pyridoxal phosphate Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
3506 54-47-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pyridoxal 5-phosphate
  • codecarboxylase
  • coenzyme B6
  • phosphopyridoxal
  • phosphopyridoxal coenzyme
  • pyridoxal 5-monophosphoric acid ester
  • pyridoxal monophosphate
  • pyridoxaldehyde phosphate
  • pyridoxyl phosphate
  • Vitamin B6 phosphate
  • Vitamin B6 (Active form)
  • pyridoxal phosphate
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
  • Molecular weight: 247.14
  • Formula: C8H10NO6P
  • CLOGP: -0.57
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 116.95
  • ALOGS: -1.64
  • ROTB: 4

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA06 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.56 acidic
pKa2 6.61 acidic
pKa3 8.45 acidic
pKa4 3.78 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
P2X purinoceptor 1 Ion channel IC50 5 CHEMBL

External reference:

IDSource
4024929 VUID
N0000023490 NUI
C0034266 UMLSCUI
5V5IOJ8338 UNII
41468-25-1 SECONDARY_CAS_RN
4024929 VANDF
259663004 SNOMEDCT_US
9004 RXNORM
003448 NDDF
227241 MMSL
30462 MMSL
1051 PUBCHEM_CID
CHEBI:18405 CHEBI
CHEMBL82202 ChEMBL_ID
DB00114 DRUGBANK_ID
PLP PDB_CHEM_ID
D011732 MESH_DESCRIPTOR_UI
CHEMBL3181870 ChEMBL_ID
5249 IUPHAR_LIGAND_ID
DB00147 DRUGBANK_ID

Pharmaceutical products:

None