70 | 12.95 | 20 | 78195 | 23801 | 34854915 |
Peripheral swelling | 13.67 | 12.95 | 244 | 77971 | 76297 | 34802419 |
Psychotic disorder | 13.61 | 12.95 | 21 | 78194 | 24431 | 34854285 |
Myositis | 13.58 | 12.95 | 5 | 78210 | 12065 | 34866651 |
Paranoia | 13.57 | 12.95 | 5 | 78210 | 12063 | 34866653 |
Thoracic vertebral fracture | 13.54 | 12.95 | 18 | 78197 | 1712 | 34877004 |
Product substitution issue | 13.53 | 12.95 | 3 | 78212 | 10092 | 34868624 |
Blood lactate dehydrogenase increased | 13.53 | 12.95 | 93 | 78122 | 22897 | 34855819 |
Heart rate decreased | 13.52 | 12.95 | 32 | 78183 | 31713 | 34847003 |
Hypercapnic coma | 13.50 | 12.95 | 7 | 78208 | 170 | 34878546 |
Speech disorder | 13.42 | 12.95 | 23 | 78192 | 25663 | 34853053 |
Intentional product use issue | 13.41 | 12.95 | 198 | 78017 | 59618 | 34819098 |
Encephalitis viral | 13.37 | 12.95 | 15 | 78200 | 1197 | 34877519 |
Protein total decreased | 13.33 | 12.95 | 33 | 78182 | 5097 | 34873619 |
Genital erythema | 13.33 | 12.95 | 8 | 78207 | 260 | 34878456 |
Therapy interrupted | 13.31 | 12.95 | 7 | 78208 | 13690 | 34865026 |
Chromaturia | 13.28 | 12.95 | 8 | 78207 | 14512 | 34864204 |
Frequent bowel movements | 13.24 | 12.95 | 6 | 78209 | 12781 | 34865935 |
Lip swelling | 13.18 | 12.95 | 10 | 78205 | 16070 | 34862646 |
Lymphocytic leukaemia | 13.17 | 12.95 | 7 | 78208 | 179 | 34878537 |
Dermatitis exfoliative generalised | 13.16 | 12.95 | 27 | 78188 | 3680 | 34875036 |
Coombs indirect test positive | 13.14 | 12.95 | 4 | 78211 | 21 | 34878695 |
Nightmare | 13.06 | 12.95 | 8 | 78207 | 14383 | 34864333 |
Influenza | 13.00 | 12.95 | 169 | 78046 | 49497 | 34829219 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Neuropathy peripheral | 3691.30 | 12.17 | 2395 | 114705 | 138910 | 79488378 |
Plasma cell myeloma | 2292.95 | 12.17 | 1248 | 115852 | 52011 | 79575277 |
Plasma cell myeloma recurrent | 1501.27 | 12.17 | 472 | 116628 | 4529 | 79622759 |
Thrombocytopenia | 1210.73 | 12.17 | 1706 | 115394 | 263553 | 79363735 |
Disease progression | 855.22 | 12.17 | 1196 | 115904 | 183166 | 79444122 |
Polyneuropathy | 840.93 | 12.17 | 493 | 116607 | 23658 | 79603630 |
Platelet count decreased | 795.14 | 12.17 | 1189 | 115911 | 193475 | 79433813 |
Pneumonia | 683.40 | 12.17 | 2322 | 114778 | 657924 | 78969364 |
Plasmacytoma | 612.47 | 12.17 | 234 | 116866 | 4169 | 79623119 |
Plasma cell myeloma refractory | 457.14 | 12.17 | 120 | 116980 | 552 | 79626736 |
Neutropenia | 406.35 | 12.17 | 1130 | 115970 | 286580 | 79340708 |
Off label use | 351.67 | 12.17 | 2403 | 114697 | 904812 | 78722476 |
Unevaluable event | 330.61 | 12.17 | 408 | 116692 | 55177 | 79572111 |
Plasma cell leukaemia | 322.46 | 12.17 | 115 | 116985 | 1671 | 79625617 |
Completed suicide | 308.57 | 12.17 | 12 | 117088 | 245755 | 79381533 |
Tumour lysis syndrome | 305.68 | 12.17 | 265 | 116835 | 23674 | 79603614 |
Arthralgia | 288.27 | 12.17 | 250 | 116850 | 571553 | 79055735 |
Diarrhoea | 286.71 | 12.17 | 2238 | 114862 | 878251 | 78749037 |
Rheumatoid arthritis | 285.17 | 12.17 | 4 | 117096 | 208466 | 79418822 |
Headache | 277.20 | 12.17 | 332 | 116768 | 653440 | 78973848 |
Pancytopenia | 271.16 | 12.17 | 688 | 116412 | 165057 | 79462231 |
Cytopenia | 256.95 | 12.17 | 224 | 116876 | 20159 | 79607129 |
Drug hypersensitivity | 256.20 | 12.17 | 62 | 117038 | 298854 | 79328434 |
Sepsis | 253.18 | 12.17 | 920 | 116180 | 268508 | 79358780 |
Peripheral sensory neuropathy | 251.69 | 12.17 | 184 | 116916 | 12849 | 79614439 |
White blood cell count decreased | 249.32 | 12.17 | 723 | 116377 | 187565 | 79439723 |
Drug interaction | 240.55 | 12.17 | 157 | 116943 | 415026 | 79212262 |
Product use in unapproved indication | 221.03 | 12.17 | 838 | 116262 | 249521 | 79377767 |
Orthostatic hypotension | 214.50 | 12.17 | 333 | 116767 | 55831 | 79571457 |
Therapy partial responder | 210.90 | 12.17 | 187 | 116913 | 17210 | 79610078 |
Deep vein thrombosis | 209.31 | 12.17 | 513 | 116587 | 120406 | 79506882 |
Septic shock | 206.25 | 12.17 | 515 | 116585 | 122286 | 79505002 |
Synovitis | 205.65 | 12.17 | 3 | 117097 | 150731 | 79476557 |
Constipation | 202.72 | 12.17 | 888 | 116212 | 282162 | 79345126 |
Herpes zoster | 202.18 | 12.17 | 432 | 116668 | 92651 | 79534637 |
Amyloidosis | 201.08 | 12.17 | 92 | 117008 | 2614 | 79624674 |
Contraindicated product administered | 187.04 | 12.17 | 11 | 117089 | 157527 | 79469761 |
Light chain analysis increased | 178.57 | 12.17 | 74 | 117026 | 1644 | 79625644 |
Myelodysplastic syndrome | 177.84 | 12.17 | 221 | 116879 | 30080 | 79597208 |
Febrile neutropenia | 170.90 | 12.17 | 732 | 116368 | 230267 | 79397021 |
Pain | 165.89 | 12.17 | 508 | 116592 | 703294 | 78923994 |
Maternal exposure during pregnancy | 163.72 | 12.17 | 9 | 117091 | 136529 | 79490759 |
Systemic lupus erythematosus | 162.78 | 12.17 | 3 | 117097 | 121146 | 79506142 |
Arthropathy | 161.25 | 12.17 | 32 | 117068 | 177079 | 79450209 |
Alopecia | 161.06 | 12.17 | 69 | 117031 | 231286 | 79396002 |
Overdose | 160.12 | 12.17 | 37 | 117063 | 184169 | 79443119 |
Drug abuse | 159.95 | 12.17 | 24 | 117076 | 162667 | 79464621 |
Autonomic neuropathy | 158.56 | 12.17 | 70 | 117030 | 1825 | 79625463 |
Anaemia | 153.96 | 12.17 | 1149 | 115951 | 443866 | 79183422 |
Joint swelling | 145.39 | 12.17 | 126 | 116974 | 288520 | 79338768 |
Atrial fibrillation | 144.73 | 12.17 | 625 | 116475 | 197261 | 79430027 |
Chalazion | 138.45 | 12.17 | 45 | 117055 | 484 | 79626804 |
Ileus paralytic | 138.22 | 12.17 | 114 | 116986 | 9506 | 79617782 |
Cardiac amyloidosis | 138.12 | 12.17 | 63 | 117037 | 1777 | 79625511 |
Musculoskeletal stiffness | 137.31 | 12.17 | 43 | 117057 | 174965 | 79452323 |
Neutrophil count decreased | 136.17 | 12.17 | 373 | 116727 | 93586 | 79533702 |
Dehydration | 135.90 | 12.17 | 721 | 116379 | 247466 | 79379822 |
Glossodynia | 133.29 | 12.17 | 4 | 117096 | 103333 | 79523955 |
Renal failure | 132.87 | 12.17 | 616 | 116484 | 200352 | 79426936 |
Therapeutic product effect decreased | 132.66 | 12.17 | 38 | 117062 | 163825 | 79463463 |
Exposure during pregnancy | 130.14 | 12.17 | 4 | 117096 | 101128 | 79526160 |
B precursor type acute leukaemia | 122.63 | 12.17 | 39 | 117061 | 389 | 79626899 |
Condition aggravated | 121.99 | 12.17 | 356 | 116744 | 500768 | 79126520 |
Acute lymphocytic leukaemia | 121.29 | 12.17 | 81 | 117019 | 4888 | 79622400 |
Hypersensitivity | 119.73 | 12.17 | 125 | 116975 | 262114 | 79365174 |
