betamethasone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
prednisone and prednisolone derivatives 348 378-44-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betamethasone
  • betadexamethasone
  • betametasone
  • betamethazone
  • bethamethasone
A glucocorticoid given orally, parenterally, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. Its lack of mineralocorticoid properties makes betamethasone particularly suitable for treating cerebral edema and congenital adrenal hyperplasia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p724)
  • Molecular weight: 392.47
  • Formula: C22H29FO5
  • CLOGP: 1.78
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 3
  • TPSA: 94.83
  • ALOGS: -3.89
  • ROTB: 2

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
1.50 mg O
1.50 mg P
0.40 mg P
0.40 mg N

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.06 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 4.80 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.38 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 1.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.80 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.36 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 5.60 hours Lombardo F, Berellini G, Obach RS
BA (Bioavailability) 0.72 % Kawashima H, Watanabe R, Esaki T, Kuroda M, Nagao C, Natsume-Kitatani Y, Ohashi R, Komura H, Mizuguchi K

Approvals:

DateAgencyCompanyOrphan
April 17, 1961 FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature delivery 1980.90 13.98 614 18775 29667 63439966
Premature baby 1128.54 13.98 366 19023 20369 63449264
Maternal exposure during pregnancy 1065.84 13.98 720 18669 219342 63250291
Low birth weight baby 757.39 13.98 211 19178 6918 63462715
Exposure during pregnancy 668.64 13.98 474 18915 155073 63314560
Foetal exposure during pregnancy 647.94 13.98 273 19116 31689 63437944
Normal labour 393.73 13.98 76 19313 441 63469192
Delivery 349.45 13.98 82 19307 1321 63468312
Macular degeneration 299.45 13.98 147 19242 24229 63445404
Product use in unapproved indication 263.46 13.98 298 19091 178782 63290851
Neonatal respiratory distress syndrome 217.06 13.98 65 19324 2753 63466880
Premature labour 204.75 13.98 92 19297 12412 63457221
Foetal growth restriction 181.63 13.98 73 19316 7480 63462153
Computerised tomogram thorax abnormal 177.16 13.98 50 19339 1713 63467920
Patent ductus arteriosus 141.27 13.98 52 19337 4198 63465435
Pre-eclampsia 130.07 13.98 61 19328 9072 63460561
Computerised tomogram thorax 121.09 13.98 28 19361 421 63469212
Live birth 106.99 13.98 77 19312 25553 63444080
Psoriasis 101.72 13.98 129 19260 86828 63382805
Steroid withdrawal syndrome 100.48 13.98 25 19364 520 63469113
Atelectasis 93.02 13.98 66 19323 21417 63448216
Normal newborn 92.61 13.98 47 19342 8294 63461339
Premature rupture of membranes 92.24 13.98 40 19349 4953 63464680
Caesarean section 92.00 13.98 60 19329 16972 63452661
Ductus arteriosus premature closure 80.32 13.98 19 19370 317 63469316
Respiratory disorder neonatal 75.88 13.98 24 19365 1221 63468412
Skin exfoliation 75.85 13.98 79 19310 43023 63426610
Gestational diabetes 72.49 13.98 40 19349 8356 63461277
Selective eating disorder 71.26 13.98 26 19363 2046 63467587
Oligohydramnios 71.05 13.98 36 19353 6330 63463303
Preterm premature rupture of membranes 68.96 13.98 23 19366 1386 63468247
Hypoxia 65.65 13.98 86 19303 59706 63409927
Drug ineffective 63.95 13.98 539 18850 1044226 62425407
Chronic sinusitis 61.54 13.98 42 19347 12801 63456832
Bradycardia neonatal 60.72 13.98 19 19370 933 63468700
Foetal hypokinesia 53.39 13.98 15 19374 505 63469128
Neonatal hypocalcaemia 52.44 13.98 9 19380 23 63469610
Weight gain poor 49.03 13.98 16 19373 900 63468733
Atrial septal defect 49.01 13.98 29 19360 6909 63462724
Diabetes mellitus inadequate control 48.85 13.98 39 19350 15087 63454546
Paraesthesia oral 48.47 13.98 43 19346 19213 63450420
Neonatal gastrointestinal haemorrhage 47.65 13.98 8 19381 17 63469616
Death 45.74 13.98 29 19360 374352 63095281
Foetal heart rate deceleration abnormality 44.70 13.98 13 19376 496 63469137
Rectal cancer metastatic 43.49 13.98 11 19378 245 63469388
Bronchopulmonary dysplasia 42.23 13.98 12 19377 421 63469212
Placental insufficiency 41.94 13.98 16 19373 1425 63468208
Polyhydramnios 41.32 13.98 18 19371 2253 63467380
Off label use 41.01 13.98 348 19041 674114 62795519
Joint swelling 40.54 13.98 25 19364 327641 63141992
Amniotic cavity infection 40.30 13.98 15 19374 1248 63468385
Asthenia 40.04 13.98 35 19354 383569 63086064
Skin weeping 39.69 13.98 13 19376 740 63468893
Foetal distress syndrome 39.46 13.98 15 19374 1323 63468310
Arthropathy 38.34 13.98 12 19377 234780 63234853
Hydrops foetalis 38.21 13.98 12 19377 596 63469037
