ribostamycin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, produced by Streptomyces strains 3526 25546-65-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • ribostamycin sulfate
  • ribostamycin
  • hetangmycin
  • vistamycin
  • ribostamycin sulfate salt
A broad-spectrum antimicrobial isolated from Streptomyces ribosifidicus.
  • Molecular weight: 454.48
  • Formula: C17H34N4O10
  • CLOGP: -5.02
  • LIPINSKI: 2
  • HAC: 14
  • HDO: 10
  • TPSA: 262.38
  • ALOGS: -0.71
  • ROTB: 6

Drug dosage:

DoseUnitRoute
1 g P

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 0.25 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.50 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.50 hours Lombardo F, Berellini G, Obach RS

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01GB10 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
AMINOGLYCOSIDE ANTIBACTERIALS
Other aminoglycosides
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
CHEBI has role CHEBI:33281 antibiotics
CHEBI has role CHEBI:33282 bactericides
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:25212 metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.57 acidic
pKa2 13.56 acidic
pKa3 13.9 acidic
pKa4 8.21 Basic
pKa5 7.69 Basic
pKa6 6.31 Basic
pKa7 5.7 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02209 KEGG_DRUG
53797-35-6 SECONDARY_CAS_RN
C0035554 UMLSCUI
CHEBI:65028 CHEBI
RIO PDB_CHEM_ID
CHEMBL221572 ChEMBL_ID
D012271 MESH_DESCRIPTOR_UI
DB03615 DRUGBANK_ID
12161 IUPHAR_LIGAND_ID
3197 INN_ID
2Q5JOU7T53 UNII
33042 PUBCHEM_CID
010978 NDDF
010979 NDDF

Pharmaceutical products:

None