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triclocarban 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3630 | 101-20-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
bacteriostat; antiseptic in soaps & other cleansing solns; germicide; structure
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | 5.040 | High | 0.85 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 1.531 | High | 0.85 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 4.457 | 10^-6 cm/s | High | 0.85 |
| dh-clint | Dog hepatocyte intrinsic clearance | 5.248 | uL/min/10^6 cells | High | 0.85 |
| dppb | Dog plasma protein binding (% unbound) | 0.100 | % | High | 0.85 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 0.120 | % | High | 0.85 |
| herg | hERG pIC50 | 4.882 | pIC50 | High | 0.85 |
| hh-clint | Human hepatocyte intrinsic clearance | 13.092 | uL/min/10^6 cells | High | 0.85 |
| hlm-clint | Human liver microsomal intrinsic clearance | 4.550 | uL/min/mg protein | High | 0.85 |
| hppb | Human plasma protein binding (% unbound) | 0.350 | % | High | 0.85 |
| kinase-safety-class | ACVR2A,ACVR2B,AKT3,ALK,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK1,CDK19,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EIF2AK3,EPHA2,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,MAP3K1,MAP3K21,MAP3K7,MAP4K1,MAP4K3,MAPK10,MAPK11,MAPK12,MAPK7,MAPK9,MARK4,MELK,MET,MTOR,NTRK2,PDK2,PDK4,PDPK1,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 | 59 | |||
| kinase-selectivity-class | ACVR2B,AURKA,AXL,BRAF,DDR1,DYRK1B,EIF2AK3,ERBB2,GRK2,MAP3K21,MAPK7,PDK4,PIK3CB,SIK2,STK33,TTK | 16 | |||
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 3.873 | High | 0.85 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 33.343 | High | 0.85 | |
| mppb | Mouse plasma protein binding (% unbound) | 0.090 | High | 0.85 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.301 | High | 0.85 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 0.150 | % | High | 0.85 |
| rh-clint | Rat hepatocyte intrinsic clearance | 16.482 | uL/min/10^6 cells | High | 0.85 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 0.280 | % | High | 0.85 |
| rppb | Rat plasma protein binding (% unbound) | 0.130 | % | High | 0.85 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 0.521 | uM | High | 0.85 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000891 | Anti-Infective Agents, Local |
| MeSH PA | D004785 | Environmental Pollutants |
| MeSH PA | D014874 | Water Pollutants, Chemical |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:48218 | antiseptic drug |
| CHEBI has role | CHEBI:48219 | disinfectant |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.93 | acidic |
| pKa2 | 12.5 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Bifunctional epoxide hydrolase 2 | Enzyme | IC50 | 7.89 | CHEMBL | |||||
| Epoxide hydrolase 1 | Enzyme | IC50 | 6.92 | CHEMBL | |||||
| Epoxide hydrolase; Epoxide hydrolase EphB | Enzyme | IC50 | 6.66 | CHEMBL | |||||
| Epoxide hydrolase 1 | Enzyme | IC50 | 6.44 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D06223 | KEGG_DRUG |
| C0077072 | UMLSCUI |
| CHEBI:48347 | CHEBI |
