neridronic acid indications/contra

Stem definitionDrug idCAS RN
calcium metabolism regulator, pharmaceutical aid 3377 79778-41-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • neridronic acid
  • neridronate
used for therapy of Paget's disease of bone & malignant hypercalcaemia
  • Molecular weight: 277.15
  • Formula: C6H17NO7P2
  • CLOGP: -4.58
  • LIPINSKI: 1
  • HAC: 8
  • HDO: 6
  • TPSA: 161.31
  • ALOGS: -1.31
  • RINGS: 0
  • ROTB: 7

Drug dosage:

None

Approvals:

None

Pharmacologic Action:

None

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Humoral hypercalcemia of malignancy indication 47709007
Osteoporosis indication 64859006 DOID:11476

Bioactivity Summary:

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TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Farnesyl pyrophosphate synthase Enzyme Ki 7.20 CHEMBL

External reference:

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IDSource
DB11620 DRUGBANK_ID
C053389 MESH_SUPPLEMENTAL_RECORD_UI
6463 INN_ID
8U27U3RIN4 UNII
CHEBI:135145 CHEBI
71237 PUBCHEM_CID
CHEMBL55214 ChEMBL_ID

Pharmaceutical products:

None