ruboxistaurin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	3533	169939-94-0

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

ruboxistaurin mesilate monohydrate
ruboxistaurin mesilate
ruboxistaurin mesylate
ruboxistaurin

inhibits protein kinase C beta

Molecular weight: 468.56
Formula: C28H28N4O3
CLOGP: 4.32
LIPINSKI: 0
HAC: 7
HDO: 1
TPSA: 68.50
ALOGS: -3.99
ROTB: 2

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Search:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Tyrosine-protein kinase JAK3	Kinase	P52333	JAK3_HUMAN		Kd	6.38		CHEMBL
Platelet-derived growth factor receptor beta	Kinase	P09619	PGFRB_HUMAN		Kd	5.15		CHEMBL
Mast/stem cell growth factor receptor Kit	Kinase	P10721	KIT_HUMAN		Kd	6.42		CHEMBL
Epidermal growth factor receptor	Kinase	P00533	EGFR_HUMAN		Kd	5.29		CHEMBL
Tyrosine-protein kinase Lck	Kinase	P06239	LCK_HUMAN		Kd	5.89		CHEMBL
Receptor-type tyrosine-protein kinase FLT3	Kinase	P36888	FLT3_HUMAN		Kd	6.89		CHEMBL
Ribosomal protein S6 kinase alpha-3	Kinase	P51812	KS6A3_HUMAN		Kd	5.66		CHEMBL
Serine/threonine-protein kinase pim-1	Kinase	P11309	PIM1_HUMAN		Kd	7.30		CHEMBL
Myosin light chain kinase, smooth muscle	Kinase	Q15746	MYLK_HUMAN		Kd	6.54		CHEMBL
Death-associated protein kinase 3	Kinase	O43293	DAPK3_HUMAN		Kd	5.89		CHEMBL

Showing 1 to 10 of 123 entries

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External reference:

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Search:

ID	Source
153999	PUBCHEM_CID
192050-59-2	SECONDARY_CAS_RN
4025269	VANDF
5263	IUPHAR_LIGAND_ID
721809WQCP	UNII
8108	INN_ID
C099154	MESH_SUPPLEMENTAL_RECORD_UI
C1307704	UMLSCUI
CHEMBL91829	ChEMBL_ID
DB11829	DRUGBANK_ID

Showing 1 to 10 of 11 entries

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Pharmaceutical products:

None

ruboxistaurin