betanidine indications/contra

Stem definitionDrug idCAS RN
antihypertensives, clonidine derivatives 359 55-73-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • esbatal
  • bethanidine
  • betanidine
  • betanidine sulfate
  • bethanidine sulfate
A guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear.
  • Molecular weight: 177.25
  • Formula: C10H15N3
  • CLOGP: 0.97
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 36.42
  • ALOGS: -2.05
  • ROTB: 2

Drug dosage:

DoseUnitRoute
0.10 g O

Approvals:

DateAgencyCompanyOrphan
None FDA ROBINS AH

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC C02CC01 CARDIOVASCULAR SYSTEM
ANTIHYPERTENSIVES
ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
Guanidine derivatives
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:37887 adrenergic antagonist
MeSH PA D018663 Adrenergic Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D001337 Autonomic Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D013565 Sympatholytics

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.96 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium-dependent noradrenaline transporter Transporter SUBSTRATE DRUGBANK CHEMBL

External reference:

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IDSource
CHEBI:37937 CHEBI
DB00217 DRUGBANK_ID
N0000166585 NUI
C0005324 UMLSCUI
7618 IUPHAR_LIGAND_ID
D01603 KEGG_DRUG
418981008 SNOMEDCT_US
N0000166585 NDFRT
1523 RXNORM
350601007 SNOMEDCT_US
003935 NDDF
CHEMBL1201260 ChEMBL_ID
D001627 MESH_DESCRIPTOR_UI
CHEMBL2110368 ChEMBL_ID
J4THI5N7O2 UNII
114-85-2 SECONDARY_CAS_RN
1484 INN_ID
2368 PUBCHEM_CID

Pharmaceutical products:

None