abarelix indications/contra

Stem definitionDrug idCAS RN
gonadotropin-releasing-hormone (GnRH) inhibitors, peptides 35 183552-38-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • abarelix
  • plenaxis
  • PPI-149
  • R3827
  • Molecular weight: 1416.09
  • Formula: C72H95ClN14O14
  • CLOGP: 2.95
  • LIPINSKI: 3
  • HAC: 28
  • HDO: 13
  • TPSA: 424.98
  • ALOGS: -5.58
  • ROTB: 38

Drug dosage:

DoseUnitRoute
3.60 mg P

Approvals:

DateAgencyCompanyOrphan
Nov. 25, 2003 FDA SPECIALITY EUROPEAN

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC L02BX01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ENDOCRINE THERAPY
HORMONE ANTAGONISTS AND RELATED AGENTS
Other hormone antagonists and related agents
MeSH PA D006727 Hormone Antagonists
MeSH PA D006730 Hormones, Hormone Substitutes, and Hormone Antagonists
CHEBI has role CHEBI:49020 hormone antagonist
CHEBI has role CHEBI:35610 antineoplastic agent

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Ischemic priapism indication 441575009
Prolonged QT interval contraindication 111975006
Liver function tests abnormal contraindication 166603001
Pregnancy, function contraindication 289908002
Breastfeeding (mother) contraindication 413712001
Obesity contraindication 414916001 DOID:9970

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Gonadotropin-releasing hormone receptor GPCR ANTAGONIST Ki 9.30 IUPHAR CHEMBL

External reference:

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IDSource
DB00106 DRUGBANK_ID
1188 IUPHAR_LIGAND_ID
4021410 VUID
N0000148825 NUI
C0965390 UMLSCUI
D02738 KEGG_DRUG
301739 RXNORM
d04908 MMSL
17679 MMSL
407128008 SNOMEDCT_US
407129000 SNOMEDCT_US
4021410 VANDF
N0000148825 NDFRT
N0000010339 NDFRT
008459 NDDF
CHEMBL1252 ChEMBL_ID
C423508 MESH_SUPPLEMENTAL_RECORD_UI
16131215 PUBCHEM_CID
W486SJ5824 UNII
7689 INN_ID
CHEBI:337298 CHEBI

Pharmaceutical products:

None