vinflunine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
vinca alkaloids	3644	162652-95-1

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

vinflunine
javlor
vinflunine ditartrate

inhibits tubulin assembly

Molecular weight: 816.94
Formula: C45H54F2N4O8
CLOGP: 4.75
LIPINSKI: 3
HAC: 12
HDO: 2
TPSA: 133.87
ALOGS: -5.16
ROTB: 10

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	L01CA05	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ANTINEOPLASTIC AGENTS PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS Vinca alkaloids and analogues
CHEBI has role	CHEBI:35610	antineoplastic agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Transitional cell carcinoma	indication	27090000	DOID:2671

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	11.32	acidic
pKa2	13.35	acidic
pKa3	7.39	Basic
pKa4	6.11	Basic
pKa5	5.01	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Tubulin beta	Tumour-associated antigen	P07437 Q9H4B7 Q13885 Q9BVA1 Q13509 P04350 P68371 Q9BUF5 Q3ZCM7	TBB5_HUMAN TBB1_HUMAN TBB2A_HUMAN TBB2B_HUMAN TBB3_HUMAN TBB4A_HUMAN TBB4B_HUMAN TBB6_HUMAN TBB8_HUMAN	INHIBITOR				SCIENTIFIC LITERATURE	SCIENTIFIC LITERATURE

External reference:

ID	Source
D09032	KEGG_DRUG
194468-36-5	SECONDARY_CAS_RN
C0672663	UMLSCUI
CHEBI:90241	CHEBI
CHEMBL2110725	ChEMBL_ID
CHEMBL2105629	ChEMBL_ID
DB11641	DRUGBANK_ID
C111217	MESH_SUPPLEMENTAL_RECORD_UI
7499	INN_ID
5BF646324K	UNII
10629256	PUBCHEM_CID
013377	NDDF
013378	NDDF
698843001	SNOMEDCT_US

Pharmaceutical products:

None