dexibuprofen 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
anti-inflammatory agents, ibuprofen derivatives 3851 51146-56-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dexibuprofen
  • Molecular weight: 206.29
  • Formula: C13H18O2
  • CLOGP: 3.68
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 37.30
  • ALOGS: -3.48
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.80 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 68.66 60.42 16 224 22148 63466634

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Sopor 58.52 48.01 15 264 32995 79711114

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC M01AE14 MUSCULO-SKELETAL SYSTEM
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
Propionic acid derivatives
CHEBI has role CHEBI:35475 non-steroidal anti-inflammatory agent

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Rheumatoid arthritis indication 69896004 DOID:7148
Headache disorder indication 230461009
Dysmenorrhea indication 266599000
Fever indication 386661006
Osteoarthritis indication 396275006
Juvenile rheumatoid arthritis indication 410795001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.37 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Prostaglandin G/H synthase 2 Enzyme IC50 6.14 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 7.01 CHEMBL
Aldo-keto reductase family 1 member C2 Enzyme IC50 4.37 CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 4.49 CHEMBL
Prostaglandin G/H synthase 1 Enzyme IC50 5.83 CHEMBL
Prostaglandin G/H synthase 2 Enzyme IC50 5.82 CHEMBL

External reference:

IDSource
D03715 KEGG_DRUG
C2714681 UMLSCUI
CHEBI:43415 CHEBI
IBP PDB_CHEM_ID
CHEMBL175 ChEMBL_ID
DB09213 DRUGBANK_ID
39912 PUBCHEM_CID
C539402 MESH_SUPPLEMENTAL_RECORD_UI
6426 INN_ID
671DKG7P5S UNII
006963 NDDF
418027007 SNOMEDCT_US
418868002 SNOMEDCT_US

Pharmaceutical products:

None