betacarotene indications/contra

Stem definitionDrug idCAS RN
arotinoid derivatives 345 7235-40-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betacarotene
  • provatene
  • beta-Carotene
  • beta carotene
A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).
  • Molecular weight: 536.89
  • Formula: C40H56
  • CLOGP: 15.23
  • LIPINSKI: 2
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS: -6.14
  • ROTB: 10

Drug dosage:

DoseUnitRoute
0.10 g O

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC A11CA02 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin A, plain
ATC D02BB01 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
PROTECTIVES AGAINST UV-RADIATION
Protectives against UV-radiation for systemic use
MeSH PA D006133 Growth Substances
MeSH PA D018977 Micronutrients
MeSH PA D000072664 Provitamins
MeSH PA D014815 Vitamins

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Primary hyperoxaluria contraindication 17901006 DOID:2977
Blood coagulation disorder contraindication 64779008 DOID:1247
Wilson's disease contraindication 88518009 DOID:893
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Hemochromatosis contraindication 399187006 DOID:2352
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Core protein Unclassified IC50 4.53 CHEMBL

External reference:

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IDSource
4020599 VUID
N0000148286 NUI
C0053396 UMLSCUI
D03101 KEGG_DRUG
6766 MMSL
19143 RXNORM
4269 MMSL
d01385 MMSL
103068006 SNOMEDCT_US
329507006 SNOMEDCT_US
5679 MMSL
4020599 VANDF
4017793 VANDF
N0000148286 NDFRT
N0000007226 NDFRT
N0000146154 NDFRT
001003 NDDF
002022 NDDF
CHEMBL1293 ChEMBL_ID
5280489 PUBCHEM_CID
DB06755 DRUGBANK_ID
D019207 MESH_DESCRIPTOR_UI
CHEBI:17579 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 13 13925-117 TABLET, CHEWABLE 1000 [iU] ORAL unapproved drug other 11 sections
Prenatal Vitamins Plus Low Iron HUMAN PRESCRIPTION DRUG LABEL 13 39328-106 TABLET 920 [iU] ORAL Unapproved drug other 8 sections
Bal-Care DHA HUMAN PRESCRIPTION DRUG LABEL 16 42546-180 KIT 2850 [iU] None unapproved drug other 4 sections
Bal-Care DHA Essential HUMAN PRESCRIPTION DRUG LABEL 16 42546-185 KIT 2850 [iU] None unapproved drug other 4 sections
Moms Choice Rx HUMAN PRESCRIPTION DRUG LABEL 14 42546-190 KIT 2840 [iU] None unapproved drug other 5 sections
PR Natal 400 ec HUMAN PRESCRIPTION DRUG LABEL 14 42546-517 KIT 3000 [iU] None unapproved drug other 11 sections
PR Natal 430 ec HUMAN PRESCRIPTION DRUG LABEL 14 42546-518 KIT 3000 [iU] None unapproved drug other 11 sections
PR Natal 400 HUMAN PRESCRIPTION DRUG LABEL 14 42546-811 KIT 3000 [iU] None unapproved drug other 11 sections
PR Natal 430 HUMAN PRESCRIPTION DRUG LABEL 14 42546-812 KIT 3000 [iU] None unapproved drug other 11 sections
Folet DHA HUMAN PRESCRIPTION DRUG LABEL 14 67555-153 KIT 2700 [iU] None unapproved drug other 5 sections