bifonazole indications/contra

Stem definitionDrug idCAS RN
systemic antifungal agents, miconazole derivatives 370 60628-96-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bifonazole
  • (+/-)-Bifonazole
  • bifazol
  • trifonazole
  • Molecular weight: 310.40
  • Formula: C22H18N2
  • CLOGP: 4.74
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 0
  • TPSA: 17.82
  • ALOGS: -5.10
  • ROTB: 4

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC D01AC10 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Imidazole and triazole derivatives
ATC D01AC60 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Imidazole and triazole derivatives
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.84 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Lanosterol 14-alpha demethylase Enzyme IC50 6.47 CHEMBL
Steroid 17-alpha-hydroxylase/17,20 lyase Enzyme Ki 7.25 CHEMBL
Indoleamine 2,3-dioxygenase 1 Enzyme IC50 4.64 CHEMBL

External reference:

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IDSource
C0053570 UMLSCUI
D01775 KEGG_DRUG
CHEMBL277535 ChEMBL_ID
19295 RXNORM
136216003 SNOMEDCT_US
396036005 SNOMEDCT_US
004316 NDDF
2378 PUBCHEM_CID
C036596 MESH_SUPPLEMENTAL_RECORD_UI
DB04794 DRUGBANK_ID
QYJ305Z91O UNII
4887 INN_ID
CHEBI:31286 CHEBI
TMI PDB_CHEM_ID

Pharmaceutical products:

None