Abdominal discomfort | 117.32 | 12.17 | 117 | 116983 | 250610 | 79376678 |
Primary amyloidosis | 116.67 | 12.17 | 30 | 117070 | 125 | 79627163 |
Full blood count decreased | 116.62 | 12.17 | 169 | 116931 | 26650 | 79600638 |
Hypercalcaemia | 115.97 | 12.17 | 205 | 116895 | 38225 | 79589063 |
Anxiety | 115.10 | 12.17 | 117 | 116983 | 248395 | 79378893 |
Swelling | 114.78 | 12.17 | 90 | 117010 | 216621 | 79410667 |
Pyrexia | 114.72 | 12.17 | 1509 | 115591 | 677200 | 78950088 |
Blood pressure increased | 114.21 | 12.17 | 86 | 117014 | 211274 | 79416014 |
Psoriasis | 113.65 | 12.17 | 4 | 117096 | 89583 | 79537705 |
Peripheral sensorimotor neuropathy | 111.49 | 12.17 | 64 | 117036 | 2946 | 79624342 |
Discomfort | 109.61 | 12.17 | 25 | 117075 | 125592 | 79501696 |
Cardiac failure | 107.05 | 12.17 | 481 | 116619 | 154361 | 79472927 |
Posterior reversible encephalopathy syndrome | 101.95 | 12.17 | 157 | 116943 | 26124 | 79601164 |
Mobility decreased | 101.37 | 12.17 | 27 | 117073 | 122148 | 79505140 |
Malignant neoplasm progression | 99.73 | 12.17 | 430 | 116670 | 135560 | 79491728 |
Wound | 99.62 | 12.17 | 24 | 117076 | 116155 | 79511133 |
Suicide attempt | 97.78 | 12.17 | 6 | 117094 | 82926 | 79544362 |
Cytomegalovirus infection | 97.28 | 12.17 | 202 | 116898 | 42442 | 79584846 |
Haematotoxicity | 97.23 | 12.17 | 117 | 116983 | 15402 | 79611886 |
Monoclonal immunoglobulin present | 97.02 | 12.17 | 42 | 117058 | 1043 | 79626245 |
Weight increased | 93.47 | 12.17 | 165 | 116935 | 277221 | 79350067 |
Injection site pain | 93.10 | 12.17 | 37 | 117063 | 129801 | 79497487 |
Osteonecrosis of jaw | 91.94 | 12.17 | 199 | 116901 | 43027 | 79584261 |
Product use issue | 90.29 | 12.17 | 572 | 116528 | 209250 | 79418038 |
Thrombosis | 89.90 | 12.17 | 300 | 116800 | 83800 | 79543488 |
Inappropriate schedule of product administration | 89.58 | 12.17 | 42 | 117058 | 133586 | 79493702 |
Stem cell transplant | 89.50 | 12.17 | 60 | 117040 | 3644 | 79623644 |
Therapy non-responder | 88.86 | 12.17 | 318 | 116782 | 91987 | 79535301 |
Pathological fracture | 85.73 | 12.17 | 91 | 117009 | 10446 | 79616842 |
Depression | 85.41 | 12.17 | 116 | 116984 | 216674 | 79410614 |
Bone marrow failure | 84.32 | 12.17 | 213 | 116887 | 50894 | 79576394 |
Malaise | 83.86 | 12.17 | 402 | 116698 | 489467 | 79137821 |
Osteolysis | 83.46 | 12.17 | 62 | 117038 | 4436 | 79622852 |
Blood cholesterol increased | 83.07 | 12.17 | 12 | 117088 | 83708 | 79543580 |
Death | 82.41 | 12.17 | 1227 | 115873 | 565287 | 79062001 |
Helicobacter infection | 82.30 | 12.17 | 5 | 117095 | 69699 | 79557589 |
Cystitis haemorrhagic | 81.42 | 12.17 | 83 | 117017 | 9089 | 79618199 |
Fibromyalgia | 81.17 | 12.17 | 3 | 117097 | 64337 | 79562951 |
Duodenal ulcer perforation | 80.50 | 12.17 | 4 | 117096 | 66207 | 79561081 |
Pleural effusion | 80.10 | 12.17 | 423 | 116677 | 144839 | 79482449 |
Rhabdomyolysis | 79.69 | 12.17 | 26 | 117074 | 103105 | 79524183 |
Guillain-Barre syndrome | 79.36 | 12.17 | 81 | 117019 | 8884 | 79618404 |
Hepatitis B reactivation | 78.73 | 12.17 | 68 | 117032 | 6040 | 79621248 |
Hyperviscosity syndrome | 78.62 | 12.17 | 28 | 117072 | 405 | 79626883 |
Spinal cord compression | 78.19 | 12.17 | 69 | 117031 | 6308 | 79620980 |
Blood pressure fluctuation | 75.84 | 12.17 | 6 | 117094 | 67139 | 79560149 |
Hordeolum | 74.84 | 12.17 | 51 | 117049 | 3182 | 79624106 |
Hypertension | 73.46 | 12.17 | 245 | 116855 | 330747 | 79296541 |
Wrong technique in product usage process | 72.35 | 12.17 | 11 | 117089 | 73864 | 79553424 |
Stress | 71.15 | 12.17 | 15 | 117085 | 79597 | 79547691 |
Blister | 70.66 | 12.17 | 44 | 117056 | 119432 | 79507856 |
Peripheral motor neuropathy | 70.64 | 12.17 | 50 | 117050 | 3317 | 79623971 |
Ileus | 70.44 | 12.17 | 133 | 116967 | 26078 | 79601210 |
Nasopharyngitis | 70.28 | 12.17 | 169 | 116931 | 253712 | 79373576 |
Haemoglobin decreased | 69.10 | 12.17 | 560 | 116540 | 221559 | 79405729 |
Arthritis | 68.37 | 12.17 | 42 | 117058 | 114838 | 79512450 |
Migraine | 67.70 | 12.17 | 22 | 117078 | 87471 | 79539817 |
Cytomegalovirus infection reactivation | 66.92 | 12.17 | 73 | 117027 | 8643 | 79618645 |
Hepatic enzyme increased | 66.72 | 12.17 | 103 | 116997 | 182507 | 79444781 |
Pulmonary embolism | 66.56 | 12.17 | 456 | 116644 | 171198 | 79456090 |
Irritable bowel syndrome | 66.44 | 12.17 | 7 | 117093 | 62234 | 79565054 |
Protein total increased | 65.48 | 12.17 | 50 | 117050 | 3729 | 79623559 |
Blood stem cell harvest failure | 65.31 | 12.17 | 18 | 117082 | 103 | 79627185 |
Colitis | 65.04 | 12.17 | 246 | 116854 | 73061 | 79554227 |
Wheezing | 64.90 | 12.17 | 46 | 117054 | 116618 | 79510670 |
Coombs indirect test positive | 64.42 | 12.17 | 16 | 117084 | 56 | 79627232 |
Pericarditis | 63.58 | 12.17 | 37 | 117063 | 104199 | 79523089 |
Injury | 60.83 | 12.17 | 19 | 117081 | 77477 | 79549811 |
Acute myeloid leukaemia | 59.84 | 12.17 | 137 | 116963 | 30748 | 79596540 |
Hypogammaglobulinaemia | 58.33 | 12.17 | 83 | 117017 | 12868 | 79614420 |
Blood creatine phosphokinase increased | 57.95 | 12.17 | 13 | 117087 | 66077 | 79561211 |
Flushing | 57.24 | 12.17 | 29 | 117071 | 88239 | 79539049 |
Blood lactate dehydrogenase increased | 56.21 | 12.17 | 155 | 116945 | 39015 | 79588273 |
Intentional product use issue | 55.98 | 12.17 | 399 | 116701 | 151713 | 79475575 |
Ill-defined disorder | 55.70 | 12.17 | 14 | 117086 | 65861 | 79561427 |
Morganella infection | 55.70 | 12.17 | 29 | 117071 | 1098 | 79626190 |
Red blood cell sedimentation rate increased | 55.14 | 12.17 | 3 | 117097 | 45939 | 79581349 |
B-cell type acute leukaemia | 55.12 | 12.17 | 23 | 117077 | 520 | 79626768 |
Folliculitis | 54.79 | 12.17 | 8 | 117092 | 55372 | 79571916 |
Loss of personal independence in daily activities | 53.78 | 12.17 | 43 | 117057 | 102537 | 79524751 |
Asthma | 53.47 | 12.17 | 72 | 117028 | 135023 | 79492265 |
Blood pressure systolic increased | 53.34 | 12.17 | 16 | 117084 | 66970 | 79560318 |
Neurotoxicity | 53.09 | 12.17 | 135 | 116965 | 32383 | 79594905 |
Treatment failure | 52.48 | 12.17 | 107 | 116993 | 170379 | 79456909 |
Bacteraemia | 52.27 | 12.17 | 135 | 116965 | 32689 | 79594599 |
Osteoarthritis | 51.83 | 12.17 | 32 | 117068 | 87277 | 79540011 |
Sleep disorder | 51.43 | 12.17 | 31 | 117069 | 85646 | 79541642 |
Metapneumovirus infection | 50.71 | 12.17 | 32 | 117068 | 1752 | 79625536 |
Bone pain | 50.23 | 12.17 | 188 | 116912 | 55554 | 79571734 |
