clindamycin phosphate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
3909 24729-96-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • clindamycin phosphate
  • cleocin phosphate
  • clindagel
  • clindamycin-2-phosphate
  • Molecular weight: 504.96
  • Formula: C18H34ClN2O8PS
  • CLOGP: -1.17
  • LIPINSKI: 1
  • HAC: 10
  • HDO: 5
  • TPSA: 148.79
  • ALOGS: -2.21
  • ROTB: 9
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 87 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pld-class Phospholipidosis risk class (1 = positive, 0 = negative) 0 High 0.82

Approvals:

DateAgencyCompanyOrphan
Oct. 2, 1972 FDA PHARMACIA AND UPJOHN

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 1718.20 10.24 1610 45189 461999 90119649
Acute generalised exanthematous pustulosis 384.18 10.24 172 46627 13531 90568117
Hidradenitis 285.81 10.24 101 46698 4246 90577402
Rash maculo-papular 229.10 10.24 181 46618 40752 90540896
Drug reaction with eosinophilia and systemic symptoms 175.21 10.24 158 46641 42600 90539048
Loss of employment 153.95 10.24 58 46741 2929 90578719
Clostridium difficile infection 152.59 10.24 136 46663 36109 90545539
Type IV hypersensitivity reaction 152.13 10.24 62 46737 3864 90577784
Rash 148.75 10.24 805 45994 795295 89786353
Synovitis 144.49 10.24 6 46793 329746 90251902
Pemphigus 139.79 10.24 7 46792 326857 90254791
Glossodynia 134.16 10.24 8 46791 321771 90259877
Toxic skin eruption 129.64 10.24 88 46711 15686 90565962
Drug ineffective 119.57 10.24 1162 45637 1383136 89198512
Hand deformity 118.76 10.24 9 46790 296353 90285295
Systemic lupus erythematosus 115.98 10.24 23 46776 361873 90219775
Dermatitis allergic 108.66 10.24 82 46717 17245 90564403
Anti-cyclic citrullinated peptide antibody positive 104.57 10.24 4 46795 236429 90345219
Pericarditis 103.33 10.24 10 46789 270141 90311507
Anaphylactic reaction 100.58 10.24 170 46629 87354 90494294
Helicobacter infection 99.77 10.24 4 46795 226846 90354802
Drug resistance 98.96 10.24 99 46700 30350 90551298
Multiple organ dysfunction syndrome 92.51 10.24 143 46656 68193 90513455
Toxic epidermal necrolysis 91.72 10.24 98 46701 32430 90549218
Clostridium difficile colitis 90.81 10.24 89 46710 26617 90555031
Arthropathy 88.79 10.24 39 46760 366203 90215445
Hepatic steatosis 86.48 10.24 101 46698 36844 90544804
Joint swelling 83.64 10.24 82 46717 503218 90078430
Acute kidney injury 83.41 10.24 357 46442 320030 90261618
Symmetrical drug-related intertriginous and flexural exanthema 80.92 10.24 27 46772 952 90580696
Abscess 79.72 10.24 71 46728 18820 90562828
Cellulitis 79.10 10.24 157 46642 91180 90490468
Muscle injury 78.06 10.24 3 46796 176651 90404997
Folliculitis 76.99 10.24 8 46791 204345 90377303
Infusion related reaction 76.31 10.24 62 46737 416718 90164930
Fibromyalgia 75.38 10.24 9 46790 206260 90375388
Erythema 73.75 10.24 273 46526 228973 90352675
Alopecia 73.04 10.24 89 46710 494982 90086666
Wound 70.72 10.24 34 46765 302946 90278702
Type 2 diabetes mellitus 67.02 10.24 12 46787 203232 90378416
Acne 65.16 10.24 77 46722 28430 90553218
Graft infection 63.83 10.24 17 46782 269 90581379
Blood cholesterol increased 62.98 10.24 15 46784 207997 90373651
Discomfort 62.18 10.24 32 46767 274303 90307345
Oesophagitis 61.49 10.24 59 46740 17190 90564458
Rheumatoid arthritis 61.45 10.24 58 46741 362556 90219092
Drug eruption 60.89 10.24 83 46716 35324 90546324
Premature delivery 59.44 10.24 86 46713 38676 90542972
Subcutaneous abscess 59.13 10.24 39 46760 6627 90575021
Irritable bowel syndrome 58.92 10.24 17 46782 207431 90374217
Pustule 58.61 10.24 29 46770 2854 90578794
Pathogen resistance 54.45 10.24 40 46759 8075 90573573
Stomatitis 53.91 10.24 38 46761 274660 90306988
Eosinophilia 53.85 10.24 70 46729 28463 90553185
Skin lesion 53.11 10.24 80 46719 37285 90544363
Urticaria 51.29 10.24 306 46493 312428 90269220
Sleep disorder due to general medical condition, insomnia type 51.26 10.24 4 46795 128690 90452958
Musculoskeletal stiffness 50.73 10.24 47 46752 296485 90285163
Ill-defined disorder 49.20 10.24 17 46782 184874 90396774
Confusional state 48.37 10.24 78 46721 386127 90195521
Leukocytosis 47.87 10.24 69 46730 30921 90550727
Septic shock 47.45 10.24 122 46677 84038 90497610
Psoriatic arthropathy 46.93 10.24 30 46769 228305 90353343
Sinobronchitis 44.98 10.24 16 46783 685 90580963
Pruritus 44.52 10.24 451 46348 541074 90040574
Product use in unapproved indication 44.11 10.24 311 46488 335925 90245723
Lower respiratory tract infection 43.74 10.24 39 46760 250620 90331028
Osteonecrosis of jaw 43.64 10.24 75 46724 39028 90542620
Peripheral swelling 43.27 10.24 93 46706 413013 90168635
Klebsiella infection 42.06 10.24 38 46761 10259 90571389
Dermatitis acneiform 41.91 10.24 31 46768 6323 90575325
Papule 41.80 10.24 34 46765 7968 90573680
Drug ineffective for unapproved indication 41.13 10.24 100 46699 66544 90515104
Pulmonary fibrosis 41.02 10.24 4 46795 107499 90474149
Wound complication 40.15 10.24 27 46772 4736 90576912
Tubulointerstitial nephritis 39.98 10.24 57 46742 25286 90556362
Tubo-ovarian abscess 39.72 10.24 13 46786 431 90581217
Type I hypersensitivity 38.54 10.24 25 46774 4130 90577518
Sleep disorder 38.05 10.24 28 46771 198002 90383646
Pseudomembranous colitis 37.67 10.24 24 46775 3844 90577804
Diarrhoea 37.65 10.24 687 46112 938503 89643145
Facet joint syndrome 36.66 10.24 4 46795 98385 90483263
Cyst 36.64 10.24 44 46755 16517 90565131
Grip strength decreased 36.52 10.24 3 46796 92573 90489075
Cardiac failure congestive 36.39 10.24 123 46676 98571 90483077
Stevens-Johnson syndrome 36.33 10.24 59 46740 29317 90552331
Mobility decreased 35.95 10.24 46 46753 250688 90330960
Death 35.55 10.24 119 46680 456432 90125216
Eczema 35.52 10.24 82 46717 52788 90528860
Lip dry 35.43 10.24 5 46794 100950 90480698
Toxic shock syndrome 35.43 10.24 15 46784 1029 90580619
Weight increased 35.30 10.24 105 46694 417822 90163826
Dermatitis 35.09 10.24 50 46749 22170 90559478
Staphylococcal infection 34.62 10.24 77 46722 48362 90533286
Hepatitis infectious mononucleosis 34.62 10.24 9 46790 129 90581519
Central pain syndrome 34.49 10.24 13 46786 657 90580991
Hypercholesterolaemia 33.15 10.24 6 46793 100886 90480762
Idiosyncratic drug reaction 33.12 10.24 14 46785 957 90580691
Skin odour abnormal 33.03 10.24 17 46782 1818 90579830
Hepatic enzyme increased 32.39 10.24 88 46711 360648 90221000
Gastric disorder 32.09 10.24 60 46739 33324 90548324
Toxic shock syndrome streptococcal 31.64 10.24 10 46789 296 90581352
Skin exfoliation 30.88 10.24 91 46708 67822 90513826
Joint range of motion decreased 30.45 10.24 16 46783 135627 90446021
Bartholinitis 30.20 10.24 7 46792 60 90581588
Pneumococcal infection 29.78 10.24 14 46785 1231 90580417
Reaction to azo-dyes 29.77 10.24 6 46793 24 90581624
Lymphadenopathy 29.66 10.24 70 46729 45705 90535943
Rash morbilliform 29.63 10.24 21 46778 4008 90577640
Contraindicated product administered 29.57 10.24 77 46722 320062 90261586
Abscess neck 29.42 10.24 12 46787 749 90580899
Scar 29.41 10.24 38 46761 15357 90566291
Upper respiratory tract infection bacterial 28.67 10.24 8 46791 152 90581496
Impaired healing 28.64 10.24 48 46751 234151 90347497
Autoimmune thyroiditis 28.61 10.24 24 46775 5869 90575779
Fistula 28.20 10.24 33 46766 12056 90569592
Allergic sinusitis 28.06 10.24 16 46783 2097 90579551
General physical health deterioration 28.01 10.24 92 46707 355023 90226625
Osteoarthritis 27.95 10.24 36 46763 195694 90385954
Gait inability 27.75 10.24 21 46778 146435 90435213
Adverse event 27.64 10.24 13 46786 117405 90464243
Decreased appetite 27.38 10.24 101 46698 376439 90205209
Oesophageal ulcer 27.27 10.24 22 46777 5097 90576551
Escherichia infection 26.93 10.24 37 46762 15858 90565790
