DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
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Structure 🔎
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L1000
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DrugCentral 2023 🐕
2022 Update-Veterinary Drugs & Uses
Search
Structure 🔎
Similarity 🔎
Smart API
Redial
About
Download
L1000
FAQ
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All
FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
tamibarotene 🐶
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
arotinoid derivatives
3580
94497-51-5
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
tamibarotene
amnolake
Am80
has retinoid-binding activity
Molecular weight: 351.45
Formula: C22H25NO3
CLOGP: 6.38
LIPINSKI: 1
HAC: 4
HDO: 2
TPSA: 66.40
ALOGS: -5.79
ROTB: 3
Drug dosage:
None
ADMET properties:
None
Approvals:
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Date
Agency
Company
Orphan
April 11, 2005
PMDA
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
CHEBI has role
CHEBI:35610
antineoplastic agents
CHEBI has role
CHEBI:50741
RAR alpha/beta agonist
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
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Disease
Relation
SNOMED_ID
DOID
Acute promyelocytic leukemia, FAB M3
indication
110004001
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🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
3.75
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
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Target
Class
Pharos
UniProt
Action
Type
Activity value
(-log[M])
Mechanism
action
Bioact source
MoA source
Retinoic acid receptor alpha
Nuclear hormone receptor
P10276
RARA_HUMAN
IC50
7.11
CHEMBL
Retinoic acid receptor beta
Nuclear hormone receptor
P10826
RARB_HUMAN
AGONIST
EC50
6.63
IUPHAR
Retinoic acid receptor gamma
Nuclear hormone receptor
P13631
RARG_HUMAN
AGONIST
EC50
6.23
IUPHAR
Flavin reductase (NADPH)
Enzyme
P30043
BLVRB_HUMAN
Kd
5.86
CHEMBL
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External reference:
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entries
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ID
Source
08V52GZ3H9
UNII
108143
PUBCHEM_CID
2648
IUPHAR_LIGAND_ID
7349
INN_ID
A80
PDB_CHEM_ID
C061133
MESH_SUPPLEMENTAL_RECORD_UI
C1567753
UMLSCUI
CHEBI:32181
CHEBI
CHEMBL25202
ChEMBL_ID
D01418
KEGG_DRUG
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Pharmaceutical products:
None
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tamibarotene