Sedation | 50.19 | 12.17 | 8 | 117092 | 51887 | 79575401 |
Hypocalcaemia | 49.75 | 12.17 | 174 | 116926 | 49750 | 79577538 |
BK virus infection | 49.71 | 12.17 | 63 | 117037 | 8741 | 79618547 |
Suicidal ideation | 49.62 | 12.17 | 25 | 117075 | 76315 | 79550973 |
Somnolence | 48.90 | 12.17 | 183 | 116917 | 238798 | 79388490 |
Pseudomyopia | 48.63 | 12.17 | 14 | 117086 | 96 | 79627192 |
Heart rate increased | 48.13 | 12.17 | 64 | 117036 | 120660 | 79506628 |
Myalgia | 47.93 | 12.17 | 128 | 116972 | 185513 | 79441775 |
Contusion | 47.84 | 12.17 | 91 | 117009 | 148685 | 79478603 |
Pneumonia fungal | 47.80 | 12.17 | 70 | 117030 | 11140 | 79616148 |
Compression fracture | 47.68 | 12.17 | 53 | 117047 | 6407 | 79620881 |
Renal amyloidosis | 47.68 | 12.17 | 15 | 117085 | 144 | 79627144 |
Progressive multifocal leukoencephalopathy | 47.47 | 12.17 | 98 | 117002 | 20502 | 79606786 |
Nasal congestion | 46.93 | 12.17 | 27 | 117073 | 76525 | 79550763 |
Squamous cell carcinoma of skin | 46.45 | 12.17 | 78 | 117022 | 13955 | 79613333 |
Respiratory failure | 46.29 | 12.17 | 437 | 116663 | 180474 | 79446814 |
Chronic inflammatory demyelinating polyradiculoneuropathy | 46.05 | 12.17 | 26 | 117074 | 1159 | 79626129 |
Syncope | 45.68 | 12.17 | 433 | 116667 | 179016 | 79448272 |
Infection | 45.55 | 12.17 | 549 | 116551 | 241163 | 79386125 |
Pruritus | 45.51 | 12.17 | 366 | 116734 | 394282 | 79233006 |
Hyperhidrosis | 45.01 | 12.17 | 97 | 117003 | 151395 | 79475893 |
Type 2 diabetes mellitus | 44.84 | 12.17 | 14 | 117086 | 57108 | 79570180 |
Blepharitis | 44.83 | 12.17 | 37 | 117063 | 3087 | 79624201 |
Thrombotic microangiopathy | 44.20 | 12.17 | 94 | 117006 | 20075 | 79607213 |
Anaphylactic reaction | 44.02 | 12.17 | 35 | 117065 | 83708 | 79543580 |
Lymphopenia | 43.93 | 12.17 | 121 | 116979 | 30436 | 79596852 |
Prescribed overdose | 43.88 | 12.17 | 3 | 117097 | 37880 | 79589408 |
Light chain analysis abnormal | 43.23 | 12.17 | 15 | 117085 | 200 | 79627088 |
Keratopathy | 43.19 | 12.17 | 25 | 117075 | 1169 | 79626119 |
Sinusitis | 43.13 | 12.17 | 145 | 116955 | 195356 | 79431932 |
Meningitis listeria | 43.02 | 12.17 | 24 | 117076 | 1045 | 79626243 |
Urticaria | 42.49 | 12.17 | 135 | 116965 | 185066 | 79442222 |
Erythema | 42.48 | 12.17 | 176 | 116924 | 223114 | 79404174 |
Pneumonia pneumococcal | 42.30 | 12.17 | 40 | 117060 | 3997 | 79623291 |
Gastrooesophageal reflux disease | 41.82 | 12.17 | 55 | 117045 | 104191 | 79523097 |
Clostridium difficile colitis | 41.70 | 12.17 | 123 | 116977 | 32160 | 79595128 |
Performance status decreased | 41.46 | 12.17 | 48 | 117052 | 6065 | 79621223 |
Anaphylactic shock | 41.26 | 12.17 | 3 | 117097 | 35993 | 79591295 |
Asthenia | 41.02 | 12.17 | 1012 | 116088 | 510677 | 79116611 |
Aggression | 40.88 | 12.17 | 12 | 117088 | 50946 | 79576342 |
Impaired healing | 40.84 | 12.17 | 41 | 117059 | 87614 | 79539674 |
Spinal compression fracture | 40.64 | 12.17 | 82 | 117018 | 16876 | 79610412 |
Bacterial sepsis | 40.60 | 12.17 | 55 | 117045 | 8143 | 79619145 |
Crossmatch incompatible | 40.49 | 12.17 | 10 | 117090 | 34 | 79627254 |
Respiratory tract infection | 40.41 | 12.17 | 160 | 116940 | 48529 | 79578759 |
Palpitations | 40.22 | 12.17 | 78 | 117022 | 126532 | 79500756 |
Obesity | 40.06 | 12.17 | 3 | 117097 | 35122 | 79592166 |
Hepatitis B | 39.91 | 12.17 | 55 | 117045 | 8277 | 79619011 |
Refractory cytopenia with multilineage dysplasia | 39.84 | 12.17 | 15 | 117085 | 256 | 79627032 |
JC virus infection | 39.80 | 12.17 | 38 | 117062 | 3843 | 79623445 |
Abdominal pain upper | 39.78 | 12.17 | 181 | 116919 | 223638 | 79403650 |
Visceral leishmaniasis | 39.26 | 12.17 | 23 | 117077 | 1100 | 79626188 |
Large intestine perforation | 39.24 | 12.17 | 74 | 117026 | 14493 | 79612795 |
Toxic skin eruption | 38.97 | 12.17 | 95 | 117005 | 22198 | 79605090 |
Dry mouth | 38.96 | 12.17 | 43 | 117057 | 87976 | 79539312 |
Neuralgia | 38.28 | 12.17 | 122 | 116978 | 33262 | 79594026 |
Hypophosphataemia | 38.21 | 12.17 | 88 | 117012 | 19825 | 79607463 |
Mucosal inflammation | 38.20 | 12.17 | 215 | 116885 | 75365 | 79551923 |
Myelosuppression | 38.06 | 12.17 | 138 | 116962 | 40158 | 79587130 |
Abdominal pain | 38.01 | 12.17 | 377 | 116723 | 389192 | 79238096 |
Diverticular perforation | 37.85 | 12.17 | 45 | 117055 | 5848 | 79621440 |
Infection in an immunocompromised host | 37.54 | 12.17 | 24 | 117076 | 1344 | 79625944 |
Cough | 37.46 | 12.17 | 351 | 116749 | 366438 | 79260850 |
Sopor | 37.14 | 12.17 | 3 | 117097 | 33007 | 79594281 |
Inflammation | 37.06 | 12.17 | 50 | 117050 | 93703 | 79533585 |
Nasal abscess | 37.02 | 12.17 | 13 | 117087 | 180 | 79627108 |
COVID-19 pneumonia | 36.40 | 12.17 | 109 | 116991 | 28740 | 79598548 |
Osteoporosis | 36.26 | 12.17 | 17 | 117083 | 54095 | 79573193 |
Hip arthroplasty | 35.76 | 12.17 | 5 | 117095 | 35751 | 79591537 |
Rash | 35.41 | 12.17 | 1105 | 115995 | 577253 | 79050035 |
Pain in extremity | 35.05 | 12.17 | 354 | 116746 | 364184 | 79263104 |
Large intestinal ulcer perforation | 34.94 | 12.17 | 10 | 117090 | 67 | 79627221 |
Joint injury | 34.83 | 12.17 | 3 | 117097 | 31332 | 79595956 |
Demyelinating polyneuropathy | 34.76 | 12.17 | 25 | 117075 | 1701 | 79625587 |
Toxicity to various agents | 34.74 | 12.17 | 837 | 116263 | 420703 | 79206585 |
Underdose | 34.69 | 12.17 | 4 | 117096 | 33147 | 79594141 |
Bone lesion | 34.45 | 12.17 | 43 | 117057 | 5876 | 79621412 |
Colitis ulcerative | 34.41 | 12.17 | 5 | 117095 | 34737 | 79592551 |
Drug withdrawal syndrome | 34.38 | 12.17 | 5 | 117095 | 34713 | 79592575 |
Enterococcal infection | 34.33 | 12.17 | 73 | 117027 | 15587 | 79611701 |
Fungal oesophagitis | 33.92 | 12.17 | 20 | 117080 | 968 | 79626320 |
Heart rate decreased | 33.79 | 12.17 | 32 | 117068 | 70284 | 79557004 |
Incorrect dose administered | 33.30 | 12.17 | 38 | 117062 | 76592 | 79550696 |
Erysipelas | 32.88 | 12.17 | 58 | 117042 | 10792 | 79616496 |
Inappropriate antidiuretic hormone secretion | 32.80 | 12.17 | 99 | 117001 | 26214 | 79601074 |
Cardiotoxicity | 32.76 | 12.17 | 62 | 117038 | 12177 | 79615111 |
COVID-19 | 32.75 | 12.17 | 365 | 116735 | 157309 | 79469979 |
VIth nerve paresis | 32.61 | 12.17 | 11 | 117089 | 134 | 79627154 |
Joint range of motion decreased | 32.48 | 12.17 | 5 | 117095 | 33277 | 79594011 |
Mesenteric abscess | 32.03 | 12.17 | 11 | 117089 | 142 | 79627146 |
Injection site swelling | 31.29 | 12.17 | 15 | 117085 | 47117 | 79580171 |