Epilepsy 26.77 10.24 5 46794 82201 90499447
Cholecystitis chronic 26.63 10.24 29 46770 9797 90571851
Pyrexia 26.34 10.24 483 46316 660002 89921646
Night sweats 26.33 10.24 17 46782 128749 90452899
Fatigue 26.23 10.24 429 46370 1153594 89428054
Intentional product use issue 26.02 10.24 45 46754 216847 90364801
Lower limb fracture 25.97 10.24 6 46793 85007 90496641
Peripheral venous disease 25.49 10.24 6 46793 83915 90497733
Acne pustular 25.33 10.24 8 46791 236 90581412
Mastitis 25.31 10.24 17 46782 2976 90578672
Swelling 25.15 10.24 121 46678 418937 90162711
Bursitis 24.79 10.24 19 46780 131635 90450013
Pneumothorax 24.39 10.24 39 46760 19128 90562520
Candida infection 24.18 10.24 54 46745 34003 90547645
Cough 23.74 10.24 293 46506 368669 90212979
Prescribed underdose 23.51 10.24 5 46794 75014 90506634
Sepsis syndrome 23.45 10.24 11 46788 962 90580686
Type IIb hyperlipidaemia 23.13 10.24 5 46794 30 90581618
Rash erythematous 23.00 10.24 80 46719 65024 90516624
Dysbiosis 22.90 10.24 13 46786 1689 90579959
Oedema 22.73 10.24 43 46756 200252 90381396
Liver injury 22.71 10.24 33 46766 170534 90411114
Emotional distress 22.60 10.24 55 46744 36607 90545041
Road traffic accident 22.29 10.24 14 46785 107612 90474036
Puerperal pyrexia 22.22 10.24 5 46794 37 90581611
Swelling face 22.16 10.24 92 46707 81260 90500388
Skin mass 22.03 10.24 23 46776 7407 90574241
Swelling of eyelid 22.03 10.24 20 46779 5434 90576214
Anti factor V antibody positive 21.89 10.24 4 46795 8 90581640
Blister 21.55 10.24 64 46735 254934 90326714
Hypoglossal nerve paresis 21.55 10.24 6 46793 113 90581535
Wound secretion 21.54 10.24 19 46780 4971 90576677
Respiratory gas exchange disorder 21.29 10.24 8 46791 401 90581247
Face oedema 21.29 10.24 41 46758 23277 90558371
Aspergillus infection 21.12 10.24 27 46772 10796 90570852
Musculoskeletal pain 21.02 10.24 35 46764 171216 90410432
Blood testosterone increased 20.89 10.24 7 46792 250 90581398
Asthenia 20.78 10.24 176 46623 533575 90048073
Osteomyelitis 20.73 10.24 45 46754 27801 90553847
Clostridial infection 20.71 10.24 18 46781 4618 90577030
Autoimmune disorder 20.51 10.24 7 46792 76737 90504911
Breast abscess 20.38 10.24 13 46786 2087 90579561
Surgical failure 20.35 10.24 10 46789 969 90580679
Bronchial obstruction 20.33 10.24 12 46787 1677 90579971
Hip arthroplasty 20.28 10.24 7 46792 76201 90505447
Sciatica 19.90 10.24 14 46785 101368 90480280
Oxygen saturation abnormal 19.87 10.24 17 46782 4271 90577377
Lower respiratory tract infection bacterial 19.62 10.24 8 46791 499 90581149
Pneumonia 19.56 10.24 223 46576 637836 89943812
Mucormycosis 19.46 10.24 16 46783 3805 90577843
Skin disorder 19.45 10.24 52 46747 36654 90544994
Serratia infection 19.38 10.24 10 46789 1075 90580573
Hypoaesthesia 19.27 10.24 90 46709 314120 90267528
Necrotising oesophagitis 19.09 10.24 8 46791 535 90581113
Fungal sepsis 18.69 10.24 11 46788 1530 90580118
Shock 18.63 10.24 44 46755 28734 90552914
Memory impairment 18.54 10.24 47 46752 197197 90384451
Toxicity to various agents 18.52 10.24 81 46718 287765 90293883
Prothrombin time prolonged 18.48 10.24 24 46775 9748 90571900
Coagulation factor decreased 18.39 10.24 6 46793 197 90581451
Syndactyly 18.38 10.24 8 46791 587 90581061
Micrococcus infection 18.38 10.24 5 46794 86 90581562
Glomerulonephritis minimal lesion 18.36 10.24 7 46792 365 90581283
Clostridium test positive 18.36 10.24 18 46781 5383 90576265
Pneumomediastinum 18.30 10.24 12 46787 2019 90579629
Tooth hypoplasia 18.28 10.24 5 46794 88 90581560
Skin plaque 18.09 10.24 24 46775 9951 90571697
Preterm premature rupture of membranes 18.05 10.24 11 46788 1630 90580018
Renal tubular necrosis 17.68 10.24 29 46770 14526 90567122
Mycobacterial infection 17.38 10.24 12 46787 2198 90579450
Fungal infection 17.36 10.24 55 46744 42606 90539042
Megacolon 17.36 10.24 12 46787 2202 90579446
Condition aggravated 17.34 10.24 416 46383 595129 89986519
Prescribed overdose 17.24 10.24 15 46784 97610 90484038
Contusion 17.20 10.24 69 46730 251147 90330501
Necrotising fasciitis 17.20 10.24 15 46784 3865 90577783
Antibiotic level below therapeutic 17.19 10.24 4 46795 35 90581613
Dry mouth 17.19 10.24 44 46755 184015 90397633
Necrosis 17.03 10.24 19 46780 6591 90575057
Lip swelling 16.85 10.24 51 46748 38559 90543089
Tinea capitis 16.80 10.24 4 46795 39 90581609
Completed suicide 16.58 10.24 31 46768 145027 90436621
Cleft lip and palate 16.55 10.24 8 46791 748 90580900
Wheezing 16.55 10.24 65 46734 238015 90343633
Product contamination microbial 16.38 10.24 6 46793 280 90581368
Lymphadenitis 16.37 10.24 15 46784 4122 90577526
Acute hepatic failure 16.27 10.24 36 46763 22525 90559123
SAPHO syndrome 16.22 10.24 5 46794 136 90581512
Upper limb fracture 16.21 10.24 35 46764 21543 90560105
Idiopathic intracranial hypertension 16.19 10.24 14 46785 3567 90578081
Thyroxine increased 16.01 10.24 8 46791 804 90580844
Venous haemorrhage 15.89 10.24 6 46793 305 90581343
Scedosporium infection 15.88 10.24 8 46791 818 90580830
Neonatal respiratory distress syndrome 15.83 10.24 13 46786 3088 90578560
Torticollis 15.80 10.24 12 46787 2546 90579102
Cutaneous vasculitis 15.73 10.24 19 46780 7174 90574474
Anterior segment ischaemia 15.68 10.24 4 46795 53 90581595
Perihepatic discomfort 15.55 10.24 3 46796 9 90581639
Frequent bowel movements 15.55 10.24 5 46794 56930 90524718
Nephritis allergic 15.54 10.24 6 46793 324 90581324
Sedation 15.53 10.24 3 46796 48168 90533480
Groin abscess 15.53 10.24 9 46790 1216 90580432
BK polyomavirus test positive 15.48 10.24 5 46794 159 90581489
Infected skin ulcer 15.46 10.24 12 46787 2630 90579018
Hyperleukocytosis 15.34 10.24 8 46791 879 90580769
Insomnia 15.31 10.24 105 46694 333369 90248279
Factor V inhibition 15.27 10.24 5 46794 166 90581482
Vulvovaginal discomfort 15.24 10.24 12 46787 2685 90578963
Adenoidal disorder 15.21 10.24 5 46794 168 90581480
Pharyngeal swelling 15.15 10.24 22 46777 9922 90571726
Plasmapheresis 15.15 10.24 6 46793 347 90581301
Seborrhoeic dermatitis 15.10 10.24 10 46789 1710 90579938
Nasopharyngitis 15.05 10.24 136 46663 406968 90174680
Geotrichum infection 14.96 10.24 7 46792 609 90581039
Product deposit 14.92 10.24 6 46793 361 90581287
Bronchopulmonary dysplasia 14.87 10.24 7 46792 617 90581031
Renal arteriosclerosis 14.83 10.24 5 46794 182 90581466
Tinea infection 14.81 10.24 9 46790 1327 90580321
Product physical consistency issue 14.79 10.24 8 46791 946 90580702
Intentional overdose 14.74 10.24 16 46783 93818 90487830
Pneumonia necrotising 14.63 10.24 7 46792 640 90581008
Abortion spontaneous 14.61 10.24 61 46738 53995 90527653
Onychomadesis 14.55 10.24 3 46796 45995 90535653
Erosive oesophagitis 14.53 10.24 10 46789 1821 90579827
Acne fulminans 14.51 10.24 3 46796 14 90581634
Disseminated mucormycosis 14.39 10.24 7 46792 664 90580984
Breast pain 14.37 10.24 22 46777 10396 90571252
Vulval abscess 14.35 10.24 8 46791 1004 90580644
Joint vibration 14.34 10.24 3 46796 15 90581633
Shock haemorrhagic 14.34 10.24 24 46775 12221 90569427
Astigmatism 14.34 10.24 9 46790 1405 90580243
Nodule 14.33 10.24 38 46761 26648 90555000
Live birth 14.16 10.24 12 46787 79095 90502553
Allergy to metals 14.15 10.24 8 46791 1032 90580616
Congenital hydrocephalus 14.10 10.24 5 46794 212 90581436
Documented hypersensitivity to administered product 13.98 10.24 7 46792 707 90580941
Post infection glomerulonephritis 13.88 10.24 3 46796 18 90581630
Medication error 13.78 10.24 14 46785 84638 90497010
Acinetobacter infection 13.70 10.24 10 46789 1998 90579650
Retinal degeneration 13.67 10.24 8 46791 1101 90580547
Hepatic cytolysis 13.64 10.24 41 46758 30875 90550773
C-reactive protein increased 13.60 10.24 48 46751 181341 90400307
Acute respiratory distress syndrome 13.57 10.24 39 46760 28647 90553001
