benzylthiouracil indications/contra

Stem definitionDrug idCAS RN
uracil derivatives used as thyroid antagonists 339 6336-50-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • bentiuracil
  • basdene
  • 6-Benzyl-2-thiouracil
  • benzylthiouracil
  • Molecular weight: 218.27
  • Formula: C11H10N2OS
  • CLOGP: 1.48
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 2
  • TPSA: 41.13
  • ALOGS: -3.64
  • ROTB: 2

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC H03BA03 SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
THYROID THERAPY
ANTITHYROID PREPARATIONS
Thiouracils

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.72 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
C0053332 UMLSCUI
19084 RXNORM
005312 NDDF
713402004 SNOMEDCT_US
CHEBI:134902 CHEBI
CHEMBL1491306 ChEMBL_ID
PZ35LUM333 UNII
C019269 MESH_SUPPLEMENTAL_RECORD_UI
685814 PUBCHEM_CID

Pharmaceutical products:

None