Product quality issue | 31.15 | 12.17 | 6 | 117094 | 33934 | 79593354 |
Nocardiosis | 31.06 | 12.17 | 40 | 117060 | 5639 | 79621649 |
Parainfluenzae virus infection | 31.04 | 12.17 | 40 | 117060 | 5642 | 79621646 |
Transplant | 30.98 | 12.17 | 19 | 117081 | 989 | 79626299 |
Pneumonia influenzal | 30.86 | 12.17 | 29 | 117071 | 2875 | 79624413 |
Drug reaction with eosinophilia and systemic symptoms | 30.66 | 12.17 | 180 | 116920 | 64064 | 79563224 |
Osteonecrosis | 30.65 | 12.17 | 108 | 116992 | 30987 | 79596301 |
Endocarditis bacterial | 30.46 | 12.17 | 22 | 117078 | 1507 | 79625781 |
Lactic acidosis | 30.45 | 12.17 | 35 | 117065 | 70324 | 79556964 |
Body dysmorphic disorder | 30.44 | 12.17 | 13 | 117087 | 312 | 79626976 |
Lip swelling | 30.41 | 12.17 | 11 | 117089 | 40900 | 79586388 |
End stage renal disease | 30.38 | 12.17 | 60 | 117040 | 12160 | 79615128 |
Hyperproteinaemia | 30.16 | 12.17 | 11 | 117089 | 171 | 79627117 |
Drug intolerance | 29.93 | 12.17 | 246 | 116854 | 263873 | 79363415 |
Drug-induced liver injury | 29.59 | 12.17 | 32 | 117068 | 66085 | 79561203 |
Bursitis | 29.57 | 12.17 | 8 | 117092 | 35836 | 79591452 |
Dyspepsia | 29.53 | 12.17 | 73 | 117027 | 108614 | 79518674 |
General physical condition abnormal | 29.47 | 12.17 | 42 | 117058 | 6521 | 79620767 |
Hypoglycaemia | 29.39 | 12.17 | 66 | 117034 | 101528 | 79525760 |
Hypoalbuminaemia | 29.30 | 12.17 | 83 | 117017 | 21214 | 79606074 |
Rib fracture | 29.23 | 12.17 | 99 | 117001 | 27848 | 79599440 |
Ageusia | 29.20 | 12.17 | 71 | 117029 | 16561 | 79610727 |
Gait disturbance | 28.98 | 12.17 | 182 | 116918 | 207324 | 79419964 |
Angioedema | 28.61 | 12.17 | 42 | 117058 | 75993 | 79551295 |
Oedema peripheral | 28.60 | 12.17 | 525 | 116575 | 251763 | 79375525 |
Oropharyngeal pain | 28.51 | 12.17 | 75 | 117025 | 109278 | 79518010 |
Cerebellar haemangioma | 28.46 | 12.17 | 9 | 117091 | 88 | 79627200 |
H1N1 influenza | 28.40 | 12.17 | 26 | 117074 | 2493 | 79624795 |
Musculoskeletal pain | 28.40 | 12.17 | 68 | 117032 | 102286 | 79525002 |
Liver injury | 28.11 | 12.17 | 25 | 117075 | 56589 | 79570699 |
Memory impairment | 28.11 | 12.17 | 78 | 117022 | 111656 | 79515632 |
Oroantral fistula | 27.82 | 12.17 | 13 | 117087 | 388 | 79626900 |
Febrile bone marrow aplasia | 27.75 | 12.17 | 60 | 117040 | 12960 | 79614328 |
Pulmonary oedema | 27.67 | 12.17 | 223 | 116877 | 88031 | 79539257 |
Swollen tongue | 27.57 | 12.17 | 14 | 117086 | 42556 | 79584732 |
Gastrointestinal fungal infection | 27.44 | 12.17 | 14 | 117086 | 508 | 79626780 |
Rhinovirus infection | 27.38 | 12.17 | 45 | 117055 | 7908 | 79619380 |
Accidental overdose | 27.20 | 12.17 | 12 | 117088 | 39569 | 79587719 |
Iron deficiency anaemia | 27.11 | 12.17 | 3 | 117097 | 25669 | 79601619 |
Cardiac failure congestive | 27.04 | 12.17 | 324 | 116776 | 142078 | 79485210 |
Depressed level of consciousness | 26.98 | 12.17 | 64 | 117036 | 96588 | 79530700 |
Failure to thrive | 26.88 | 12.17 | 56 | 117044 | 11788 | 79615500 |
Dysarthria | 26.79 | 12.17 | 36 | 117064 | 67586 | 79559702 |
Polyomavirus-associated nephropathy | 26.74 | 12.17 | 37 | 117063 | 5590 | 79621698 |
N-terminal prohormone brain natriuretic peptide decreased | 26.70 | 12.17 | 7 | 117093 | 32 | 79627256 |
Seizure | 26.69 | 12.17 | 165 | 116935 | 188669 | 79438619 |
Rectal adenocarcinoma | 26.65 | 12.17 | 20 | 117080 | 1453 | 79625835 |
Tear break up time decreased | 26.58 | 12.17 | 6 | 117094 | 12 | 79627276 |
Pallor | 26.21 | 12.17 | 21 | 117079 | 50041 | 79577247 |
Hypersensitivity myocarditis | 26.03 | 12.17 | 11 | 117089 | 257 | 79627031 |
Autonomic nervous system imbalance | 25.93 | 12.17 | 33 | 117067 | 4597 | 79622691 |
Depressed mood | 25.81 | 12.17 | 20 | 117080 | 48460 | 79578828 |
Dyskinesia | 25.76 | 12.17 | 17 | 117083 | 44756 | 79582532 |
Throat irritation | 25.73 | 12.17 | 14 | 117086 | 40932 | 79586356 |
Adenocarcinoma of colon | 25.68 | 12.17 | 36 | 117064 | 5505 | 79621783 |
Diabetic ketoacidosis | 25.66 | 12.17 | 9 | 117091 | 34113 | 79593175 |
Pneumonia cytomegaloviral | 25.62 | 12.17 | 34 | 117066 | 4935 | 79622353 |
Amnesia | 25.56 | 12.17 | 33 | 117067 | 63024 | 79564264 |
Frequent bowel movements | 25.51 | 12.17 | 6 | 117094 | 29533 | 79597755 |
Chest discomfort | 25.50 | 12.17 | 110 | 116990 | 137934 | 79489354 |
Meningitis pneumococcal | 25.39 | 12.17 | 13 | 117087 | 475 | 79626813 |
Multiple organ dysfunction syndrome | 25.25 | 12.17 | 279 | 116821 | 119967 | 79507321 |
Escherichia sepsis | 25.16 | 12.17 | 45 | 117055 | 8463 | 79618825 |
Bronchopulmonary aspergillosis | 25.13 | 12.17 | 81 | 117019 | 22213 | 79605075 |
Refractory anaemia with an excess of blasts | 25.13 | 12.17 | 16 | 117084 | 890 | 79626398 |
Respirovirus test positive | 25.03 | 12.17 | 9 | 117091 | 134 | 79627154 |
VIth nerve paralysis | 24.92 | 12.17 | 20 | 117080 | 1604 | 79625684 |
Venoocclusive liver disease | 24.81 | 12.17 | 54 | 117046 | 11717 | 79615571 |
Medication error | 24.78 | 12.17 | 39 | 117061 | 68603 | 79558685 |
Nephrolithiasis | 24.74 | 12.17 | 25 | 117075 | 53266 | 79574022 |
Feeling abnormal | 24.69 | 12.17 | 135 | 116965 | 159064 | 79468224 |
Hiccups | 24.63 | 12.17 | 49 | 117051 | 9982 | 79617306 |
Target skin lesion | 24.61 | 12.17 | 9 | 117091 | 141 | 79627147 |
Staphylococcal bacteraemia | 24.56 | 12.17 | 55 | 117045 | 12163 | 79615125 |
Oral surgery | 24.34 | 12.17 | 17 | 117083 | 1104 | 79626184 |
Basal cell carcinoma | 24.23 | 12.17 | 114 | 116986 | 37261 | 79590027 |
Sinus polyp | 24.20 | 12.17 | 13 | 117087 | 525 | 79626763 |
Neutropenic sepsis | 24.14 | 12.17 | 91 | 117009 | 26973 | 79600315 |
Renal impairment | 24.10 | 12.17 | 345 | 116755 | 157438 | 79469850 |
Coma | 24.04 | 12.17 | 72 | 117028 | 100577 | 79526711 |
Acute respiratory distress syndrome | 24.04 | 12.17 | 128 | 116972 | 43939 | 79583349 |
Therapy interrupted | 24.03 | 12.17 | 8 | 117092 | 31333 | 79595955 |
Accidental exposure to product | 24.01 | 12.17 | 8 | 117092 | 31314 | 79595974 |
Blood immunoglobulin A increased | 23.93 | 12.17 | 16 | 117084 | 967 | 79626321 |
Hypothyroidism | 23.84 | 12.17 | 25 | 117075 | 52367 | 79574921 |
Pulmonary sepsis | 23.27 | 12.17 | 28 | 117072 | 3684 | 79623604 |
Respiratory depression | 23.11 | 12.17 | 6 | 117094 | 27624 | 79599664 |
Engraftment syndrome | 23.01 | 12.17 | 18 | 117082 | 1391 | 79625897 |
Device dislocation | 22.98 | 12.17 | 5 | 117095 | 25965 | 79601323 |
