biriperone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
tranquillizers, neuroleptics, 4'-fluoro-4-piperidinobutyrophenone derivatives 3883 42021-34-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • biriperone
  • centbutindole
  • Molecular weight: 391.49
  • Formula: C24H26FN3O
  • CLOGP: 4.57
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 39.34
  • ALOGS: -4.23
  • ROTB: 5

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.44 acidic
pKa2 7.64 Basic
pKa3 3.59 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(3) dopamine receptor GPCR Ki 7.96 CHEMBL
D(2) dopamine receptor GPCR Ki 7.88 CHEMBL
5-hydroxytryptamine receptor 2A GPCR Ki 7.62 CHEMBL
D(1A) dopamine receptor GPCR Ki 6.37 CHEMBL

External reference:

IDSource
C2698513 UMLSCUI
CHEBI:135615 CHEBI
CHEMBL136711 ChEMBL_ID
68663 PUBCHEM_CID
C039923 MESH_SUPPLEMENTAL_RECORD_UI
5472 INN_ID
5776HBV7UD UNII
41510-23-0 SECONDARY_CAS_RN

Pharmaceutical products:

None