bitolterol indications/contra

Stem definitionDrug idCAS RN
bronchodilators, phenethylamine derivatives 384 30392-40-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bitolterol methanesulfonate
  • tornalate
  • bitolterol mesylate
  • bitolterol
  • bitolterol mesilate
a short-acting beta2 adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and COPD
  • Molecular weight: 461.56
  • Formula: C28H31NO5
  • CLOGP: 5.59
  • LIPINSKI: 1
  • HAC: 6
  • HDO: 2
  • TPSA: 84.86
  • ALOGS: -5.98
  • ROTB: 10

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Dec. 28, 1984 FDA SANOFI AVENTIS US

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC R03AC17 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
ADRENERGICS, INHALANTS
Selective beta-2-adrenoreceptor agonists
MeSH PA D018663 Adrenergic Agents
MeSH PA D000322 Adrenergic Agonists
MeSH PA D058666 Adrenergic beta-2 Receptor Agonists
MeSH PA D000318 Adrenergic beta-Agonists
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D001337 Autonomic Agents
MeSH PA D001993 Bronchodilator Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D019141 Respiratory System Agents
CHEBI has role CHEBI:35523 bronchodilator agent
CHEBI has role CHEBI:49167 anti-asthmatic drug
CHEBI has role CHEBI:35522 beta-adrenergic agonist
CHEBI has role CHEBI:50266 prodrug

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Bronchiectasis indication 12295008 DOID:9563
Bronchitis indication 32398004 DOID:6132
Pulmonary emphysema indication 87433001
Asthma indication 195967001 DOID:2841
Asthma management indication 406162001
Acute exacerbation of asthma indication 708038006
Bronchospasm Prevention indication

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 14.0 acidic
pKa2 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-2 adrenergic receptor GPCR AGONIST CHEMBL CHEMBL

External reference:

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IDSource
4019101 VUID
N0000147359 NUI
C0106575 UMLSCUI
D00684 KEGG_DRUG
4E53T3611U UNII
30392-41-7 SECONDARY_CAS_RN
DB00901 DRUGBANK_ID
4019636 VANDF
N0000147729 NDFRT
N0000005972 NDFRT
d00754 MMSL
19499 RXNORM
387233000 SNOMEDCT_US
41985001 SNOMEDCT_US
004733 NDDF
3855 INN_ID
35330 PUBCHEM_CID
CHEMBL1200405 ChEMBL_ID
CHEMBL1201295 ChEMBL_ID
C011685 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:3133 CHEBI

Pharmaceutical products:

None