Pityriasis rubra pilaris | 22.70 | 12.17 | 8 | 117092 | 112 | 79627176 |
Blood potassium decreased | 22.64 | 12.17 | 131 | 116969 | 46381 | 79580907 |
Disturbance in social behaviour | 22.60 | 12.17 | 32 | 117068 | 4938 | 79622350 |
Pneumonia bacterial | 22.49 | 12.17 | 71 | 117029 | 19260 | 79608028 |
Hallucination, visual | 22.37 | 12.17 | 10 | 117090 | 32719 | 79594569 |
Fatigue | 22.35 | 12.17 | 1618 | 115482 | 928109 | 78699179 |
Acute febrile neutrophilic dermatosis | 22.33 | 12.17 | 28 | 117072 | 3844 | 79623444 |
Bronchiolitis | 22.13 | 12.17 | 29 | 117071 | 4159 | 79623129 |
Taste disorder | 22.09 | 12.17 | 62 | 117038 | 15761 | 79611527 |
Neurogenic bladder | 22.00 | 12.17 | 29 | 117071 | 4183 | 79623105 |
Hot flush | 21.96 | 12.17 | 29 | 117071 | 54848 | 79572440 |
Clostridium bacteraemia | 21.87 | 12.17 | 11 | 117089 | 387 | 79626901 |
Superficial spreading melanoma stage unspecified | 21.73 | 12.17 | 10 | 117090 | 288 | 79627000 |
Conjunctival irritation | 21.72 | 12.17 | 8 | 117092 | 128 | 79627160 |
Blood culture positive | 21.70 | 12.17 | 42 | 117058 | 8387 | 79618901 |
Adenovirus infection | 21.63 | 12.17 | 42 | 117058 | 8405 | 79618883 |
Laboratory test abnormal | 21.55 | 12.17 | 90 | 117010 | 27958 | 79599330 |
Feeling hot | 21.51 | 12.17 | 34 | 117066 | 59700 | 79567588 |
Bacterial infection | 21.45 | 12.17 | 97 | 117003 | 31183 | 79596105 |
Procedural pain | 21.35 | 12.17 | 4 | 117096 | 23080 | 79604208 |
Pseudomonal sepsis | 21.35 | 12.17 | 35 | 117065 | 6139 | 79621149 |
Crying | 21.30 | 12.17 | 4 | 117096 | 23039 | 79604249 |
Meningitis cryptococcal | 21.26 | 12.17 | 26 | 117074 | 3480 | 79623808 |
Lung infiltration | 21.24 | 12.17 | 78 | 117022 | 22834 | 79604454 |
Meibomian gland dysfunction | 21.23 | 12.17 | 9 | 117091 | 212 | 79627076 |
Blood immunoglobulin G increased | 21.17 | 12.17 | 24 | 117076 | 2965 | 79624323 |
Graft versus host disease | 21.10 | 12.17 | 59 | 117041 | 14967 | 79612321 |
Leukaemia | 21.05 | 12.17 | 34 | 117066 | 5891 | 79621397 |
Neck pain | 21.00 | 12.17 | 50 | 117050 | 75367 | 79551921 |
Bradycardia | 20.99 | 12.17 | 115 | 116985 | 135442 | 79491846 |
Surgery | 20.89 | 12.17 | 11 | 117089 | 32755 | 79594533 |
Bacterial parotitis | 20.86 | 12.17 | 6 | 117094 | 41 | 79627247 |
Stomatitis | 20.86 | 12.17 | 128 | 116972 | 146629 | 79480659 |
Extrapyramidal disorder | 20.83 | 12.17 | 4 | 117096 | 22675 | 79604613 |
Product prescribing error | 20.83 | 12.17 | 21 | 117079 | 44792 | 79582496 |
Chromaturia | 20.77 | 12.17 | 6 | 117094 | 25740 | 79601548 |
Acne | 20.74 | 12.17 | 7 | 117093 | 27183 | 79600105 |
Refractory cancer | 20.66 | 12.17 | 9 | 117091 | 227 | 79627061 |
Irritability | 20.63 | 12.17 | 18 | 117082 | 41126 | 79586162 |
Foot deformity | 20.58 | 12.17 | 5 | 117095 | 24069 | 79603219 |
Periodontitis | 20.52 | 12.17 | 29 | 117071 | 4467 | 79622821 |
Injection site bruising | 20.48 | 12.17 | 18 | 117082 | 40984 | 79586304 |
Phrenic nerve paralysis | 20.44 | 12.17 | 10 | 117090 | 331 | 79626957 |
Tachycardia | 20.39 | 12.17 | 165 | 116935 | 177603 | 79449685 |
Atrial flutter | 20.37 | 12.17 | 74 | 117026 | 21551 | 79605737 |
Leukopenia | 20.35 | 12.17 | 261 | 116839 | 116252 | 79511036 |
Multiple sclerosis | 20.32 | 12.17 | 4 | 117096 | 22278 | 79605010 |
Lymphocytic leukaemia | 20.23 | 12.17 | 9 | 117091 | 239 | 79627049 |
Hyperthyroidism | 20.22 | 12.17 | 4 | 117096 | 22205 | 79605083 |
Monoclonal gammopathy | 20.20 | 12.17 | 14 | 117086 | 898 | 79626390 |
Disturbance in attention | 20.17 | 12.17 | 27 | 117073 | 50774 | 79576514 |
Electrolyte imbalance | 19.88 | 12.17 | 94 | 117006 | 30787 | 79596501 |
Visual impairment | 19.85 | 12.17 | 69 | 117031 | 92062 | 79535226 |
Varicella | 19.85 | 12.17 | 23 | 117077 | 2909 | 79624379 |
Small intestinal obstruction | 19.79 | 12.17 | 86 | 117014 | 27186 | 79600102 |
Troponin T increased | 19.57 | 12.17 | 25 | 117075 | 3497 | 79623791 |
Enterococcal sepsis | 19.49 | 12.17 | 22 | 117078 | 2704 | 79624584 |
Therapeutic response decreased | 19.39 | 12.17 | 166 | 116934 | 66687 | 79560601 |
Hypercholesterolaemia | 19.35 | 12.17 | 5 | 117095 | 23090 | 79604198 |
N-terminal prohormone brain natriuretic peptide increased | 19.28 | 12.17 | 29 | 117071 | 4726 | 79622562 |
Nodule | 19.22 | 12.17 | 5 | 117095 | 22989 | 79604299 |
Peritonitis viral | 19.13 | 12.17 | 6 | 117094 | 57 | 79627231 |
Body temperature decreased | 18.77 | 12.17 | 12 | 117088 | 32133 | 79595155 |
Tooth deposit | 18.77 | 12.17 | 9 | 117091 | 285 | 79627003 |
Intentional product misuse | 18.72 | 12.17 | 74 | 117026 | 95091 | 79532197 |
Haematochezia | 18.64 | 12.17 | 66 | 117034 | 87579 | 79539709 |
Torsade de pointes | 18.62 | 12.17 | 3 | 117097 | 19309 | 79607979 |
Sciatica | 18.60 | 12.17 | 13 | 117087 | 33209 | 79594079 |
Glycosylated haemoglobin increased | 18.55 | 12.17 | 3 | 117097 | 19257 | 79608031 |
Malignant fibrous histiocytoma | 18.47 | 12.17 | 8 | 117092 | 199 | 79627089 |
Poisoning | 18.44 | 12.17 | 7 | 117093 | 25265 | 79602023 |
Brief psychotic disorder with marked stressors | 18.34 | 12.17 | 9 | 117091 | 300 | 79626988 |
Rash pruritic | 18.29 | 12.17 | 173 | 116927 | 71456 | 79555832 |
Paraproteinaemia | 18.26 | 12.17 | 10 | 117090 | 420 | 79626868 |
Sleep apnoea syndrome | 18.24 | 12.17 | 16 | 117084 | 36462 | 79590826 |
Pneumonia parainfluenzae viral | 18.20 | 12.17 | 9 | 117091 | 305 | 79626983 |
Gastrointestinal toxicity | 18.01 | 12.17 | 38 | 117062 | 8071 | 79619217 |
Dyspnoea | 17.96 | 12.17 | 1053 | 116047 | 855972 | 78771316 |
Hypocalcaemic seizure | 17.94 | 12.17 | 6 | 117094 | 71 | 79627217 |
Clostridial infection | 17.91 | 12.17 | 31 | 117069 | 5683 | 79621605 |
Grip strength decreased | 17.82 | 12.17 | 5 | 117095 | 21864 | 79605424 |
Product substitution issue | 17.72 | 12.17 | 4 | 117096 | 20252 | 79607036 |
Plasma cells present | 17.72 | 12.17 | 4 | 117096 | 8 | 79627280 |
Intraductal proliferative breast lesion | 17.64 | 12.17 | 20 | 117080 | 2471 | 79624817 |
Gastrointestinal amyloidosis | 17.57 | 12.17 | 6 | 117094 | 76 | 79627212 |
Mantle cell lymphoma recurrent | 17.57 | 12.17 | 11 | 117089 | 594 | 79626694 |
Hypoaesthesia | 17.53 | 12.17 | 365 | 116735 | 178987 | 79448301 |
Nightmare | 17.52 | 12.17 | 8 | 117092 | 25853 | 79601435 |
Oncologic complication | 17.50 | 12.17 | 9 | 117091 | 332 | 79626956 |
Listeria sepsis | 17.45 | 12.17 | 12 | 117088 | 760 | 79626528 |
