vinflunine indications/contra

Stem definitionDrug idCAS RN
vinca alkaloids 3644 162652-95-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vinflunine
  • javlor
  • vinflunine ditartrate
inhibits tubulin assembly
  • Molecular weight: 816.94
  • Formula: C45H54F2N4O8
  • CLOGP: 5.37
  • LIPINSKI: 3
  • HAC: 12
  • HDO: 2
  • TPSA: 133.87
  • ALOGS: -5.16
  • ROTB: 10

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Constipation 83.99 43.88 20 72 30792 3354975
Neutropenia 72.05 43.88 18 74 33368 3352399
Abdominal pain 47.69 43.88 14 78 46211 3339556

Pharmacologic Action:

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SourceCodeDescription
ATC L01CA05 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Vinca alkaloids and analogues
CHEBI has role CHEBI:35610 antineoplastic agent

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Transitional cell carcinoma indication 27090000 DOID:2671

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.32 acidic
pKa2 13.35 acidic
pKa3 7.39 Basic
pKa4 6.11 Basic
pKa5 5.01 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Tubulin beta Structural INHIBITOR SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

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IDSource
D09032 KEGG_DRUG
33MG53C7XW UNII
194468-36-5 SECONDARY_CAS_RN
7499 INN_ID
013377 NDDF
698843001 SNOMEDCT_US
C111217 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2110725 ChEMBL_ID
CHEMBL2218881 ChEMBL_ID
6918295 PUBCHEM_CID
DB11641 DRUGBANK_ID
CHEBI:90241 CHEBI

Pharmaceutical products:

None