pantethine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
3417 16816-67-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pantethine
  • lipodel
  • pantetina
  • panthecin
  • pantomin
  • pantosin
  • Molecular weight: 554.72
  • Formula: C22H42N4O8S2
  • CLOGP: -1.44
  • LIPINSKI: 3
  • HAC: 12
  • HDO: 8
  • TPSA: 197.32
  • ALOGS: -3.67
  • ROTB: 19

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 48.72 39.40 25 744 116097 63372156

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pneumonia 37.07 33.35 39 610 362588 34593694

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Platelet count decreased 59.15 29.62 41 1584 194623 79548140
Hepatic function abnormal 50.02 29.62 26 1599 73081 79669682
Ileus 45.94 29.62 18 1607 26193 79716570
Interstitial lung disease 44.55 29.62 28 1597 112572 79630191
Neutrophil count decreased 41.31 29.62 25 1600 93934 79648829
Pneumonia 37.88 29.62 56 1569 660190 79082573
Decreased appetite 33.68 29.62 38 1587 342380 79400383
Salivary hypersecretion 33.01 29.62 12 1613 14212 79728551
Pyrexia 29.82 29.62 51 1574 678658 79064105

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA32 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
CHEBI has role CHEBI:23354 coenzymes
CHEBI has role CHEBI:50733 Dietary Supplement

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 12.1 acidic
pKa2 12.7 acidic
pKa3 13.1 acidic
pKa4 13.7 acidic
pKa5 13.9 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D01234 KEGG_DRUG
C0070034 UMLSCUI
CHEBI:31959 CHEBI
CHEMBL2104786 ChEMBL_ID
DB11190 DRUGBANK_ID
C005425 MESH_SUPPLEMENTAL_RECORD_UI
7K81IL792L UNII
452306 PUBCHEM_CID
32863 RXNORM
006957 NDDF

Pharmaceutical products:

None