Bullous haemorrhagic dermatosis 13.57 10.24 5 46794 237 90581411
Purpura 13.51 10.24 26 46773 14752 90566896
Drug intolerance 13.47 10.24 157 46642 447434 90134214
Pseudomonas infection 13.40 10.24 26 46773 14839 90566809
Crystal nephropathy 13.39 10.24 8 46791 1143 90580505
Sexual inhibition 13.36 10.24 3 46796 22 90581626
Adenovirus reactivation 13.35 10.24 5 46794 248 90581400
Chills 13.34 10.24 115 46684 131866 90449782
Knee arthroplasty 13.27 10.24 14 46785 83168 90498480
Hypervigilance 13.16 10.24 6 46793 492 90581156
Night blindness 13.08 10.24 6 46793 499 90581149
Chronic kidney disease 13.07 10.24 56 46743 50135 90531513
Sinus pain 13.05 10.24 15 46784 5374 90576274
Autoimmune neutropenia 13.04 10.24 5 46794 265 90581383
Coma 13.02 10.24 11 46788 72621 90509027
Glomerulosclerosis 12.91 10.24 6 46793 514 90581134
Dysarthria 12.87 10.24 6 46793 54476 90527172
Lemierre syndrome 12.83 10.24 4 46795 113 90581535
Babesiosis 12.78 10.24 5 46794 280 90581368
Weaning failure 12.76 10.24 6 46793 528 90581120
Product use issue 12.73 10.24 109 46690 329810 90251838
Underdose 12.68 10.24 6 46793 54011 90527637
Chronic respiratory disease 12.51 10.24 5 46794 296 90581352
Haemodynamic instability 12.42 10.24 22 46777 11717 90569931
Paraesthesia 12.40 10.24 77 46722 250249 90331399
Exophthalmos 12.35 10.24 9 46790 1793 90579855
Overdose 12.32 10.24 41 46758 157668 90423980
Nasal polyps 12.31 10.24 21 46778 10859 90570789
Bone erosion 12.28 10.24 6 46793 53015 90528633
Infection protozoal 12.27 10.24 3 46796 33 90581615
Plasma cell myeloma 12.24 10.24 3 46796 40825 90540823
Disease recurrence 12.21 10.24 45 46754 37608 90544040
Injection site erythema 12.21 10.24 20 46779 98482 90483166
Serum sickness-like reaction 12.21 10.24 6 46793 582 90581066
Paranasal sinus abscess 12.13 10.24 4 46795 136 90581512
Staphylococcal bacteraemia 12.08 10.24 17 46782 7452 90574196
Acute respiratory failure 12.05 10.24 49 46750 42869 90538779
Cerebral toxoplasmosis 11.93 10.24 8 46791 1397 90580251
Wound infection 11.93 10.24 23 46776 106379 90475269
Perfume sensitivity 11.80 10.24 7 46792 988 90580660
Eczema asteatotic 11.80 10.24 5 46794 344 90581304
Viral uveitis 11.78 10.24 4 46795 149 90581499
Erythema multiforme 11.76 10.24 22 46777 12224 90569424
Amnesia 11.69 10.24 24 46775 108481 90473167
White matter lesion 11.69 10.24 10 46789 2511 90579137
Bone sequestrum 11.69 10.24 8 46791 1445 90580203
Oxygen saturation increased 11.67 10.24 5 46794 353 90581295
Abdominal sepsis 11.66 10.24 8 46791 1451 90580197
Superinfection bacterial 11.62 10.24 7 46792 1015 90580633
Hyphaema 11.57 10.24 5 46794 361 90581287
Abscess jaw 11.55 10.24 8 46791 1473 90580175
Adenocarcinoma 11.52 10.24 11 46788 3185 90578463
Joint stiffness 11.51 10.24 14 46785 78028 90503620
Gas gangrene 11.48 10.24 4 46795 161 90581487
Lip oedema 11.38 10.24 13 46786 4626 90577022
Tendinous contracture 11.32 10.24 4 46795 168 90581480
Drug interaction 11.27 10.24 203 46596 276250 90305398
Hepatorenal failure 11.24 10.24 6 46793 691 90580957
Sepsis 11.20 10.24 142 46657 179672 90401976
Rash pustular 11.10 10.24 17 46782 8032 90573616
Injury corneal 11.08 10.24 4 46795 179 90581469
Premature rupture of membranes 11.06 10.24 14 46785 5544 90576104
Inflammation 11.03 10.24 51 46748 178541 90403107
Deep vein thrombosis 10.98 10.24 83 46716 91537 90490111
Blood pressure diastolic increased 10.94 10.24 22 46777 12884 90568764
Nausea 10.91 10.24 688 46111 1109628 89472020
Disseminated intravascular coagulation 10.89 10.24 30 46769 21508 90560140
Hypoglycaemia 10.87 10.24 12 46787 69836 90511812
Purulence 10.86 10.24 8 46791 1621 90580027
Skin oedema 10.84 10.24 7 46792 1147 90580501
Hepatic cirrhosis 10.83 10.24 10 46789 63243 90518405
Device material issue 10.79 10.24 5 46794 425 90581223
Multi-organ disorder 10.76 10.24 9 46790 2191 90579457
Nonspecific reaction 10.76 10.24 10 46789 2799 90578849
Allergy to animal 10.75 10.24 8 46791 1646 90580002
Vulvovaginal pain 10.74 10.24 11 46788 3463 90578185
Tonsillar hypertrophy 10.74 10.24 7 46792 1165 90580483
X-ray abnormal 10.73 10.24 5 46794 45419 90536229
Liver function test increased 10.73 10.24 17 46782 84838 90496810
Manipulation 10.65 10.24 3 46796 59 90581589
Lupus-like syndrome 10.61 10.24 6 46793 48840 90532808
Hormone level abnormal 10.57 10.24 10 46789 2863 90578785
Coagulation factor deficiency 10.56 10.24 3 46796 61 90581587
Muscular weakness 10.53 10.24 63 46736 206603 90375045
Gait disturbance 10.52 10.24 85 46714 260411 90321237
Furuncle 10.47 10.24 16 46783 7545 90574103
Aphonia 10.44 10.24 21 46778 12298 90569350
Exposure during pregnancy 10.40 10.24 177 46622 238233 90343415
Ophthalmoplegia 10.35 10.24 8 46791 1741 90579907
Abdominal wall disorder 10.26 10.24 4 46795 222 90581426
Product administration interrupted 10.24 10.24 21 46778 12471 90569177

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 254.59 11.48 306 25335 99083 42496611
Rash maculo-papular 253.05 11.48 197 25444 37306 42558388
Type IV hypersensitivity reaction 233.56 11.48 78 25563 2359 42593335
Drug ineffective 222.29 11.48 853 24788 629344 41966350
Drug reaction with eosinophilia and systemic symptoms 202.83 11.48 182 25459 41893 42553801
Acute generalised exanthematous pustulosis 183.95 11.48 94 25547 8501 42587193
Rash 129.72 11.48 413 25228 276541 42319153
Clostridium difficile colitis 106.45 11.48 94 25547 21158 42574536
Death 73.82 11.48 106 25535 471079 42124615
Drug resistance 66.37 11.48 92 25549 34156 42561538
Drug ineffective for unapproved indication 55.99 11.48 100 25541 46063 42549631
Erythema 53.21 11.48 165 25476 108628 42487066
Kounis syndrome 50.21 11.48 29 25612 3339 42592355
Toxic skin eruption 50.14 11.48 51 25590 13679 42582015
Methaemoglobinaemia 49.35 11.48 35 25606 5739 42589955
Hidradenitis 49.11 11.48 23 25618 1718 42593976
Drug-induced liver injury 46.52 11.48 83 25558 38190 42557504
Drug eruption 46.22 11.48 63 25578 23012 42572682
Graft infection 45.37 11.48 15 25626 439 42595255
Rash morbilliform 44.61 11.48 29 25612 4124 42591570
Pathogen resistance 42.66 11.48 43 25598 11407 42584287
Oesophageal ulcer 42.23 11.48 27 25614 3732 42591962
Rash erythematous 42.13 11.48 72 25569 32019 42563675
Toxic epidermal necrolysis 41.88 11.48 65 25576 26685 42569009
Pseudomembranous colitis 41.52 11.48 25 25616 3108 42592586
Dermatitis allergic 41.42 11.48 37 25604 8446 42587248
Pruritus 41.28 11.48 223 25418 188548 42407146
Hyper IgE syndrome 40.06 11.48 11 25630 167 42595527
Drug abuse 38.58 11.48 8 25633 104763 42490931
Cutaneous vasculitis 37.68 11.48 32 25609 6828 42588866
Megacolon 37.64 11.48 21 25620 2264 42593430
Cellulitis 36.42 11.48 100 25541 61485 42534209
Treatment failure 35.37 11.48 100 25541 62524 42533170
Abscess 34.94 11.48 43 25598 14205 42581489
Dermatitis acneiform 34.35 11.48 32 25609 7707 42587987
Tubulointerstitial nephritis 34.04 11.48 65 25576 31483 42564211
Staphylococcal infection 33.98 11.48 72 25569 37571 42558123
Necrotising fasciitis 33.06 11.48 25 25616 4521 42591173
Urinary tract inflammation 32.20 11.48 10 25631 238 42595456
Abscess of salivary gland 31.59 11.48 6 25635 13 42595681
Scrotal infection 29.68 11.48 13 25628 830 42594864
Urine alcohol test positive 29.68 11.48 7 25634 55 42595639
Electrocardiogram U wave present 29.27 11.48 6 25635 22 42595672
Surgical failure 28.80 11.48 8 25633 127 42595567
Scar 28.43 11.48 27 25614 6661 42589033
Venolymphatic malformation 28.11 11.48 6 25635 28 42595666
Condition aggravated 27.44 11.48 258 25383 260496 42335198
Skin graft failure 27.31 11.48 8 25633 155 42595539
Acne fulminans 26.54 11.48 9 25632 285 42595409
Rash pustular 26.25 11.48 25 25616 6190 42589504
Resorption bone increased 26.19 11.48 9 25632 297 42595397
