blonanserin indications/contra

Stem definitionDrug idCAS RN
serotonin receptor antagonists (mostly 5-HT2) 388 132810-10-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • blonanserin
  • lonasen
  • AD-5423
  • Molecular weight: 367.51
  • Formula: C23H30FN3
  • CLOGP: 6.48
  • LIPINSKI: 1
  • HAC: 3
  • HDO: 0
  • TPSA: 19.37
  • ALOGS: -4.01
  • ROTB: 3

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 25, 2008 PMDA Dainippon Sumitomo Pharma Co., Ltd.

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Schizophrenia indication 58214004

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.05 Basic
pKa2 5.85 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR ANTAGONIST Ki 9.85 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
5-hydroxytryptamine receptor 2A GPCR ANTAGONIST Ki 9.09 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 6.54 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR Ki 7.25 WOMBAT-PK

External reference:

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IDSource
7670 IUPHAR_LIGAND_ID
D01176 KEGG_DRUG
AQ316B4F8C UNII
7563 INN_ID
CHEMBL178803 ChEMBL_ID
125564 PUBCHEM_CID
C079310 MESH_SUPPLEMENTAL_RECORD_UI
DB09223 DRUGBANK_ID
CHEBI:31296 CHEBI

Pharmaceutical products:

None