tamibarotene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
arotinoid derivatives	3580	94497-51-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

tamibarotene
amnolake
Am80

has retinoid-binding activity

Molecular weight: 351.45
Formula: C22H25NO3
CLOGP: 6.38
LIPINSKI: 1
HAC: 4
HDO: 2
TPSA: 66.40
ALOGS: -5.79
ROTB: 3

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
April 11, 2005	PMDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:50741	RAR alpha/beta agonist

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Acute promyelocytic leukemia, FAB M3	indication	110004001

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.75	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Retinoic acid receptor alpha	Nuclear hormone receptor	P10276	RARA_HUMAN		IC50	7.11		CHEMBL
Retinoic acid receptor beta	Nuclear hormone receptor	P10826	RARB_HUMAN	AGONIST	EC50	6.63		IUPHAR
Retinoic acid receptor gamma	Nuclear hormone receptor	P13631	RARG_HUMAN	AGONIST	EC50	6.23		IUPHAR
Flavin reductase (NADPH)	Enzyme	P30043	BLVRB_HUMAN		Kd	5.86		CHEMBL

External reference:

ID	Source
D01418	KEGG_DRUG
C1567753	UMLSCUI
CHEBI:32181	CHEBI
A80	PDB_CHEM_ID
CHEMBL25202	ChEMBL_ID
DB04942	DRUGBANK_ID
C061133	MESH_SUPPLEMENTAL_RECORD_UI
108143	PUBCHEM_CID
2648	IUPHAR_LIGAND_ID
7349	INN_ID
08V52GZ3H9	UNII

Pharmaceutical products:

None