bevantolol indications/contra

Stem definitionDrug idCAS RN
beta-adrenoreceptor antagonists 360 59170-23-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • calvan
  • CI 775
  • bevantolol
  • bevantolol hydrochloride
  • bevantolol HCl
a beta-1 adrenoceptor antagonist that has been shown to be as effective as other beta blockers for the treatment of angina pectoris and hypertension
  • Molecular weight: 345.44
  • Formula: C20H27NO4
  • CLOGP: 3
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 59.95
  • ALOGS: -4.40
  • ROTB: 10

Drug dosage:

DoseUnitRoute
0.30 g O

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1987 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC C07AB06 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS
Beta blocking agents, selective
ATC C07BB06 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS AND THIAZIDES
Beta blocking agents, selective, and thiazides
MeSH PA D018663 Adrenergic Agents
MeSH PA D018674 Adrenergic Antagonists
MeSH PA D058671 Adrenergic beta-1 Receptor Antagonists
MeSH PA D000319 Adrenergic beta-Antagonists
CHEBI has role CHEBI:35530 beta-adrenergic antagonist
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:38070 anti-arrhythmia drug
MeSH PA D018377 Neurotransmitter Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.28 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Beta-1 adrenergic receptor GPCR ANTAGONIST WOMBAT-PK SCIENTIFIC LITERATURE

External reference:

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IDSource
D01369 KEGG_DRUG
34ZXW6ZV21 UNII
4115 INN_ID
42864-78-8 SECONDARY_CAS_RN
008146 NDDF
CHEMBL314010 ChEMBL_ID
2372 PUBCHEM_CID
C021148 MESH_SUPPLEMENTAL_RECORD_UI
DB01295 DRUGBANK_ID
CHEMBL2106060 ChEMBL_ID
CHEBI:238698 CHEBI

Pharmaceutical products:

None