prucalopride indications/contra

Stem definitionDrug idCAS RN
sulpiride derivatives 3502 179474-81-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prucalopride succinate
  • resolor
  • prucalopride
  • R093877
a 5-HT4 agonist enterokinetic compound
  • Molecular weight: 367.87
  • Formula: C18H26ClN3O3
  • CLOGP: 1.41
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 76.82
  • ALOGS: -3.46
  • ROTB: 6

Drug dosage:

DoseUnitRoute
2 mg O

Approvals:

DateAgencyCompanyOrphan
Oct. 15, 2009 EMA

FDA Adverse Event Reporting System

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MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Vomiting 49.18 45.70 12 13 89519 3296315

Pharmacologic Action:

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SourceCodeDescription
ATC A06AX05 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR CONSTIPATION
DRUGS FOR CONSTIPATION
Other drugs for constipation
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D054368 Laxatives
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D058828 Serotonin 5-HT4 Receptor Agonists
MeSH PA D018490 Serotonin Agents
MeSH PA D017366 Serotonin Receptor Agonists

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Constipation indication 14760008 DOID:2089

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.83 acidic
pKa2 8.57 Basic
pKa3 1.07 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
5-hydroxytryptamine receptor 4 GPCR AGONIST Ki 8.60 CHEMBL DRUG LABEL
5-hydroxytryptamine receptor 3A Ion channel Ki 5.40 CHEMBL
D(4) dopamine receptor GPCR Ki 5.63 PDSP

External reference:

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IDSource
243 IUPHAR_LIGAND_ID
D09205 KEGG_DRUG
0A09IUW5TP UNII
7702 INN_ID
179474-85-2 SECONDARY_CAS_RN
013402 NDDF
699273008 SNOMEDCT_US
CHEMBL117287 ChEMBL_ID
3052762 PUBCHEM_CID
DB06480 DRUGBANK_ID
CHEMBL2105748 ChEMBL_ID
C406662 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:135552 CHEBI

Pharmaceutical products:

None