Perineal infection 26.07 11.48 11 25630 641 42595053
Glomerulosclerosis 26.06 11.48 12 25629 862 42594832
Stevens-Johnson syndrome 25.55 11.48 47 25594 22131 42573563
Pustule 25.52 11.48 13 25628 1166 42594528
Optic nerve operation 25.50 11.48 10 25631 482 42595212
Infected dermal cyst 25.31 11.48 12 25629 921 42594773
Rash pruritic 24.44 11.48 59 25582 33544 42562150
Overgrowth bacterial 23.55 11.48 7 25634 143 42595551
Mucormycosis 23.33 11.48 25 25616 7118 42588576
Arteriovenous fistula 22.91 11.48 12 25629 1140 42594554
General physical health deterioration 22.61 11.48 35 25606 151211 42444483
Erysipelas 22.28 11.48 23 25618 6273 42589421
Osteomyelitis salmonella 22.10 11.48 5 25636 32 42595662
Tooth injury 21.99 11.48 12 25629 1239 42594455
Premature baby 21.72 11.48 45 25596 23108 42572586
Conductive deafness 21.60 11.48 9 25632 508 42595186
Dermal cyst 21.54 11.48 14 25627 1989 42593705
Acne conglobata 21.35 11.48 5 25636 38 42595656
Acute kidney injury 21.17 11.48 324 25317 367013 42228681
Renal hypoplasia 21.06 11.48 6 25635 105 42595589
Gastrointestinal mucosa hyperaemia 20.96 11.48 8 25633 358 42595336
Urticaria 20.80 11.48 94 25547 73942 42521752
Swelling face 20.71 11.48 49 25592 27505 42568189
Subcutaneous abscess 20.63 11.48 19 25622 4509 42591185
Pyrexia 20.25 11.48 341 25300 393701 42201993
Purpura 20.19 11.48 30 25611 11849 42583845
Skin plaque 20.00 11.48 21 25620 5842 42589852
Hepatitis cholestatic 19.94 11.48 27 25614 9797 42585897
Vestibular disorder 19.88 11.48 11 25630 1166 42594528
Cyst 19.77 11.48 20 25621 5326 42590368
Cholestatic liver injury 19.76 11.48 17 25624 3692 42592002
Oesophagitis chemical 19.69 11.48 5 25636 55 42595639
Calcium deficiency 19.31 11.48 7 25634 271 42595423
Overdose 19.18 11.48 21 25620 105243 42490451
Folliculitis 19.12 11.48 20 25621 5538 42590156
Anamnestic reaction 19.07 11.48 5 25636 63 42595631
Pulmonary venous thrombosis 18.71 11.48 6 25635 159 42595535
Acne 18.41 11.48 31 25610 13613 42582081
Antibiotic level below therapeutic 18.39 11.48 5 25636 73 42595621
Papule 18.34 11.48 20 25621 5806 42589888
Leukocytosis 18.31 11.48 49 25592 29659 42566035
Cholestasis 18.06 11.48 52 25589 32827 42562867
Device toxicity 17.90 11.48 4 25637 24 42595670
Cardiac failure 17.68 11.48 23 25618 106833 42488861
Genital rash 17.51 11.48 9 25632 823 42594871
Tenderness 17.40 11.48 24 25617 8859 42586835
Fatigue 17.38 11.48 173 25468 435468 42160226
Tendon pain 17.32 11.48 15 25626 3285 42592409
Toxic shock syndrome streptococcal 17.01 11.48 4 25637 31 42595663
Tremor 16.94 11.48 20 25621 96909 42498785
Product use in unapproved indication 16.70 11.48 177 25464 184279 42411415
Toxicity to various agents 16.67 11.48 76 25565 229060 42366634
Vitamin B1 deficiency 16.54 11.48 7 25634 411 42595283
Torsade de pointes 16.51 11.48 23 25618 8571 42587123
Skin candida 16.41 11.48 8 25633 653 42595041
Toxic shock syndrome 15.95 11.48 7 25634 449 42595245
Oesophagitis 15.93 11.48 31 25610 15216 42580478
Vascular purpura 15.85 11.48 12 25629 2174 42593520
Intracranial aneurysm 15.76 11.48 11 25630 1757 42593937
Drug clearance increased 15.68 11.48 5 25636 130 42595564
Cardiac failure congestive 15.68 11.48 17 25624 85585 42510109
Malaise 15.65 11.48 70 25571 212086 42383608
Biopsy liver 15.61 11.48 6 25635 274 42595420
Myocardial infarction 15.55 11.48 32 25609 123977 42471717
Hypersensitivity vasculitis 15.54 11.48 14 25627 3230 42592464
Vitamin A deficiency 15.36 11.48 4 25637 49 42595645
Low birth weight baby 15.31 11.48 24 25617 9931 42585763
Eosinophilia 15.23 11.48 49 25592 32850 42562844
Vanishing bile duct syndrome 15.20 11.48 11 25630 1860 42593834
Intentional overdose 15.12 11.48 6 25635 51450 42544244
Gastroenteritis yersinia 15.10 11.48 3 25638 9 42595685
Asthenia 15.05 11.48 103 25538 280690 42315004
Acute respiratory distress syndrome 15.00 11.48 46 25595 30062 42565632
Fistula 14.94 11.48 21 25620 7891 42587803
Sialoadenitis 14.83 11.48 8 25633 807 42594887
Lymphadenopathy 14.82 11.48 49 25592 33316 42562378
Proctitis 14.73 11.48 13 25628 2920 42592774
Candida infection 14.71 11.48 37 25604 21573 42574121
Coma 14.54 11.48 7 25634 53547 42542147
Arthrofibrosis 14.49 11.48 4 25637 62 42595632
Exophthalmos 14.44 11.48 8 25633 850 42594844
Pneumatosis intestinalis 14.42 11.48 16 25625 4736 42590958
Osteomyelitis 14.34 11.48 33 25608 18190 42577504
Clostridium test positive 14.12 11.48 17 25624 5488 42590206
Beta haemolytic streptococcal infection 14.08 11.48 8 25633 893 42594801
Diarrhoea 13.91 11.48 369 25272 460480 42135214
Tinea manuum 13.88 11.48 3 25638 15 42595679
Laryngitis 13.88 11.48 12 25629 2623 42593071
Pouchitis 13.69 11.48 8 25633 941 42594753
COVID-19 13.64 11.48 31 25610 115917 42479777
Kidney fibrosis 13.54 11.48 12 25629 2710 42592984
Septic shock 13.53 11.48 98 25543 91574 42504120
Debridement 13.50 11.48 8 25633 966 42594728
Lung disorder 13.42 11.48 6 25635 47917 42547777
Alopecia scarring 13.42 11.48 3 25638 18 42595676
Product dose omission issue 13.23 11.48 48 25593 154317 42441377
Immune thrombocytopenia 13.21 11.48 24 25617 11192 42584502
SAPHO syndrome 13.14 11.48 6 25635 423 42595271
Ototoxicity 13.09 11.48 11 25630 2314 42593380
Completed suicide 12.87 11.48 24 25617 96441 42499253
Pneumonia staphylococcal 12.85 11.48 13 25628 3463 42592231
Abscess limb 12.79 11.48 14 25627 4083 42591611
Somnolence 12.68 11.48 43 25598 141062 42454632
Umbilical hernia 12.65 11.48 16 25625 5431 42590263
Drug intolerance 12.60 11.48 18 25623 80406 42515288
Bronchopulmonary dysplasia 12.58 11.48 7 25634 750 42594944
Anal fistula 12.49 11.48 17 25624 6196 42589498
Neuropsychiatric symptoms 12.46 11.48 7 25634 765 42594929
Limb fracture 12.26 11.48 3 25638 28 42595666
Cerebrovascular accident 12.24 11.48 25 25616 97135 42498559
Macule 12.23 11.48 10 25631 2025 42593669
Dry gangrene 12.18 11.48 6 25635 501 42595193
Gastrointestinal submucosal tumour 12.16 11.48 4 25637 115 42595579
Anal ulcer 12.14 11.48 8 25633 1163 42594531
Thrombosis 12.11 11.48 14 25627 68497 42527197
Leg amputation 11.94 11.48 11 25630 2612 42593082
Platelet count decreased 11.93 11.48 43 25598 138538 42457156
Endocarditis histoplasma 11.82 11.48 3 25638 33 42595661
Lymphopenia 11.74 11.48 34 25607 21529 42574165
Post procedural fistula 11.70 11.48 4 25637 130 42595564
Hepatocellular injury 11.63 11.48 36 25605 23642 42572052
Dermatitis atopic 11.50 11.48 24 25617 12380 42583314

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Acute generalised exanthematous pustulosis 510.13 10.33 244 59276 21420 110508359
Rash maculo-papular 496.70 10.33 371 59149 73851 110455928
Drug hypersensitivity 482.35 10.33 870 58650 453220 110076559
Type IV hypersensitivity reaction 390.35 10.33 140 59380 5893 110523886
Drug reaction with eosinophilia and systemic symptoms 386.50 10.33 334 59186 81761 110448018
Drug ineffective 285.45 10.33 1584 57936 1518956 109010823
Rash 261.28 10.33 1000 58520 819964 109709815
Hidradenitis 215.18 10.33 87 59433 5093 110524686
Clostridium difficile colitis 189.69 10.33 170 59350 43608 110486171
Toxic skin eruption 173.88 10.33 133 59387 27382 110502397
Drug resistance 162.17 10.33 175 59345 56199 110473580
Loss of employment 148.73 10.33 59 59461 3285 110526494
Synovitis 122.47 10.33 6 59514 274086 110255693
Toxic epidermal necrolysis 114.68 10.33 147 59373 56580 110473199
Graft infection 106.79 10.33 32 59488 756 110529023
Erythema 104.76 10.33 370 59150 291077 110238702
Abscess 102.20 10.33 98 59422 27371 110502408
Drug eruption 100.62 10.33 134 59386 53525 110476254
Drug ineffective for unapproved indication 96.16 10.33 187 59333 102651 110427128
Cellulitis 95.34 10.33 210 59310 125806 110403973
