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| Stem definition | Drug id | CAS RN |
|---|---|---|
| 346 | 5638-76-6 |
| Dose | Unit | Route |
|---|---|---|
| 24 | mg | O |
| Property | Value | Reference |
|---|---|---|
| S (Water solubility) | 38 mg/mL | Bocci G, Oprea TI, Benet LZ |
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Bocci G, Oprea TI, Benet LZ |
| BA (Bioavailability) | 100 % |
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| azlogd74 | LogD at pH 7.4 | -1.963 | High | 1 | |
| caco2-efflux | Caco-2 efflux ratio (BA/AB) | 0.594 | High | 1 | |
| caco2-intrinsic-papp | Caco-2 intrinsic apparent permeability | 5.754 | 10^-6 cm/s | High | 1 |
| dh-clint | Dog hepatocyte intrinsic clearance | 1.968 | uL/min/10^6 cells | High | 1 |
| dppb | Dog plasma protein binding (% unbound) | 92.930 | % | High | 1 |
| fcs-ppb | Fetal calf serum protein binding (% unbound) | 71.620 | % | High | 1 |
| herg | hERG pIC50 | 3.852 | pIC50 | High | 1 |
| hh-clint | Human hepatocyte intrinsic clearance | 1.552 | uL/min/10^6 cells | High | 1 |
| hlm-clint | Human liver microsomal intrinsic clearance | 3.614 | uL/min/mg protein | High | 1 |
| hppb | Human plasma protein binding (% unbound) | 90.640 | % | High | 1 |
| mdck-mdr1-efflux | MDCK-MDR1 efflux ratio | 1.570 | High | 1 | |
| mh-clint | Mouse hepatocyte intrinsic clearance | 6.823 | High | 1 | |
| mppb | Mouse plasma protein binding (% unbound) | 96.020 | High | 1 | |
| nih-mdck-mdr1-efflux | NIH MDCK-MDR1 efflux ratio | 0.673 | High | 1 | |
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 | |||
| pppb | Pig plasma protein binding (% unbound) | 89.050 | % | High | 1 |
| rh-clint | Rat hepatocyte intrinsic clearance | 3.228 | uL/min/10^6 cells | High | 1 |
| rh-fuinc | Rat hepatocyte fraction unbound in incubation | 92.770 | % | High | 1 |
| rppb | Rat plasma protein binding (% unbound) | 92.590 | % | High | 1 |
| solubility-dd | Solubility at pH 7.4 in DMSO | 788.860 | uM | High | 1 |
None
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Parkinsonism | 174.18 | 17.47 | 71 | 14922 | 13994 | 90599460 |
| Hyponatraemia | 156.12 | 17.47 | 148 | 14845 | 133390 | 90480064 |
| Dementia | 135.37 | 17.47 | 70 | 14923 | 23791 | 90589663 |
| Blood cholesterol decreased | 120.40 | 17.47 | 33 | 14960 | 1898 | 90611556 |
| Atrioventricular block first degree | 119.35 | 17.47 | 47 | 14946 | 8464 | 90604990 |
| Peripheral circulatory failure | 112.13 | 17.47 | 30 | 14963 | 1574 | 90611880 |
| Multiple drug therapy | 109.98 | 17.47 | 42 | 14951 | 6967 | 90606487 |
| Hypoglycaemia | 108.57 | 17.47 | 91 | 14902 | 69757 | 90543697 |
| Fall | 99.61 | 17.47 | 235 | 14758 | 481575 | 90131879 |
| Dizziness | 99.45 | 17.47 | 266 | 14727 | 589018 | 90024436 |
| Melaena | 98.44 | 17.47 | 65 | 14928 | 34732 | 90578722 |
| Neuroglycopenia | 97.94 | 17.47 | 25 | 14968 | 1090 | 90612364 |
