All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

oxidronic acid 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
calcium metabolism regulator, pharmaceutical aid	3409	15468-10-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: oxidronic acid hydroxymethanediphosphonic acid hydroxymethylenediphosphonate hydroxymethylenediphosphonic acid oxidronate disodium	Molecular weight: 192 Formula: CH6O7P2 CLOGP: -1 LIPINSKI: 0 HAC: 7 HDO: 5 TPSA: 135.29 ALOGS: -1.15 ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AKT3,ALK,AURKA,AURKC,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,CSF1R,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT1,FLT3,GRK2,GSK3B,ITK,JAK1,JAK2,JAK3,KDR,MAP2K6,MAP3K14,MAP3K2,MAP3K21,MAP3K7,MAP4K1,MAPK10,MAPK7,MAPK9,MTOR,NTRK1,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PIM2,PRKCD,PRKDC,SIK2,SIK3,SRC,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ZAP70	61
kinase-selectivity-class	AURKA,AXL,BMX,BRAF,CDK4,CDK9,DDR1,DYRK1B,EPHB4,ERBB2,GRK2,JAK2,MAP2K6,MAP3K14,MAPK7,PIK3CB,PIK3CD,PIK3CG,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70	24
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Bone scan abnormal	100.05	67.38	10	66	249	110588974

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	1.15	acidic
pKa2	5.22	acidic
pKa3	6.21	acidic
pKa4	10.27	acidic
pKa5	12.13	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D05296	KEGG_DRUG
14255-61-9	SECONDARY_CAS_RN
4018176	VANDF
C1337343	UMLSCUI
CHEBI:134844	CHEBI
CHEMBL1615775	ChEMBL_ID
DB14159	DRUGBANK_ID
27304	PUBCHEM_CID
C029285	MESH_SUPPLEMENTAL_RECORD_UI
4727	INN_ID
71MR4V32TI	UNII
1306067	RXNORM
23069	MMSL
009835	NDDF
009836	NDDF
1210491000168103	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Technescan HDP	HUMAN PRESCRIPTION DRUG LABEL	1	69945-091	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	3.15 mg	INTRAVENOUS	NDA	19 sections