Cervical incompetence 38.04 13.98 12 19377 605 63469028
Foetal non-stress test abnormal 37.47 13.98 7 19382 33 63469600
Catarrh 37.33 13.98 15 19374 1534 63468099
Hypotonia neonatal 36.86 13.98 14 19375 1232 63468401
Drug intolerance 36.21 13.98 25 19364 308636 63160997
HELLP syndrome 35.53 13.98 13 19376 1031 63468602
Steroid dependence 35.44 13.98 15 19374 1749 63467884
Neonatal cholestasis 35.25 13.98 7 19382 48 63469585
Procedural pain 35.21 13.98 38 19351 21531 63448102
Fall 33.94 13.98 42 19347 392292 63077341
Burns second degree 33.79 13.98 15 19374 1963 63467670
Glossodynia 33.30 13.98 7 19382 178869 63290764
Multiple drug therapy 33.21 13.98 18 19371 3628 63466005
Therapeutic product effect decreased 33.14 13.98 9 19380 193178 63276455
Blood pressure inadequately controlled 33.07 13.98 20 19369 4958 63464675
Acute pulmonary oedema 32.87 13.98 24 19365 8134 63461499
Ophthalmic herpes simplex 32.80 13.98 10 19379 450 63469183
Umbilical erythema 32.63 13.98 7 19382 73 63469560
Neonatal respiratory failure 32.59 13.98 9 19380 284 63469349
Hand deformity 32.37 13.98 5 19384 159452 63310181
Starvation ketoacidosis 32.13 13.98 7 19382 79 63469554
Infantile apnoea 31.98 13.98 12 19377 1021 63468612
Rheumatoid arthritis 31.89 13.98 19 19370 253800 63215833
Ventricular septal defect 30.14 13.98 18 19371 4360 63465273
Exercise tolerance decreased 28.79 13.98 19 19370 5478 63464155
Discomfort 28.33 13.98 8 19381 167366 63302267
Pneumocystis jirovecii pneumonia 27.96 13.98 30 19359 16884 63452749
Gastrointestinal disorder 27.14 13.98 95 19294 131144 63338489
Hypopnoea 27.12 13.98 16 19373 3790 63465843
Corneal perforation 27.03 13.98 9 19380 539 63469094
Neonatal intestinal perforation 26.52 13.98 5 19384 25 63469608
Toxicity to various agents 26.45 13.98 22 19367 247228 63222405
Maternal condition affecting foetus 25.98 13.98 7 19382 201 63469432
Pemphigus 25.65 13.98 12 19377 183714 63285919
Hepatic enzyme increased 25.61 13.98 15 19374 202313 63267320
Libido increased 25.58 13.98 11 19378 1334 63468299
Pyrexia 25.52 13.98 237 19152 470241 62999392
Wound 25.49 13.98 9 19380 163254 63306379
Vomiting 25.34 13.98 87 19302 559530 62910103
White matter lesion 24.96 13.98 12 19377 1883 63467750
Pericarditis 24.80 13.98 5 19384 131574 63338059
Eczema 24.51 13.98 39 19350 32252 63437381
Perioral dermatitis 24.25 13.98 7 19382 260 63469373
Sepsis neonatal 24.21 13.98 8 19381 468 63469165
Pulmonary hypoplasia 23.61 13.98 7 19382 286 63469347
Skin burning sensation 23.58 13.98 24 19365 12710 63456923
Cerebral haemorrhage neonatal 23.46 13.98 6 19383 140 63469493
Soft tissue injury 23.41 13.98 11 19378 1641 63467992
Cholestasis of pregnancy 23.24 13.98 10 19379 1215 63468418
Arthralgia 22.90 13.98 93 19296 569617 62900016
Anti-cyclic citrullinated peptide antibody positive 22.78 13.98 4 19385 116208 63353425
Meningitis chemical 22.77 13.98 6 19383 158 63469475
Jaundice neonatal 22.44 13.98 9 19380 916 63468717
Right ventricular dysfunction 22.40 13.98 11 19378 1808 63467825
Pneumocephalus 22.21 13.98 6 19383 174 63469459
Gestational hypertension 22.20 13.98 12 19377 2405 63467228
Intraventricular haemorrhage neonatal 22.18 13.98 6 19383 175 63469458
Pulmonary valve stenosis congenital 22.15 13.98 6 19383 176 63469457
Hostility 22.10 13.98 11 19378 1861 63467772
Nightmare 21.66 13.98 28 19361 19166 63450467
Drug ineffective for unapproved indication 21.65 13.98 38 19351 34025 63435608
Aplastic anaemia 21.40 13.98 20 19369 9549 63460084
Meconium abnormal 21.28 13.98 3 19386 0 63469633
Pulmonary valve disease 21.22 13.98 4 19385 20 63469613
Post-traumatic neck syndrome 21.04 13.98 11 19378 2063 63467570
Diarrhoea 20.67 13.98 131 19258 715235 62754398
Decreased appetite 20.53 13.98 28 19361 251024 63218609
Foetal anaemia 20.42 13.98 5 19384 97 63469536
Sternal fracture 20.18 13.98 11 19378 2243 63467390
Breech presentation 20.08 13.98 9 19380 1205 63468428
Small for dates baby 19.73 13.98 13 19376 3738 63465895
Toxic anterior segment syndrome 19.72 13.98 10 19379 1761 63467872
Pulmonary haemorrhage neonatal 19.60 13.98 4 19385 32 63469601
Stomatitis 19.45 13.98 9 19380 138716 63330917
Alopecia 19.25 13.98 47 19342 337489 63132144
Oesophageal atresia 19.22 13.98 7 19382 548 63469085
Delayed delivery 19.08 13.98 4 19385 37 63469596
Papule 19.07 13.98 15 19374 5676 63463957
Tracheo-oesophageal fistula 18.78 13.98 7 19382 585 63469048
Skin infection 18.70 13.98 23 19366 14979 63454654
Serratia infection 18.64 13.98 8 19381 965 63468668
Synovitis 18.35 13.98 18 19371 186900 63282733
Anaemia neonatal 18.33 13.98 6 19383 341 63469292
Angiotensin converting enzyme inhibitor foetopathy 18.29 13.98 4 19385 46 63469587
Gingival pain 18.14 13.98 17 19372 8145 63461488
