nifuroxime 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
5-nitrofuran derivatives 3381 6236-05-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nifuroxime
  • nitrofuraldoxime
  • micofur
  • mycofur
  • nitrofuroxime
was MH 1976-92 (see under NITROFURANS 1976-90); use NITROFURANS to search NIFUROXIME 1976-92; topical anti-infective agent used in protozoal & fungal infections; proposed as a radiosensitizing agent with solid tumors
  • Molecular weight: 156.10
  • Formula: C5H4N2O4
  • CLOGP: 1.10
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 1
  • TPSA: 88.87
  • ALOGS: -2.56
  • ROTB: 2

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,ACVRL1,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK2,CDK4,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,IGF1R,IKBKB,ITK,JAK1,JAK2,JAK3,KIT,MAP2K6,MAP3K14,MAP3K21,MAP3K7,MAP4K1,MAPK1,MAPK10,MAPK12,MAPK7,MAPK8,MAPK9,MAPKAPK2,MAPKAPK5,MARK4,MELK,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ULK1,ULK2,ZAP70 75
kinase-selectivity-class AXL,BRAF,CDK9,DDR1,DYRK1B,EIF2AK3,GRK2,GSK3B,HIPK2,MAP2K3,MAP2K6,MAP3K14,MAPK1,MAPK7,MAPK8,PRKDC,STK33,SYK,TEK,TTK,UHMK1 21
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.59 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02515 KEGG_DRUG
C0028072 UMLSCUI
CHEMBL15721 ChEMBL_ID
5373493 PUBCHEM_CID
1002 INN_ID
C073332 MESH_SUPPLEMENTAL_RECORD_UI
465N7P5U85 UNII
002901 NDDF
6717002 SNOMEDCT_US
CHEBI:134784 CHEBI

Pharmaceutical products:

None