| 9EG | PDB_CHEM_ID |
| CHEMBL1076347 | ChEMBL_ID |
| DB11155 | DRUGBANK_ID |
| C009540 | MESH_SUPPLEMENTAL_RECORD_UI |
| 7547 | PUBCHEM_CID |
| 2017 | INN_ID |
| BGG1Y1ED0Y | UNII |
| 38609 | RXNORM |
| 003183 | NDDF |
| 23701001 | SNOMEDCT_US |
| 411346009 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Dial Gold BarAntibacterial Deodorant Soap | HUMAN OTC DRUG LABEL | 1 | 10889-100 | SOAP | 0.60 1 | CUTANEOUS | OTC monograph not final | 8 sections |
| DG BodyAntibacterial Deodorant 3.5 oz bar | HUMAN OTC DRUG LABEL | 1 | 10889-301 | SOAP | 0.60 1 | CUTANEOUS | OTC monograph not final | 7 sections |
| Rite Aid Renewal Gold Deodorant | HUMAN OTC DRUG LABEL | 1 | 11822-8453 | SOAP | 0.30 g | TOPICAL | OTC monograph not final | 10 sections |
| Luckyantibacterial deodorant | HUMAN OTC DRUG LABEL | 1 | 20276-048 | SOAP | 0.30 g | TOPICAL | OTC monograph not final | 10 sections |
| Personal Care Antibacterial | HUMAN OTC DRUG LABEL | 1 | 29500-9208 | SOAP | 0.67 g | TOPICAL | OTC monograph not final | 11 sections |
| Image Essentials Gold | HUMAN OTC DRUG LABEL | 1 | 49738-731 | SOAP | 0.30 g | TOPICAL | OTC monograph not final | 8 sections |
| Dial antibacterial | HUMAN OTC DRUG LABEL | 1 | 51815-300 | SOAP | 0.34 g | TOPICAL | OTC monograph not final | 7 sections |
| DialWhite | HUMAN OTC DRUG LABEL | 1 | 51815-301 | SOAP | 113 g | TOPICAL | OTC monograph not final | 8 sections |
| Dial Aloe Aloe | HUMAN OTC DRUG LABEL | 1 | 51815-302 | SOAP | 1.02 g | TOPICAL | OTC monograph not final | 8 sections |
| Dial Odor ArmorOdor Armor | HUMAN OTC DRUG LABEL | 1 | 51815-303 | SOAP | 1.02 g | TOPICAL | OTC monograph not final | 9 sections |
| Antibacterial Golden Burst | HUMAN OTC DRUG LABEL | 1 | 52862-120 | SOAP | 0.30 g | TOPICAL | OTC monograph not final | 11 sections |
| Antibacterial Ocean Fresh | HUMAN OTC DRUG LABEL | 1 | 52862-130 | SOAP | 0.30 g | TOPICAL | OTC monograph not final | 11 sections |
| DEODORANT | HUMAN OTC DRUG LABEL | 1 | 53507-001 | SOAP | 0.29 g | TOPICAL | OTC monograph not final | 7 sections |
| MegaFresh Antibacterial Deodorant | HUMAN OTC DRUG LABEL | 1 | 54157-101 | SOAP | 0.30 g | TOPICAL | OTC monograph not final | 8 sections |
| Dollar General Gold | HUMAN OTC DRUG LABEL | 1 | 55910-301 | SOAP | 0.60 g | TOPICAL | OTC monograph not final | 9 sections |
| Coralite Ultra Antibacterial Deodorant | HUMAN OTC DRUG LABEL | 1 | 65923-807 | SOAP | 0.30 g | TOPICAL | OTC monograph not final | 10 sections |
| Antibacterial Gold | HUMAN OTC DRUG LABEL | 1 | 67510-0016 | SOAP | 0.10 g | TOPICAL | OTC monograph not final | 8 sections |
| Antibacterial Beauty | HUMAN OTC DRUG LABEL | 1 | 67510-0017 | SOAP | 0.10 g | TOPICAL | OTC monograph not final | 8 sections |
| 1st Date antibacterial Deodorant (White) | HUMAN OTC DRUG LABEL | 1 | 70012-101 | SOAP | 0.30 g | TOPICAL | OTC monograph not final | 10 sections |
| 1st Date antibacterial Deodorant (Gold) | HUMAN OTC DRUG LABEL | 1 | 70012-102 | SOAP | 0.30 g | TOPICAL | OTC monograph not final | 10 sections |
| 1st Date antibacterial Deodorant (Green) | HUMAN OTC DRUG LABEL | 1 | 70012-103 | SOAP | 0.30 g | TOPICAL | OTC monograph not final | 10 sections |