tolnaftate indications/contra

Stem definitionDrug idCAS RN
3617 2398-96-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tolnaftate
  • tolnaphthate
  • tolsanil
  • tonoftal
A synthetic antifungal agent.
  • Molecular weight: 307.41
  • Formula: C19H17NOS
  • CLOGP: 5.34
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 0
  • TPSA: 12.47
  • ALOGS: -5.75
  • ROTB: 3

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC D01AE18 DERMATOLOGICALS
ANTIFUNGALS FOR DERMATOLOGICAL USE
ANTIFUNGALS FOR TOPICAL USE
Other antifungals for topical use
CHEBI has role CHEBI:86327 antifungal drug
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000935 Antifungal Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Tinea capitis indication 5441008
Tinea pedis indication 6020002 DOID:12403
Tinea manus indication 48971001 DOID:13369
Pityriasis versicolor indication 56454009 DOID:9060
Tinea corporis indication 84849002 DOID:12179
Tinea cruris indication 399029005
Tinea barbae indication 399329002

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 2B GPCR Ki 5.89 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 5.52 DRUG MATRIX
Lanosterol 14-alpha demethylase Enzyme IC50 4.30 CHEMBL

External reference:

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IDSource
DB00525 DRUGBANK_ID
4019415 VUID
N0000147552 NUI
C0040379 UMLSCUI
D00381 KEGG_DRUG
06KB629TKV UNII
1730 INN_ID
4019415 VANDF
N0000005933 NDFRT
N0000147552 NDFRT
4874 MMSL
10637 RXNORM
38166006 SNOMEDCT_US
387204001 SNOMEDCT_US
5599 MMSL
002904 NDDF
CHEMBL83668 ChEMBL_ID
5510 PUBCHEM_CID
CHEBI:9620 CHEBI
D014047 MESH_DESCRIPTOR_UI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
LAMISL AF HUMAN OTC DRUG LABEL 1 0067-6114 AEROSOL, SPRAY 10 mg TOPICAL OTC monograph final 14 sections
LAMISL AF HUMAN OTC DRUG LABEL 1 0067-6266 CREAM 10 mg TOPICAL OTC monograph final 13 sections
good sense athletes foot HUMAN OTC DRUG LABEL 1 0113-0154 SPRAY 1 g TOPICAL OTC monograph final 9 sections
good sense jock itch HUMAN OTC DRUG LABEL 1 0113-0695 SPRAY 1 g TOPICAL OTC monograph final 9 sections
Kaiser Permanente HUMAN OTC DRUG LABEL 1 0179-8019 CREAM 10 mg TOPICAL OTC MONOGRAPH FINAL 10 sections
Athletes Foot HUMAN OTC DRUG LABEL 1 0363-0154 SPRAY 1 g TOPICAL OTC monograph final 9 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-0216 AEROSOL, SPRAY 1.30 g TOPICAL OTC monograph final 9 sections
jock itch HUMAN OTC DRUG LABEL 1 0363-0695 SPRAY 1 g TOPICAL OTC monograph final 9 sections
WALGREENS TOLNAFTATE HUMAN OTC DRUG LABEL 1 0363-1298 CREAM 10 mg TOPICAL OTC monograph final 11 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0363-8042 SPRAY 1.50 g TOPICAL OTC monograph final 9 sections
Anti-Fungal HUMAN OTC DRUG LABEL 1 0536-5150 POWDER 1 g TOPICAL OTC monograph final 10 sections
Fungoid-D HUMAN OTC DRUG LABEL 1 0884-8211 CREAM 1 g TOPICAL OTC MONOGRAPH FINAL 10 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 0904-0722 CREAM 10 mg TOPICAL OTC monograph final 9 sections
TOLNAFTATE ANTIFUNGAL HUMAN OTC DRUG LABEL 1 0904-0726 POWDER 1 g TOPICAL OTC monograph final 10 sections
Foot Works Healthy HUMAN OTC DRUG LABEL 1 10096-0272 SPRAY 10 mg TOPICAL OTC monograph final 6 sections
Foot Works Healthy HUMAN OTC DRUG LABEL 1 10096-0303 POWDER 10 mg TOPICAL OTC monograph final 6 sections
Blistex HUMAN OTC DRUG LABEL 1 10157-4645 SPRAY 1 g TOPICAL OTC MONOGRAPH FINAL 8 sections
Odor Eaters Foot and Sneaker HUMAN OTC DRUG LABEL 1 11509-0411 SPRAY 10 mg TOPICAL OTC MONOGRAPH FINAL 8 sections
Tinactin HUMAN OTC DRUG LABEL 1 11523-0072 AEROSOL, POWDER 10 mg TOPICAL OTC monograph final 10 sections
Tinactin HUMAN OTC DRUG LABEL 1 11523-0165 AEROSOL, SPRAY 10 mg TOPICAL OTC monograph final 10 sections
Tinactin HUMAN OTC DRUG LABEL 1 11523-0777 AEROSOL, POWDER 10 mg TOPICAL OTC monograph final 10 sections
Tinactin HUMAN OTC DRUG LABEL 1 11523-0934 CREAM 10 mg TOPICAL OTC monograph final 10 sections
Tinactin HUMAN OTC DRUG LABEL 1 11523-1190 CREAM 10 mg TOPICAL OTC monograph final 10 sections
Tinactin HUMAN OTC DRUG LABEL 1 11523-4162 AEROSOL, POWDER 10 mg TOPICAL OTC monograph final 10 sections
Dr. Scholls HUMAN OTC DRUG LABEL 1 11523-4336 AEROSOL, POWDER 10 mg TOPICAL OTC monograph final 10 sections
Tinactin HUMAN OTC DRUG LABEL 1 11523-4362 POWDER 10 mg TOPICAL OTC monograph final 12 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 11527-051 CREAM 10 mg TOPICAL OTC monograph final 10 sections
up and up antifungal HUMAN OTC DRUG LABEL 1 11673-154 SPRAY 1 g TOPICAL OTC monograph final 9 sections
Tolnaftate HUMAN OTC DRUG LABEL 1 11673-586 AEROSOL, POWDER 1.10 g TOPICAL OTC monograph final 9 sections
Target HUMAN OTC DRUG LABEL 1 11673-912 CREAM 10 mg TOPICAL OTC MONOGRAPH FINAL 10 sections