betamethasone valerate indications/contra

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 354 2152-44-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betamethasone valerate
  • bextasol
  • celeston valerate
  • valisone
  • bedermin
Betamethasone valerate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.
  • Molecular weight: 476.59
  • Formula: C27H37FO6
  • CLOGP: 3.91
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 100.90
  • ALOGS: -4.85
  • ROTB: 7

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 2, 1967 FDA SCHERING

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D000305 Adrenal Cortex Hormones
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D006730 Hormones, Hormone Substitutes, and Hormone Antagonists

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Lichen simplex chronicus indication 53891004
Granuloma annulare indication 65508009 DOID:3777
Pruritus ani indication 90446007
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Scalp psoriasis indication 238608008
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Primary cutaneous T-cell lymphoma indication 400122007
Dermatosis of scalp indication 402694007 DOID:3136
Telangiectasia disorder contraindication 247479008 DOID:1272
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006 DOID:2733
Peripheral vascular disease contraindication 400047006

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.24 acidic
pKa2 11.86 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

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IDSource
4018643 VUID
N0000167463 NUI
C0750848 UMLSCUI
D01357 KEGG_DRUG
227897 RXNORM
396005002 SNOMEDCT_US
66854004 SNOMEDCT_US
3225 MMSL
4278 MMSL
4018643 VANDF
N0000146956 NDFRT
N0000167463 NDFRT
002173 NDDF
9IFA5XM7R2 UNII
CHEMBL1497 ChEMBL_ID
16533 PUBCHEM_CID
DB00443 DRUGBANK_ID
D001624 MESH_DESCRIPTOR_UI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0033 OINTMENT 1 mg TOPICAL NDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0040 CREAM 1 mg TOPICAL NDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0168-0041 LOTION 1 mg TOPICAL NDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0378-8180 AEROSOL, FOAM 1.20 mg TOPICAL NDA authorized generic 13 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0472-0370 CREAM 1.20 mg TOPICAL ANDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0472-0371 OINTMENT 1.20 mg TOPICAL ANDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0326 CREAM 1.20 mg TOPICAL NDA 18 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 0713-0327 OINTMENT 1.20 mg TOPICAL ANDA 18 sections
BETAMETHASONE VALERATE HUMAN PRESCRIPTION DRUG LABEL 1 16590-034 CREAM 1 mg TOPICAL ANDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 21695-584 CREAM 1 mg TOPICAL ANDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 21695-586 OINTMENT 1 mg TOPICAL ANDA 11 sections
Luxiq HUMAN PRESCRIPTION DRUG LABEL 1 40076-021 AEROSOL, FOAM 1.20 mg TOPICAL NDA 13 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 45802-053 AEROSOL, FOAM 1.20 mg TOPICAL ANDA 13 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 50090-0165 OINTMENT 1 mg TOPICAL NDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 50090-0237 CREAM 1.20 mg TOPICAL ANDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 50090-0309 CREAM 1.20 mg TOPICAL ANDA 11 sections
BETAMETHASONE VALERATE HUMAN PRESCRIPTION DRUG LABEL 1 50090-1647 CREAM 1 mg TOPICAL ANDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 50742-315 AEROSOL, FOAM 1.20 mg TOPICAL ANDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 51125-407 AEROSOL, FOAM 1.20 mg TOPICAL ANDA 11 sections
BETAMETHASONE VALERATE HUMAN PRESCRIPTION DRUG LABEL 1 51672-1269 CREAM 1 mg TOPICAL ANDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 51672-4188 AEROSOL, FOAM 1.20 mg TOPICAL ANDA 14 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 54868-0520 CREAM 1 mg TOPICAL ANDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 54868-2994 OINTMENT 1 mg TOPICAL ANDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 54868-5002 LOTION 1 mg TOPICAL ANDA 11 sections
LUXIQ HUMAN PRESCRIPTION DRUG LABEL 1 54868-5424 AEROSOL, FOAM 1.20 mg TOPICAL NDA 14 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 54879-004 LOTION 1 mg CUTANEOUS ANDA 11 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 63187-276 OINTMENT 1.20 mg TOPICAL ANDA 10 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 63187-687 CREAM 1.20 mg TOPICAL ANDA 10 sections
Betamethasone Valerate HUMAN PRESCRIPTION DRUG LABEL 1 66267-984 CREAM 1.20 mg TOPICAL ANDA 10 sections
BETAMETHASONE VALERATE HUMAN PRESCRIPTION DRUG LABEL 1 68071-4278 CREAM 1 mg TOPICAL ANDA 11 sections