Clostridium difficile infection 92.91 10.33 127 59393 52002 110477777
Joint swelling 90.45 10.33 64 59456 442781 110086998
Pathogen resistance 87.36 10.33 74 59446 17598 110512181
Pemphigus 86.22 10.33 8 59512 214562 110315217
Pericarditis 85.87 10.33 9 59511 219105 110310674
Hand deformity 85.57 10.33 9 59511 218497 110311282
Glossodynia 84.78 10.33 10 59510 221994 110307785
Anti-cyclic citrullinated peptide antibody positive 81.23 10.33 4 59516 181980 110347799
Systemic lupus erythematosus 80.48 10.33 19 59501 254319 110275460
Tubulointerstitial nephritis 80.24 10.33 121 59399 54163 110475616
Acute kidney injury 79.27 10.33 599 58921 634831 109894948
Helicobacter infection 78.09 10.33 5 59515 181872 110347907
Staphylococcal infection 73.86 10.33 134 59386 69810 110459969
Anaphylactic reaction 73.82 10.33 179 59341 114121 110415658
Leukocytosis 72.58 10.33 115 59405 53713 110476066
Fibromyalgia 72.49 10.33 5 59515 170904 110358875
Rash morbilliform 72.33 10.33 48 59472 7903 110521876
Oesophageal ulcer 72.26 10.33 48 59472 7916 110521863
Oesophagitis 72.01 10.33 83 59437 28632 110501147
Death 71.49 10.33 170 59350 698699 109831080
Symmetrical drug-related intertriginous and flexural exanthema 69.08 10.33 29 59491 1868 110527911
Drug abuse 65.29 10.33 9 59511 177402 110352377
Eosinophilia 65.03 10.33 114 59406 57822 110471957
Pruritus 64.67 10.33 534 58986 581026 109948753
Pyrexia 62.95 10.33 749 58771 897516 109632263
Multiple organ dysfunction syndrome 62.75 10.33 202 59318 151508 110378271
Pseudomembranous colitis 61.59 10.33 40 59480 6351 110523428
Stevens-Johnson syndrome 60.22 10.33 98 59422 46803 110482976
Hepatic steatosis 58.63 10.33 99 59421 48732 110481047
Rash erythematous 58.10 10.33 133 59387 81699 110448080
Muscle injury 57.23 10.33 5 59515 140802 110388977
Arthropathy 56.79 10.33 43 59477 287479 110242300
Blood cholesterol increased 56.14 10.33 15 59505 184770 110345009
Megacolon 54.34 10.33 32 59488 4273 110525506
Septic shock 53.98 10.33 197 59323 157331 110372448
Rheumatoid arthritis 52.81 10.33 50 59470 299563 110230216
Cutaneous vasculitis 52.31 10.33 48 59472 12681 110517098
Type 2 diabetes mellitus 50.88 10.33 16 59504 177216 110352563
Methaemoglobinaemia 50.76 10.33 41 59479 9127 110520652
Sinobronchitis 50.21 10.33 16 59504 466 110529313
Alopecia 49.27 10.33 75 59445 364678 110165101
Urticaria 48.10 10.33 315 59205 318542 110211237
Premature delivery 47.73 10.33 70 59450 30562 110499217
Surgical failure 46.91 10.33 18 59502 916 110528863
Irritable bowel syndrome 46.82 10.33 15 59505 164200 110365579
Lymphadenopathy 44.48 10.33 103 59417 63732 110466047
Mucormycosis 43.53 10.33 40 59480 10588 110519191
Sleep disorder 42.81 10.33 27 59493 198617 110331162
Kounis syndrome 42.70 10.33 31 59489 5894 110523885
Wound 42.64 10.33 38 59482 234399 110295380
Sleep disorder due to general medical condition, insomnia type 42.26 10.33 4 59516 105639 110424140
Infusion related reaction 41.94 10.33 89 59431 381073 110148706
Toxic shock syndrome 41.58 10.33 19 59501 1501 110528278
Glomerulosclerosis 41.47 10.33 18 59502 1259 110528520
Acne fulminans 40.35 10.33 12 59508 276 110529503
Psoriatic arthropathy 39.39 10.33 29 59491 196732 110333047
Dermatitis acneiform 39.31 10.33 41 59479 12654 110517125
Diarrhoea 39.24 10.33 844 58676 1138661 109391118
Osteoarthritis 39.11 10.33 25 59495 182598 110347181
Type I hypersensitivity 38.41 10.33 30 59490 6363 110523416
Musculoskeletal stiffness 38.30 10.33 57 59463 279765 110250014
Pulmonary fibrosis 37.96 10.33 5 59515 102037 110427742
Facet joint syndrome 37.86 10.33 4 59516 96824 110432955
Drug-induced liver injury 37.68 10.33 146 59374 119921 110409858
Antibiotic level below therapeutic 37.49 10.33 9 59511 87 110529692
Swelling face 37.32 10.33 122 59398 92199 110437580
Folliculitis 37.22 10.33 22 59498 167631 110362148
Lip dry 37 10.33 5 59515 100078 110429701
Purpura 36.94 10.33 55 59465 24333 110505446
Stomatitis 36.06 10.33 56 59464 270186 110259593
Necrotising fasciitis 35.91 10.33 31 59489 7560 110522219
Rash pustular 35.44 10.33 39 59481 12790 110516989
Idiosyncratic drug reaction 35.23 10.33 17 59503 1519 110528260
Candida infection 35.15 10.33 79 59441 47930 110481849
Confusional state 34.89 10.33 132 59388 468548 110061231
Klebsiella infection 34.52 10.33 48 59472 19961 110509818
Hepatitis infectious mononucleosis 34.22 10.33 10 59510 216 110529563
Mobility decreased 33.83 10.33 47 59473 237375 110292404
Lower respiratory tract infection 33.77 10.33 49 59471 243057 110286722
Clostridium test positive 33.41 10.33 35 59485 10858 110518921
Erysipelas 32.93 10.33 38 59482 13120 110516659
Peripheral swelling 32.59 10.33 110 59410 403924 110125855
Hypercholesterolaemia 32.51 10.33 5 59515 90832 110438947
Grip strength decreased 32.17 10.33 3 59517 80171 110449608
General physical health deterioration 32.16 10.33 119 59401 425176 110104603
Tubo-ovarian abscess 32.12 10.33 11 59509 403 110529376
Condition aggravated 31.91 10.33 564 58956 734272 109795507
Ill-defined disorder 31.54 10.33 23 59497 156830 110372949
Pustule 31.50 10.33 21 59499 3483 110526296
Central pain syndrome 31.42 10.33 13 59507 807 110528972
Urine alcohol test positive 31.42 10.33 7 59513 47 110529732
Acne 31.37 10.33 61 59459 33459 110496320
Toxic shock syndrome streptococcal 31.01 10.33 10 59510 303 110529476
Bartholinitis 30.92 10.33 7 59513 51 110529728
Reaction to azo-dyes 30.86 10.33 6 59514 18 110529761
Discomfort 30.09 10.33 43 59477 214664 110315115
Allergic sinusitis 30.00 10.33 16 59504 1765 110528014
Acute respiratory distress syndrome 29.83 10.33 79 59441 53119 110476660
Skin lesion 29.29 10.33 77 59443 51554 110478225
Peripheral venous disease 29.27 10.33 5 59515 84112 110445667
Toxicity to various agents 29.26 10.33 146 59374 480409 110049370
Abscess of salivary gland 29.14 10.33 6 59514 26 110529753
Fungal infection 29.05 10.33 76 59444 50730 110479049
Completed suicide 28.87 10.33 54 59466 242327 110287452
Cholestatic liver injury 28.74 10.33 27 59493 7349 110522430
Subcutaneous abscess 28.69 10.33 30 59490 9287 110520492
Scrotal infection 28.66 10.33 12 59508 768 110529011
Urinary tract inflammation 28.65 10.33 10 59510 388 110529391
SAPHO syndrome 28.22 10.33 11 59509 584 110529195
Escherichia infection 28.21 10.33 48 59472 23768 110506011
Abscess neck 27.97 10.33 14 59506 1354 110528425
Overdose 27.92 10.33 52 59468 233742 110296037
Asthenia 27.88 10.33 237 59283 688762 109841017
Face oedema 27.85 10.33 58 59462 33411 110496368
Perineal infection 27.43 10.33 12 59508 855 110528924
Intentional product use issue 27.15 10.33 58 59462 247848 110281931
Conductive deafness 27.12 10.33 9 59511 299 110529480
Mastitis 27.11 10.33 17 59503 2541 110527238
Aspergillus infection 26.94 10.33 49 59471 25567 110504212
Fatigue 26.85 10.33 477 59043 1215481 109314298
Hyper IgE syndrome 26.79 10.33 11 59509 670 110529109
Optic nerve operation 26.54 10.33 10 59510 484 110529295
Eye swelling 26.03 10.33 56 59464 32992 110496787
Hypoglossal nerve paresis 25.75 10.33 7 59513 115 110529664
Epilepsy 25.46 10.33 11 59509 100198 110429581
Coma 25.42 10.33 16 59504 117853 110411926
Sciatica 25.36 10.33 9 59511 92390 110437389
Weight increased 25.25 10.33 128 59392 419516 110110263
Hepatic cytolysis 25.24 10.33 76 59444 54977 110474802
Scedosporium infection 25.21 10.33 16 59504 2442 110527337
Lower limb fracture 25.10 10.33 5 59515 75343 110454436
Gait inability 24.91 10.33 22 59498 136354 110393425
Autoimmune disorder 24.86 10.33 3 59517 65480 110464299
Skin graft failure 24.82 10.33 8 59512 242 110529537
Oedema 24.81 10.33 47 59473 209929 110319850
Acute hepatic failure 24.48 10.33 58 59462 36410 110493369
Decreased appetite 24.38 10.33 153 59367 475693 110054086