Retroplacental haematoma 18.07 13.98 5 19384 159 63469474
Contraindicated product administered 18.07 13.98 24 19365 217624 63252009
Seizure 17.99 13.98 9 19380 132625 63337008
Tachycardia foetal 17.89 13.98 5 19384 165 63469468
Skin plaque 17.86 13.98 17 19372 8303 63461330
Jarisch-Herxheimer reaction 17.84 13.98 6 19383 371 63469262
Neonatal respiratory distress 17.56 13.98 6 19383 389 63469244
Human herpesvirus 6 infection 17.40 13.98 11 19378 2946 63466687
Foetal growth abnormality 17.24 13.98 4 19385 61 63469572
Twin pregnancy 17.21 13.98 8 19381 1165 63468468
Duodenal ulcer perforation 17.10 13.98 3 19386 87206 63382427
Neutropenia 17.01 13.98 17 19372 174988 63294645
Pain 16.89 13.98 145 19244 740483 62729150
Ultrasound uterus abnormal 16.73 13.98 4 19385 70 63469563
Gait disturbance 16.46 13.98 19 19370 183159 63286474
Systemic lupus erythematosus 16.38 13.98 24 19365 208894 63260739
Concussion 16.35 13.98 17 19372 9227 63460406
Impetigo 16.16 13.98 8 19381 1338 63468295
Right aortic arch 16.11 13.98 5 19384 239 63469394
Breast injury 15.99 13.98 4 19385 85 63469548
Hirsutism 15.89 13.98 8 19381 1387 63468246
Rash erythematous 15.81 13.98 38 19351 42472 63427161
Ulcerative keratitis 15.75 13.98 10 19379 2700 63466933
Stenotrophomonas infection 15.71 13.98 9 19380 2018 63467615
Medication error 15.59 13.98 43 19346 52241 63417392
Adenovirus infection 15.52 13.98 11 19378 3560 63466073
Death neonatal 15.40 13.98 7 19382 968 63468665
Swelling 15.18 13.98 39 19350 275339 63194294
Scab 15.05 13.98 15 19374 7748 63461885
Shared psychotic disorder 14.93 13.98 3 19386 22 63469611
Corneal neovascularisation 14.91 13.98 4 19385 113 63469520
Intermittent positive pressure breathing 14.70 13.98 3 19386 24 63469609
Adrenal haematoma 14.70 13.98 3 19386 24 63469609
Helicobacter infection 14.68 13.98 5 19384 92780 63376853
Cardiac failure congestive 14.59 13.98 5 19384 92428 63377205
Dry gangrene 14.56 13.98 6 19383 654 63468979
Pustule 14.41 13.98 8 19381 1691 63467942
Umbilical cord prolapse 14.38 13.98 3 19386 27 63469606
Rheumatoid factor positive 14.34 13.98 4 19385 84402 63385231
Hypopituitarism 14.31 13.98 7 19382 1141 63468492
Decreased insulin requirement 14.23 13.98 4 19385 135 63469498
Fatigue 14.13 13.98 189 19200 887839 62581794

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature baby 960.65 19.21 338 13021 19295 34924277
Low birth weight baby 597.06 19.21 189 13170 7716 34935856
Foetal exposure during pregnancy 550.19 19.21 275 13084 37826 34905746
Appendicolith 419.55 19.21 148 13211 8453 34935119
Appendicitis 348.06 19.21 150 13209 14657 34928915
Drug eruption 311.66 19.21 152 13207 19746 34923826
Stress 296.30 19.21 169 13190 30178 34913394
Cardiogenic shock 269.97 19.21 152 13207 26466 34917106
Stomatitis 225.29 19.21 161 13198 42353 34901219
Hepatic function abnormal 214.62 19.21 159 13200 44204 34899368
Ascites 201.16 19.21 156 13203 46415 34897157
Urticaria 192.57 19.21 172 13187 62205 34881367
Hypersensitivity 183.86 19.21 166 13193 60869 34882703
Ventricular fibrillation 179.88 19.21 111 13248 22843 34920729
Blood phosphorus increased 174.05 19.21 76 13283 7645 34935927
Abdominal distension 168.17 19.21 155 13204 58337 34885235
Hyponatraemia 167.34 19.21 181 13178 82510 34861062
Epistaxis 164.83 19.21 153 13206 58098 34885474
Multiple organ dysfunction syndrome 146.89 19.21 163 13196 76403 34867169
Muscle spasms 139.29 19.21 157 13202 74844 34868728
Pain in extremity 124.70 19.21 194 13165 126319 34817253
Patent ductus arteriosus 116.48 19.21 45 13314 3309 34940263
Neonatal respiratory distress syndrome 105.07 19.21 44 13315 3990 34939582
Constipation 97.77 19.21 182 13177 136800 34806772
Atrial septal defect 93.72 19.21 49 13310 7343 34936229
Sepsis 88.75 19.21 196 13163 166365 34777207
Abdominal pain 84.31 19.21 190 13169 163428 34780144
General physical health deterioration 79.95 19.21 161 13198 128108 34815464
Dry mouth 79.02 19.21 76 13283 30089 34913483
Myasthenia gravis 76.73 19.21 42 13317 6898 34936674
Foetal growth restriction 72.10 19.21 34 13325 4083 34939489
Drug ineffective 69.23 19.21 350 13009 456401 34487171
Blood uric acid increased 66.47 19.21 43 13316 9581 34933991
Toxicity to various agents 58.12 19.21 5 13354 200357 34743215
Drug therapy 45.72 19.21 17 13342 1124 34942448
Analgesic therapy 44.18 19.21 16 13343 982 34942590
Blood cholesterol increased 43.24 19.21 46 13313 20497 34923075
Psoriasis 41.60 19.21 62 13297 38750 34904822
Foetal heart rate deceleration abnormality 41.53 19.21 13 13346 508 34943064
Sleep disorder therapy 40.11 19.21 15 13344 1008 34942564
Septum pellucidum agenesis 37.30 19.21 8 13351 65 34943507
Steroid withdrawal syndrome 36.77 19.21 10 13349 236 34943336
Polydipsia 35.99 19.21 21 13338 3894 34939678
