benzylhydrochlorothiazide indications/contra

Stem definitionDrug idCAS RN
336 1824-50-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzylhydrochlorothiazide
  • benclortriazide
  • benzclortriazide
  • behyd
thiazide diuretic used as a blood pressure-lowering agent
  • Molecular weight: 387.85
  • Formula: C14H14ClN3O4S2
  • CLOGP: 1.57
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 3
  • TPSA: 118.36
  • ALOGS: -3.34
  • ROTB: 3

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

None

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Congestive heart failure indication 42343007 DOID:6000
Malignant hypertension indication 70272006 DOID:10824

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.84 acidic
pKa2 10.95 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
D01246 KEGG_DRUG
176437APQH UNII
008191 NDDF
2348 PUBCHEM_CID
CHEMBL1562084 ChEMBL_ID
C042169 MESH_SUPPLEMENTAL_RECORD_UI
CHEBI:31269 CHEBI

Pharmaceutical products:

None