biotin indications/contra

Stem definitionDrug idCAS RN
373 58-85-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • biotin
  • coenzyme R
  • D-Biotin
A water-soluble, enzyme co-factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk.
  • Molecular weight: 244.31
  • Formula: C10H16N2O3S
  • CLOGP: -0.08
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 78.43
  • ALOGS: -2.30
  • ROTB: 5

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Product compounding quality issue 56.99 40.54 6 63 51 3385739
Laboratory test interference 47.48 40.54 6 63 272 3385518

Pharmacologic Action:

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SourceCodeDescription
ATC A11HA05 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
CHEBI has role CHEBI:75769 B vitamin
CHEBI has role CHEBI:50733 nutraceutical
MeSH PA D006133 Growth Substances
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Biotin deficiency disease indication 49607006
Constipation contraindication 14760008 DOID:2089
Sarcoidosis contraindication 31541009 DOID:13404
Dehydration contraindication 34095006
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Kidney disease contraindication 90708001 DOID:2527
Kidney stone contraindication 95570007
Osteolysis contraindication 203522001
Biotinidase deficiency off-label use 8808004 DOID:856
Propionic acidemia off-label use 69080001 DOID:14701
Holocarboxylase synthase deficiency off-label use 360369003 DOID:859

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.79 acidic
pKa2 13.37 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Insulin-degrading enzyme Enzyme EC50 5.60 CHEMBL

External reference:

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IDSource
DB00121 DRUGBANK_ID
4787 IUPHAR_LIGAND_ID
4017638 VUID
N0000146018 NUI
C0005575 UMLSCUI
D00029 KEGG_DRUG
6SO6U10H04 UNII
1203 INN_ID
CHEMBL857 ChEMBL_ID
171548 PUBCHEM_CID
4017638 VANDF
118935 MMSL
11819 MMSL
d06867 MMSL
13813003 SNOMEDCT_US
N0000005852 NDFRT
N0000146018 NDFRT
001035 NDDF
1588 RXNORM
8919000 SNOMEDCT_US
CHEBI:15956 CHEBI
D001710 MESH_DESCRIPTOR_UI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
PreferaOB plus DHA HUMAN PRESCRIPTION DRUG LABEL 12 0037-0083 KIT 30 ug ORAL Unapproved drug other 13 sections
PreferaOB HUMAN PRESCRIPTION DRUG LABEL 12 0037-0084 TABLET, COATED 30 ug ORAL Unapproved drug other 12 sections
PreferaOB ONE HUMAN PRESCRIPTION DRUG LABEL 11 0037-0086 CAPSULE, LIQUID FILLED 30 ug ORAL Unapproved drug other 13 sections
Strovite Forte HUMAN PRESCRIPTION DRUG LABEL 11 0642-0204 TABLET, COATED 0.15 mg ORAL UNAPPROVED DRUG OTHER 11 sections
Strovite One HUMAN PRESCRIPTION DRUG LABEL 16 0642-0207 TABLET 100 ug ORAL UNAPPROVED DRUG OTHER 10 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 15 0682-3001 TABLET, COATED 150 ug ORAL UNAPPROVED DRUG OTHER 9 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 10 10542-009 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 8 10542-010 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 9 10542-011 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 8 10542-012 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 9 10542-014 TABLET, COATED 300 ug ORAL Unapproved drug other 7 sections
TL-HEM 150 HUMAN PRESCRIPTION DRUG LABEL 8 13811-606 TABLET, FILM COATED 150 ug ORAL Unapproved drug other 11 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 12 15370-102 LIQUID 3 ug ORAL UNAPPROVED DRUG OTHER 8 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 8 17856-0010 TABLET, COATED 300 ug ORAL Unapproved drug other 8 sections
PNV-Select HUMAN PRESCRIPTION DRUG LABEL 18 42192-320 TABLET, FILM COATED 300 ug ORAL UNAPPROVED DRUG OTHER 10 sections
PNV-Omega HUMAN PRESCRIPTION DRUG LABEL 13 42192-332 CAPSULE, GELATIN COATED 250 ug ORAL unapproved drug other 9 sections
HairQ-Plus HUMAN OTC DRUG LABEL 1 49658-2001 SHAMPOO 0.06 mL TOPICAL unapproved drug other 7 sections
HairQ-Plus HUMAN OTC DRUG LABEL 1 49658-4001 SOLUTION 0.06 mL TOPICAL unapproved drug other 7 sections
Bonogen HUMAN OTC DRUG LABEL 3 50653-1001 SHAMPOO 0.06 g TOPICAL unapproved drug other 1 sections
Bonogen Plus HUMAN OTC DRUG LABEL 3 50653-2001 SHAMPOO 0.06 g TOPICAL unapproved drug other 1 sections
Bonogen Activator HUMAN OTC DRUG LABEL 1 50653-3001 LIQUID 0.00 mL TOPICAL unapproved drug other 1 sections
Born Hair HUMAN OTC DRUG LABEL 3 50653-4001 SHAMPOO 0.06 g TOPICAL unapproved drug other 7 sections
IROSPAN 24/6 HUMAN PRESCRIPTION DRUG LABEL 21 50967-126 KIT 300 ug None unapproved drug other 9 sections
IROSPAN 24/6 HUMAN PRESCRIPTION DRUG LABEL 21 50967-126 KIT 300 ug None unapproved drug other 9 sections
Doll Lash HUMAN OTC DRUG LABEL 3 51329-1001 LIQUID 0.06 mL TOPICAL unapproved drug other 7 sections
Prenatal Mega Antioxidant HUMAN OTC DRUG LABEL 11 51861-103 TABLET 75 ug ORAL UNAPPROVED DRUG OTHER 8 sections
Divista HUMAN PRESCRIPTION DRUG LABEL 5 52747-110 CAPSULE 2 mg ORAL unapproved drug other 2 sections
Concept OB HUMAN PRESCRIPTION DRUG LABEL 15 52747-620 CAPSULE 300 ug ORAL unapproved drug other 1 sections
Concept DHA HUMAN PRESCRIPTION DRUG LABEL 14 52747-621 CAPSULE, LIQUID FILLED 300 ug ORAL unapproved drug other 1 sections
Integra Plus HUMAN PRESCRIPTION DRUG LABEL 9 52747-712 CAPSULE 300 ug ORAL unapproved drug other 2 sections