resorcinol indications/contra

Stem definitionDrug idCAS RN
3524 108-46-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • resorcinol
  • resorcin
  • benzene-1,3-diol
an antiseptic and disinfectant used for temporary relief of itching
  • Molecular weight: 110.11
  • Formula: C6H6O2
  • CLOGP: 0.81
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 40.46
  • ALOGS: -0.13
  • ROTB: 0

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC D10AX02 DERMATOLOGICALS
ANTI-ACNE PREPARATIONS
ANTI-ACNE PREPARATIONS FOR TOPICAL USE
Other anti-acne preparations for topical use
ATC S01AX06 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Other antiinfectives

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Acne vulgaris indication 88616000
Skin irritation indication 367466007
Acneiform eruption indication 402644006
Itching of skin indication 418363000
Minor Skin Wound Pain indication
Folliculitis contraindication 13600006 DOID:4409
Infection of skin AND/OR subcutaneous tissue contraindication 19824006
Methemoglobinemia contraindication 38959009 DOID:10783
Conduction disorder of the heart contraindication 44808001
Diabetes mellitus contraindication 73211009 DOID:9351
Decreased respiratory function contraindication 80954004
Kidney disease contraindication 90708001 DOID:2527
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009
Open wound contraindication 125643001
Seizure disorder contraindication 128613002 DOID:1826
Condyloma acuminatum contraindication 240542006 DOID:11168
Eruption of skin contraindication 271807003 DOID:0050486
Peripheral vascular disease contraindication 400047006
Blister contraindication 417237009
Denuded skin contraindication 418242004
Inflammatory dermatosis contraindication 703938007 DOID:2723

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.01 acidic
pKa2 11.02 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Carbonic anhydrase 14 Enzyme Ki 4.97 CHEMBL
Carbonic anhydrase 5A, mitochondrial Enzyme Ki 5.06 CHEMBL
Carbonic anhydrase 9 Enzyme Ki 4.16 CHEMBL
Carbonic anhydrase 12 Enzyme Ki 5.12 CHEMBL
Carbonic anhydrase 5B, mitochondrial Enzyme Ki 5.15 CHEMBL
Carbonic anhydrase 2 Enzyme Ki 5.11 CHEMBL
Carbonic anhydrase 13 Enzyme Ki 4.20 CHEMBL
Carbonic anhydrase Unclassified Ki 5.19 CHEMBL
Prostaglandin G/H synthase 1 Enzyme Kd 4.06 CHEMBL

External reference:

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IDSource
CHEBI:27810 CHEBI
4019032 VUID
N0000147303 NUI
C0073085 UMLSCUI
D00133 KEGG_DRUG
CHEMBL24147 ChEMBL_ID
4019032 VANDF
N0000147303 NDFRT
N0000006923 NDFRT
5418 MMSL
35382 RXNORM
5052 MMSL
78032005 SNOMEDCT_US
411296008 SNOMEDCT_US
001950 NDDF
C031389 MESH_SUPPLEMENTAL_RECORD_UI
DB11085 DRUGBANK_ID
YUL4LO94HK UNII
5054 PUBCHEM_CID
RCO PDB_CHEM_ID