Vomiting 34.64 19.21 186 13173 247435 34696137
Incorrect route of product administration 34.39 19.21 35 13324 14810 34928762
Maternal exposure during pregnancy 34.02 19.21 22 13337 4896 34938676
Hyperphosphataemia 33.56 19.21 21 13338 4416 34939156
Acute kidney injury 32.93 19.21 41 13318 304947 34638625
Iron deficiency 32.21 19.21 22 13337 5359 34938213
Asthenia 32.06 19.21 28 13331 245223 34698349
Condition aggravated 31.50 19.21 151 13208 192045 34751527
Respiratory disorder neonatal 30.20 19.21 14 13345 1616 34941956
Congenital hearing disorder 29.17 19.21 7 13352 98 34943474
Somnolence 29.11 19.21 101 13258 111015 34832557
Neonatal respiratory failure 28.57 19.21 9 13350 359 34943213
Congenital cystic lung 28.04 19.21 8 13351 226 34943346
Corneal endotheliitis 27.95 19.21 6 13353 49 34943523
Perioral dermatitis 26.79 19.21 7 13352 141 34943431
Death 25.76 19.21 73 13286 397976 34545596
Fall 25.50 19.21 24 13335 202861 34740711
Neuralgia 25.23 19.21 30 13329 15083 34928489
Drug abuse 24.92 19.21 4 13355 99092 34844480
Ciliary hyperaemia 24.49 19.21 5 13354 31 34943541
Hydrops foetalis 24.41 19.21 10 13349 857 34942715
Cryptorchism 24.36 19.21 13 13346 2028 34941544
Bronchopulmonary dysplasia 24.29 19.21 9 13350 589 34942983
Persistent corneal epithelial defect 23.97 19.21 5 13354 35 34943537
Polyhydramnios 23.30 19.21 7 13352 238 34943334
Anaplastic astrocytoma 23.29 19.21 6 13353 114 34943458
Vertical infection transmission 22.77 19.21 4 13355 9 34943563
Hypothalamic pituitary adrenal axis suppression 22.08 19.21 6 13353 141 34943431
Congenital pulmonary valve atresia 21.95 19.21 5 13354 55 34943517
Skin indentation 21.94 19.21 4 13355 12 34943560
Haemangioma congenital 21.79 19.21 8 13351 510 34943062
Meningitis aseptic 21.26 19.21 14 13345 3210 34940362
Trisomy 21 20.82 19.21 8 13351 579 34942993
Ventricular septal defect 20.79 19.21 15 13344 3986 34939586
Shared psychotic disorder 20.67 19.21 4 13355 18 34943554
Pulmonary vasculitis 20.66 19.21 8 13351 591 34942981
Bradycardia foetal 20.57 19.21 7 13352 357 34943215
Large for dates baby 20.56 19.21 9 13350 909 34942663
Craniosynostosis 20.28 19.21 7 13352 373 34943199
Cerebral ventricle dilatation 20.12 19.21 9 13350 957 34942615
Cough 19.76 19.21 17 13342 150123 34793449
Back pain 19.72 19.21 11 13348 121778 34821794
Nausea 19.58 19.21 207 13152 339701 34603871
Cardiac failure congestive 19.56 19.21 4 13355 83266 34860306
Haemoglobin decreased 19.43 19.21 11 13348 120761 34822811
Glioblastoma 19.32 19.21 9 13350 1050 34942522

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Premature delivery 1370.27 13.59 444 25564 23023 79695357
Maternal exposure during pregnancy 792.07 13.59 514 25494 136024 79582356
Exposure during pregnancy 643.83 13.59 404 25604 100728 79617652
Appendicolith 439.02 13.59 147 25861 8404 79709976
Appendicitis 318.54 13.59 149 25859 20645 79697735
Drug eruption 245.65 13.59 162 25846 43773 79674607
Cardiogenic shock 218.56 13.59 148 25860 41766 79676614
Premature labour 206.50 13.59 84 25924 8306 79710074
Stress 204.72 13.59 185 25823 79427 79638953
Hepatic function abnormal 192.14 13.59 172 25836 72935 79645445
Ascites 173.76 13.59 165 25843 75397 79642983
Ventricular fibrillation 164.67 13.59 112 25896 31814 79686566
Blood phosphorus increased 164.18 13.59 76 25932 10271 79708109
Computerised tomogram thorax abnormal 158.29 13.59 50 25958 2369 79716011
Psoriasis 123.24 13.59 149 25859 89438 79628942
Epistaxis 122.72 13.59 166 25842 111349 79607031
Abdominal distension 122.50 13.59 172 25836 119478 79598902
Pre-eclampsia 122.03 13.59 55 25953 6986 79711394
Multiple organ dysfunction syndrome 121.84 13.59 172 25836 120074 79598306
Urticaria 120.11 13.59 216 25792 184985 79533395
Computerised tomogram thorax 119.19 13.59 28 25980 422 79717958
Live birth 109.30 13.59 71 25937 18673 79699707
Steroid withdrawal syndrome 106.08 13.59 28 25980 693 79717687
Caesarean section 94.71 13.59 56 25952 12479 79705901
Hyponatraemia 92.59 13.59 189 25819 177659 79540721
Stomatitis 88.58 13.59 166 25842 146591 79571789
Premature rupture of membranes 84.17 13.59 36 25972 4033 79714347
Product use in unapproved indication 83.09 13.59 223 25785 250136 79468244
Normal newborn 82.22 13.59 42 25966 7030 79711350
Premature baby 76.73 13.59 33 25975 3747 79714633
Muscle spasms 74.14 13.59 171 25837 174559 79543821
Corneal endotheliitis 71.48 13.59 14 25994 82 79718298
Atelectasis 71.36 13.59 69 25939 32188 79686192
Toxicity to various agents 70.11 13.59 25 25983 421515 79296865
Gestational diabetes 69.20 13.59 36 25972 6257 79712123
Drug ineffective 67.47 13.59 590 25418 1080323 78638057
Myasthenia gravis 67.11 13.59 42 25966 10357 79708023
Sepsis 66.46 13.59 216 25792 269212 79449168
Constipation 66.32 13.59 223 25785 282827 79435553