| Syncope | 97.71 | 17.47 | 115 | 14878 | 132548 | 90480906 |
| Pituitary tumour benign | 94.86 | 17.47 | 28 | 14965 | 2104 | 90611350 |
| Drug dependence | 93.34 | 17.47 | 59 | 14934 | 29268 | 90584186 |
| Gastric polyps | 91.69 | 17.47 | 33 | 14960 | 4639 | 90608815 |
| Cognitive disorder | 90.85 | 17.47 | 82 | 14911 | 69325 | 90544129 |
| Urinary retention | 88.98 | 17.47 | 63 | 14930 | 37681 | 90575773 |
| Initial insomnia | 79.04 | 17.47 | 36 | 14957 | 9274 | 90604180 |
| Bradykinesia | 76.35 | 17.47 | 32 | 14961 | 6756 | 90606698 |
| Stupor | 75.90 | 17.47 | 30 | 14963 | 5452 | 90608002 |
| Enthesopathy | 75.56 | 17.47 | 35 | 14958 | 9369 | 90604085 |
| Lichen planopilaris | 70.71 | 17.47 | 14 | 14979 | 186 | 90613268 |
| Hyperkalaemia | 70.16 | 17.47 | 69 | 14924 | 64895 | 90548559 |
| Diabetes mellitus inadequate control | 68.13 | 17.47 | 41 | 14952 | 18643 | 90594811 |
| Polyp | 66.29 | 17.47 | 30 | 14963 | 7614 | 90605840 |
| Palpitations | 65.57 | 17.47 | 96 | 14897 | 136632 | 90476822 |
| Vertigo | 64.21 | 17.47 | 68 | 14925 | 69743 | 90543711 |
| Vitamin B12 decreased | 59.61 | 17.47 | 25 | 14968 | 5285 | 90608169 |
| Blood creatine increased | 59.33 | 17.47 | 27 | 14966 | 6940 | 90606514 |
| Tenosynovitis | 58.43 | 17.47 | 34 | 14959 | 14533 | 90598921 |
| Dysuria | 56.42 | 17.47 | 49 | 14944 | 39352 | 90574102 |
| Hyperprolactinaemia | 55.75 | 17.47 | 24 | 14969 | 5409 | 90608045 |
| Hypotension | 52.79 | 17.47 | 145 | 14848 | 325252 | 90288202 |
| Osteoporosis | 52.51 | 17.47 | 72 | 14921 | 96459 | 90516995 |
| Hypotonia | 52.10 | 17.47 | 29 | 14964 | 11397 | 90602057 |
| Eye pruritus | 51.77 | 17.47 | 41 | 14952 | 28986 | 90584468 |
| Muscle rigidity | 51.14 | 17.47 | 31 | 14962 | 14278 | 90599176 |
| Secondary adrenocortical insufficiency | 47.85 | 17.47 | 17 | 14976 | 2301 | 90611153 |
| Neuropathy, ataxia, retinitis pigmentosa syndrome | 46.10 | 17.47 | 8 | 14985 | 48 | 90613406 |
| Motor dysfunction | 45.08 | 17.47 | 32 | 14961 | 19198 | 90594256 |
| Oral pain | 43.50 | 17.47 | 39 | 14954 | 32644 | 90580810 |
| Hiatus hernia | 43.47 | 17.47 | 35 | 14958 | 25326 | 90588128 |
| Synovitis | 42.94 | 17.47 | 3 | 14990 | 329749 | 90283705 |
| Confabulation | 42.47 | 17.47 | 10 | 14983 | 310 | 90613144 |
| Swelling | 42.07 | 17.47 | 9 | 14984 | 419049 | 90194405 |
| Blood urea increased | 41.89 | 17.47 | 37 | 14956 | 30376 | 90583078 |
| Sinus bradycardia | 41.57 | 17.47 | 29 | 14964 | 16923 | 90596531 |
| Dopamine transporter scintigraphy abnormal | 41.00 | 17.47 | 8 | 14985 | 98 | 90613356 |
| Poor peripheral circulation | 38.75 | 17.47 | 17 | 14976 | 4008 | 90609446 |
| Metastases to fallopian tube | 37.94 | 17.47 | 7 | 14986 | 62 | 90613392 |
| Hypomagnesaemia | 36.93 | 17.47 | 37 | 14956 | 35551 | 90577903 |
| Micturition disorder | 36.54 | 17.47 | 15 | 14978 | 3005 | 90610449 |
| Arthropathy | 36.48 | 17.47 | 8 | 14985 | 366234 | 90247220 |
