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betanidine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| alpha-2 adrenoreceptor agonists | 359 | 55-73-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A guanidinium antihypertensive agent that acts by blocking adrenergic transmission. The precise mode of action is not clear.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.10 | g | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,MAP3K21,MAP3K7,MAPK7,MAPK9,MARK4,NTRK2,PAK4,PDK2,PDK4,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK | 37 | |||
| kinase-selectivity-class | GRK2,PDK4 | 2 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| None | FDA | ROBINS AH |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C02CC01 | CARDIOVASCULAR SYSTEM ANTIHYPERTENSIVES ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING Guanidine derivatives |
| MeSH PA | D000959 | Antihypertensive Agents |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D013565 | Sympatholytics |
| MeSH PA | D018377 | Neurotransmitter Agents |
| MeSH PA | D018663 | Adrenergic Agents |
| CHEBI has role | CHEBI:35674 | antihypertensive agent |
| CHEBI has role | CHEBI:37887 | adrenergic antagonist |
Related Drugs by ATC class:
C02CC Guanidine derivatives 6 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.96 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium-dependent noradrenaline transporter | Transporter | SUBSTRATE | DRUGBANK | CHEMBL |
External reference:
| ID | Source |
|---|---|
| N0000166585 | NUI |
| D01603 | KEGG_DRUG |
| 1523 | RXNORM |
| CHEBI:37937 | CHEBI |
| CHEMBL1201260 | ChEMBL_ID |
| CHEMBL2110368 | ChEMBL_ID |
| 7618 | IUPHAR_LIGAND_ID |
| 114-85-2 | SECONDARY_CAS_RN |
| DB00217 | DRUGBANK_ID |
| C0005324 | UMLSCUI |
| D001627 | MESH_DESCRIPTOR_UI |
| 1484 | INN_ID |
| 135449343 | PUBCHEM_CID |
| W8S3YM7AUU | UNII |
| 003935 | NDDF |
| 003936 | NDDF |
| 350601007 | SNOMEDCT_US |
| 391845009 | SNOMEDCT_US |
| 418981008 | SNOMEDCT_US |
Pharmaceutical products:
None