Preterm premature rupture of membranes 65.77 13.59 22 25986 1251 79717129
Hypersensitivity 62.67 13.59 208 25800 262031 79456349
Blood uric acid increased 62.13 13.59 44 25964 13316 79705064
Off label use 57.43 13.59 497 25511 906718 78811662
Chronic sinusitis 56.22 13.59 41 25967 12985 79705395
Asthenia 55.68 13.59 51 25957 511638 79206742
Macular degeneration 54.38 13.59 38 25970 11258 79707122
Perioral dermatitis 52.23 13.59 14 25994 368 79718012
Skin exfoliation 51.63 13.59 76 25932 55024 79663356
Foetal growth restriction 51.39 13.59 21 25987 2098 79716282
Incorrect route of product administration 51.12 13.59 60 25948 34869 79683511
Pain in extremity 49.18 13.59 242 25766 364296 79354084
Drug therapy 47.50 13.59 17 25991 1184 79717196
Analgesic therapy 46.48 13.59 16 25992 993 79717387
Skin weeping 45.90 13.59 16 25992 1031 79717349
Paraesthesia oral 45.67 13.59 44 25964 20427 79697953
Oligohydramnios 44.77 13.59 22 25986 3390 79714990
Catarrh 44.16 13.59 19 25989 2159 79716221
Burns second degree 43.86 13.59 20 25988 2608 79715772
Steroid dependence 43.85 13.59 20 25988 2610 79715770
Sleep disorder therapy 42.41 13.59 15 25993 1009 79717371
Fall 41.73 13.59 59 25949 487570 79230810
Amniotic cavity infection 41.57 13.59 14 25994 813 79717567
Polyhydramnios 41.56 13.59 17 25991 1703 79716677
Abdominal pain 41.24 13.59 242 25766 389327 79329053
General physical health deterioration 39.45 13.59 186 25822 275052 79443328
Ophthalmic herpes simplex 39.24 13.59 13 25995 717 79717663
Dry mouth 38.24 13.59 87 25921 87932 79630448
HELLP syndrome 37.98 13.59 13 25995 793 79717587
Placental insufficiency 37.38 13.59 14 25994 1109 79717271
Acute kidney injury 36.85 13.59 71 25937 519333 79199047
Hypoxia 36.25 13.59 94 25914 103149 79615231
Rectal cancer metastatic 36.03 13.59 11 25997 465 79717915
Shared psychotic disorder 35.88 13.59 7 26001 40 79718340
Pneumocystis jirovecii pneumonia 35.12 13.59 48 25960 32460 79685920
Ulcerative keratitis 34.64 13.59 19 25989 3670 79714710
Nausea 34.14 13.59 468 25540 956728 78761652
Drug abuse 34.03 13.59 6 26002 162685 79555695
Eczema 33.57 13.59 53 25955 40765 79677615
Joint swelling 33.51 13.59 27 25981 288619 79429761
Arthralgia 33.35 13.59 87 25921 571716 79146664
Death 33.19 13.59 86 25922 566428 79151952
Procedural pain 32.70 13.59 39 25969 23045 79695335
Hyperphosphataemia 31.98 13.59 22 25986 6354 79712026
Pulmonary valve stenosis congenital 31.68 13.59 5 26003 5 79718375
Polydipsia 31.28 13.59 22 25986 6583 79711797
Cerebral haemorrhage neonatal 31.20 13.59 5 26003 6 79718374
Corneal perforation 30.93 13.59 11 25997 752 79717628
Hypothalamic pituitary adrenal axis suppression 30.81 13.59 9 25999 326 79718054
Cervical incompetence 30.81 13.59 10 25998 517 79717863
Hypopnoea 30.60 13.59 20 25988 5309 79713071
Hypotension 30.51 13.59 61 25947 440256 79278124
Diabetes mellitus inadequate control 29.55 13.59 38 25970 24226 79694154
Gastrointestinal disorder 29.19 13.59 97 25911 122108 79596272
Haemoglobin decreased 28.07 13.59 19 25989 222100 79496280
Starvation ketoacidosis 27.89 13.59 7 26001 141 79718239
Multiple drug therapy 27.65 13.59 17 25991 4061 79714319
Rheumatoid arthritis 27.48 13.59 17 25991 208453 79509927
Maternal condition affecting foetus 27.01 13.59 7 26001 161 79718219
Arthropathy 26.95 13.59 12 25996 177099 79541281
Dehydration 26.63 13.59 25 25983 248162 79470218
Somnolence 26.24 13.59 150 25858 238831 79479549
Diarrhoea 26.24 13.59 174 25834 880315 78838065
Nightmare 26.16 13.59 37 25971 25824 79692556
Foetal hypokinesia 25.80 13.59 8 26000 356 79718024
Parosmia 25.66 13.59 20 25988 6994 79711386
Blood pressure inadequately controlled 25.66 13.59 19 25989 6158 79712222
Condition aggravated 25.27 13.59 262 25746 500862 79217518
Gingival pain 25.26 13.59 22 25986 8976 79709404
Skin burning sensation 24.95 13.59 26 25982 13246 79705134
Cholestasis of pregnancy 24.63 13.59 10 25998 983 79717397
Foetal exposure during pregnancy 24.48 13.59 18 25990 5772 79712608
Gestational hypertension 24.31 13.59 12 25996 1867 79716513
Cardiac failure congestive 22.70 13.59 9 25999 142393 79575987
Persistent corneal epithelial defect 22.57 13.59 5 26003 57 79718323
Decreased appetite 22.39 13.59 49 25959 342369 79376011
Blood cholesterol increased 22.31 13.59 69 25939 83651 79634729
Therapeutic product effect decreased 22.10 13.59 13 25995 163850 79554530
Anaplastic astrocytoma 22.09 13.59 6 26002 166 79718214
Iron deficiency 22.08 13.59 22 25986 10632 79707748
Soft tissue injury 21.94 13.59 11 25997 1770 79716610
Ciliary hyperaemia 21.63 13.59 5 26003 70 79718310
Neutropenia 21.55 13.59 38 25970 287672 79430708
Bradycardia 20.91 13.59 9 25999 135548 79582832
Libido increased 20.73 13.59 11 25997 1990 79716390
