mebrofenin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
diagnostic aids; (phenylcarbamoyl)methyl iminodiacetic acid derivatives	3332	78266-06-5

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

mebrofenin

Molecular weight: 387.23
Formula: C15H19BrN2O5
CLOGP: 1.36
LIPINSKI: 0
HAC: 7
HDO: 3
TPSA: 106.94
ALOGS: -3.83
ROTB: 7

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,ACVRL1,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GSK3B,IKBKB,ITK,JAK1,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPK9,MAPKAPK2,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CA,PIK3CB,PIK3CD,PIK3CG,PIM2,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TGFBR1,TTK,ZAP70	53
kinase-selectivity-class	AXL,BRAF,CDK9,DDR1,EPHB4,ERBB2,GRK2,MAP2K6,MAPK7,PIK3CD,PRKDC,TEK	12
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple use of single-use product	190.05	110.78	21	35	1802	90626589

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Multiple use of single-use product	270.30	139.33	28	43	1268	110587960

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

None

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	1.35	acidic
pKa2	2.54	acidic
pKa3	12.95	acidic
pKa4	7.72	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
D04869	KEGG_DRUG
4038253	VANDF
C1337345	UMLSCUI
CHEBI:135608	CHEBI
CHEMBL1605443	ChEMBL_ID
DB15779	DRUGBANK_ID
C000714007	MESH_SUPPLEMENTAL_RECORD_UI
54158	PUBCHEM_CID
5184	INN_ID
7PV0B6ED98	UNII
1311500	RXNORM
25101	MMSL
d07088	MMSL
009840	NDDF

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Choletec	HUMAN PRESCRIPTION DRUG LABEL	1	0270-0083	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	45 mg	INTRAVENOUS	NDA	17 sections
Kit for the Preparation of Technetium Tc 99m Mebrofenin	HUMAN PRESCRIPTION DRUG LABEL	1	45567-0455	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	45 mg	INTRAVENOUS	ANDA	15 sections
Mebrofenin	HUMAN PRESCRIPTION DRUG LABEL	1	51808-216	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	10 mg	INTRAVENOUS	Unapproved drug other	5 sections