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Adult Acnomel Tinted HUMAN OTC DRUG LABEL 2 0295-9116 CREAM 2 g TOPICAL OTC monograph final 12 sections
Anti Itch HUMAN OTC DRUG LABEL 2 0363-0673 CREAM 2 g TOPICAL OTC monograph not final 9 sections
Well at Walgreens Anti-Itch HUMAN OTC DRUG LABEL 2 0363-0674 CREAM 3 g TOPICAL OTC monograph final 8 sections
REZAMID HUMAN OTC DRUG LABEL 2 11086-022 LOTION 2 1 TOPICAL OTC monograph final 9 sections
Vagisil Anti Itch Original Strength HUMAN OTC DRUG LABEL 2 11509-0360 CREAM 20 mg TOPICAL OTC MONOGRAPH NOT FINAL 8 sections
Vagisil Anti Itch Maximum Strength HUMAN OTC DRUG LABEL 2 11509-0372 CREAM 30 mg TOPICAL OTC MONOGRAPH NOT FINAL 8 sections
VAGISIL Anti-Itch Medicated Creme Maximum Strength HUMAN OTC DRUG LABEL 2 11509-4402 CREAM 30 mg TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
VAGISIL Anti-Itch Creme Regular Strength HUMAN OTC DRUG LABEL 2 11509-5103 CREAM 20 mg TOPICAL OTC MONOGRAPH NOT FINAL 8 sections
Benzal Vagisil Creme Regular Strength HUMAN OTC DRUG LABEL 2 11509-6940 CREAM 20 mg TOPICAL OTC MONOGRAPH NOT FINAL 10 sections
Up and up vagicaine HUMAN OTC DRUG LABEL 2 11673-142 CREAM 3 g TOPICAL OTC monograph not final 9 sections
BENZOCAINE and RESORCINOL HUMAN OTC DRUG LABEL 2 11822-2890 OINTMENT 20 mg TOPICAL OTC monograph not final 7 sections
Rite Aid Original Strength Vagicaine HUMAN OTC DRUG LABEL 2 11822-2891 CREAM 20 mg TOPICAL OTC monograph not final 7 sections
Rite Aid Original Strength Vagicaine HUMAN OTC DRUG LABEL 2 11822-9974 CREAM 2 g TOPICAL OTC monograph not final 9 sections
signature care vagicaine HUMAN OTC DRUG LABEL 2 21130-142 CREAM 3 g TOPICAL OTC monograph not final 9 sections
Budpak Feminine Anti-Itch HUMAN OTC DRUG LABEL 2 27293-022 CREAM 0.02 g TOPICAL OTC monograph not final 9 sections
Vagicaine HUMAN OTC DRUG LABEL 2 29500-7820 CREAM 0.85 g TOPICAL OTC monograph not final 12 sections
Assured HUMAN OTC DRUG LABEL 2 33992-2014 CREAM 2 g TOPICAL OTC monograph not final 10 sections
Vagicaine HUMAN OTC DRUG LABEL 2 41250-142 CREAM 3 g TOPICAL OTC monograph not final 9 sections
Equate vagicaine HUMAN OTC DRUG LABEL 2 49035-142 CREAM 3 g TOPICAL OTC monograph not final 9 sections
smart sense vagicaine HUMAN OTC DRUG LABEL 2 49738-142 CREAM 3 g TOPICAL OTC monograph not final 9 sections
Image Essentials Vagicaine HUMAN OTC DRUG LABEL 2 49738-269 CREAM 3 g TOPICAL OTC monograph not final 9 sections
Leader Anti-Itch HUMAN OTC DRUG LABEL 2 49781-092 CREAM 30 mg TOPICAL OTC monograph final 8 sections
Leader Anti-Itch HUMAN OTC DRUG LABEL 2 49781-093 CREAM 20 mg TOPICAL OTC monograph final 8 sections
Family Wellness HUMAN OTC DRUG LABEL 2 55621-014 CREAM 0.03 g TOPICAL OTC monograph not final 8 sections
CLARIFYING MASK HUMAN OTC DRUG LABEL 2 55878-102 PASTE 2 g TOPICAL OTC monograph final 10 sections
CLARIFYING MASK HUMAN OTC DRUG LABEL 2 55878-106 PASTE 2 g TOPICAL OTC monograph final 10 sections
BENZOCAINE and RESORCINOL HUMAN OTC DRUG LABEL 2 55910-185 CREAM 20 mg TOPICAL OTC monograph not final 7 sections
REXALL FEMININE MAXIMUM STRENGTH ANTI-ITCH HUMAN OTC DRUG LABEL 2 55910-415 CREAM 3 g TOPICAL OTC monograph final 8 sections
Vagicaine Maximum Strength Anti-Itch Cream HUMAN OTC DRUG LABEL 2 59779-588 CREAM 0.84 g TOPICAL OTC monograph not final 8 sections
BENZOCAINE and RESORCINOL HUMAN OTC DRUG LABEL 2 59779-810 CREAM 20 mg TOPICAL OTC monograph not final 7 sections