tolnaftate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3617 2398-96-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tolnaftate
  • tolnaphthate
  • tolsanil
  • tonoftal
A synthetic antifungal agent.
  • Molecular weight: 307.41
  • Formula: C19H17NOS
  • CLOGP: 5.34
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 12.47
  • ALOGS: -5.75
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood uric acid decreased 36.06 30.33 6 427 795 63487794
Hypertrophy 32.11 30.33 5 428 436 63488153

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Blood uric acid decreased 32.74 30.97 6 581 1282 79742519
Blood creatinine decreased 31.58 30.97 8 579 7817 79735984

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D01AE18 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use
CHEBI has role CHEBI:86327 pharmaceutical fungicide
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tinea capitis indication 5441008
Tinea pedis indication 6020002 DOID:12403
Tinea manus indication 48971001 DOID:13369
Pityriasis versicolor indication 56454009 DOID:9060
Tinea corporis indication 84849002
Tinea cruris indication 399029005
Tinea barbae indication 399329002




🐶 Veterinary Drug Use

SpeciesUseRelation
Cats Treatment of ringworm lesions caused by Microsporum canis Indication
Cats Treatment of ringworm lesions caused by Microsporum gypseum Indication
Dogs Treatment of ringworm lesions caused by Microsporum canis Indication
Dogs Treatment of ringworm lesions caused by Microsporum gypseum Indication

🐶 Veterinary products

ProductApplicantIngredients
Tinavet Cream 1% Intervet Inc. 1

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2B GPCR Ki 5.89 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 5.52 DRUG MATRIX
Lanosterol 14-alpha demethylase Enzyme IC50 4.30 CHEMBL

External reference:

IDSource
4019415 VUID
N0000147552 NUI
D00381 KEGG_DRUG
4019415 VANDF
C0040379 UMLSCUI
CHEBI:9620 CHEBI
CHEMBL83668 ChEMBL_ID
DB00525 DRUGBANK_ID
D014047 MESH_DESCRIPTOR_UI
5510 PUBCHEM_CID
1730 INN_ID
06KB629TKV UNII
10637 RXNORM
4874 MMSL
5599 MMSL
002904 NDDF
38166006 SNOMEDCT_US
387204001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
good sense athletes foot HUMAN OTC DRUG LABEL 1 0113-0154 SPRAY 1 g TOPICAL OTC monograph final 13 sections
Kaiser PermanenteTolnaftate HUMAN OTC DRUG LABEL 1 0179-8019 CREAM 10 mg TOPICAL OTC monograph final 14 sections
HC Max Anti Fungal HUMAN OTC DRUG LABEL 1 0295-6629 OINTMENT 1 g TOPICAL OTC monograph final 11 sections
Fungi Nail Toe and Foot HUMAN OTC DRUG LABEL 1 0295-8604 OINTMENT 1 g TOPICAL OTC monograph final 12 sections
Fungi Nail Toe and Foot HUMAN OTC DRUG LABEL 1 0295-8604 OINTMENT 1 g TOPICAL OTC monograph final 12 sections
Maximum Strength Anti Fungal Tolnaftate 1% HUMAN OTC DRUG LABEL 1 0295-9017 LIQUID 1 g TOPICAL OTC monograph final 11 sections
Maximum Strength Anti Fungal Tolnaftate 1% HUMAN OTC DRUG LABEL 1 0295-9017 LIQUID 1 g TOPICAL OTC monograph final 11 sections
Maximum Strength Anti Fungal Tolnaftate 1% HUMAN OTC DRUG LABEL 1 0295-9017 LIQUID 1 g TOPICAL OTC monograph final 11 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 0363-0154 SPRAY 1 g TOPICAL OTC monograph final 13 sections
Walgreens Athletes Foot HUMAN OTC DRUG LABEL 1 0363-0155 AEROSOL, SPRAY 1 g TOPICAL OTC monograph final 13 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-0186 LIQUID 0.30 g TOPICAL OTC monograph final 13 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-0186 LIQUID 0.30 g TOPICAL OTC monograph final 13 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-0216 AEROSOL, SPRAY 1.30 g TOPICAL OTC monograph final 14 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-0216 AEROSOL, SPRAY 1.30 g TOPICAL OTC monograph final 14 sections
jock itch HUMAN OTC DRUG LABEL 1 0363-0695 SPRAY 1 g TOPICAL OTC monograph final 13 sections
athletes footmedicated antifungal HUMAN OTC DRUG LABEL 1 0363-0891 SPRAY 1 g TOPICAL OTC monograph final 13 sections
athletes footmedicated antifungal HUMAN OTC DRUG LABEL 1 0363-0891 SPRAY 1 g TOPICAL OTC monograph final 13 sections
WALGREENS TOLNAFTATE HUMAN OTC DRUG LABEL 1 0363-1298 CREAM 10 mg TOPICAL OTC monograph final 14 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-1746 SPRAY 1.30 g TOPICAL OTC monograph final 12 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-1746 SPRAY 1.30 g TOPICAL OTC monograph final 12 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-8042 SPRAY 1.50 g TOPICAL OTC monograph final 13 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-8042 SPRAY 1.50 g TOPICAL OTC monograph final 13 sections
CR-371059 Tolnaftate 1% Cream HUMAN OTC DRUG LABEL 1 0536-1315 CREAM 1 g TOPICAL OTC monograph final 12 sections
CR-371059 Tolnaftate 1% Cream HUMAN OTC DRUG LABEL 1 0536-1315 CREAM 1 g TOPICAL OTC monograph final 12 sections
Rugby Tolnaftate 1% Powder HUMAN OTC DRUG LABEL 1 0536-1329 POWDER 1 g TOPICAL OTC monograph final 13 sections
Rugby Tolnaftate 1% Powder HUMAN OTC DRUG LABEL 1 0536-1329 POWDER 1 g TOPICAL OTC monograph final 13 sections
Anti-Fungal HUMAN OTC DRUG LABEL 1 0536-5150 POWDER 1 g TOPICAL OTC monograph final 10 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0904-0722 CREAM 10 mg TOPICAL OTC monograph final 13 sections
TOLNAFTATE ANTIFUNGAL HUMAN OTC DRUG LABEL 1 0904-0726 POWDER 1 g TOPICAL OTC monograph final 10 sections
Foot Works HealthyAntifungal HUMAN OTC DRUG LABEL 1 10096-0272 SPRAY 10 mg TOPICAL OTC monograph final 13 sections