| Hyperreflexia | 36.22 | 17.47 | 19 | 14974 | 6638 | 90606816 |
| Wound | 36.08 | 17.47 | 4 | 14989 | 302976 | 90310478 |
| Infusion related reaction | 36.08 | 17.47 | 12 | 14981 | 416768 | 90196686 |
| Constipation | 35.96 | 17.47 | 115 | 14878 | 280280 | 90333174 |
| Atrial fibrillation | 35.21 | 17.47 | 72 | 14921 | 133539 | 90479915 |
| Pain | 35.18 | 17.47 | 70 | 14923 | 996271 | 89617183 |
| Rash | 33.50 | 17.47 | 50 | 14943 | 796050 | 89817404 |
| Lacrimation increased | 33.49 | 17.47 | 31 | 14962 | 27031 | 90586423 |
| Drug interaction | 33.30 | 17.47 | 111 | 14882 | 276342 | 90337112 |
| Sinusitis | 33.16 | 17.47 | 8 | 14985 | 343080 | 90270374 |
| Perseveration | 33.12 | 17.47 | 8 | 14985 | 277 | 90613177 |
| Therapy partial responder | 32.74 | 17.47 | 28 | 14965 | 22015 | 90591439 |
| Blood pressure decreased | 32.19 | 17.47 | 50 | 14943 | 74845 | 90538609 |
| Cerebellar ataxia | 31.99 | 17.47 | 10 | 14983 | 912 | 90612542 |
| Haemorrhoids | 31.91 | 17.47 | 30 | 14963 | 26672 | 90586782 |
| Hepatic enzyme increased | 31.90 | 17.47 | 10 | 14983 | 360726 | 90252728 |
| Scleritis | 31.61 | 17.47 | 16 | 14977 | 5192 | 90608262 |
| Labelled drug-drug interaction issue | 30.01 | 17.47 | 12 | 14981 | 2246 | 90611208 |
| Apraxia | 29.99 | 17.47 | 12 | 14981 | 2250 | 90611204 |
| Serum serotonin increased | 29.79 | 17.47 | 7 | 14986 | 215 | 90613239 |
| Drug intolerance | 29.30 | 17.47 | 19 | 14974 | 447572 | 90165882 |
| Metastases to bladder | 29.25 | 17.47 | 7 | 14986 | 233 | 90613221 |
| Blister | 28.81 | 17.47 | 4 | 14989 | 254994 | 90358460 |
| Endometrial cancer stage I | 28.64 | 17.47 | 7 | 14986 | 255 | 90613199 |
| Blood potassium increased | 28.09 | 17.47 | 25 | 14968 | 20724 | 90592730 |
| Orthostatic hypotension | 27.07 | 17.47 | 34 | 14959 | 41793 | 90571661 |
| Maternal exposure during pregnancy | 26.85 | 17.47 | 13 | 14980 | 360050 | 90253404 |
| Crystal arthropathy | 26.60 | 17.47 | 7 | 14986 | 344 | 90613110 |
| Depressed mood | 26.60 | 17.47 | 37 | 14956 | 50185 | 90563269 |
| Weight increased | 25.68 | 17.47 | 19 | 14974 | 417908 | 90195546 |
| Carcinoid tumour | 25.25 | 17.47 | 7 | 14986 | 420 | 90613034 |
| Peptic ulcer | 25.24 | 17.47 | 14 | 14979 | 5461 | 90607993 |
| Hyperglycaemia | 24.71 | 17.47 | 36 | 14957 | 50934 | 90562520 |
| Disorientation | 24.11 | 17.47 | 33 | 14960 | 44081 | 90569373 |
| Loss of control of legs | 23.87 | 17.47 | 9 | 14984 | 1441 | 90612013 |
| Metastases to ovary | 23.79 | 17.47 | 7 | 14986 | 520 | 90612934 |
| Joint swelling | 23.78 | 17.47 | 29 | 14964 | 503271 | 90110183 |
| Dropped head syndrome | 23.56 | 17.47 | 6 | 14987 | 259 | 90613195 |
| Serotonin syndrome | 23.26 | 17.47 | 30 | 14963 | 37857 | 90575597 |
| Oedema | 22.96 | 17.47 | 3 | 14990 | 200292 | 90413162 |
| Lethargy | 22.85 | 17.47 | 39 | 14954 | 63100 | 90550354 |
| Sputum discoloured | 22.64 | 17.47 | 22 | 14971 | 20369 | 90593085 |