Cerebral aspergillosis | 17.32 | 12.17 | 17 | 117083 | 1779 | 79625509 |
Empyema | 17.22 | 12.17 | 26 | 117074 | 4250 | 79623038 |
Illness | 17.20 | 12.17 | 26 | 117074 | 46485 | 79580803 |
Enteric neuropathy | 17.10 | 12.17 | 4 | 117096 | 10 | 79627278 |
Light chain analysis | 17.10 | 12.17 | 4 | 117096 | 10 | 79627278 |
Hypokalaemia | 17.10 | 12.17 | 302 | 116798 | 143738 | 79483550 |
Plasma cells decreased | 17.04 | 12.17 | 5 | 117095 | 37 | 79627251 |
Squamous cell carcinoma | 16.92 | 12.17 | 56 | 117044 | 15566 | 79611722 |
Tendonitis | 16.73 | 12.17 | 7 | 117093 | 23823 | 79603465 |
Bone erosion | 16.71 | 12.17 | 3 | 117097 | 17844 | 79609444 |
Thrombotic thrombocytopenic purpura | 16.69 | 12.17 | 32 | 117068 | 6344 | 79620944 |
Pneumonia respiratory syncytial viral | 16.59 | 12.17 | 17 | 117083 | 1873 | 79625415 |
Varicella zoster virus infection | 16.48 | 12.17 | 26 | 117074 | 4415 | 79622873 |
Adenoviral haemorrhagic cystitis | 16.40 | 12.17 | 10 | 117090 | 515 | 79626773 |
Klebsiella sepsis | 16.38 | 12.17 | 22 | 117078 | 3230 | 79624058 |
Clostridium difficile infection | 16.29 | 12.17 | 113 | 116987 | 42572 | 79584716 |
Malignant melanoma in situ | 16.21 | 12.17 | 19 | 117081 | 2433 | 79624855 |
Fear | 16.19 | 12.17 | 6 | 117094 | 21980 | 79605308 |
Spinal column injury | 16.16 | 12.17 | 18 | 117082 | 2180 | 79625108 |
Movement disorder | 16.16 | 12.17 | 10 | 117090 | 27249 | 79600039 |
Pulmonary alveolar haemorrhage | 16.10 | 12.17 | 45 | 117055 | 11412 | 79615876 |
Neuromyotonia | 15.80 | 12.17 | 6 | 117094 | 105 | 79627183 |
Disability | 15.76 | 12.17 | 3 | 117097 | 17117 | 79610171 |
Eosinophil count increased | 15.75 | 12.17 | 3 | 117097 | 17102 | 79610186 |
Laryngeal cancer metastatic | 15.71 | 12.17 | 5 | 117095 | 50 | 79627238 |
Panic attack | 15.63 | 12.17 | 8 | 117092 | 24208 | 79603080 |
Myocardial infarction | 15.59 | 12.17 | 184 | 116916 | 183945 | 79443343 |
Escherichia infection | 15.59 | 12.17 | 60 | 117040 | 17957 | 79609331 |
Obstructive airways disorder | 15.49 | 12.17 | 14 | 117086 | 31445 | 79595843 |
Organising pneumonia | 15.41 | 12.17 | 43 | 117057 | 10896 | 79616392 |
Venous thrombosis | 15.40 | 12.17 | 33 | 117067 | 7083 | 79620205 |
Respiratory arrest | 15.36 | 12.17 | 39 | 117061 | 57511 | 79569777 |
Respiratory syncytial virus infection | 15.31 | 12.17 | 39 | 117061 | 9363 | 79617925 |
Blood creatinine increased | 15.29 | 12.17 | 316 | 116784 | 154741 | 79472547 |
Ulcer | 15.16 | 12.17 | 13 | 117087 | 29959 | 79597329 |
Impaired work ability | 15.13 | 12.17 | 5 | 117095 | 19676 | 79607612 |
Hypoglossal nerve paresis | 15.11 | 12.17 | 6 | 117094 | 119 | 79627169 |
Parkinsonism | 15.07 | 12.17 | 3 | 117097 | 16581 | 79610707 |
Genital erythema | 15.05 | 12.17 | 8 | 117092 | 316 | 79626972 |
Infection reactivation | 14.98 | 12.17 | 19 | 117081 | 2638 | 79624650 |
Klebsiella infection | 14.98 | 12.17 | 54 | 117046 | 15666 | 79611622 |
Atrial rupture | 14.97 | 12.17 | 5 | 117095 | 59 | 79627229 |
Precursor B-lymphoblastic lymphoma | 14.96 | 12.17 | 4 | 117096 | 20 | 79627268 |
Toxic neuropathy | 14.89 | 12.17 | 12 | 117088 | 968 | 79626320 |
Hyperlipidaemia | 14.89 | 12.17 | 10 | 117090 | 26083 | 79601205 |
Immunosuppression | 14.87 | 12.17 | 47 | 117053 | 12756 | 79614532 |
Prescribed underdose | 14.69 | 12.17 | 13 | 117087 | 29501 | 79597787 |
Pneumococcal sepsis | 14.68 | 12.17 | 15 | 117085 | 1647 | 79625641 |
Capillary leak syndrome | 14.60 | 12.17 | 23 | 117077 | 3902 | 79623386 |
Cholelithiasis | 14.59 | 12.17 | 35 | 117065 | 52629 | 79574659 |
Cardiac pacemaker evaluation | 14.57 | 12.17 | 6 | 117094 | 131 | 79627157 |
Faeces discoloured | 14.29 | 12.17 | 13 | 117087 | 29114 | 79598174 |
Prinzmetal angina | 14.25 | 12.17 | 15 | 117085 | 1705 | 79625583 |
Blood pressure diastolic decreased | 14.23 | 12.17 | 14 | 117086 | 30202 | 79597086 |
Gastrointestinal disorder | 14.21 | 12.17 | 113 | 116987 | 122092 | 79505196 |
Minimal residual disease | 14.18 | 12.17 | 9 | 117091 | 498 | 79626790 |
Pseudomembranous colitis | 14.11 | 12.17 | 27 | 117073 | 5347 | 79621941 |
Protein total decreased | 14.07 | 12.17 | 37 | 117063 | 9055 | 79618233 |
Transitional cell carcinoma | 14.06 | 12.17 | 18 | 117082 | 2523 | 79624765 |
Cardiomegaly | 14.00 | 12.17 | 76 | 117024 | 26276 | 79601012 |
Eosinophilic pneumonia chronic | 14.00 | 12.17 | 9 | 117091 | 509 | 79626779 |
Oesophageal adenocarcinoma | 13.98 | 12.17 | 11 | 117089 | 857 | 79626431 |
Poor quality sleep | 13.94 | 12.17 | 8 | 117092 | 22714 | 79604574 |
Hepatitis | 13.94 | 12.17 | 39 | 117061 | 55688 | 79571600 |
Therapy cessation | 13.88 | 12.17 | 21 | 117079 | 37541 | 79589747 |
Atelectasis | 13.88 | 12.17 | 88 | 117012 | 32169 | 79595119 |
Drug level increased | 13.87 | 12.17 | 23 | 117077 | 39628 | 79587660 |
Plasmablastic lymphoma | 13.86 | 12.17 | 9 | 117091 | 518 | 79626770 |
Encephalitis viral | 13.85 | 12.17 | 18 | 117082 | 2561 | 79624727 |
Aphasia | 13.81 | 12.17 | 30 | 117070 | 46702 | 79580586 |
Road traffic accident | 13.77 | 12.17 | 27 | 117073 | 43637 | 79583651 |
Squamous cell carcinoma of lung | 13.77 | 12.17 | 17 | 117083 | 2297 | 79624991 |
Mucosal erosion | 13.75 | 12.17 | 17 | 117083 | 2301 | 79624987 |
Drug ineffective for unapproved indication | 13.70 | 12.17 | 125 | 116975 | 51113 | 79576175 |
Mouth ulceration | 13.68 | 12.17 | 22 | 117078 | 38372 | 79588916 |
Psychotic disorder | 13.59 | 12.17 | 25 | 117075 | 41377 | 79585911 |
Lip dry | 13.58 | 12.17 | 3 | 117097 | 15415 | 79611873 |
Osteopenia | 13.54 | 12.17 | 5 | 117095 | 18359 | 79608929 |
Hypoperfusion | 13.52 | 12.17 | 18 | 117082 | 2621 | 79624667 |
Scrotal pain | 13.51 | 12.17 | 9 | 117091 | 541 | 79626747 |
Blood triglycerides increased | 13.51 | 12.17 | 7 | 117093 | 21033 | 79606255 |
Cerebral toxoplasmosis | 13.49 | 12.17 | 17 | 117083 | 2345 | 79624943 |
Fall | 13.49 | 12.17 | 582 | 116518 | 487047 | 79140241 |
Gastric ulcer | 13.48 | 12.17 | 18 | 117082 | 33887 | 79593401 |
Haemorrhagic fever | 13.47 | 12.17 | 4 | 117096 | 31 | 79627257 |
Paranoid personality disorder | 13.47 | 12.17 | 4 | 117096 | 31 | 79627257 |
Exostosis | 13.47 | 12.17 | 4 | 117096 | 16854 | 79610434 |
Muscle twitching | 13.46 | 12.17 | 10 | 117090 | 24754 | 79602534 |
Oxygen saturation decreased | 13.36 | 12.17 | 123 | 116977 | 128924 | 79498364 |
Heart rate irregular | 13.35 | 12.17 | 17 | 117083 | 32662 | 79594626 |
