bepotastine indications/contra

Stem definitionDrug idCAS RN
antihistaminics 341 125602-71-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bepotastine
  • bepotastine besilate
  • bepreve
  • bepotastine besylate
  • Molecular weight: 388.89
  • Formula: C21H25ClN2O3
  • CLOGP: 0.28
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 62.66
  • ALOGS: -3.89
  • ROTB: 8

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Sept. 8, 2009 FDA BAUSCH AND LOMB INC

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
FDA EPC N0000175587 Histamine-1 Receptor Antagonist
MeSH PA D018926 Anti-Allergic Agents
CHEBI has role CHEBI:37955 H1-receptor antagonist
CHEBI has role CHEBI:50857 anti-allergic agent

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Allergic conjunctivitis indication 473460002 DOID:11204

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.54 acidic
pKa2 9.51 Basic
pKa3 4.25 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Histamine H1 receptor GPCR ANTAGONIST DRUGBANK CHEMBL

External reference:

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IDSource
4029223 VUID
N0000181653 NUI
C2698371 UMLSCUI
7466 IUPHAR_LIGAND_ID
D01654 KEGG_DRUG
6W18MO1QR3 UNII
190786-44-8 SECONDARY_CAS_RN
863035 RXNORM
4029223 VANDF
N0000181653 NDFRT
010865 NDDF
707083009 SNOMEDCT_US
164522 PUBCHEM_CID
CHEMBL1201758 ChEMBL_ID
CHEMBL1201759 ChEMBL_ID
C108476 MESH_SUPPLEMENTAL_RECORD_UI
DB04890 DRUGBANK_ID
7648 INN_ID
C511534 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:71204 CHEBI

Pharmaceutical products:

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ProductCategoryIngredientsNDCFormQuantityRoute MarketingLabel
Bepreve HUMAN PRESCRIPTION DRUG LABEL 1 24208-629 SOLUTION/ DROPS 15 mg OPHTHALMIC NDA 14 sections
BEPREVE HUMAN PRESCRIPTION DRUG LABEL 1 54868-6299 SOLUTION/ DROPS 15 mg OPHTHALMIC NDA 14 sections