Delayed delivery 20.48 13.59 4 26004 23 79718357
Meningitis chemical 20.42 13.59 6 26002 222 79718158
Scab 20.40 13.59 21 25987 10551 79707829
Post-traumatic neck syndrome 20.26 13.59 11 25997 2083 79716297
Acute pulmonary oedema 20.08 13.59 24 25984 14206 79704174
Pulmonary vasculitis 20.03 13.59 8 26000 753 79717627
Impaired quality of life 19.87 13.59 24 25984 14362 79704018
Foetal distress syndrome 19.59 13.59 7 26001 485 79717895
Patent ductus arteriosus 19.50 13.59 5 26003 110 79718270
Hand deformity 19.34 13.59 5 26003 103914 79614466
Exercise tolerance decreased 19.30 13.59 19 25989 9052 79709328
Depressed level of consciousness 19.28 13.59 4 26004 96648 79621732
Hostility 19.25 13.59 11 25997 2299 79716081
Glossodynia 19.18 13.59 5 26003 103332 79615048
Neuritis 19.16 13.59 10 25998 1748 79716632
Retroplacental haematoma 18.89 13.59 5 26003 125 79718255
Hepatic enzyme increased 18.88 13.59 19 25989 182591 79535789
Gait disturbance 18.83 13.59 24 25984 207482 79510898
Twin pregnancy 18.77 13.59 8 26000 888 79717492
Renal failure 18.49 13.59 23 25985 200945 79517435
Coma 18.43 13.59 5 26003 100644 79617736
Atrial septal defect 18.33 13.59 10 25998 1912 79716468
Sternal fracture 18.32 13.59 11 25997 2519 79715861
Seizure 18.02 13.59 21 25987 188813 79529567
Pyrexia 18.02 13.59 316 25692 678393 79039987
Low birth weight baby 17.98 13.59 7 26001 616 79717764
White blood cell count decreased 17.91 13.59 21 25987 188267 79530113
Pneumocephalus 17.82 13.59 6 26002 348 79718032
Rhinitis 17.73 13.59 23 25985 14784 79703596
Glucocorticoid deficiency 17.61 13.59 7 26001 651 79717729
Colitis ulcerative 16.96 13.59 36 25972 34706 79683674
Skin infection 16.84 13.59 25 25983 18220 79700160
Glioblastoma 16.84 13.59 9 25999 1651 79716729
Delivery 16.80 13.59 7 26001 735 79717645
Neuralgia 16.77 13.59 35 25973 33349 79685031
Frequent bowel movements 16.06 13.59 32 25976 29507 79688873
Transient aphasia 16.03 13.59 6 26002 474 79717906
Overdose 16.00 13.59 22 25986 184184 79534196
Myocardial infarction 15.99 13.59 22 25986 184107 79534273
Dermatitis atopic 15.93 13.59 18 25990 10038 79708342
International normalised ratio increased 15.91 13.59 4 26004 84717 79633663
Breast injury 15.82 13.59 4 26004 83 79718297
Rhabdomyolysis 15.66 13.59 7 26001 103124 79615256
Meningitis aseptic 15.66 13.59 15 25993 6913 79711467
Alanine aminotransferase increased 15.60 13.59 18 25990 162552 79555828
Ventricular septal defect 15.56 13.59 6 26002 515 79717865
Anti-cyclic citrullinated peptide antibody positive 15.47 13.59 4 26004 83139 79635241
Hirsutism 15.46 13.59 8 26000 1374 79717006
Arthritis allergic 15.40 13.59 3 26005 17 79718363
Mucosal inflammation 15.34 13.59 3 26005 75577 79642803
Drug ineffective for unapproved indication 15.32 13.59 44 25964 51194 79667186
Adverse drug reaction 15.23 13.59 52 25956 66340 79652040
Synovitis 15.22 13.59 16 25992 150718 79567662
Self-consciousness 15.15 13.59 4 26004 99 79718281
Medication error 15.08 13.59 53 25955 68589 79649791
Pharyngeal erythema 15.07 13.59 9 25999 2041 79716339
Umbilical cord prolapse 14.98 13.59 3 26005 20 79718360
Toxic anterior segment syndrome 14.97 13.59 10 25998 2754 79715626
Hospitalisation 14.94 13.59 6 26002 94230 79624150
Therapeutic product effect incomplete 14.94 13.59 88 25920 141557 79576823
Impetigo 14.94 13.59 9 25999 2074 79716306
Foetal heart rate deceleration abnormality 14.86 13.59 4 26004 107 79718273
Wound 14.59 13.59 10 25998 116169 79602211
Sinusitis 14.47 13.59 26 25982 195475 79522905
Pericarditis 14.43 13.59 8 26000 104228 79614152
Keratitis fungal 14.39 13.59 5 26003 319 79718061
Heart rate increased 14.36 13.59 11 25997 120713 79597667
Back pain 14.32 13.59 51 25957 304129 79414251
Discomfort 14.25 13.59 12 25996 125605 79592775
Rash 14.17 13.59 266 25742 578092 79140288
Hypokalaemia 13.76 13.59 16 25992 144024 79574356
Fluid retention 13.70 13.59 3 26005 69806 79648574
Decreased insulin requirement 13.64 13.59 4 26004 147 79718233

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A07EA04 ALIMENTARY TRACT AND METABOLISM
ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
INTESTINAL ANTIINFLAMMATORY AGENTS
Corticosteroids acting locally
ATC C05AA05 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Corticosteroids
ATC D07AC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, PLAIN
Corticosteroids, potent (group III)
ATC D07BC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTISEPTICS
Corticosteroids, potent, combinations with antiseptics
ATC D07CC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, COMBINATIONS WITH ANTIBIOTICS
Corticosteroids, potent, combinations with antibiotics
ATC D07XC01 DERMATOLOGICALS
CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
