alitretinoin Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
retinol derivatives 3862 5300-03-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • alitretinoin
  • panrexin
  • panretyn
  • panretin
  • 9-cis-retinoic acid
an RXR agonist
  • Molecular weight: 300.44
  • Formula: C20H28O2
  • CLOGP: 6.74
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -4.80
  • ROTB: 5

Drug dosage:

DoseUnitRoute
20 mg O

Approvals:

DateAgencyCompanyOrphan
Feb. 2, 1999 FDA EISAI INC

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AH04 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Agents for dermatitis, excluding corticosteroids
ATC L01XX22 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
OTHER ANTINEOPLASTIC AGENTS
Other antineoplastic agents
FDA EPC N0000175607 Retinoid
FDA Chemical/Ingredient N0000007700 Retinoids
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:50176 keratolytic drug
MeSH PA D000970 Antineoplastic Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Kaposi's Sarcoma Skin Lesions indication
Mycosis fungoides contraindication 118618005 DOID:8691
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.17 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Retinoic acid receptor gamma Nuclear hormone receptor AGONIST EC50 7.13 WOMBAT-PK CHEMBL
Retinoic acid receptor beta Nuclear hormone receptor AGONIST EC50 7.30 WOMBAT-PK CHEMBL
Retinoic acid receptor RXR-gamma Nuclear hormone receptor AGONIST EC50 6.66 WOMBAT-PK CHEMBL
Retinoic acid receptor RXR-beta Nuclear hormone receptor AGONIST EC50 6.70 WOMBAT-PK CHEMBL
Retinoic acid receptor RXR-alpha Nuclear hormone receptor AGONIST EC50 6.50 WOMBAT-PK CHEMBL
Retinoic acid receptor alpha Nuclear hormone receptor AGONIST EC50 6.52 WOMBAT-PK CHEMBL
Nuclear receptor ROR-gamma Nuclear hormone receptor EC50 4.85 CHEMBL
Retinoic acid receptor alpha Transcription factor Kd 8.15 CHEMBL
Retinoic acid receptor RXR-gamma Transcription factor Kd 8.40 CHEMBL
Retinoic acid receptor RXR-beta Transcription factor Kd 7.92 CHEMBL
Retinoic acid receptor gamma Transcription factor Kd 7.77 CHEMBL
Retinoic acid receptor RXR-alpha Transcription factor Kd 7.49 CHEMBL
Retinoic acid receptor RXR-alpha Unclassified EC50 6.96 CHEMBL
Retinoic acid receptor beta Transcription factor Kd 8.15 CHEMBL

External reference:

IDSource
DB00523 DRUGBANK_ID
2645 IUPHAR_LIGAND_ID
4021155 VUID
N0000148606 NUI
C0281666 UMLSCUI
D02815 KEGG_DRUG
1UA8E65KDZ UNII
7781 INN_ID
CHEMBL705 ChEMBL_ID
409488005 SNOMEDCT_US
4021155 VANDF
N0000006664 NDFRT
N0000148606 NDFRT
007747 NDDF
7957 MMSL
81864 RXNORM
116086005 SNOMEDCT_US
449171 PUBCHEM_CID
CHEBI:50648 CHEBI
C103303 MESH_SUPPLEMENTAL_RECORD_UI
9CR PDB_CHEM_ID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Panretin HUMAN PRESCRIPTION DRUG LABEL 1 62856-601 GEL 60 mg TOPICAL NDA 13 sections