melarsoprol indications/contra

Stem definitionDrug idCAS RN
3336 494-79-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • melarsoprol
  • arsobal
  • melarsen B
  • melarsaprol
Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.
  • Molecular weight: 398.33
  • Formula: C12H15AsN6OS2
  • CLOGP: 2.48
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 4
  • TPSA: 122.97
  • ALOGS: -2.70
  • ROTB: 4

Drug dosage:

DoseUnitRoute
60 mg P

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC P01CD01 ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
ANTIPROTOZOALS
AGENTS AGAINST LEISHMANIASIS AND TRYPANOSOMIASIS
Arsenic compounds
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000977 Antiparasitic Agents
MeSH PA D000981 Antiprotozoal Agents
MeSH PA D014344 Trypanocidal Agents

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
African trypanosomiasis indication 27031003 DOID:10112

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.55 Basic
pKa2 1.28 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
D00832 KEGG_DRUG
17990002 SNOMEDCT_US
N0000166777 NDFRT
002964 NDDF
714136007 SNOMEDCT_US
CHEMBL166 ChEMBL_ID
10311 PUBCHEM_CID
D008549 MESH_DESCRIPTOR_UI
DB12864 DRUGBANK_ID
ZF3786Q2E8 UNII
457 INN_ID
CHEBI:6729 CHEBI

Pharmaceutical products:

None