CORTICOSTEROIDS, OTHER COMBINATIONS
Corticosteroids, potent, other combinations
ATC H02AB01 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
CORTICOSTEROIDS FOR SYSTEMIC USE
CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
Glucocorticoids
ATC R01AD06 RESPIRATORY SYSTEM
NASAL PREPARATIONS
DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
Corticosteroids
ATC R03BA04 RESPIRATORY SYSTEM
DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
Glucocorticoids
ATC S01BA06 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids, plain
ATC S01BB04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS
Corticosteroids and mydriatics in combination
ATC S01CA05 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
ATC S01CB04 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFLAMMATORY AGENTS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids/antiinfectives/mydriatics in combination
ATC S02BA07 SENSORY ORGANS
OTOLOGICALS
CORTICOSTEROIDS
Corticosteroids
ATC S03BA03 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS
Corticosteroids
ATC S03CA06 SENSORY ORGANS
OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
CORTICOSTEROIDS AND ANTIINFECTIVES IN COMBINATION
Corticosteroids and antiinfectives in combination
FDA MoA N0000175450 Corticosteroid Hormone Receptor Agonists
FDA EPC N0000175576 Corticosteroid
CHEBI has role CHEBI:35472 anti-inflammatory drugs
CHEBI has role CHEBI:35705 immunosuppressive agents
CHEBI has role CHEBI:65023 anti-asthmatic agents
MeSH PA D018927 Anti-Asthmatic Agents
MeSH PA D000893 Anti-Inflammatory Agents
MeSH PA D005938 Glucocorticoids
MeSH PA D006728 Hormones
MeSH PA D019141 Respiratory System Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Disorder of musculoskeletal system indication 928000 DOID:17
Cerebral edema indication 2032001
Tinea pedis indication 6020002 DOID:12403
Berylliosis indication 8247009 DOID:10322
Psoriasis indication 9014002 DOID:8893
Ankylosing spondylitis indication 9631008 DOID:7147
Rheumatic heart disease indication 23685000
Atopic dermatitis indication 24079001 DOID:3310
Inflammatory bowel disease indication 24526004 DOID:0050589
Multiple sclerosis indication 24700007 DOID:2377
Severe adrenal insufficiency indication 24867002
Sarcoidosis indication 31541009 DOID:11335
Idiopathic thrombocytopenic purpura indication 32273002 DOID:8924
Psoriasis with arthropathy indication 33339001
Crohn's disease indication 34000006
Tendinitis indication 34840004 DOID:971
Erythema multiforme indication 36715001
Contact dermatitis indication 40275004 DOID:2773
Angioedema indication 41291007 DOID:1558
Miliary tuberculosis indication 47604008 DOID:9861
Humoral hypercalcemia of malignancy indication 47709007
Articular gout indication 48440001 DOID:13189
Seborrheic dermatitis indication 50563003 DOID:8741
Edema of larynx indication 51599000
Nephrotic syndrome indication 52254009 DOID:1184
Lichen simplex chronicus indication 53891004
Systemic lupus erythematosus indication 55464009 DOID:9074
Allergic rhinitis indication 61582004
Lรถffler's syndrome indication 64936001 DOID:9503
Pemphigus indication 65172003 DOID:9182
Granuloma annulare indication 65508009 DOID:3777
Tenosynovitis indication 67801009 DOID:970
Rheumatoid arthritis indication 69896004 DOID:7148
Transfusion reaction due to serum protein reaction indication 72284000
Epicondylitis indication 73583000 DOID:14087
Acquired thrombocytopenia indication 74576004 DOID:11126
Thyroiditis indication 82119001 DOID:7166
Bursitis indication 84017003 DOID:2965
Tinea corporis indication 84849002
Autoimmune disease indication 85828009
Infection by larvae of Trichinella spiralis indication 88264003
Congenital hypoplastic anemia indication 88854002 DOID:1339
Pruritus ani indication 90446007
Acute lymphoid leukemia indication 91857003 DOID:9952
Disorder of skin indication 95320005 DOID:37
Dermatitis herpetiformis indication 111196000 DOID:8505
Hodgkin's disease indication 118599009
Non-Hodgkin's lymphoma indication 118601006
Mycosis fungoides indication 118618005
Aspiration pneumonitis indication 155597006
Asthma indication 195967001 DOID:2841
Discoid lupus erythematosus indication 200938002
Plaque psoriasis indication 200965009
Transplanted organ rejection indication 213148006
Congenital adrenal hyperplasia indication 237751000
Scalp psoriasis indication 238608008
Adrenogenital disorder indication 267395000 DOID:0050811
Pruritus of genital organs indication 267802000
Eruption of skin indication 271807003 DOID:0050486
Follicular non-Hodgkin's lymphoma indication 308121000
Disorder of eye indication 371405004 DOID:5614
Primary adrenocortical insufficiency indication 373662000
Adrenal cortical hypofunction indication 386584007 DOID:10493
Tinea cruris indication 399029005
