toliprolol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 3616 2933-94-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • toliprolol
  • racemic toliprolol
  • doberol
  • KO-592
was MH 1975-92 (see under PROPANOLAMINES 1981-90, was DOBEROL see under PROPANOLAMINES 1975-80); KOE 592 was see TOLIPROLOL 1975-92; use PROPANOLAMINES to search TOLIPROLOL 1975-92; beta adrenergic blockader with some stimulant action; it has been proposed for angina pectoris
  • Molecular weight: 223.32
  • Formula: C13H21NO2
  • CLOGP: 2.08
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 41.49
  • ALOGS: -1.96
  • ROTB: 6

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 90 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.19 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR Kd 9.42 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 8.92 CHEMBL
Beta-2 adrenergic receptor GPCR Kd 7.36 CHEMBL
Beta-1 adrenergic receptor GPCR Kd 8.75 CHEMBL

External reference:

IDSource
C0033442 UMLSCUI
CHEBI:134918 CHEBI
CHEMBL251484 ChEMBL_ID
CHEMBL252319 ChEMBL_ID
CHEMBL67096 ChEMBL_ID
18047 PUBCHEM_CID
C073327 MESH_SUPPLEMENTAL_RECORD_UI
3318 INN_ID
DCP58J201D UNII

Pharmaceutical products:

None