Bence Jones proteinuria | 13.29 | 12.17 | 3 | 117097 | 6 | 79627282 |
Hyperamylasaemia | 13.25 | 12.17 | 12 | 117088 | 1135 | 79626153 |
Gastrointestinal infection | 13.24 | 12.17 | 42 | 117058 | 11419 | 79615869 |
Decreased appetite | 13.19 | 12.17 | 622 | 116478 | 341796 | 79285492 |
Procalcitonin increased | 13.15 | 12.17 | 19 | 117081 | 2987 | 79624301 |
Eczema | 13.08 | 12.17 | 25 | 117075 | 40793 | 79586495 |
Liver function test increased | 13.07 | 12.17 | 24 | 117076 | 39749 | 79587539 |
Malignant neoplasm of unknown primary site | 13.05 | 12.17 | 10 | 117090 | 750 | 79626538 |
Febrile infection | 12.99 | 12.17 | 20 | 117080 | 3326 | 79623962 |
Delayed engraftment | 12.98 | 12.17 | 7 | 117093 | 285 | 79627003 |
Follicle centre lymphoma, follicular grade I, II, III recurrent | 12.97 | 12.17 | 3 | 117097 | 7 | 79627281 |
Cytomegalovirus enterocolitis | 12.95 | 12.17 | 14 | 117086 | 1641 | 79625647 |
Injection site exfoliation | 12.91 | 12.17 | 7 | 117093 | 288 | 79627000 |
Ejection fraction decreased | 12.88 | 12.17 | 91 | 117009 | 34486 | 79592802 |
Sputum discoloured | 12.86 | 12.17 | 8 | 117092 | 21735 | 79605553 |
Delusion | 12.81 | 12.17 | 7 | 117093 | 20416 | 79606872 |
Restlessness | 12.80 | 12.17 | 31 | 117069 | 46461 | 79580827 |
Hypotension | 12.79 | 12.17 | 779 | 116321 | 439538 | 79187750 |
Vertigo | 12.78 | 12.17 | 55 | 117045 | 69027 | 79558261 |
Cytomegalovirus hepatitis | 12.77 | 12.17 | 10 | 117090 | 774 | 79626514 |
Malnutrition | 12.71 | 12.17 | 66 | 117034 | 22436 | 79604852 |
Cholangiocarcinoma | 12.70 | 12.17 | 17 | 117083 | 2489 | 79624799 |
Paraesthesia | 12.69 | 12.17 | 344 | 116756 | 175979 | 79451309 |
Ventricular fibrillation | 12.64 | 12.17 | 17 | 117083 | 31909 | 79595379 |
Congestive cardiomyopathy | 12.56 | 12.17 | 42 | 117058 | 11738 | 79615550 |
Amyotrophy | 12.53 | 12.17 | 9 | 117091 | 611 | 79626677 |
Clostridium colitis | 12.50 | 12.17 | 18 | 117082 | 2821 | 79624467 |
Meningoencephalitis herpetic | 12.47 | 12.17 | 15 | 117085 | 1974 | 79625314 |
Acute kidney injury | 12.43 | 12.17 | 904 | 116196 | 518500 | 79108788 |
Electrodesiccation | 12.43 | 12.17 | 3 | 117097 | 9 | 79627279 |
Spinal fracture | 12.39 | 12.17 | 56 | 117044 | 17998 | 79609290 |
Pneumocystis jirovecii pneumonia | 12.37 | 12.17 | 86 | 117014 | 32422 | 79594866 |
Cellulitis | 12.36 | 12.17 | 227 | 116873 | 108833 | 79518455 |
Red blood cell count decreased | 12.32 | 12.17 | 134 | 116966 | 57379 | 79569909 |
Enterocolitis | 12.29 | 12.17 | 48 | 117052 | 14464 | 79612824 |
Impaired quality of life | 12.27 | 12.17 | 3 | 117097 | 14383 | 79612905 |
Electrocardiogram QT prolonged | 12.24 | 12.17 | 80 | 117020 | 90306 | 79536982 |
Lung disorder | 12.24 | 12.17 | 176 | 116924 | 80381 | 79546907 |
Pneumocystis jirovecii infection | 12.23 | 12.17 | 18 | 117082 | 2876 | 79624412 |
Adenocarcinoma pancreas | 12.20 | 12.17 | 15 | 117085 | 2018 | 79625270 |
None
Source | Code | Description |
---|---|---|
ATC | L01XG01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS OTHER ANTINEOPLASTIC AGENTS Proteasome inhibitors |
FDA MoA | N0000175075 | Proteasome Inhibitors |
MeSH PA | D000970 | Antineoplastic Agents |
FDA EPC | N0000175604 | Proteasome Inhibitor |
CHEBI has role | CHEBI:35610 | antineoplastic agents |
CHEBI has role | CHEBI:35820 | antiprotozoal drugs |
CHEBI has role | CHEBI:37670 | protease inhibitors |
CHEBI has role | CHEBI:52726 | proteasome inhibitors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Systemic AL amyloidosis | indication | 23132008 | |
Multiple myeloma | indication | 109989006 | DOID:9538 |
Mantle cell lymphoma | indication | 443487006 | |
Orthostatic hypotension | contraindication | 28651003 | |
Dehydration | contraindication | 34095006 | |
Low blood pressure | contraindication | 45007003 | |
Chronic heart failure | contraindication | 48447003 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Interstitial pneumonia | contraindication | 64667001 | |
Adult respiratory distress syndrome | contraindication | 67782005 | DOID:11394 |
Pulmonary hypertension | contraindication | 70995007 | DOID:6432 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Intestinal obstruction | contraindication | 81060008 | DOID:8437 |
Prolonged QT interval | contraindication | 111975006 | |
Pneumonia | contraindication | 233604007 | DOID:552 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Syncope | contraindication | 271594007 | |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Peripheral nerve disease | contraindication | 302226006 | |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Breastfeeding (mother) | contraindication | 413712001 | |
Posterior reversible encephalopathy syndrome | contraindication | 450886002 | |
Chemotherapy-Induced Hyperuricemia | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.39 | acidic |
pKa2 | 12.09 | acidic |
pKa3 | 13.65 | acidic |
pKa4 | 2.9 | Basic |
Formulation strength | Trade name | Applicant | Application number | Approval date | Type | Dose form | Route | Patent number | Patent expiration date | Patent use |
---|---|---|---|---|---|---|---|---|---|---|
3.5MG/1.4ML (2.5MG/ML) | BORTEZOMIB | MAIA PHARMS INC | N215331 | July 27, 2022 | RX | SOLUTION | INTRAVENOUS | 11679119 | Sept. 23, 2042 | TREATMENT OF ADULT PATIENTS WITH MANTLE CELL LYMPHOMA |
3.5MG/1.4ML (2.5MG/ML) | BORTEZOMIB | MAIA PHARMS INC | N215331 | July 27, 2022 | RX | SOLUTION | INTRAVENOUS | 11679119 | Sept. 23, 2042 | TREATMENT OF ADULT PATIENTS WITH MULTIPLE MYELOMA |
3.5MG/3.5ML (1MG/ML) | BORTEZOMIB | MAIA PHARMS INC | N215331 | July 27, 2022 | DISCN | SOLUTION | INTRAVENOUS | 11679119 | Sept. 23, 2042 | TREATMENT OF ADULT PATIENTS WITH MANTLE CELL LYMPHOMA |
3.5MG/3.5ML (1MG/ML) | BORTEZOMIB | MAIA PHARMS INC | N215331 | July 27, 2022 | DISCN | SOLUTION | INTRAVENOUS | 11679119 | Sept. 23, 2042 | TREATMENT OF ADULT PATIENTS WITH MULTIPLE MYELOMA |
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Proteasome subunit alpha type-1 | Enzyme | INHIBITOR | Ki | 9.21 | WOMBAT-PK | CHEMBL | |||
Proteasome subunit beta type-1 | Enzyme | INHIBITOR | IC50 | 7.28 | CHEMBL | CHEMBL | |||
Proteasome subunit beta type-2 | Enzyme | INHIBITOR | IC50 | 6.23 | CHEMBL | CHEMBL | |||
Proteasome subunit beta type-5 | Enzyme | INHIBITOR | Ki | 9.26 | CHEMBL | CHEMBL | |||
Proteasome subunit beta type-8 | Enzyme | INHIBITOR | IC50 | 8.09 | CHEMBL | CHEMBL | |||