Erythroderma indication 399992009
Primary cutaneous T-cell lymphoma indication 400122007
Dermatosis of scalp indication 402694007 DOID:3136
Juvenile rheumatoid arthritis indication 410795001
Autoimmune hemolytic anemia indication 413603009 DOID:718
Synovitis indication 416209007 DOID:2703
Post traumatic osteoarthritis indication 699262001
Systemic Dermatomyositis indication
Diagnostic Test for Cushing's Syndrome indication
Erythroblastic Anemia indication
Synovitis due to Osteoarthritis indication
Transfusion Reaction Urticaria indication
Pericarditis off-label use 3238004 DOID:1787
Chronic obstructive lung disease off-label use 13645005 DOID:3083
West syndrome off-label use 28055006
Vasculitis off-label use 31996006 DOID:865
Bronchitis off-label use 32398004 DOID:6132
Eczema off-label use 43116000
Respiratory distress syndrome in the newborn off-label use 46775006
Nasal polyp off-label use 52756005
Rheumatic fever off-label use 58718002 DOID:1586
Pseudogout off-label use 60782007
Polymyalgia rheumatica off-label use 65323003 DOID:853
Chronic hepatitis off-label use 76783007 DOID:2237
Pemphigoid off-label use 86142006
Hepatic necrosis off-label use 87248009
Multiple myeloma off-label use 109989006 DOID:9538
Polyarteritis nodosa off-label use 155441006 DOID:9810
Celiac disease off-label use 396331005 DOID:10608
Carditis off-label use 399617002
Giant cell arteritis off-label use 414341000 DOID:13375
Hypercalcemia associated with Sarcoidosis off-label use
Neonatal Bronchopulmonary Dysplasia off-label use
Infection by Strongyloides contraindication 1214006 DOID:10955
Mycosis contraindication 3218000 DOID:1564
Gastritis contraindication 4556007 DOID:4029
Inactive tuberculosis contraindication 11999007
Congenital ichthyosis of skin contraindication 13059002
Peptic ulcer contraindication 13200003 DOID:750
Hypercholesterolemia contraindication 13644009
Measles contraindication 14189004 DOID:8622
Cirrhosis of liver contraindication 19943007 DOID:5082
Arginase deficiency contraindication 23501004 DOID:9278
Hypervitaminosis D contraindication 27712000 DOID:9971
Guttate psoriasis contraindication 37042000
Immunosuppression contraindication 38013005
Hypertensive disorder contraindication 38341003 DOID:10763
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Cerebral malaria contraindication 53622003 DOID:14069
Tuberculosis contraindication 56717001
Congenital hyperammonemia, type I contraindication 62522004
Osteoporosis contraindication 64859006 DOID:11476
Hypercalcemia contraindication 66931009 DOID:12678
Psychotic disorder contraindication 69322001
Disorder of calcium metabolism contraindication 71638002 DOID:10575
Hypercalciuria contraindication 71938000
Diabetes mellitus contraindication 73211009 DOID:9351
Hypopituitarism contraindication 74728003 DOID:9406
Hyperglycemia contraindication 80394007 DOID:4195
Ornithine Carbamyltransferase Deficiency contraindication 80908008 DOID:9271
Open-angle glaucoma contraindication 84494001 DOID:1067
Muscle atrophy contraindication 88092000 DOID:767
Herpes simplex contraindication 88594005 DOID:8566
Bilateral cataracts contraindication 95722004
Seizure disorder contraindication 128613002
Disorder of muscle contraindication 129565002 DOID:423
Ophthalmic herpes simplex contraindication 186542001
Pustular psoriasis contraindication 200973000
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Edema contraindication 267038008
Pathological fracture contraindication 268029009
Diverticulitis of gastrointestinal tract contraindication 271366000
Cerebral trauma contraindication 275382005
Varicella-zoster virus infection contraindication 309465005
Osteopenia contraindication 312894000
Avascular necrosis of bone contraindication 397758007 DOID:10159
Citrullinemia contraindication 398680004 DOID:9273
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Traumatic rupture of tendon contraindication 415749005
Exposure to varicella contraindication 444453009
Arginosuccinate Lyase Deficiency contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 11.06 acidic
pKa2 12.45 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Glucocorticoid receptor Nuclear hormone receptor AGONIST IC50 8.07 WOMBAT-PK CHEMBL
Annexin A1 Cytosolic other WOMBAT-PK

External reference:

IDSource
4018644 VUID
N0000146957 NUI
D00244 KEGG_DRUG
1514 RXNORM
C0005308 UMLSCUI
CHEBI:3077 CHEBI
CHEMBL632 ChEMBL_ID
D001623 MESH_DESCRIPTOR_UI
DB00443 DRUGBANK_ID
7061 IUPHAR_LIGAND_ID
1045 INN_ID
9842X06Q6M UNII
9782 PUBCHEM_CID
10006 MMSL
4270 MMSL
d00628 MMSL
116571008 SNOMEDCT_US
29896003 SNOMEDCT_US
4018644 VANDF
002168 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
DR. THROWERS BETA HUMAN PRESCRIPTION DRUG LABEL 1 69299-202 OINTMENT 0.05 g TOPICAL unapproved drug other 4 sections