betamethasone benzoate indications/contra

Stem definitionDrug idCAS RN
351 22298-29-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betamethasone benzoate
  • betamethasone 17-benzoate
  • Molecular weight: 496.58
  • Formula: C29H33FO6
  • CLOGP: 3.97
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 100.90
  • ALOGS: -5.12
  • ROTB: 5

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
None FDA PARKE DAVIS

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 27.20 0 3 4 530 3385322

Pharmacologic Action:

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SourceCodeDescription
MeSH PA D000305 Adrenal Cortex Hormones
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D006730 Hormones, Hormone Substitutes, and Hormone Antagonists

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Atopic dermatitis indication 24079001 DOID:3310
Contact dermatitis indication 40275004 DOID:2773
Seborrheic dermatitis indication 50563003 DOID:8741
Lichen simplex chronicus indication 53891004
Granuloma annulare indication 65508009 DOID:3777
Pruritus ani indication 90446007
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Scalp psoriasis indication 238608008
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Primary cutaneous T-cell lymphoma indication 400122007
Telangiectasia disorder contraindication 247479008 DOID:1272
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006 DOID:2733
Peripheral vascular disease contraindication 400047006

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.29 acidic
pKa2 11.94 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST CHEMBL CHEMBL

External reference:

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IDSource
4018641 VUID
N0000146954 NUI
C0005311 UMLSCUI
D02286 KEGG_DRUG
N0000146954 NDFRT
002170 NDDF
1517 RXNORM
17908000 SNOMEDCT_US
4272 MMSL
4018641 VANDF
877K0XW47A UNII
5282492 PUBCHEM_CID
CHEMBL1200376 ChEMBL_ID
C015706 MESH_SUPPLEMENTAL_RECORD_UI
DB00443 DRUGBANK_ID
CHEBI:135798 CHEBI

Pharmaceutical products:

None