| Injury | 22.52 | 17.47 | 3 | 14990 | 197346 | 90416108 |
| Pharyngeal mass | 22.36 | 17.47 | 6 | 14987 | 318 | 90613136 |
| Hypomenorrhoea | 22.30 | 17.47 | 7 | 14986 | 647 | 90612807 |
| Cardiospasm | 22.13 | 17.47 | 11 | 14982 | 3435 | 90610019 |
| Palmoplantar keratoderma | 21.95 | 17.47 | 11 | 14982 | 3496 | 90609958 |
| Death | 21.88 | 17.47 | 26 | 14967 | 456525 | 90156929 |
| Discomfort | 21.87 | 17.47 | 9 | 14984 | 274326 | 90339128 |
| Autoimmune thyroiditis | 21.66 | 17.47 | 13 | 14980 | 5880 | 90607574 |
| Subcutaneous haematoma | 21.59 | 17.47 | 9 | 14984 | 1874 | 90611580 |
| Basal ganglia haemorrhage | 21.26 | 17.47 | 7 | 14986 | 754 | 90612700 |
| Urine output decreased | 20.77 | 17.47 | 17 | 14976 | 12586 | 90600868 |
| Product administration error | 19.57 | 17.47 | 23 | 14970 | 26400 | 90587054 |
| Endometrial hyperplasia | 19.53 | 17.47 | 7 | 14986 | 972 | 90612482 |
| Sleep terror | 19.45 | 17.47 | 11 | 14982 | 4453 | 90609001 |
| Medication error | 19.27 | 17.47 | 43 | 14950 | 84609 | 90528845 |
| Pruritus genital | 19.24 | 17.47 | 11 | 14982 | 4547 | 90608907 |
| Nystagmus | 19.22 | 17.47 | 13 | 14980 | 7214 | 90606240 |
| Vision blurred | 18.68 | 17.47 | 50 | 14943 | 110243 | 90503211 |
| Brain injury | 18.42 | 17.47 | 13 | 14980 | 7725 | 90605729 |
| Lip swelling | 18.32 | 17.47 | 27 | 14966 | 38583 | 90574871 |
| Pericarditis | 18.31 | 17.47 | 11 | 14982 | 270140 | 90343314 |
| Carotid artery occlusion | 18.30 | 17.47 | 12 | 14981 | 6330 | 90607124 |
| Renal failure | 17.93 | 17.47 | 55 | 14938 | 130952 | 90482502 |
| Sedation | 17.75 | 17.47 | 30 | 14963 | 48141 | 90565313 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Soft tissue mass | 139.78 | 22.55 | 30 | 4403 | 982 | 42615920 |
| Oesophageal perforation | 139.36 | 22.55 | 31 | 4402 | 1202 | 42615700 |
| Multimorbidity | 136.37 | 22.55 | 29 | 4404 | 908 | 42615994 |
| Superinfection | 107.88 | 22.55 | 30 | 4403 | 2921 | 42613981 |
| Transplant failure | 102.83 | 22.55 | 31 | 4402 | 4013 | 42612889 |
| Immunosuppressant drug level increased | 94.24 | 22.55 | 34 | 4399 | 7697 | 42609205 |
| Oesophageal carcinoma | 93.85 | 22.55 | 36 | 4397 | 9660 | 42607242 |
| Lung consolidation | 83.77 | 22.55 | 30 | 4403 | 6647 | 42610255 |
| Inflammatory marker increased | 83.42 | 22.55 | 30 | 4403 | 6726 | 42610176 |
| Rales | 68.21 | 22.55 | 30 | 4403 | 11370 | 42605532 |
| Myocardial ischaemia | 66.99 | 22.55 | 34 | 4399 | 17728 | 42599174 |
| Cardiomegaly | 57.19 | 22.55 | 30 | 4403 | 16736 | 42600166 |
| Labelled drug-drug interaction medication error | 53.48 | 22.55 | 28 | 4405 | 15554 | 42601348 |
| Anticoagulation drug level above therapeutic | 49.65 | 22.55 | 16 | 4417 | 2574 | 42614328 |
| Hypoglycaemia | 48.43 | 22.55 | 44 | 4389 | 59810 | 42557092 |
| Lower respiratory tract infection | 47.17 | 22.55 | 37 | 4396 | 41169 | 42575733 |
