abarelix 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| gonadotropin-releasing-hormone (GnRH) inhibitors, peptides | 35 | 183552-38-7 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 3.60 | mg | P |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.03 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Nov. 25, 2003 | FDA | SPECIALITY EUROPEAN |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | L02BX01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS ENDOCRINE THERAPY HORMONE ANTAGONISTS AND RELATED AGENTS Other hormone antagonists and related agents |
| MeSH PA | D006727 | Hormone Antagonists |
| CHEBI has role | CHEBI:35610 | antineoplastic agents |
| CHEBI has role | CHEBI:49020 | hormone antagonists |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Ischemic priapism | indication | 441575009 | |
| Prolonged QT interval | contraindication | 111975006 | |
| Liver function tests abnormal | contraindication | 166603001 | |
| Pregnancy, function | contraindication | 289908002 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Obesity | contraindication | 414916001 | DOID:9970 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.32 | acidic |
| pKa2 | 12.48 | acidic |
| pKa3 | 12.52 | acidic |
| pKa4 | 13.01 | acidic |
| pKa5 | 13.47 | acidic |
| pKa6 | 13.53 | acidic |
| pKa7 | 9.93 | Basic |
| pKa8 | 5.35 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor | GPCR | ANTAGONIST | Ki | 9.49 | IUPHAR | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021410 | VUID |
| N0000148825 | NUI |
| D02738 | KEGG_DRUG |
| 301739 | RXNORM |
| C0965390 | UMLSCUI |
| CHEBI:337298 | CHEBI |
| CHEMBL1252 | ChEMBL_ID |
| DB00106 | DRUGBANK_ID |
| C423508 | MESH_SUPPLEMENTAL_RECORD_UI |
| 1188 | IUPHAR_LIGAND_ID |
| 7689 | INN_ID |
| W486SJ5824 | UNII |
| 16131215 | PUBCHEM_CID |
| 407128008 | SNOMEDCT_US |
| 407129000 | SNOMEDCT_US |
| 4021410 | VANDF |
| 17679 | MMSL |
| 47872 | MMSL |
| d04908 | MMSL |
| 008459 | NDDF |
Pharmaceutical products:
None