biapenem indications/contra

Stem definitionDrug idCAS RN
analogues of penicillanic acid antibiotics modified in the five-membered ring 365 120410-24-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • biapenem
  • omegacin
  • biapenern
  • CL-186815
  • L-627
  • LJC-10627
  • Molecular weight: 350.39
  • Formula: C15H18N4O4S
  • CLOGP: -8.73
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 1
  • TPSA: 102.37
  • ALOGS: -2.17
  • ROTB: 4

Drug dosage:

DoseUnitRoute
1.20 g P

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 2002 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC J01DH05 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
OTHER BETA-LACTAM ANTIBACTERIALS
Carbapenems
CHEBI has role CHEBI:36047 antibacterial drug
MeSH PA D000890 Anti-Infective Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.26 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Penicillin-binding protein 2 Enzyme WOMBAT-PK
Penicillin-binding protein 4 Enzyme WOMBAT-PK
D-ala-D-ala-carboxypeptidase; D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase family protein; Penicillin-binding protein 5 Enzyme WOMBAT-PK
Penicillin-binding protein 1 Enzyme WOMBAT-PK
D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase penicillin-binding protein 6 Enzyme WOMBAT-PK

External reference:

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IDSource
D01057 KEGG_DRUG
CHEMBL285347 ChEMBL_ID
725572002 SNOMEDCT_US
71339 PUBCHEM_CID
C065257 MESH_SUPPLEMENTAL_RECORD_UI
DB13028 DRUGBANK_ID
YR5U3L9ZH1 UNII
7074 INN_ID
CHEBI:3089 CHEBI

Pharmaceutical products:

None