| Drug level increased | 40.03 | 22.55 | 28 | 4405 | 26172 | 42590730 |
| Hepatitis acute | 36.23 | 22.55 | 18 | 4415 | 8957 | 42607945 |
| Haemoptysis | 31.69 | 22.55 | 31 | 4402 | 46136 | 42570766 |
| Product prescribing error | 31.06 | 22.55 | 24 | 4409 | 26088 | 42590814 |
| Vertigo | 29.24 | 22.55 | 26 | 4407 | 34321 | 42582581 |
| Productive cough | 28.82 | 22.55 | 31 | 4402 | 51536 | 42565366 |
| Loss of proprioception | 28.08 | 22.55 | 7 | 4426 | 445 | 42616457 |
| Dysphagia | 27.82 | 22.55 | 36 | 4397 | 72683 | 42544219 |
| Intercepted medication error | 27.20 | 22.55 | 7 | 4426 | 506 | 42616396 |
| Vascular dementia | 26.76 | 22.55 | 7 | 4426 | 539 | 42616363 |
| Ascites | 26.42 | 22.55 | 31 | 4402 | 56647 | 42560255 |
| Malaise | 26.42 | 22.55 | 64 | 4369 | 212092 | 42404810 |
| Renal impairment | 24.10 | 22.55 | 42 | 4391 | 110186 | 42506716 |
| Atrial thrombosis | 23.37 | 22.55 | 9 | 4424 | 2435 | 42614467 |
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hypoglycaemia | 132.19 | 16.37 | 130 | 19175 | 115974 | 110454020 |
| Parkinsonism | 130.83 | 16.37 | 68 | 19237 | 22119 | 110547875 |
| Hyponatraemia | 130.77 | 16.37 | 175 | 19130 | 217478 | 110352516 |
| Dizziness | 114.74 | 16.37 | 323 | 18982 | 697870 | 109872124 |
| Oesophageal perforation | 109.53 | 16.37 | 30 | 19275 | 1629 | 110568365 |
| Blood cholesterol decreased | 107.51 | 16.37 | 33 | 19272 | 2683 | 110567311 |
| Soft tissue mass | 107.17 | 16.37 | 29 | 19276 | 1504 | 110568490 |
| Peripheral circulatory failure | 106.79 | 16.37 | 30 | 19275 | 1789 | 110568205 |
| Dementia | 103.28 | 16.37 | 66 | 19239 | 31607 | 110538387 |
| Multimorbidity | 102.74 | 16.37 | 28 | 19277 | 1492 | 110568502 |
| Multiple drug therapy | 102.32 | 16.37 | 42 | 19263 | 7972 | 110562022 |
| Fall | 101.83 | 16.37 | 282 | 19023 | 603200 | 109966794 |
| Atrioventricular block first degree | 96.70 | 16.37 | 48 | 19257 | 14177 | 110555817 |
| Neuroglycopenia | 96.35 | 16.37 | 25 | 19280 | 1101 | 110568893 |
| Pituitary tumour benign | 89.45 | 16.37 | 29 | 19276 | 2818 | 110567176 |
| Vertigo | 87.38 | 16.37 | 91 | 19214 | 86779 | 110483215 |
| Gastric polyps | 84.58 | 16.37 | 33 | 19272 | 5490 | 110564504 |
| Syncope | 82.84 | 16.37 | 136 | 19169 | 202400 | 110367594 |
| Transplant failure | 73.54 | 16.37 | 30 | 19275 | 5605 | 110564389 |
| Initial insomnia | 73.42 | 16.37 | 36 | 19269 | 10353 | 110559641 |
| Drug dependence | 72.29 | 16.37 | 64 | 19241 | 49956 | 110520038 |
| Lichen planopilaris | 72.23 | 16.37 | 14 | 19291 | 156 | 110569838 |
| Cognitive disorder | 71.19 | 16.37 | 82 | 19223 | 87429 | 110482565 |
| Urinary retention | 70.07 | 16.37 | 73 | 19232 | 69610 | 110500384 |
| Superinfection | 69.50 | 16.37 | 29 | 19276 | 5734 | 110564260 |
| Palpitations | 67.92 | 16.37 | 109 | 19196 | 159103 | 110410891 |
| Oesophageal carcinoma | 67.01 | 16.37 | 35 | 19270 | 11489 | 110558505 |
