bopindolol indications/contra

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 389 62658-63-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • LT 31-200
  • bopindolol
  • bopindolol malonate
  • Molecular weight: 380.49
  • Formula: C23H28N2O3
  • CLOGP: 4.98
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 63.35
  • ALOGS: -5.38
  • ROTB: 9

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1985 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC C07AA17 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, non-selective
ATC C07CA17 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND OTHER DIURETICS
Beta blocking agents, non-selective, and other diuretics
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.62 acidic
pKa2 9.12 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST Ki 9.51 WOMBAT-PK SCIENTIFIC LITERATURE
Beta-2 adrenergic receptor GPCR ANTAGONIST Ki 9.65 WOMBAT-PK SCIENTIFIC LITERATURE
5-hydroxytryptamine receptor 2B GPCR Ki 6.01 DRUG MATRIX
Beta-3 adrenergic receptor GPCR Ki 6.46 DRUG MATRIX
Cytochrome P450 2D6 Enzyme IC50 5.26 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 6.82 DRUG MATRIX
5-hydroxytryptamine receptor 2A GPCR Ki 6.34 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR IC50 6.57 CHEMBL

External reference:

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IDSource
C0053941 UMLSCUI
D01794 KEGG_DRUG
19605 RXNORM
007137 NDDF
CHEMBL357995 ChEMBL_ID
44112 PUBCHEM_CID
C036007 MESH_SUPPLEMENTAL_RECORD_UI
DB08807 DRUGBANK_ID
KT304VZO57 UNII
4695 INN_ID
82857-38-3 SECONDARY_CAS_RN
CHEBI:31298 CHEBI

Pharmaceutical products:

None