Joint range of motion decreased 24.32 10.33 18 59502 121814 110407965
Pneumococcal infection 24.22 10.33 14 59506 1805 110527974
Fungal sepsis 24.04 10.33 15 59505 2222 110527557
Intentional overdose 23.46 10.33 22 59498 132479 110397300
Insomnia 23.43 10.33 107 59413 360483 110169296
Adverse event 23.15 10.33 15 59505 108794 110420985
Cholecystitis chronic 23.05 10.33 27 59493 9473 110520306
Night sweats 22.85 10.33 23 59497 133960 110395819
Type IIb hyperlipidaemia 22.79 10.33 5 59515 31 110529748
Scar 22.66 10.33 36 59484 16845 110512934
Wound secretion 22.65 10.33 23 59497 6878 110522901
Idiopathic intracranial hypertension 22.57 10.33 18 59502 3934 110525845
Clostridial infection 22.53 10.33 22 59498 6280 110523499
Sedation 22.44 10.33 5 59515 69678 110460101
Prescribed underdose 22.40 10.33 4 59516 65170 110464609
Infected dermal cyst 22.40 10.33 12 59508 1336 110528443
Puerperal pyrexia 22.39 10.33 5 59515 34 110529745
Autoimmune thyroiditis 22.14 10.33 22 59498 6412 110523367
Dermatitis allergic 22.14 10.33 41 59479 21683 110508096
Osteonecrosis of jaw 21.74 10.33 66 59454 47951 110481828
Musculoskeletal pain 21.60 10.33 41 59479 182982 110346797
Arteriovenous fistula 21.31 10.33 12 59508 1473 110528306
Osteomyelitis 21.18 10.33 55 59465 36545 110493234
Osteomyelitis salmonella 20.86 10.33 5 59515 48 110529731
Disease recurrence 20.79 10.33 76 59444 60708 110469071
Rash pruritic 20.72 10.33 106 59414 97963 110431816
Pseudomonas infection 20.58 10.33 46 59474 27807 110501972
Abscess limb 20.37 10.33 24 59496 8473 110521306
Electrocardiogram U wave present 20.30 10.33 6 59514 135 110529644
Bursitis 20.28 10.33 24 59496 129894 110399885
Overgrowth bacterial 20.24 10.33 7 59513 264 110529515
Skin exfoliation 20.12 10.33 97 59423 87554 110442225
Neoplasm progression 20.08 10.33 5 59515 64590 110465189
Anamnestic reaction 20.00 10.33 5 59515 58 110529721
Pneumonia 19.92 10.33 342 59178 876372 109653407
Ophthalmoplegia 19.92 10.33 16 59504 3534 110526245
Cholestasis 19.86 10.33 78 59442 64440 110465339
Swelling of eyelid 19.73 10.33 21 59499 6632 110523147
Dysbiosis 19.71 10.33 13 59507 2119 110527660
Post infection glomerulonephritis 19.62 10.33 6 59514 152 110529627
Product use in unapproved indication 19.59 10.33 344 59176 447033 110082746
Breast abscess 19.54 10.33 12 59508 1729 110528050
Swelling 19.49 10.33 110 59410 350931 110178848
Respiratory failure 19.37 10.33 189 59331 215143 110314636
Gastric disorder 19.18 10.33 50 59470 33307 110496472
Tooth injury 19.09 10.33 13 59507 2233 110527546
Vascular purpura 19.07 10.33 16 59504 3755 110526024
Hypersensitivity vasculitis 19.01 10.33 21 59499 6916 110522863
Hepatitis cholestatic 18.98 10.33 34 59486 17532 110512247
Wheezing 18.89 10.33 72 59448 255158 110274621
Coagulation factor decreased 18.63 10.33 7 59513 336 110529443
Agranulocytosis 18.48 10.33 74 59446 61686 110468093
Gastrointestinal mucosa hyperaemia 18.42 10.33 8 59512 560 110529219
Device toxicity 18.34 10.33 4 59516 24 110529755
Rash macular 18.29 10.33 54 59466 38632 110491147
Skin odour abnormal 18.05 10.33 13 59507 2441 110527338
Sepsis syndrome 17.91 10.33 11 59509 1585 110528194
Necrotising oesophagitis 17.88 10.33 11 59509 1589 110528190
Dry mouth 17.82 10.33 52 59468 199896 110329883
Hypoaesthesia 17.69 10.33 98 59422 314125 110215654
Skin disorder 17.60 10.33 57 59463 42856 110486923
Skin infection 17.56 10.33 38 59482 22471 110507308
Cerebral toxoplasmosis 17.28 10.33 14 59506 3128 110526651
Sialoadenitis 17.06 10.33 13 59507 2660 110527119
Tremor 17.02 10.33 54 59466 202178 110327601
Memory impairment 16.99 10.33 52 59468 196892 110332887
Medication error 16.94 10.33 19 59501 105347 110424432
Prothrombin time prolonged 16.87 10.33 32 59488 17229 110512550
Pulmonary venous thrombosis 16.74 10.33 6 59514 252 110529527
Muscle necrosis 16.71 10.33 11 59509 1786 110527993
Anti factor V antibody positive 16.63 10.33 4 59516 39 110529740
Angioedema 16.49 10.33 100 59420 98400 110431379
Infected skin ulcer 16.38 10.33 15 59505 3952 110525827
Tinea infection 16.05 10.33 10 59510 1478 110528301
Tonsillar hypertrophy 15.96 10.33 11 59509 1927 110527852
Eczema 15.87 10.33 79 59441 72214 110457565
Ototoxicity 15.86 10.33 15 59505 4116 110525663
Resorption bone increased 15.77 10.33 10 59510 1524 110528255
Orthostatic hypotension 15.71 10.33 8 59512 66241 110463538
Paraesthesia 15.69 10.33 86 59434 276435 110253344
Anterior segment ischaemia 15.51 10.33 4 59516 53 110529726
Pneumothorax 15.51 10.33 48 59472 35237 110494542
Weaning failure 15.48 10.33 8 59512 828 110528951
Erosive oesophagitis 15.47 10.33 13 59507 3056 110526723
Bronchial obstruction 15.44 10.33 13 59507 3066 110526713
Perihepatic discomfort 15.43 10.33 3 59517 9 110529770
Gastroenteritis yersinia 15.43 10.33 3 59517 9 110529770
Cyst 15.41 10.33 30 59490 16466 110513313
Oxygen saturation abnormal 15.40 10.33 17 59503 5594 110524185
Acute febrile neutrophilic dermatosis 15.39 10.33 16 59504 4920 110524859
Tendon pain 15.38 10.33 18 59502 6308 110523471
Postoperative wound infection 15.15 10.33 29 59491 15724 110514055
Shock 15.07 10.33 63 59457 53525 110476254
Dermal cyst 15.05 10.33 13 59507 3173 110526606
Hepatic enzyme increased 15 10.33 106 59414 320786 110208993
Gas gangrene 14.99 10.33 6 59514 342 110529437
Respiratory gas exchange disorder 14.94 10.33 8 59512 890 110528889
Soft tissue infection 14.93 10.33 16 59504 5091 110524688
Torticollis 14.93 10.33 13 59507 3208 110526571
Vulval abscess 14.85 10.33 8 59512 901 110528878
Drug effective for unapproved indication 14.77 10.33 27 59493 14140 110515639
Night blindness 14.76 10.33 7 59513 602 110529177
Clostridium colitis 14.60 10.33 13 59507 3302 110526477
Skin reaction 14.60 10.33 34 59486 21110 110508669
Venous haemorrhage 14.52 10.33 6 59514 371 110529408
Micrococcus infection 14.50 10.33 5 59515 187 110529592
Serratia infection 14.44 10.33 11 59509 2248 110527531
Hip arthroplasty 14.38 10.33 6 59514 55807 110473972
Thyroxine increased 14.25 10.33 8 59512 976 110528803
Impaired healing 14.23 10.33 56 59464 196661 110333118
Joint vibration 14.22 10.33 3 59517 15 110529764
Suicide attempt 14.19 10.33 21 59499 103373 110426406
Oesophagitis chemical 14.07 10.33 4 59516 78 110529701
Leg amputation 13.74 10.33 14 59506 4204 110525575
Frequent bowel movements 13.67 10.33 11 59509 71379 110458400
Emotional distress 13.63 10.33 54 59466 44793 110484986
Odynophagia 13.61 10.33 26 59494 14075 110515704
Post procedural fistula 13.60 10.33 6 59514 436 110529343
Erythema multiforme 13.57 10.33 33 59487 21064 110508715
Adenoidal disorder 13.53 10.33 5 59515 229 110529550
Lower respiratory tract infection bacterial 13.52 10.33 8 59512 1077 110528702
Groin abscess 13.49 10.33 10 59510 1962 110527817
Hepatic cirrhosis 13.48 10.33 10 59510 67616 110462163
Gait disturbance 13.45 10.33 91 59429 278117 110251662
Muscle spasms 13.43 10.33 91 59429 278066 110251713
Interstitial lung disease 13.33 10.33 35 59485 139299 110390480
Onychomadesis 13.32 10.33 4 59516 45659 110484120
Allergy to metals 13.29 10.33 7 59513 753 110529026
Contraindicated product administered 13.13 10.33 79 59441 248188 110281591
Injection site erythema 13.05 10.33 19 59501 94157 110435622
Lip swelling 13.05 10.33 58 59462 50609 110479170
Drug intolerance 12.98 10.33 148 59372 406364 110123415
Breast pain 12.98 10.33 21 59499 9979 110519800
Vestibular disorder 12.96 10.33 11 59509 2621 110527158
Babesiosis 12.95 10.33 6 59514 489 110529290
Platelet count decreased 12.89 10.33 72 59448 230371 110299408
Vulvovaginal discomfort 12.83 10.33 10 59510 2114 110527665
Arthrofibrosis 12.81 10.33 4 59516 109 110529670
Haemolytic anaemia 12.69 10.33 32 59488 20888 110508891
Nephropathy toxic 12.65 10.33 38 59482 27440 110502339