| Stupor | 65.56 | 16.37 | 31 | 19274 | 8234 | 110561760 |
| Vitamin B12 decreased | 61.88 | 16.37 | 26 | 19279 | 5231 | 110564763 |
| Immunosuppressant drug level increased | 60.82 | 16.37 | 33 | 19272 | 11691 | 110558303 |
| Bradykinesia | 60.56 | 16.37 | 32 | 19273 | 10756 | 110559238 |
| Enthesopathy | 58.90 | 16.37 | 33 | 19272 | 12445 | 110557549 |
| Melaena | 56.88 | 16.37 | 65 | 19240 | 68692 | 110501302 |
| Polyp | 54.31 | 16.37 | 29 | 19276 | 9951 | 110560043 |
| Diabetes mellitus inadequate control | 53.09 | 16.37 | 43 | 19262 | 29732 | 110540262 |
| Lung consolidation | 52.99 | 16.37 | 29 | 19276 | 10447 | 110559547 |
| Hyperkalaemia | 52.56 | 16.37 | 89 | 19216 | 135707 | 110434287 |
| Osteoporosis | 52.13 | 16.37 | 70 | 19235 | 87082 | 110482912 |
| Inflammatory marker increased | 51.80 | 16.37 | 32 | 19273 | 14437 | 110555557 |
| Hyperprolactinaemia | 50.13 | 16.37 | 24 | 19281 | 6551 | 110563443 |
| Tenosynovitis | 48.34 | 16.37 | 32 | 19273 | 16251 | 110553743 |
| Eye pruritus | 47.48 | 16.37 | 42 | 19263 | 32733 | 110537261 |
| Neuropathy, ataxia, retinitis pigmentosa syndrome | 45.67 | 16.37 | 8 | 19297 | 48 | 110569946 |
| Blood creatine increased | 45.15 | 16.37 | 27 | 19278 | 11494 | 110558500 |
| Hypotonia | 42.10 | 16.37 | 29 | 19276 | 15716 | 110554278 |
| Dysuria | 41.68 | 16.37 | 52 | 19253 | 60179 | 110509815 |
| Muscle rigidity | 41.36 | 16.37 | 34 | 19271 | 23997 | 110545997 |
| Death | 41.04 | 16.37 | 37 | 19268 | 698832 | 109871162 |
| Constipation | 40.61 | 16.37 | 146 | 19159 | 357640 | 110212354 |
| Cardiomegaly | 39.57 | 16.37 | 36 | 19269 | 29094 | 110540900 |
| Hiatus hernia | 39.24 | 16.37 | 35 | 19270 | 27571 | 110542423 |
| Metastases to fallopian tube | 37.67 | 16.37 | 7 | 19298 | 61 | 110569933 |
| Sinus bradycardia | 37.27 | 16.37 | 35 | 19270 | 29448 | 110540546 |
| Confabulation | 37.09 | 16.37 | 10 | 19295 | 511 | 110569483 |
| Motor dysfunction | 36.80 | 16.37 | 32 | 19273 | 24374 | 110545620 |
| Secondary adrenocortical insufficiency | 36.30 | 16.37 | 17 | 19288 | 4417 | 110565577 |
| Myocardial ischaemia | 36.29 | 16.37 | 33 | 19272 | 26651 | 110543343 |
| Lacrimation increased | 35.82 | 16.37 | 35 | 19270 | 30915 | 110539079 |
| Hypomagnesaemia | 35.35 | 16.37 | 48 | 19257 | 60322 | 110509672 |
| Drug interaction | 34.89 | 16.37 | 176 | 19129 | 500007 | 110069987 |
| Oral pain | 33.70 | 16.37 | 37 | 19268 | 37407 | 110532587 |
| Rales | 32.48 | 16.37 | 30 | 19275 | 24709 | 110545285 |
| Endometrial cancer stage I | 30.39 | 16.37 | 7 | 19298 | 186 | 110569808 |
| Labelled drug-drug interaction medication error | 29.99 | 16.37 | 31 | 19274 | 29271 | 110540723 |
| Anticoagulation drug level above therapeutic | 29.63 | 16.37 | 15 | 19290 | 4615 | 110565379 |
| Perseveration | 29.48 | 16.37 | 8 | 19297 | 419 | 110569575 |
| Arthropathy | 29.45 | 16.37 | 7 | 19298 | 287515 | 110282479 |
