pamaquine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
quinoline derivatives 3416 491-92-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pamaquine
  • aminoquin
  • beprochine
  • pamaquin
  • plasmoquin
  • plasmoquine
  • praequine
  • prequine
  • Molecular weight: 315.46
  • Formula: C19H29N3O
  • CLOGP: 4.34
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 37.39
  • ALOGS: -3.78
  • ROTB: 9

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.470 Moderate 0.73
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.789 Moderate 0.73
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 37.584 10^-6 cm/s Moderate 0.73
dh-clint Dog hepatocyte intrinsic clearance 15.560 uL/min/10^6 cells Moderate 0.73
dppb Dog plasma protein binding (% unbound) 22.590 % Moderate 0.73
fcs-ppb Fetal calf serum protein binding (% unbound) 50.690 % Moderate 0.73
herg hERG pIC50 5.900 pIC50 Moderate 0.73
hh-clint Human hepatocyte intrinsic clearance 1.698 uL/min/10^6 cells Moderate 0.73
hlm-clint Human liver microsomal intrinsic clearance 15.596 uL/min/mg protein Moderate 0.73
hppb Human plasma protein binding (% unbound) 22.670 % Moderate 0.73
kinase-safety-class ACVR2A,ACVR2B,ALK,AURKA,AXL,BRAF,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK1,JAK2,KIT,MAP3K21,MAP3K7,MAP4K1,MAPK7,MARK4,MET,MTOR,NTRK2,PDK2,PDK4,PIK3CB,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 42
kinase-selectivity-class AXL,EIF2AK3,PDK4 3
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.703 Moderate 0.73
mh-clint Mouse hepatocyte intrinsic clearance 74.131 Moderate 0.73
mppb Mouse plasma protein binding (% unbound) 21.280 Moderate 0.73
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 5.649 Moderate 0.73
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 36.150 % Moderate 0.73
rh-clint Rat hepatocyte intrinsic clearance 82.414 uL/min/10^6 cells Moderate 0.73
rh-fuinc Rat hepatocyte fraction unbound in incubation 51.380 % Moderate 0.73
rppb Rat plasma protein binding (% unbound) 29.330 % Moderate 0.73
solubility-dd Solubility at pH 7.4 in DMSO 912.011 uM Moderate 0.73

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.0 Basic
pKa2 3.96 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
C0069991 UMLSCUI
CHEBI:135350 CHEBI
CHEMBL472698 ChEMBL_ID
C004331 MESH_SUPPLEMENTAL_RECORD_UI
10290 PUBCHEM_CID
408 INN_ID
99QVL5KPSU UNII

Pharmaceutical products:

None