bifemelane indications/contra

Stem definitionDrug idCAS RN
369 90293-01-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bifemelane
  • 4-(o-Benzylphenoxy)-N-methylbutylamine
  • bifemelane hydrochloride
  • bifemelane HCl
  • Molecular weight: 269.39
  • Formula: C18H23NO
  • CLOGP: 3.97
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 1
  • TPSA: 21.26
  • ALOGS: -5.22
  • ROTB: 8

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC N06AX08 NERVOUS SYSTEM
PSYCHOANALEPTICS
ANTIDEPRESSANTS
Other antidepressants
MeSH PA D000928 Antidepressive Agents
MeSH PA D002491 Central Nervous System Agents
MeSH PA D011619 Psychotropic Drugs

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Cerebrovascular disease indication 62914000 DOID:6713

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.48 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Lethal(3)malignant brain tumor-like protein 1 Unclassified IC50 4.04 CHEMBL

External reference:

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IDSource
C0106291 UMLSCUI
D01793 KEGG_DRUG
2N52S01UFY UNII
62232-46-6 SECONDARY_CAS_RN
2377 PUBCHEM_CID
47111 RXNORM
006415 NDDF
CHEBI:31285 CHEBI
CHEMBL1192517 ChEMBL_ID
C031906 MESH_SUPPLEMENTAL_RECORD_UI
5902 INN_ID

Pharmaceutical products:

None