| Micturition disorder | 29.42 | 16.37 | 15 | 19290 | 4683 | 110565311 |
| Hyperreflexia | 29.03 | 16.37 | 19 | 19286 | 9466 | 110560528 |
| Crystal arthropathy | 28.21 | 16.37 | 7 | 19298 | 257 | 110569737 |
| Orthostatic hypotension | 27.74 | 16.37 | 45 | 19260 | 66204 | 110503790 |
| Vascular dementia | 27.31 | 16.37 | 9 | 19296 | 920 | 110569074 |
| Sinusitis | 27.09 | 16.37 | 9 | 19296 | 296679 | 110273315 |
| Hypotension | 27.02 | 16.37 | 170 | 19135 | 523679 | 110046315 |
| Malaise | 26.97 | 16.37 | 205 | 19100 | 671614 | 109898380 |
| Blister | 26.55 | 16.37 | 4 | 19301 | 227372 | 110342622 |
| Metastases to bladder | 26.39 | 16.37 | 7 | 19298 | 336 | 110569658 |
| Serum serotonin increased | 25.64 | 16.37 | 7 | 19298 | 375 | 110569619 |
| Hepatic enzyme increased | 25.58 | 16.37 | 12 | 19293 | 320880 | 110249114 |
| Metastases to ovary | 25.33 | 16.37 | 7 | 19298 | 393 | 110569601 |
| Blood urea increased | 25.31 | 16.37 | 39 | 19266 | 54918 | 110515076 |
| Disease progression | 24.87 | 16.37 | 6 | 19299 | 244028 | 110325966 |
| Apraxia | 24.22 | 16.37 | 12 | 19293 | 3528 | 110566466 |
| Hypomenorrhoea | 23.96 | 16.37 | 7 | 19298 | 480 | 110569514 |
| Infusion related reaction | 23.78 | 16.37 | 19 | 19286 | 381143 | 110188851 |
| Blood pressure decreased | 23.62 | 16.37 | 58 | 19247 | 115033 | 110454961 |
| Cerebellar ataxia | 23.49 | 16.37 | 10 | 19295 | 2078 | 110567916 |
| Haemorrhoids | 23.41 | 16.37 | 30 | 19275 | 35642 | 110534352 |
| Loss of control of legs | 23.28 | 16.37 | 10 | 19295 | 2122 | 110567872 |
| Drug intolerance | 23.26 | 16.37 | 22 | 19283 | 406490 | 110163504 |
| Carcinoid tumour | 22.58 | 16.37 | 7 | 19298 | 588 | 110569406 |
| Labelled drug-drug interaction issue | 22.55 | 16.37 | 12 | 19293 | 4089 | 110565905 |
| Autoimmune thyroiditis | 22.45 | 16.37 | 14 | 19291 | 6420 | 110563574 |
| Lethargy | 22.30 | 16.37 | 50 | 19255 | 93526 | 110476468 |
| Oedema | 21.72 | 16.37 | 5 | 19300 | 209971 | 110360023 |
| Lentigo maligna | 21.64 | 16.37 | 7 | 19298 | 675 | 110569319 |
| Lactic acidosis | 21.46 | 16.37 | 49 | 19256 | 92762 | 110477232 |
| Endometrial hyperplasia | 21.44 | 16.37 | 7 | 19298 | 695 | 110569299 |
| Femur fracture | 21.10 | 16.37 | 32 | 19273 | 44437 | 110525557 |
| Pharyngeal mass | 21.10 | 16.37 | 6 | 19299 | 374 | 110569620 |
| Depressed mood | 21.10 | 16.37 | 38 | 19267 | 60771 | 110509223 |
| Injury | 20.96 | 16.37 | 3 | 19302 | 177262 | 110392732 |
| Off label use | 20.91 | 16.37 | 165 | 19140 | 1500020 | 109069974 |
| Weight increased | 20.38 | 16.37 | 26 | 19279 | 419618 | 110150376 |
| Peptic ulcer | 20.29 | 16.37 | 14 | 19291 | 7605 | 110562389 |
| Pain | 20.16 | 16.37 | 92 | 19213 | 954863 | 109615131 |
| Loss of proprioception | 19.63 | 16.37 | 7 | 19298 | 907 | 110569087 |
| Vestibular neuronitis | 19.34 | 16.37 | 7 | 19298 | 946 | 110569048 |
| Sputum discoloured | 19.13 | 16.37 | 24 | 19281 | 27921 | 110542073 |
