tioxolone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
prednisone and prednisolone derivatives	3607	4991-65-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

acnosan
camyna
thidoxol
thioxolon
thioxolone
tioxolon
tioxolone

antiseborrheic agent

Molecular weight: 168.17
Formula: C7H4O3S
CLOGP: 1.26
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 46.53
ALOGS: -1.66
ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	D10AB03	DERMATOLOGICALS ANTI-ACNE PREPARATIONS ANTI-ACNE PREPARATIONS FOR TOPICAL USE Preparations containing sulfur
CHEBI has role	CHEBI:59010	antiseborrheics

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	10.02	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Carbonic anhydrase 2	Enzyme	P00918	CAH2_HUMAN		IC50	5.75		CHEMBL
Amine oxidase [flavin-containing] B	Enzyme	P27338	AOFB_HUMAN		IC50	5.02		CHEMBL
Amine oxidase [flavin-containing] A	Enzyme	P21397	AOFA_HUMAN		IC50	5.01		CHEMBL

External reference:

ID	Source
D07211	KEGG_DRUG
C2699951	UMLSCUI
CHEBI:568021	CHEBI
CHEMBL442687	ChEMBL_ID
DB13343	DRUGBANK_ID
72139	PUBCHEM_CID
2002	INN_ID
C009474	MESH_SUPPLEMENTAL_RECORD_UI
S0FAJ1R9CD	UNII
2059173	RXNORM
007419	NDDF
VUO	PDB_CHEM_ID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Anubis Barcelona Regul Oil	HUMAN OTC DRUG LABEL	31	83021-300	CREAM	0.30 g	TOPICAL	OTC monograph final	9 sections
Anubis Barcelona Regul Oil	HUMAN OTC DRUG LABEL	31	83021-300	CREAM	0.30 g	TOPICAL	OTC monograph final	9 sections
Anubis Barcelona	HUMAN OTC DRUG LABEL	27	83021-617	CONCENTRATE	0.01 g	TOPICAL	OTC monograph final	9 sections
Anubis Barcelona	HUMAN OTC DRUG LABEL	27	83021-617	CONCENTRATE	0.01 g	TOPICAL	OTC monograph final	9 sections
Anubis Barcelona Regul OIl	HUMAN OTC DRUG LABEL	27	83021-624	CONCENTRATE	0.02 g	TOPICAL	OTC monograph final	9 sections
Anubis Barcelona Regul OIl	HUMAN OTC DRUG LABEL	27	83021-624	CONCENTRATE	0.02 g	TOPICAL	OTC monograph final	9 sections
Anubis Barcelona Regul Oil	HUMAN OTC DRUG LABEL	17	83021-740	LOTION	0.25 g	TOPICAL	OTC monograph final	9 sections
Anubis Barcelona Regul Oil	HUMAN OTC DRUG LABEL	17	83021-740	LOTION	0.25 g	TOPICAL	OTC monograph final	9 sections
Anubis Barcelona Regul Oil	HUMAN OTC DRUG LABEL	38	83021-742	CREAM	0.30 g	TOPICAL	OTC monograph final	9 sections
Anubis Barcelona Regul Oil	HUMAN OTC DRUG LABEL	38	83021-742	CREAM	0.30 g	TOPICAL	OTC monograph final	9 sections