tiratricol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 3611 | 51-24-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Acute coronary syndrome | 28.16 | 28.16 | 4 | 3 | 21129 | 79723252 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D11AX08 | DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals |
| ATC | H03AA04 | SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS THYROID THERAPY THYROID PREPARATIONS Thyroid hormones |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 3.95 | acidic |
| pKa2 | 8.29 | acidic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Thyroid hormone receptor alpha | Nuclear hormone receptor | IC50 | 9.85 | CHEMBL | |||||
| Thyroid hormone receptor beta | Nuclear hormone receptor | IC50 | 10.39 | CHEMBL | |||||
| Androgen receptor | Nuclear hormone receptor | IC50 | 4.46 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | Kd | 6.70 | CHEMBL | |||||
| Retinoic acid receptor RXR-alpha | Nuclear hormone receptor | Kd | 5.88 | CHEMBL | |||||
| Proliferating cell nuclear antigen | Nuclear other | IC50 | 4.60 | CHEMBL | |||||
| Sodium/bile acid cotransporter | Transporter | IC50 | 5.16 | CHEMBL | |||||
| Thyroid hormone receptor beta | Transcription factor | IC50 | 9.82 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D07214 | KEGG_DRUG |
| C0046882 | UMLSCUI |
| CHEMBL41632 | ChEMBL_ID |
| DB03604 | DRUGBANK_ID |
| C010642 | MESH_SUPPLEMENTAL_RECORD_UI |
| 2637 | IUPHAR_LIGAND_ID |
| 4368 | INN_ID |
| 29OQ9EU4R1 | UNII |
| 5803 | PUBCHEM_CID |
| 13982 | RXNORM |
| 005357 | NDDF |
| 3066001 | SNOMEDCT_US |
| 703716002 | SNOMEDCT_US |
| 4HY | PDB_CHEM_ID |
Pharmaceutical products:
None