Premature rupture of membranes 12.64 10.33 14 59506 4623 110525156
Astigmatism 12.45 10.33 9 59511 1700 110528079
Infective uveitis 12.41 10.33 3 59517 30 110529749
Dermatitis 12.35 10.33 38 59482 27799 110501980
Umbilical hernia 12.34 10.33 17 59503 7005 110522774
Menstrual disorder 12.28 10.33 14 59506 4770 110525009
Neuropsychiatric symptoms 12.26 10.33 8 59512 1280 110528499
Haemorrhagic vasculitis 12.17 10.33 4 59516 129 110529650
Pneumonia necrotising 12.14 10.33 9 59511 1766 110528013
BK polyomavirus test positive 12.14 10.33 5 59515 307 110529472
Transient ischaemic attack 12.08 10.33 10 59510 63972 110465807
Gastrointestinal submucosal tumour 12.02 10.33 4 59516 134 110529645
Sensory disturbance 12.00 10.33 28 59492 17401 110512378
Fall 11.94 10.33 241 59279 603241 109926538
Hepatic vein occlusion 11.94 10.33 5 59515 320 110529459
Bone erosion 11.92 10.33 5 59515 46366 110483413
Acinetobacter infection 11.90 10.33 12 59508 3561 110526218
Neutrophil count decreased 11.86 10.33 30 59490 120911 110408868
Candida osteomyelitis 11.83 10.33 3 59517 37 110529742
Skin plaque 11.82 10.33 23 59497 12622 110517157
Prescribed overdose 11.82 10.33 18 59502 87563 110442216
Normochromic anaemia 11.81 10.33 6 59514 599 110529180
Intracranial mass 11.80 10.33 10 59510 2378 110527401
Cognitive disorder 11.79 10.33 18 59502 87493 110442286
Live birth 11.76 10.33 12 59508 69472 110460307
Pain in extremity 11.70 10.33 188 59332 486930 110042849
Vitamin B1 deficiency 11.69 10.33 7 59513 963 110528816
Limb fracture 11.69 10.33 3 59517 39 110529740
Renal failure 11.68 10.33 179 59341 226395 110303384
Leukopenia 11.67 10.33 127 59393 148664 110381115
Endocarditis histoplasma 11.55 10.33 3 59517 41 110529738
Rectal haemorrhage 11.54 10.33 30 59490 119803 110409976
Kidney fibrosis 11.53 10.33 13 59507 4379 110525400
Intentional product misuse 11.52 10.33 35 59485 132869 110396910
Sinus pain 11.51 10.33 15 59505 5864 110523915
Mycobacterial infection 11.47 10.33 13 59507 4404 110525375
Dermatitis atopic 11.46 10.33 35 59485 25506 110504273
Papule 11.44 10.33 20 59500 10113 110519666
Biopsy liver 11.38 10.33 6 59514 647 110529132
Ischaemic stroke 11.35 10.33 4 59516 41259 110488520
Bullous haemorrhagic dermatosis 11.35 10.33 5 59515 362 110529417
Hypervigilance 11.34 10.33 6 59514 651 110529128
Colitis ulcerative 11.33 10.33 15 59505 77348 110452431
Lip oedema 11.31 10.33 17 59503 7583 110522196
Vitamin A deficiency 11.27 10.33 4 59516 163 110529616
Somnolence 11.26 10.33 104 59416 297345 110232434
Amnesia 11.25 10.33 25 59495 105383 110424396
Lemierre syndrome 11.23 10.33 4 59516 165 110529614
Dizziness 11.22 10.33 288 59232 697905 109831874
Vanishing bile duct syndrome 11.21 10.33 11 59509 3157 110526622
Skin oedema 11.19 10.33 9 59511 1990 110527789
Renal tubular necrosis 11.19 10.33 39 59481 30436 110499343
Fungaemia 11.10 10.33 15 59505 6071 110523708
Cerebrovascular accident 11.06 10.33 55 59465 181229 110348550
Wound infection 11.04 10.33 22 59498 96443 110433336
Inflammation 11.01 10.33 60 59460 193178 110336601
Nephritis allergic 11.01 10.33 7 59513 1072 110528707
Joint abscess 10.98 10.33 6 59514 695 110529084
Product deposit 10.95 10.33 6 59514 699 110529080
Perfume sensitivity 10.94 10.33 7 59513 1084 110528695
Glomerulonephritis minimal lesion 10.94 10.33 7 59513 1084 110528695
Factor V inhibition 10.93 10.33 5 59515 396 110529383
Drug clearance increased 10.92 10.33 5 59515 397 110529382
Product contamination microbial 10.92 10.33 7 59513 1087 110528692
International normalised ratio increased 10.87 10.33 82 59438 86690 110443089
Haemodynamic instability 10.87 10.33 32 59488 22856 110506923
Abdominal tenderness 10.85 10.33 22 59498 12435 110517344
Pyoderma gangrenosum 10.76 10.33 14 59506 5462 110524317
Underdose 10.73 10.33 11 59509 63543 110466236
Upper limb fracture 10.69 10.33 30 59490 20858 110508921
Documented hypersensitivity to administered product 10.69 10.33 7 59513 1127 110528652
Drug interaction 10.60 10.33 348 59172 499835 110029944
Lymph node palpable 10.59 10.33 4 59516 195 110529584
White matter lesion 10.57 10.33 10 59510 2744 110527035
Acute myocardial infarction 10.57 10.33 18 59502 83759 110446020
Nasopharyngitis 10.56 10.33 149 59371 394212 110135567
Viral uveitis 10.49 10.33 4 59516 200 110529579
Disseminated intravascular coagulation 10.44 10.33 47 59473 41239 110488540
Calcium deficiency 10.42 10.33 7 59513 1175 110528604
Retinal degeneration 10.41 10.33 8 59512 1658 110528121

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
FDA CS M0515779 Lincosamides
FDA PE N0000009982 Decreased Sebaceous Gland Activity
FDA EPC N0000175443 Lincosamide Antibacterial
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents
CHEBI has role CHEBI:35703 xenobiotic
CHEBI has role CHEBI:78298 environmental contaminant
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D011500 Protein Synthesis Inhibitors
FDA PE N0000175731 Neuromuscular Blockade

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Anaerobic septicemia indication 1976008
Bacterial septicemia indication 10001005 DOID:0040085
Infection of skin AND/OR subcutaneous tissue indication 19824006
Staphylococcal pneumonia indication 22754005
Streptococcal septicemia indication 29577008
Pneumonia due to Streptococcus indication 34020007
Empyema of pleura indication 58554001 DOID:3798
Acne vulgaris indication 88616000
Infection of bone indication 111253001
Staphylococcal septicemia indication 111821004
Infectious disease of abdomen indication 128070006
Pneumococcal pneumonia indication 233607000
Gas gangrene caused by clostridium perfringens indication 266093005
Streptococcus pyogenes infection indication 302809008
Infectious disorder of joint indication 363162000
Infection due to Staphylococcus aureus indication 406602003
Aspiration pneumonia indication 422588002 DOID:3240
Infection due to anaerobic bacteria indication 423451008
Osteomyelitis due to Staphylococcus aureus indication 428783003
Skin and Skin Structure Anaerobic Infection indication
Anaerobic Tubo-Ovarian Abscess indication
Prevention of Bacterial Endocarditis indication
Anaerobic Lung Abscess indication
Anaerobic Endometritis indication
Clostridium Perfringens Empyema indication
Anaerobic Peritonitis indication
Anaerobic Joint Infection indication
Anaerobic Pelvic Cellulitis indication
Intra-Abdominal Anaerobic Abscess indication
Inflammatory Disease of Female Pelvic Organs indication
Pyrexia of unknown origin off-label use 7520000
Inhalational anthrax off-label use 11389007
Actinomycotic infection off-label use 11817007 DOID:8478
Babesiosis off-label use 21061004 DOID:9643
Sinusitis off-label use 36971009
Erysipelas off-label use 44653001 DOID:11330
Malaria off-label use 61462000 DOID:12365
Cutaneous anthrax off-label use 84980006 DOID:7426
Gastrointestinal anthrax off-label use 111798006 DOID:13386
Bacterial infection of skin off-label use 128936008
Toxoplasmosis off-label use 187192000 DOID:9965
Diverticulitis of gastrointestinal tract off-label use 271366000
Infective otitis media off-label use 312218008
Rosacea off-label use 398909004 DOID:8881
Pneumocystosis jiroveci pneumonia off-label use 415125002 DOID:11339
Toxoplasmosis associated with acquired immunodeficiency syndrome off-label use 421666009
Chloroquine Resistant Plasmodium Falciparum Malaria off-label use
Diabetic Foot Infection off-label use
Encephalitis due to Toxoplasmosis off-label use
Atopic dermatitis contraindication 24079001 DOID:3310
Crohn's disease contraindication 34000006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Pseudomembranous enterocolitis contraindication 397683000
Bloody Stools contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.46 acidic
pKa2 6.51 acidic