Prothrombin | Enzyme | Ki | 4.89 | CHEMBL | |||||
Carbonic anhydrase 5A, mitochondrial | Enzyme | Ki | 5.16 | CHEMBL | |||||
Carbonic anhydrase 5B, mitochondrial | Enzyme | Ki | 5.17 | CHEMBL | |||||
Carbonic anhydrase 7 | Enzyme | Ki | 5.16 | CHEMBL | |||||
Cytochrome P450 2C19 | Enzyme | Ki | 4.75 | WOMBAT-PK | |||||
26S proteasome non-ATPase regulatory subunit 1 | Cytosolic other | Ki | 7.75 | WOMBAT-PK | |||||
Histone deacetylase 2 | Enzyme | IC50 | 6.10 | CHEMBL | |||||
Histone deacetylase 1 | Enzyme | IC50 | 6.21 | CHEMBL | |||||
Histone deacetylase 3 | Enzyme | IC50 | 5.93 | CHEMBL | |||||
Histone deacetylase 6 | Enzyme | IC50 | 4.16 | CHEMBL | |||||
Neutrophil elastase | Enzyme | Ki | 5.64 | CHEMBL | |||||
Carbonic anhydrase 3 | Enzyme | Ki | 5.34 | CHEMBL | |||||
Carbonic anhydrase 6 | Enzyme | Ki | 5.36 | CHEMBL | |||||
Histone deacetylase 8 | Enzyme | IC50 | 7.14 | CHEMBL | |||||
Cathepsin G | Enzyme | Ki | 6.20 | CHEMBL | |||||
Carbonic anhydrase 14 | Enzyme | Ki | 5.48 | CHEMBL | |||||
Chymase | Enzyme | IC50 | 5.92 | CHEMBL | |||||
Chymotrypsinogen B | Enzyme | Ki | 6.49 | CHEMBL | |||||
Lysosomal protective protein | Enzyme | IC50 | 5.04 | CHEMBL | |||||
Carbonic anhydrase 13 | Enzyme | Ki | 5.07 | CHEMBL | |||||
PH and SEC7 domain-containing protein 1 | Unclassified | Ki | 7.75 | WOMBAT-PK | |||||
Nuclear factor NF-kappa-B complex | Transcription factor | IC50 | 8.01 | CHEMBL | |||||
Proteasome subunit beta type-9 | Enzyme | IC50 | 8.52 | CHEMBL | |||||
Proteasome subunit beta type-10 | Enzyme | IC50 | 6.03 | CHEMBL | |||||
Carbonic anhydrase 2 | Enzyme | Ki | 5.94 | CHEMBL | |||||
Lon protease homolog, mitochondrial | Enzyme | IC50 | 6.74 | CHEMBL | |||||
Carbonic anhydrase 1 | Enzyme | Ki | 5.89 | CHEMBL | |||||
Carbonic anhydrase 4 | Enzyme | Ki | 5.19 | CHEMBL | |||||
Carbonic anhydrase 9 | Enzyme | Ki | 5.47 | CHEMBL | |||||
Carbonic anhydrase 12 | Enzyme | Ki | 5.23 | CHEMBL | |||||
Carbonic anhydrase 15 | Enzyme | Ki | 5.57 | CHEMBL | |||||
Beta-carbonic anhydrase 1 | Enzyme | Ki | 5.14 | CHEMBL | |||||
Alpha-chymotrypsin | Enzyme | Ki | 5.62 | CHEMBL | |||||
Proteasome subunit beta | Enzyme | IC50 | 7.51 | IUPHAR | |||||
Proteasome subunit beta type-8 | Enzyme | IC50 | 7.78 | CHEMBL | |||||
ATP-dependent Clp protease proteolytic subunit | Enzyme | IC50 | 5.28 | CHEMBL | |||||
NACHT, LRR and PYD domains-containing protein 3 | Unclassified | IC50 | 7.39 | CHEMBL |
ID | Source |
---|---|
4021393 | VUID |
N0000148811 | NUI |
D03150 | KEGG_DRUG |
356733 | RXNORM |
C1176309 | UMLSCUI |
CHEBI:52717 | CHEBI |
BO2 | PDB_CHEM_ID |
CHEMBL325041 | ChEMBL_ID |
DB00188 | DRUGBANK_ID |
D000069286 | MESH_DESCRIPTOR_UI |
387447 | PUBCHEM_CID |
6391 | IUPHAR_LIGAND_ID |
8331 | INN_ID |
69G8BD63PP | UNII |
17263 | MMSL |
233935 | MMSL |
46756 | MMSL |
d04871 | MMSL |
398907002 | SNOMEDCT_US |
407097007 | SNOMEDCT_US |
4021393 | VANDF |
009985 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9098 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1700 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 33 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1703 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 2.50 mg | INTRAVENOUS | NDA | 34 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1703 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 2.50 mg | INTRAVENOUS | NDA | 34 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1704 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | NDA | 34 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1704 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | NDA | 34 sections |
bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-3258 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 27 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10019-991 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 28 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 10019-991 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 28 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 25021-244 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-426 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 30 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43598-865 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | NDA | 26 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50742-484 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51817-586 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 32 sections |
BORTEZOMIB | Human Prescription Drug Label | 1 | 55150-337 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 28 sections |
BORTEZOMIB | Human Prescription Drug Label | 1 | 55150-337 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 28 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60505-6050 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 28 sections |
VELCADE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63020-049 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | NDA | 31 sections |
VELCADE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63020-049 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | NDA | 31 sections |
VELCADE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63020-049 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | NDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-721 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | NDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-721 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | NDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 63323-821 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 30 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 67184-0530 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-534 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-540 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68001-541 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 3.50 mg | INTRAVENOUS | ANDA | 26 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70511-161 | INJECTION | 1 mg | INTRAVENOUS | NDA | 31 sections |
Bortezomib | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70511-162 | INJECTION | 2.50 mg | INTRAVENOUS | NDA | 31 sections |
BORTEZOMIB | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70710-1411 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 1 mg | INTRAVENOUS | ANDA | 26 sections |