| Product prescribing error | 19.00 | 16.37 | 33 | 19272 | 51298 | 110518696 |
| Joint swelling | 18.97 | 16.37 | 30 | 19275 | 442815 | 110127179 |
| Dropped head syndrome | 18.93 | 16.37 | 6 | 19299 | 542 | 110569452 |
| Irritable bowel syndrome | 18.91 | 16.37 | 3 | 19302 | 164212 | 110405782 |
| Maternal exposure during pregnancy | 18.15 | 16.37 | 11 | 19294 | 254872 | 110315122 |
| Renal impairment | 18.13 | 16.37 | 73 | 19232 | 188372 | 110381622 |
| Completed suicide | 17.91 | 16.37 | 10 | 19295 | 242371 | 110327623 |
| Psoriatic arthropathy | 17.90 | 16.37 | 6 | 19299 | 196755 | 110373239 |
| Calcium deficiency | 17.88 | 16.37 | 7 | 19298 | 1175 | 110568819 |
| Therapy non-responder | 17.83 | 16.37 | 3 | 19302 | 157304 | 110412690 |
| Cardiospasm | 17.82 | 16.37 | 11 | 19294 | 4956 | 110565038 |
| Vision blurred | 17.56 | 16.37 | 56 | 19249 | 128966 | 110441028 |
| Blood potassium increased | 17.32 | 16.37 | 25 | 19280 | 33224 | 110536770 |
| Subcutaneous haematoma | 17.02 | 16.37 | 9 | 19296 | 3027 | 110566967 |
| Palmoplantar keratoderma | 17.00 | 16.37 | 11 | 19294 | 5376 | 110564618 |
| Drug level increased | 16.78 | 16.37 | 30 | 19275 | 47689 | 110522305 |
None
| Source | Code | Description |
|---|---|---|
| ATC | N07CA01 | NERVOUS SYSTEM OTHER NERVOUS SYSTEM DRUGS ANTIVERTIGO PREPARATIONS Antivertigo preparations |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D014665 | Vasodilator Agents |
| MeSH PA | D017442 | Histamine Agonists |
| MeSH PA | D018377 | Neurotransmitter Agents |
| CHEBI has role | CHEBI:35620 | vasodilator agent |
| CHEBI has role | CHEBI:71173 | H<small><sub>1</sub></small>-receptor agonist |
| CHEBI has role | CHEBI:74518 | anti-obesity agent |
| CHEBI has role | CHEBI:35469 | antidepressant |
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Ménière's disease | indication | 13445001 | DOID:9849 |
None
None
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.53 | Basic |
| pKa2 | 3.77 | Basic |
None
None
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | GPCR | INVERSE AGONIST | EC50 | 9.52 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Histamine H3 receptor | GPCR | Ki | 5.69 | CHEMBL |
| ID | Source |
|---|---|
| 4027336 | VUID |
| N0000179397 | NUI |
| D01592 | KEGG_DRUG |
| 5579-84-0 | SECONDARY_CAS_RN |
| 1511 | RXNORM |
| C0005301 | UMLSCUI |
| CHEBI:35677 | CHEBI |
| CHEMBL4298035 | ChEMBL_ID |
| CHEMBL24441 | ChEMBL_ID |
| 2366 | PUBCHEM_CID |
| DB06698 | DRUGBANK_ID |
| CHEMBL1446813 | ChEMBL_ID |
| D001621 | MESH_DESCRIPTOR_UI |
| 1502 | INN_ID |
| 11937 | IUPHAR_LIGAND_ID |
| 54856-23-4 | SECONDARY_CAS_RN |
| X32KK4201D | UNII |
| NOCODE | MMSL |
| 4027336 | VANDF |
| 4033254 | VANDF |
| 000702 | NDDF |
| 004531 | NDDF |
| 005313 | NDDF |
| 006923 | NDDF |
| 322052003 | SNOMEDCT_US |
| 350631001 | SNOMEDCT_US |
| 418067008 | SNOMEDCT_US |
| 708177006 | SNOMEDCT_US |
None