benzquinamide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
331 63-12-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzquinamide
  • benzquinamide hydrochloride
  • emeticon
  • promecon
  • benzquinamide HCl
  • Molecular weight: 404.51
  • Formula: C22H32N2O5
  • CLOGP: 2.82
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 0
  • TPSA: 68.31
  • ALOGS: -2.92
  • ROTB: 7

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 36 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
March 12, 1974 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
CHEBI has role CHEBI:35476 neuroleptics
CHEBI has role CHEBI:35717 hypnotics
CHEBI has role CHEBI:37955 H1 receptor antagonists
CHEBI has role CHEBI:48876 muscarinic antagonists
CHEBI has role CHEBI:50919 antiemetico

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Postoperative nausea and vomiting indication 1488000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.72 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
D(2) dopamine receptor GPCR AGONIST Ki 5.40 IUPHAR CHEMBL
D(3) dopamine receptor GPCR Ki 5.45 PDSP
Prostaglandin G/H synthase 2 Enzyme INHIBITOR IC50 8.32 IUPHAR
Alpha-2A adrenergic receptor GPCR Ki 5.87 SCIENTIFIC LITERATURE
Alpha-2B adrenergic receptor GPCR Ki 6.16 SCIENTIFIC LITERATURE
Alpha-2C adrenergic receptor GPCR Ki 6.26 SCIENTIFIC LITERATURE
D(4) dopamine receptor GPCR Ki 6.24 PDSP

External reference:

IDSource
4019629 VUID
N0000147722 NUI
D00243 KEGG_DRUG
113-69-9 SECONDARY_CAS_RN
19041 RXNORM
C0053284 UMLSCUI
CHEBI:27662 CHEBI
CHEMBL1201250 ChEMBL_ID
DB00767 DRUGBANK_ID
C100234 MESH_SUPPLEMENTAL_RECORD_UI
2342 PUBCHEM_CID
7124 IUPHAR_LIGAND_ID
1402 INN_ID
0475EA27Q3 UNII
13659003 SNOMEDCT_US
400718006 SNOMEDCT_US
CHEMBL1200707 ChEMBL_ID
4018510 VANDF
4019629 VANDF
23844-24-8 SECONDARY_CAS_RN
001683 NDDF
004681 NDDF

Pharmaceutical products:

None