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methyltestosterone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
androgens/anabolic steroids	3356	58-18-4

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: methyltestosterone 17-Methyltestosteron androsan androsten	A synthetic hormone used for androgen replacement therapy and as an hormonal antineoplastic agent (ANTINEOPLASTIC AGENTS, HORMONAL). Molecular weight: 302.46 Formula: C20H30O2 CLOGP: 3.93 LIPINSKI: 0 HAC: 2 HDO: 1 TPSA: 37.30 ALOGS: -4.34 ROTB: 0 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

methyltestosterone
17-Methyltestosteron
androsan
androsten

A synthetic hormone used for androgen replacement therapy and as an hormonal antineoplastic agent (ANTINEOPLASTIC AGENTS, HORMONAL).

Molecular weight: 302.46
Formula: C20H30O2
CLOGP: 3.93
LIPINSKI: 0
HAC: 2
HDO: 1
TPSA: 37.30
ALOGS: -4.34
ROTB: 0

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
25	mg	O

ADMET properties:

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Property	Value	Reference
BA (Bioavailability)	50 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Bocci G, Oprea TI, Benet LZ
S (Water solubility)	0.03 mg/mL	Bocci G, Oprea TI, Benet LZ

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Approvals:

Date	Agency	Company	Orphan
Dec. 3, 1973	FDA	VALEANT PHARM INTL

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	G03BA02	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM ANDROGENS 3-oxoandrosten (4) derivatives
ATC	G03EA01	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM ANDROGENS AND FEMALE SEX HORMONES IN COMBINATION Androgens and estrogens
ATC	G03EK01	GENITO URINARY SYSTEM AND SEX HORMONES SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM ANDROGENS AND FEMALE SEX HORMONES IN COMBINATION Androgens and female sex hormones in combination with other drugs
CHEBI has role	CHEBI:35610	antineoplastic agents
CHEBI has role	CHEBI:50113	androgene
FDA CS	M0001109	Androstanes
FDA EPC	N0000175824	Androgen
FDA MoA	N0000000146	Androgen Receptor Agonists
MeSH PA	D045930	Anabolic Agents
MeSH PA	D000970	Antineoplastic Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID
Deficiency of testosterone biosynthesis	indication	38825009
Inhibition of lactation procedure	indication	43141007
Male hypogonadism	indication	48723006
Menopausal flushing	indication	198436008
Delayed puberty	indication	400003000
Hormone receptor positive malignant neoplasm of breast	indication	417181009
Primary Hypogonadism due to Orchitis	indication
Primary Hypogonadism due to Bilateral Torsion	indication
LHRH Deficiency	indication
Bilateral Anorchia	indication

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Androgen receptor	Nuclear hormone receptor	P10275	ANDR_HUMAN	AGONIST	EC50	9.66	IUPHAR	CHEMBL
Glucocorticoid receptor	Nuclear hormone receptor	P04150	GCR_HUMAN		Ki	6.08	DRUG MATRIX
Sex hormone-binding globulin	Secreted	P04278	SHBG_HUMAN		Kd	8.43	CHEMBL
Androgen receptor	Transcription factor		ANDR_RAT		IC50	7.80	CHEMBL
Progesterone receptor	Transcription factor		Q690N0_BOVIN		Ki	7.48	DRUG MATRIX

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External reference:

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ID	Source
001249	NDDF
1048	MMSL
126161000	SNOMEDCT_US
399	INN_ID
4017433	VUID
4017433	VANDF
42348003	SNOMEDCT_US
5096	MMSL
6010	PUBCHEM_CID
6904	RXNORM

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
COVARYX	HUMAN PRESCRIPTION DRUG LABEL	2	11528-010	TABLET, COATED	2.50 mg	ORAL	unapproved drug other	14 sections
COVARYXHS	HUMAN PRESCRIPTION DRUG LABEL	2	11528-020	TABLET, COATED	1.25 mg	ORAL	unapproved drug other	14 sections
EEMT	HUMAN PRESCRIPTION DRUG LABEL	2	15310-010	TABLET, COATED	2.50 mg	ORAL	unapproved drug other	13 sections
EEMTHS	HUMAN PRESCRIPTION DRUG LABEL	2	15310-020	TABLET, COATED	1.25 mg	ORAL	unapproved drug other	13 sections
Esterified Estrogen and Methyltestosterone	HUMAN PRESCRIPTION DRUG LABEL	2	13925-180	TABLET	1.25 mg	ORAL	unapproved drug other	22 sections
Esterified Estrogen and Methyltestosterone	HUMAN PRESCRIPTION DRUG LABEL	2	13925-181	TABLET	2.50 mg	ORAL	unapproved drug other	22 sections
Esterified Estrogens and Methyltestosterone	HUMAN PRESCRIPTION DRUG LABEL	2	50220-001	TABLET, FILM COATED	1.25 mg	ORAL	Unapproved drug other	13 sections
Esterified Estrogens and Methyltestosterone	HUMAN PRESCRIPTION DRUG LABEL	2	50220-002	TABLET, FILM COATED	2.50 mg	ORAL	Unapproved drug other	13 sections
Esterified Estrogens and Methyltestosterone	HUMAN PRESCRIPTION DRUG LABEL	2	51293-639	TABLET	1.25 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections
Esterified Estrogens and Methyltestosterone	HUMAN PRESCRIPTION DRUG LABEL	2	51293-639	TABLET	1.25 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections

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