pKa3 12.55 acidic
pKa4 13.71 acidic
pKa5 7.52 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 2% BASE CLINDESSE PADAGIS US N050793 Nov. 30, 2004 RX CREAM VAGINAL 9789057 Dec. 2, 2026 METHOD OF TREATING BACTERIAL VAGINOSIS
2.5%;EQ 1.2% BASE ACANYA BAUSCH N050819 Oct. 23, 2008 RX GEL TOPICAL 10220049 June 3, 2029 TOPICAL TREATMENT OF ACNE VULGARIS IN PATIENTS 12 YEARS OR OLDER
2.5%;EQ 1.2% BASE ACANYA BAUSCH N050819 Oct. 23, 2008 RX GEL TOPICAL 10624918 June 3, 2029 TOPICAL TREATMENT OF ACNE VULGARIS IN PATIENTS 12 YEARS OR OLDER
2.5%;EQ 1.2% BASE ACANYA BAUSCH N050819 Oct. 23, 2008 RX GEL TOPICAL 8663699 June 3, 2029 TREATMENT OF ACNE
2.5%;EQ 1.2% BASE ACANYA BAUSCH N050819 Oct. 23, 2008 RX GEL TOPICAL 8895070 June 3, 2029 TREATMENT OF ACNE
3.75%;EQ 1.2% BASE ONEXTON BAUSCH N050819 Nov. 24, 2014 RX GEL TOPICAL 10137142 June 3, 2029 TOPICAL TREATMENT OF ACNE VULGARIS IN PATIENTS 12 YEARS OR OLDER
3.75%;EQ 1.2% BASE ONEXTON BAUSCH N050819 Nov. 24, 2014 RX GEL TOPICAL 10220049 June 3, 2029 TOPICAL TREATMENT OF ACNE VULGARIS IN PATIENTS 12 YEARS OR OLDER
3.75%;EQ 1.2% BASE ONEXTON BAUSCH N050819 Nov. 24, 2014 RX GEL TOPICAL 9504704 June 3, 2029 TOPICAL TREATMENT OF ACNE VULGARIS
3.75%;EQ 1.2% BASE ONEXTON BAUSCH N050819 Nov. 24, 2014 RX GEL TOPICAL 9504704 June 3, 2029 TOPICAL TREATMENT OF ACNE VULGARIS IN PATIENTS 12 YEARS OR OLDER
3.75%;EQ 1.2% BASE ONEXTON BAUSCH N050819 Nov. 24, 2014 RX GEL TOPICAL 9504704 June 3, 2029 TREATMENT OF ACNE
3.75%;EQ 1.2% BASE ONEXTON BAUSCH N050819 Nov. 24, 2014 RX GEL TOPICAL 9504704 June 3, 2029 TREATMENT OF ACNE VULGARIS
3.75%;EQ 1.2% BASE ONEXTON BAUSCH N050819 Nov. 24, 2014 RX GEL TOPICAL 9561208 June 3, 2029 TOPICAL TREATMENT OF ACNE VULGARIS IN PATIENTS 12 YEARS OR OLDER
0.15%;3.1%;1.2% CABTREO BAUSCH N216632 Oct. 20, 2023 RX GEL TOPICAL 10220049 June 3, 2029 TOPICAL TREATMENT OF ACNE VULGARIS IN ADULT AND PEDIATRIC PATIENTS 12 YEARS OF AGE AND OLDER
0.15%;3.1%;1.2% CABTREO BAUSCH N216632 Oct. 20, 2023 RX GEL TOPICAL 10624918 June 3, 2029 TOPICAL TREATMENT OF ACNE VULGARIS IN ADULT AND PEDIATRIC PATIENTS 12 YEARS OF AGE AND OLDER
0.15%;3.1%;1.2% CABTREO BAUSCH N216632 Oct. 20, 2023 RX GEL TOPICAL 9561208 June 3, 2029 TOPICAL TREATMENT OF ACNE VULGARIS IN ADULT AND PEDIATRIC PATIENTS 12 YEARS OF AGE AND OLDER
2.5%;EQ 1.2% BASE ACANYA BAUSCH N050819 Oct. 23, 2008 RX GEL TOPICAL 8288434 Aug. 5, 2029 TREATMENT OF ACNE
3.75%;EQ 1.2% BASE ONEXTON BAUSCH N050819 Nov. 24, 2014 RX GEL TOPICAL 8288434 Aug. 5, 2029 TOPICAL TREATMENT OF ACNE VULGARIS
3.75%;EQ 1.2% BASE ONEXTON BAUSCH N050819 Nov. 24, 2014 RX GEL TOPICAL 8288434 Aug. 5, 2029 TOPICAL TREATMENT OF ACNE VULGARIS IN PATIENTS 12 YEARS OR OLDER
3.75%;EQ 1.2% BASE ONEXTON BAUSCH N050819 Nov. 24, 2014 RX GEL TOPICAL 8288434 Aug. 5, 2029 TREATMENT OF ACNE
3.75%;EQ 1.2% BASE ONEXTON BAUSCH N050819 Nov. 24, 2014 RX GEL TOPICAL 8288434 Aug. 5, 2029 TREATMENT OF ACNE VULGARIS
0.15%;3.1%;1.2% CABTREO BAUSCH N216632 Oct. 20, 2023 RX GEL TOPICAL 8288434 Aug. 5, 2029 TOPICAL TREATMENT OF ACNE VULGARIS IN ADULT AND PEDIATRIC PATIENTS 12 YEARS OF AGE AND OLDER
EQ 2% BASE XACIATO ORGANON LLC N215650 Dec. 7, 2021 RX GEL VAGINAL 11129896 Sept. 22, 2036 METHOD OF TREATING BACTERIAL VAGINOSIS BY SINGLE DOSE ADMINISTRATION OF A CLINDAMYCIN PHARMACEUTICAL GEL FORMULATION
0.15%;3.1%;1.2% CABTREO BAUSCH N216632 Oct. 20, 2023 RX GEL TOPICAL 12128059 July 31, 2040 TOPICAL TREATMENT OF ACNE VULGARIS IN ADULT AND PEDIATRIC PATIENTS 12 YEARS OF AGE AND OLDER
0.15%;3.1%;1.2% CABTREO BAUSCH N216632 Oct. 20, 2023 RX GEL TOPICAL 11389467 Dec. 28, 2040 TOPICAL TREATMENT OF ACNE VULGARIS IN ADULT AND PEDIATRIC PATIENTS 12 YEARS OF AGE AND OLDER

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 2% BASE XACIATO ORGANON LLC N215650 Dec. 7, 2021 RX GEL VAGINAL Dec. 7, 2024 NEW PRODUCT
0.15%;3.1%;1.2% CABTREO BAUSCH N216632 Oct. 20, 2023 RX GEL TOPICAL Oct. 20, 2026 NEW PRODUCT
EQ 2% BASE XACIATO ORGANON LLC N215650 Dec. 7, 2021 RX GEL VAGINAL Dec. 7, 2029 GENERATING ANTIBIOTIC INCENTIVES NOW

Bioactivity Summary:

None

External reference:

IDSource
4018084 VUID
N0000179085 NUI
D01073 KEGG_DRUG
4018084 VANDF
4019683 VANDF
C0055881 UMLSCUI
CHEBI:3746 CHEBI
CLY PDB_CHEM_ID
CHEMBL3184512 ChEMBL_ID
C007084 MESH_SUPPLEMENTAL_RECORD_UI
EH6D7113I8 UNII
443385 PUBCHEM_CID
2582 RXNORM
29382 MMSL
3963 MMSL
41731 MMSL
4466 MMSL
4469 MMSL
4813 MMSL
d00043 MMSL
002794 NDDF
002796 NDDF
372786004 SNOMEDCT_US
37648000 SNOMEDCT_US
58883005 SNOMEDCT_US
C0008947 UMLSCUI
DB01190 DRUGBANK_ID
446598 PUBCHEM_CID
2550 INN_ID
D002981 MESH_DESCRIPTOR_UI
CHEBI:3745 CHEBI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-0728 INJECTION, SOLUTION 150 mg INTRAMUSCULAR NDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-0728 INJECTION, SOLUTION 150 mg INTRAMUSCULAR NDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-0775 INJECTION, SOLUTION 150 mg INTRAMUSCULAR NDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-0775 INJECTION, SOLUTION 150 mg INTRAMUSCULAR NDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-0870 INJECTION, SOLUTION 150 mg INTRAMUSCULAR NDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-0870 INJECTION, SOLUTION 150 mg INTRAMUSCULAR NDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-0902 INJECTION, SOLUTION 150 mg INTRAMUSCULAR NDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-0902 INJECTION, SOLUTION 150 mg INTRAMUSCULAR NDA 28 sections
DALACIN T HUMAN PRESCRIPTION DRUG LABEL 1 0009-1208 GEL 10 mg TOPICAL Export only 1 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-3051 INJECTION, SOLUTION 150 mg INTRAMUSCULAR NDA 27 sections
Cleocin T HUMAN PRESCRIPTION DRUG LABEL 1 0009-3116 SOLUTION 10 mg TOPICAL NDA 23 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-3124 INJECTION, SOLUTION 150 mg INTRAVENOUS ANDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-3124 INJECTION, SOLUTION 150 mg INTRAVENOUS ANDA 28 sections
Cleocin T HUMAN PRESCRIPTION DRUG LABEL 1 0009-3329 LOTION 10 mg TOPICAL NDA 23 sections
Cleocin T HUMAN PRESCRIPTION DRUG LABEL 1 0009-3331 GEL 10 mg TOPICAL NDA 23 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-3375 INJECTION, SOLUTION 12 mg INTRAVENOUS NDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-3375 INJECTION, SOLUTION 12 mg INTRAVENOUS NDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-3381 INJECTION, SOLUTION 6 mg INTRAVENOUS NDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-3381 INJECTION, SOLUTION 6 mg INTRAVENOUS NDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-3382 INJECTION, SOLUTION 18 mg INTRAVENOUS NDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-3382 INJECTION, SOLUTION 18 mg INTRAVENOUS NDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-3447 INJECTION, SOLUTION 150 mg INTRAVENOUS ANDA 28 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-3447 INJECTION, SOLUTION 150 mg INTRAVENOUS ANDA 28 sections
Cleocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-3448 CREAM 20 mg VAGINAL NDA 25 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-4073 INJECTION, SOLUTION 150 mg INTRAMUSCULAR NDA 27 sections
Cleocin Phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0009-5095 INJECTION, SOLUTION 150 mg INTRAMUSCULAR NDA 27 sections
CLEOCIN PHOSPHATE (0009-6582) (STANDALONE) HUMAN PRESCRIPTION DRUG LABEL 1 0009-6582 INJECTION, SOLUTION 150 mg INTRAVENOUS ANDA 28 sections
CLEOCIN PHOSPHATE (0009-6582) (STANDALONE) HUMAN PRESCRIPTION DRUG LABEL 1 0009-6582 INJECTION, SOLUTION 150 mg INTRAVENOUS ANDA 28 sections
Cleocin HUMAN PRESCRIPTION DRUG LABEL 1 0009-7667 SUPPOSITORY 100 mg VAGINAL NDA 24 sections
clindamycin phosphate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0201 SOLUTION 10 mg TOPICAL ANDA 18 sections